PA8582901A1 - Compuestos de piperidinil-imidazopiridina n- sustituidos como moduladores del receptor 5 ht4 - Google Patents

Compuestos de piperidinil-imidazopiridina n- sustituidos como moduladores del receptor 5 ht4

Info

Publication number
PA8582901A1
PA8582901A1 PA20038582901A PA8582901A PA8582901A1 PA 8582901 A1 PA8582901 A1 PA 8582901A1 PA 20038582901 A PA20038582901 A PA 20038582901A PA 8582901 A PA8582901 A PA 8582901A PA 8582901 A1 PA8582901 A1 PA 8582901A1
Authority
PA
Panama
Prior art keywords
groups
group
compound
pharmaceutically acceptable
carbon atoms
Prior art date
Application number
PA20038582901A
Other languages
English (en)
Inventor
Yasuhiro Katsu
Hirohide Noguchi
Kana Kon-I
Mikio Morita
Chikara Uchida
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32030864&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8582901(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of PA8582901A1 publication Critical patent/PA8582901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

ESTA INVENCION PROPORCIONA UN COMPUESTO DE FORMULA (1): EN LA R1 REPRESENTA UN ATOMO DE HIDROGENO O UN ATOMO DE HALOGENO; R2 REPRESENTA UN ATOMO DE HIDROGENO, ETC.; R3 REPRESENTA UN GRUPO ALQUILO QUE TIENE DE 1 A 10 ATOMOS DE CARBONO, DICHO GRUPO ALQUILO EN R3 ESTA SUSTITUIDO CON AL MENOS UN SUSTITUYENTE SELECCIONADO DEL GRUPO QUE CONSTA DE SUSTITUYENTES ALPHA; DICHOS SUSTITUYENTES ALPHA SE SELECCIONAN DEL GRUPO QUE CONSTA DE GRUPOS ARILO, GRUPOS OXO, ETC.; DICHOS GRUPOS ARILO TIENE DE 6 A 10 ATOMOS DE CARBONO; DICHOS GRUPOS ARILO NO ESTAN SUSTITUIDOS O ESTAN SUSTITUIDOS CON AL MENOS UN GRUPO ALQUILO QUE TIENE DE 1 A 6 ATOMOS DE CARBONO; DICHOS GRUPOS HETEROCICLO Y RESTO HETEROCICLO EN LOS GRUPOS HETEROCICLOCARBONILO SON GRUPOS CICLICOS DE 5 A 10 MIEMBROS QUE CONTIENEN DE 1 A 4 HETEROATOMOS SELECCIONADOS DEL GRUPO QUE CONSTA DE ATOMOS DE NITROGENO, ETC.; O UNA AMIDA FARMACEUTICAMENTE ACEPTABLE DE DICHO COMPUESTO, O UN ESTER FARMACEUTICAMENTE ACEPTABLE DE DICHO COMPUESTO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS TIENEN ACTIVIDAD DE UNION AL RECEPTOR 5-HT4, Y POR LO TANTO SON UTILES PARA TRATAR LA ENFERMEDAD DE REFLUJO GASTROESOFAGICO, DISPEPSIA NO ULCEROSA, DISPEPSIA FUNCIONAL, SINDROME DEL INTESTINO IRRITABLE O SIMILARES, EN UN MAMIFERO, ESPECIALMENTE SERES HUMANOS. ESTA INVENCION TAMBIEN PROPORCIONA UNA COMPOSICION FARMACEUTICA QUE COMPRENDE EL COMPUESTO ANTERIOR.
PA20038582901A 2002-09-20 2003-09-16 Compuestos de piperidinil-imidazopiridina n- sustituidos como moduladores del receptor 5 ht4 PA8582901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41242602P 2002-09-20 2002-09-20

Publications (1)

Publication Number Publication Date
PA8582901A1 true PA8582901A1 (es) 2004-05-26

Family

ID=32030864

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038582901A PA8582901A1 (es) 2002-09-20 2003-09-16 Compuestos de piperidinil-imidazopiridina n- sustituidos como moduladores del receptor 5 ht4

Country Status (13)

Country Link
US (1) US6951867B2 (es)
EP (1) EP1543004A1 (es)
JP (1) JP2006502180A (es)
AR (1) AR041303A1 (es)
AU (1) AU2003259482A1 (es)
BR (1) BR0314584A (es)
CA (1) CA2499494A1 (es)
GT (1) GT200300208A (es)
MX (1) MXPA05003065A (es)
PA (1) PA8582901A1 (es)
TW (1) TW200406412A (es)
UY (1) UY27992A1 (es)
WO (1) WO2004026868A1 (es)

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DK1689742T3 (da) * 2003-11-24 2010-05-17 Pfizer Quinoloncarboxylsyreforbindelser med 5-HT-receptor-agonistisk aktivitet
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
MXPA06014486A (es) * 2004-06-15 2007-03-01 Pfizer Derivados de acido carboxilico de bencimidazolona.
US7737163B2 (en) * 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
EP1807422B1 (en) 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
US7396933B2 (en) 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
ATE469897T1 (de) 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
BRPI0608392A2 (pt) 2005-03-02 2009-12-29 Theravance Inc compostos de quinolinona como agonistas do receptor 5-ht4
MY147756A (en) 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
GB0603550D0 (en) * 2006-02-22 2006-04-05 Glaxo Group Ltd Novel compounds
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009023253A2 (en) * 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
EP3239170B1 (en) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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US8232315B2 (en) 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
JP5901528B2 (ja) 2009-11-06 2016-04-13 エスケー バイオファーマスティカルズ カンパニー リミテッド 線維筋痛症候群の治療方法
JP5836280B2 (ja) 2009-11-06 2015-12-24 エスケー バイオファーマスティカルズ カンパニー リミテッド 注意欠陥／多動性障害（ａｄｈｄ）の治療方法
MX343165B (es) * 2010-02-12 2016-10-26 Raqualia Pharma Inc Agonistas del receptor 5-ht4 para el tratamiento de demencia.
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2015342887B2 (en) 2014-11-06 2020-09-10 Bial - R&D Investments, S.A. Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
JP7034935B2 (ja) 2016-04-06 2022-03-14 リソソーマル・セラピューティクス・インコーポレイテッド ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
WO2017176961A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
MX2018012211A (es) 2016-04-06 2019-03-28 Lysosomal Therapeutics Inc Compuestos de pirazol[1,5-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos.
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Also Published As

Publication number Publication date
AU2003259482A1 (en) 2004-04-08
WO2004026868A1 (en) 2004-04-01
MXPA05003065A (es) 2005-05-27
EP1543004A1 (en) 2005-06-22
AR041303A1 (es) 2005-05-11
TW200406412A (en) 2004-05-01
US20040127514A1 (en) 2004-07-01
GT200300208A (es) 2004-05-20
CA2499494A1 (en) 2004-04-01
UY27992A1 (es) 2004-04-30
US6951867B2 (en) 2005-10-04
BR0314584A (pt) 2005-08-09
JP2006502180A (ja) 2006-01-19

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