CO4940496A1 - HIV PROTEASE INHIBITORS - Google Patents
HIV PROTEASE INHIBITORSInfo
- Publication number
- CO4940496A1 CO4940496A1 CO98014251A CO98014251A CO4940496A1 CO 4940496 A1 CO4940496 A1 CO 4940496A1 CO 98014251 A CO98014251 A CO 98014251A CO 98014251 A CO98014251 A CO 98014251A CO 4940496 A1 CO4940496 A1 CO 4940496A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- group
- cycloalkyl
- aryl
- acyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula (9): donde: R y R´ se seleccionan independientemente de H, un grupo de alquil-OR1 sustituido por mercapto, tioéter, nitro (NO2 ), amino, ariloxi, halógeno, hidroxilo, alcoxilo, acilo, arilo, cicloalquilo, heterociclos saturados y parcialmente saturados, o no sustituido, un grupo cicloalquilo sustituido con un grupo alquilo de (C1 -C6 ) o un grupo alquil-OH de (C1 -C6 ), un grupo heterociclo sustituido con un grupo alquilo de (C1 -C6 ) o un grupo alquil-OH de (C1 -C6 ), un grupo alquil-NR2 R3 o un grupo alquil- S(X)(Y)R4 , dondeR1 es H, un grupo alquilo sustituido por mercapto, tioéter, nitro (NO2 ), amino, ariloxi, halógeno, hidroxilo, alcoxilo, acilo, arilo, cicloalquilo, heterociclos saturados y parcialmente saturados, o no sustituido o un grupo acilo; R2 y R3 se seleccionan cada uno independientemente de H, grupos alquilos, cicloalquilos, heterociclos y arilos sustituidos o no sustituidos y grupos acilos y sulfonilos;donde los sustituyentes de los grupos alquilo y arilos son mercapto, tioéster, nitro (NO2 ), amino, ariloxi, halógeno, hidroxilo, alcoxilo, acilo, arilo, cicloalquilo, heterociclos saturados y parcialmente saturados. y los sustituyentes de los grupos cicloalquilos y heterociclos son mercapto, tioéster, nitro, amino, ariloxi, halógeno, hidroxilo, alcoxilo, acilo, arilo, cicloalquilo, heterociclos saturados y parcialmente saturados y alquilo, R4 es H, un grupo alquilo, cicloalquilo, heterociclo o arilo sustituido o no sustituido; donde los sustituyentes del grupo alquilo y arilo son mercapto, tioéter, nitro (NO2 ) amino, ariloxilo, halógeno, hiroxilo, alcoxilo, acilo, arilo, cicloalquilo, heterociclos saturados y parcialmente saturados. Y los sustituyentes del grupo cicloalquilo y heterociclo son mercapto, tioéter, nitro, amino, ariloxi, halógeno, hidroxilo, alcoxilo, acilo, arilo, cicloalquilo, heterociclos, saturados y parcialmente saturados y alquilo.X es Y se seleccionan cada uno independientemente de = O y nada; o una prodroga, sal o solvato farmacéuticamente aceptable de los mismos.A compound of formula (9): where: R and R 'are independently selected from H, a group of alkyl-OR1 substituted by mercapto, thioether, nitro (NO2), amino, aryloxy, halogen, hydroxyl, alkoxy, acyl, aryl, cycloalkyl, saturated and partially saturated, or unsubstituted heterocycles, a cycloalkyl group substituted with an alkyl group of (C1-C6) or an alkyl-OH group of (C1-C6), a heterocycle group substituted with an alkyl group of (C1-C6) or an alkyl-OH group of (C1-C6), an alkyl-NR2 group R3 or an alkyl-S (X) (Y) R4 group, where R1 is H, an alkyl group substituted by mercapto, thioether , nitro (NO2), amino, aryloxy, halogen, hydroxyl, alkoxy, acyl, aryl, cycloalkyl, saturated and partially saturated, or unsubstituted heterocycles or an acyl group; R2 and R3 are each independently selected from H, substituted or unsubstituted alkyl, cycloalkyl, heterocycles and aryl groups and acyl and sulfonyl groups; where the substituents on the alkyl and aryl groups are mercapto, thioester, nitro (NO2), amino, aryloxy, halogen, hydroxyl, alkoxy, acyl, aryl, cycloalkyl, saturated and partially saturated heterocycles. and the substituents for the cycloalkyl groups and heterocycles are mercapto, thioester, nitro, amino, aryloxy, halogen, hydroxyl, alkoxy, acyl, aryl, cycloalkyl, saturated and partially saturated heterocycles and alkyl, R4 is H, an alkyl, cycloalkyl group, heterocycle or substituted or unsubstituted aryl; where the substituents of the alkyl and aryl group are mercapto, thioether, nitro (NO2) amino, aryloxy, halogen, hiroxy, alkoxy, acyl, aryl, cycloalkyl, saturated and partially saturated heterocycles. And the substituents of the cycloalkyl and heterocycle group are mercapto, thioether, nitro, amino, aryloxy, halogen, hydroxyl, alkoxy, acyl, aryl, cycloalkyl, heterocycles, saturated and partially saturated and alkyl.X is Y are each independently selected from = O and nothing; or a pharmaceutically acceptable prodrug, salt or solvate thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81595197A | 1997-03-13 | 1997-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4940496A1 true CO4940496A1 (en) | 2000-07-24 |
