PA8843901A1 - INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR - Google Patents
INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TORInfo
- Publication number
- PA8843901A1 PA8843901A1 PA20098843901A PA8843901A PA8843901A1 PA 8843901 A1 PA8843901 A1 PA 8843901A1 PA 20098843901 A PA20098843901 A PA 20098843901A PA 8843901 A PA8843901 A PA 8843901A PA 8843901 A1 PA8843901 A1 PA 8843901A1
- Authority
- PA
- Panama
- Prior art keywords
- pyrimidinone
- pi3k
- alfa
- tor
- inhibitors
- Prior art date
Links
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 title 1
- YCIPQJTZJGUXND-UHFFFAOYSA-N Aglaia odorata Alkaloid Natural products C1=CC(OC)=CC=C1C1(C(C=2C(=O)N3CCCC3=NC=22)C=3C=CC=CC=3)C2(O)C2=C(OC)C=C(OC)C=C2O1 YCIPQJTZJGUXND-UHFFFAOYSA-N 0.000 title 1
- 108091007960 PI3Ks Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19476108P | 2008-09-30 | 2008-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8843901A1 true PA8843901A1 (es) | 2010-05-26 |
Family
ID=41572575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20098843901A PA8843901A1 (es) | 2008-09-30 | 2009-09-29 | INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8101622B2 (enExample) |
| EP (1) | EP2350070A1 (enExample) |
| JP (1) | JP2012504628A (enExample) |
| AR (1) | AR073524A1 (enExample) |
| PA (1) | PA8843901A1 (enExample) |
| TW (1) | TW201018685A (enExample) |
| UY (1) | UY32153A (enExample) |
| WO (1) | WO2010039740A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1931645T3 (pl) * | 2005-10-07 | 2014-12-31 | Exelixis Inc | Pochodne N-(3-amino-chinoksalin-2-ylo)-sulfonamidu i ich zastosowanie jako inhibitorów kinazy-3 fosfatydyloinozytolu |
| BRPI0617159B8 (pt) * | 2005-10-07 | 2021-05-25 | Exelixis Inc | compostos de piridopirimidinone inibidores de pi3ka, composições que os contem e processo para preparo |
| EP2056829B9 (en) | 2006-08-16 | 2012-09-26 | Exelixis, Inc. | Using pi3k and mek modulators in treatments of cancer |
| ATE514695T1 (de) | 2006-09-15 | 2011-07-15 | Pfizer Prod Inc | Pyrido(2,3-d)pyrimidinonverbindungen und ihre verwendung als pi3-inhibitoren |
| NZ580110A (en) * | 2007-04-10 | 2012-06-29 | Exelixis Inc | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha |
| JP2010523677A (ja) * | 2007-04-11 | 2010-07-15 | エクセリクシス， インク． | 癌の治療のためのＰＩ３Ｋα阻害剤としてのピリド［２，３−Ｄ］ピリミジン−７−オン |
| AR080151A1 (es) | 2010-02-09 | 2012-03-14 | Exelixis Inc | Metodos para tratar cancer usando inhibidores de piridopirimidinona de pi 3k y mtor en combinacion con inhibidores de autofagia |
| ES2693257T3 (es) | 2010-09-14 | 2018-12-10 | Exelixis, Inc. | Inhibidores de PI3K-delta y métodos para su uso y fabricación |
| JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン， エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
| MX2013012486A (es) * | 2011-04-29 | 2014-05-28 | Exelixis Inc | Metodo para tratar linfoma usando inhibidores de piridopirimidinona de fosfonio sitol 3-cinasa/diana de rapalamina en celulas de mamifero (pi3k/mtor). |
| JP6013498B2 (ja) | 2011-11-01 | 2016-10-25 | エクセリクシス， インク． | リンパ増殖性悪性疾患の治療のためのホスファチジルイノシトール３−キナーゼ阻害剤としてのｎ−（３−｛［（３−｛［２−クロロ−５−（メトキシ）フェニル］アミノ｝キノキサリン−２−イル）アミノ］スルホニル｝フェニル）−２−メチルアラニンアミド |
| EP3266455B1 (en) | 2015-03-06 | 2020-12-30 | Korea Advanced Institute of Science and Technology | Composition for prevention or treatment of intractable epilepsy comprising mtor inhibitor |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| EP3980010A4 (en) | 2019-06-04 | 2023-06-07 | Arcus Biosciences, Inc. | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS |
| WO2021139775A1 (zh) * | 2020-01-10 | 2021-07-15 | 江苏先声药业有限公司 | 吡啶酮化合物及应用 |
| CN113577080B (zh) * | 2020-04-30 | 2022-12-09 | 广州嘉越医药科技有限公司 | 一种含杂环的化合物的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| AU749750B2 (en) | 1997-02-05 | 2002-07-04 | Warner-Lambert Company | Pyrido {2,3-d} pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
| BR0017075A (pt) | 2000-01-27 | 2002-11-05 | Warner Lambert Co | Derivados de piridopirimidinona para tratamento de doença neurodegenerativa |
| KR20020075805A (ko) | 2000-03-06 | 2002-10-05 | 워너-램버트 캄파니 | 5-알킬피리도[2,3-ｄ]피리미딘 타이로신 카이나제 억제제 |
| ES2360933T3 (es) | 2000-04-27 | 2011-06-10 | Astellas Pharma Inc. | Derivados de heteroarilo condensados. |
| NZ527741A (en) | 2001-02-26 | 2005-02-25 | Tanabe Seiyaku Co | Pyridopyrimidine or naphthyridine derivative |
| WO2003000270A1 (en) * | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel pyridopyrimidones and uses thereof |
| US7019002B2 (en) | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
| DE60315826T2 (de) | 2002-04-19 | 2008-05-21 | Smithkline Beecham Corp. | Neue verbindungen |
