PA8448801A1 - HIV PROTEASE INHIBITORS - Google Patents

HIV PROTEASE INHIBITORS

Info

Publication number
PA8448801A1
PA8448801A1 PA19988448801A PA8448801A PA8448801A1 PA 8448801 A1 PA8448801 A1 PA 8448801A1 PA 19988448801 A PA19988448801 A PA 19988448801A PA 8448801 A PA8448801 A PA 8448801A PA 8448801 A1 PA8448801 A1 PA 8448801A1
Authority
PA
Panama
Prior art keywords
hiv protease
hiv
protease inhibitors
compounds
viruses
Prior art date
Application number
PA19988448801A
Other languages
Spanish (es)
Inventor
Kim ALBIZATI
Siegfried Heinz Reich
Michael D Varney
Kanyin E Zhang
Takuo Kobayashi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PA8448801A1 publication Critical patent/PA8448801A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/36Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS INHIBIDORES DE LA PROTEASA DEL VIH, OBTENIBLES POR SINTESIS QUIMICA, INHIBEN O BLOQUEAN LA ACTIVIDAD BIOLOGICA DE LA ENZIMA DE LA PROTEASA DEL VIH, HACIENDO QUE TERMINE LA REPLICACION DEL VIRUS DEL VIH. ESTOS COMPUESTOS, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y OPCIONALMENTE OTROS AGENTES ANTIVIRICOS COMO INGREDIENTES ACTIVOS, SON APTOS PARA TRATAR A PACIENTES O HUESPEDES INFECTADOS CON EL VIRUS DEL VIH QUE SE CONOCE COMO CAUSA DEL SIDA.INHIBITORS OF HIV PROTEASE, OBTAINABLE BY CHEMICAL SYNTHESIS, INHIBIT OR BLOCK THE BIOLOGICAL ACTIVITY OF THE HIV PROTEASE ENZYME, CAUSING THE REPLICATION OF HIV VIRUSES TO END. THESE COMPOUNDS, AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND OPTIONALLY OTHER ANTIVIRICAL AGENTS AS ACTIVE INGREDIENTS, ARE SUITABLE FOR TREATING PATIENTS OR HOSTS INFECTED WITH THE HIV VIRUSES THAT ARE KNOWN AS AIDS CAUSES.

PA19988448801A 1997-03-13 1998-03-13 HIV PROTEASE INHIBITORS PA8448801A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81595197A 1997-03-13 1997-03-13

Publications (1)

Publication Number Publication Date
PA8448801A1 true PA8448801A1 (en) 2000-05-24

Family

ID=25219265

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988448801A PA8448801A1 (en) 1997-03-13 1998-03-13 HIV PROTEASE INHIBITORS

Country Status (35)

Country Link
EP (1) EP0970055A2 (en)
JP (1) JP2001516350A (en)
KR (1) KR100511089B1 (en)
CN (1) CN1179948C (en)
AP (1) AP1358A (en)
AR (1) AR012556A1 (en)
AU (1) AU743078B2 (en)
BG (1) BG63540B1 (en)
BR (1) BR9808867A (en)
CA (1) CA2284163A1 (en)
CO (1) CO4940496A1 (en)
CZ (1) CZ296647B6 (en)
EA (1) EA002378B1 (en)
EE (1) EE04114B1 (en)
GE (1) GEP20022764B (en)
HR (1) HRP980112A2 (en)
HU (1) HUP0001380A3 (en)
IL (2) IL131870A0 (en)
IS (1) IS5176A (en)
MX (1) MXPA99008395A (en)
MY (1) MY117535A (en)
NO (1) NO315555B1 (en)
NZ (1) NZ337706A (en)
OA (1) OA11196A (en)
PA (1) PA8448801A1 (en)
PE (1) PE58799A1 (en)
PL (1) PL192786B1 (en)
SA (1) SA98181116B1 (en)
SK (1) SK283636B6 (en)
SV (1) SV1998000038A (en)
TR (1) TR199902508T2 (en)
TW (1) TW200517112A (en)
UA (1) UA57772C2 (en)
WO (1) WO1998040357A2 (en)
ZA (1) ZA982047B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
CO4940496A1 (en) 2000-07-24
HUP0001380A2 (en) 2000-09-28
IS5176A (en) 1999-09-10
IL131870A0 (en) 2001-03-19
KR20000076236A (en) 2000-12-26
EE9900416A (en) 2000-04-17
SV1998000038A (en) 1999-02-15
CA2284163A1 (en) 1998-09-17
CZ296647B6 (en) 2006-05-17
EA002378B1 (en) 2002-04-25
AU743078B2 (en) 2002-01-17
HUP0001380A3 (en) 2001-12-28
BG103727A (en) 2000-04-28
CZ319199A3 (en) 2000-06-14
KR100511089B1 (en) 2005-08-31
SA98181116B1 (en) 2006-10-04
EA199900823A1 (en) 2000-04-24
EP0970055A2 (en) 2000-01-12
PL192786B1 (en) 2006-12-29
JP2001516350A (en) 2001-09-25
NO994415L (en) 1999-11-10
MY117535A (en) 2004-07-31
NZ337706A (en) 2001-04-27
NO315555B1 (en) 2003-09-22
NO994415D0 (en) 1999-09-10
SK283636B6 (en) 2003-11-04
TW200517112A (en) 2005-06-01
UA57772C2 (en) 2003-07-15
BR9808867A (en) 2000-07-11
WO1998040357A2 (en) 1998-09-17
AP1358A (en) 2004-12-03
EE04114B1 (en) 2003-08-15
AR012556A1 (en) 2000-11-08
PL335672A1 (en) 2000-05-08
AP9901648A0 (en) 1999-09-30
AU6457598A (en) 1998-09-29
PE58799A1 (en) 1999-07-12
CN1253548A (en) 2000-05-17
IL131870A (en) 2006-04-10
BG63540B1 (en) 2002-04-30
HRP980112A2 (en) 1998-12-31
WO1998040357A3 (en) 1998-11-26
SK122299A3 (en) 2000-05-16
OA11196A (en) 2003-05-21
TR199902508T2 (en) 2000-02-21
ZA982047B (en) 1998-09-28
MXPA99008395A (en) 2003-08-12
CN1179948C (en) 2004-12-15
GEP20022764B (en) 2002-08-26