Family
ID=25219265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98014251A CO4940496A1 (en) | 1997-03-13 | 1998-03-13 | HIV PROTEASE INHIBITORS |
Country Status (35)
| Country | Link |
|---|---|
| EP (1) | EP0970055A2 (en) |
| JP (1) | JP2001516350A (en) |
| KR (1) | KR100511089B1 (en) |
| CN (1) | CN1179948C (en) |
| AP (1) | AP1358A (en) |
| AR (1) | AR012556A1 (en) |
| AU (1) | AU743078B2 (en) |
| BG (1) | BG63540B1 (en) |
| BR (1) | BR9808867A (en) |
| CA (1) | CA2284163A1 (en) |
| CO (1) | CO4940496A1 (en) |
| CZ (1) | CZ296647B6 (en) |
| EA (1) | EA002378B1 (en) |
| EE (1) | EE04114B1 (en) |
| GE (1) | GEP20022764B (en) |
| HR (1) | HRP980112A2 (en) |
| HU (1) | HUP0001380A3 (en) |
| IL (2) | IL131870A0 (en) |
| IS (1) | IS5176A (en) |
| MX (1) | MXPA99008395A (en) |
| MY (1) | MY117535A (en) |
| NO (1) | NO315555B1 (en) |
| NZ (1) | NZ337706A (en) |
| OA (1) | OA11196A (en) |
| PA (1) | PA8448801A1 (en) |
| PE (1) | PE58799A1 (en) |
| PL (1) | PL192786B1 (en) |
| SA (1) | SA98181116B1 (en) |
| SK (1) | SK283636B6 (en) |
| SV (1) | SV1998000038A (en) |
| TR (1) | TR199902508T2 (en) |
| TW (1) | TW200517112A (en) |
| UA (1) | UA57772C2 (en) |
| WO (1) | WO1998040357A2 (en) |
| ZA (1) | ZA982047B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
-
1998
- 1998-03-04 HR HR08/815,951A patent/HRP980112A2/en not_active Application Discontinuation
- 1998-03-11 ZA ZA982047A patent/ZA982047B/en unknown
- 1998-03-12 AR ARP980101104A patent/AR012556A1/en active IP Right Grant
- 1998-03-12 IL IL13187098A patent/IL131870A0/en active IP Right Grant
- 1998-03-12 SK SK1222-99A patent/SK283636B6/en not_active IP Right Cessation
- 1998-03-12 BR BR9808867-0A patent/BR9808867A/en not_active Application Discontinuation
- 1998-03-12 PL PL335672A patent/PL192786B1/en not_active IP Right Cessation
- 1998-03-12 EA EA199900823A patent/EA002378B1/en unknown
- 1998-03-12 PE PE1998000171A patent/PE58799A1/en not_active Application Discontinuation
- 1998-03-12 CN CNB988045389A patent/CN1179948C/en not_active Expired - Fee Related
- 1998-03-12 JP JP53974598A patent/JP2001516350A/en not_active Ceased
- 1998-03-12 EP EP98910300A patent/EP0970055A2/en not_active Withdrawn
- 1998-03-12 WO PCT/US1998/004735 patent/WO1998040357A2/en active IP Right Grant
- 1998-03-12 CA CA002284163A patent/CA2284163A1/en not_active Abandoned
- 1998-03-12 MY MYPI98001071A patent/MY117535A/en unknown
- 1998-03-12 GE GEAP19984984A patent/GEP20022764B/en unknown
- 1998-03-12 HU HU0001380A patent/HUP0001380A3/en unknown
- 1998-03-12 TW TW094100045A patent/TW200517112A/en unknown
- 1998-03-12 NZ NZ337706A patent/NZ337706A/en unknown
- 1998-03-12 AU AU64575/98A patent/AU743078B2/en not_active Ceased
- 1998-03-12 KR KR10-1999-7008331A patent/KR100511089B1/en not_active IP Right Cessation
- 1998-03-12 MX MXPA99008395A patent/MXPA99008395A/en not_active IP Right Cessation
- 1998-03-12 CZ CZ0319199A patent/CZ296647B6/en not_active IP Right Cessation
- 1998-03-12 TR TR1999/02508T patent/TR199902508T2/en unknown
- 1998-03-12 AP APAP/P/1999/001648A patent/AP1358A/en active
- 1998-03-12 EE EEP199900416A patent/EE04114B1/en not_active IP Right Cessation
- 1998-03-13 CO CO98014251A patent/CO4940496A1/en unknown
- 1998-03-13 SV SV1998000038A patent/SV1998000038A/en not_active Application Discontinuation
- 1998-03-13 PA PA19988448801A patent/PA8448801A1/en unknown
- 1998-04-21 SA SA98181116A patent/SA98181116B1/en unknown
- 1998-12-03 UA UA99095049A patent/UA57772C2/en unknown
-
1999
- 1999-09-10 IS IS5176A patent/IS5176A/en unknown
- 1999-09-10 NO NO19994415A patent/NO315555B1/en not_active IP Right Cessation
- 1999-09-10 IL IL131870A patent/IL131870A/en not_active IP Right Cessation
- 1999-09-13 OA OA9900207A patent/OA11196A/en unknown
- 1999-09-13 BG BG103727A patent/BG63540B1/en unknown
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