| MXPA04010983A (es) | 2002-05-06 | 2005-02-14 | Genelabs Tech Inc | Derivados de nucleosidos para tratar infecciones por el virus de la hepatitis c. |
| JP2004083587A (ja) | 2002-08-06 | 2004-03-18 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| WO2004063195A1 (en) | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
| WO2004089930A1 (en) | 2003-04-02 | 2004-10-21 | Imclone Systems Incorporated | 4-fluoroquinolone derivatives and their use as kinase inhibitors |
| WO2005040337A2 (en) | 2003-05-20 | 2005-05-06 | The Regents Of The University Of California | METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES |
| CA2555724A1 (en) | 2004-02-18 | 2005-09-09 | Warner-Lambert Company Llc | 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
| WO2005105801A1 (en) * | 2004-05-04 | 2005-11-10 | Warner-Lambert Company Llc | Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and derivatives thereof as therapeutic agents |
| AU2005316668B2 (en) | 2004-12-13 | 2012-09-06 | Millennium Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
| BRPI0617159B8 (pt) * | 2005-10-07 | 2021-05-25 | Exelixis Inc | compostos de piridopirimidinone inibidores de pi3ka, composições que os contem e processo para preparo |
| CN102746298A (zh) * | 2005-10-07 | 2012-10-24 | 埃克塞里艾克西斯公司 | PI3Kα的吡啶并嘧啶酮抑制剂 |
| ATE514695T1 (de) * | 2006-09-15 | 2011-07-15 | Pfizer Prod Inc | Pyrido(2,3-d)pyrimidinonverbindungen und ihre verwendung als pi3-inhibitoren |
| MX2009010815A (es) * | 2007-04-11 | 2009-10-29 | Exelixis Inc | Inhibidores de piridopirimidinona de pi3k-alfa. |
-
2009
- 2009-09-29 UY UY0001032153A patent/UY32153A/es not_active Application Discontinuation
- 2009-09-29 JP JP2011530150A patent/JP2012504628A/ja active Pending
- 2009-09-29 US US12/569,760 patent/US8101622B2/en not_active Expired - Fee Related
- 2009-09-29 PA PA20098843901A patent/PA8843901A1/es unknown
- 2009-09-29 EP EP09737495A patent/EP2350070A1/en not_active Withdrawn
- 2009-09-29 AR ARP090103759A patent/AR073524A1/es not_active Application Discontinuation
- 2009-09-29 WO PCT/US2009/058881 patent/WO2010039740A1/en not_active Ceased
- 2009-09-29 TW TW098133017A patent/TW201018685A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR073524A1 (es) | 2010-11-10 |
| TW201018685A (en) | 2010-05-16 |
| US20100087456A1 (en) | 2010-04-08 |
| US8101622B2 (en) | 2012-01-24 |
| WO2010039740A1 (en) | 2010-04-08 |
| JP2012504628A (ja) | 2012-02-23 |
| EP2350070A1 (en) | 2011-08-03 |
| UY32153A (es) | 2011-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PA8843901A1 (es) | INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR | |
| ECSP12011799A (es) | Compuestos de espiropiperidina y uso farmacéutico de los mismos | |
| ECSP11011258A (es) | Pirimidinas fusionadas | |
| BR112012011086A2 (pt) | uso de betanecol para o tratamento de xerostomia | |
| CR11232A (es) | Compuestos de tiazolopirina modulares de sirtuina | |
| CY1116987T1 (el) | Συμπυκνωμενα ιμιδαζολυλιμιδαζολια ως αντιϊικες ενωσεις | |
| DOP2014000133A (es) | Triazolopiridinas sustituidas | |
| CO6620055A2 (es) | Ciertas amino-pirimidinas, composiciones de las mismas y métodos para el uso de los mismos | |
| CL2012002189A1 (es) | Compuestos derivados de pirrolidina-2-carboxamidas sustituidas; inhibidores de la interaccion mdm2-p53; composicion farmaceutica; y su uso para el tratamiento del cancer, en particular de tumores solidos. | |
| ECSP13012596A (es) | Proceso de elaboración para derivados de pirimidina | |
| SV2011003853A (es) | Compuestos organicos | |
| ECSP109856A (es) | Derivados de oxadiazol y su uso como potenciadores de los receptores metabotrópicos de glutamato - 842 | |
| MX2016006336A (es) | Compuestos pirazolopirimidina. | |
| MX386224B (es) | Activadores de cinasa de piruvato para su uso en terapia. | |
| GT201200164A (es) | "nuevos compuestos de espiropiperidina" | |
| ECSP13013011A (es) | Triazolopiridinas | |
| CR20110264A (es) | Pirazolilaminopiridinas como inhibidores de fak | |
| ECSP12012338A (es) | Triazolopiridinas sustituidas | |
| EA201270280A1 (ru) | Соединения пиримидина в качестве ингибиторов при лечении туберкулеза | |
| CL2011002911A1 (es) | Compuestos derivados de benzamidas, inhibidores de serina proteasa; composición farmacéutica; uso del compuesto para tratar cáncer. | |
| CL2008001074A1 (es) | Uso de compuestos de triazol, antagonistas de smo para tratar cancer. | |
| SV2009003389A (es) | Compuestos de pirido [2,3-d] pirimidina-7-ona como inhibidores de p13k-alfa para el tratamiento del cancer | |
| CL2013003487A1 (es) | Uso de un compuesto derivado de fosforamidato de nucleosido para tratar la fiebre dengue y compuestos especificos. | |
| DOP2015000176A (es) | Compuestos de azetidiniloxifenilpirrolidina | |
| EA201590656A1 (ru) | Азаиндолины |