Similar Documents

Publication Publication Date Title
ES2181725T3 (en) HIV PROTEASA INHIBITORS.
ES2171670T3 (en) SULFONAMIDS CONTAINING OXYGEN HETEROCICLES AS INHIBITORS OF THE ASPARTIL PROTEASA.
ES2151600T3 (en) DERIVATIVES OF N- (3-AMINO-2-HYDROXIBUTE) SULFONAMIDE USED AS HIV PROTEASE INHIBITORS.
MX9307821A (en) NEW KIND OF PROTEASE ASPARTILE INHIBITORS.
ES2065471T3 (en) ANTIBACTERIAL AQUEOUS COMPOSITIONS INCLUDING A SURFACTANT AND BACTERIOPHAGUS.
AR031520A1 (en) AN INHIBITOR COMPOSITE OF ASPARTILO PROTEASA, A COMPOSITION THAT INCLUDES IT AND A METHOD TO TREAT A PATIENT WITH SUCH COMPOSITION
EA200400026A1 (en) HIV PROTEASE INHIBITORS, CONTAINING THEIR COMPOSITIONS, THEIR PHARMACEUTICAL APPLICATIONS AND SUBSTANCES FOR THEIR SYNTHESIS
PE20060148A1 (en) PHARMACEUTICAL COMPOSITION TO TREAT HIV INFECTION
PA8429901A1 (en) ANTIPICORNAVIRAL COMPOUNDS AND METHODS FOR USE AND PREPARATION
BR9711647A (en) New derivatives of Dicafeoilquímica, their use, compositions with them and treatment methods using them.
UY28048A1 (en) HIV-INTEGRESS INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
ES2132383T3 (en) PROTEASE HIV INHIBITORS.
AR009935A1 (en) AN EFFECTIVE COMPOUND TO INHIBIT ASPARTILPROTEASE, COMPOSITIONS THAT INCORPORATE IT AND METHODS TO PREVENT OR TREAT HIV INFECTIONS
PA8448801A1 (en) HIV PROTEASE INHIBITORS
ECSP982442A (en) HIV PROTEASE INHIBITORS
GT199800049A (en) METHOD FOR OBTAINING VHI PROTEASE INHIBITORS.
ES2076248T3 (en) SUBSTITUTED DIBENZOFURANES AND METHODS FOR THE USE OF THEM.
AR013087A1 (en) FORM V OF AMPRENAVIR, ITS USE AS ANTIVIRAL COMPOUND, A PROCESS TO PREPARE IT, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT
EE9900188A (en) 1- (3-Aminoindazol-5-yl) -3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
DOP2003000733A (en) HIV-INTEGRESS INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
ES2081782T3 (en) EXTRACTS FROM PILIOSTIGMA THONNINGIL, ITS USE AND FORMULATIONS CONTAINING THEM.
ECSP003786A (en) RANGE-HYDROXIL-2 (FLUOROALQUILOAMINOCARBONIL) -1-PIPERACINAPENTANAMIDAS AND USES OF THEM
UY27331A1 (en) HIV PROTEASE INHIBITORS, COMPOSITIONS THAT CONTAIN THEM, THEIR PHARMACEUTICAL AND MATERIAL USES FOR SYNTHESIS
MX9400210A (en) TREATMENT OF VIRAL INFECTIONS.
ECSP972118A (en) ANTICORNAVIRAL COMPOUNDS AND METHODS FOR USE AND PREPARATION