OA12076A - Method and compositions for treating pulmonary diseases. - Google Patents
Method and compositions for treating pulmonary diseases. Download PDFInfo
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- OA12076A OA12076A OA1200200124A OA1200200124A OA12076A OA 12076 A OA12076 A OA 12076A OA 1200200124 A OA1200200124 A OA 1200200124A OA 1200200124 A OA1200200124 A OA 1200200124A OA 12076 A OA12076 A OA 12076A
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- OA
- OAPI
- Prior art keywords
- pde
- rolipram
- pde4
- asthma
- compounds
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- 239000007937 lozenge Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 description 1
- 229940002297 nasacort Drugs 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940003691 nasonex Drugs 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940124624 oral corticosteroid Drugs 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 229940072266 pulmicort Drugs 0.000 description 1
- 208000024981 pyrosis Diseases 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 description 1
- 229950004432 rofleponide Drugs 0.000 description 1
- 229960002586 roflumilast Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16315899P | 1999-11-02 | 1999-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA12076A true OA12076A (en) | 2006-05-04 |
Family
ID=22588737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200200124A OA12076A (en) | 1999-11-02 | 2000-11-01 | Method and compositions for treating pulmonary diseases. |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1225866A4 (cs) |
| JP (1) | JP2003513028A (cs) |
| KR (1) | KR20020057988A (cs) |
| CN (1) | CN1387404A (cs) |
| AP (1) | AP2002002496A0 (cs) |
| AR (1) | AR029189A1 (cs) |
| AU (1) | AU1357501A (cs) |
| BG (1) | BG106748A (cs) |
| BR (1) | BR0015270A (cs) |
| CA (1) | CA2388333A1 (cs) |
| CO (1) | CO5261512A1 (cs) |
| CZ (1) | CZ20021512A3 (cs) |
| DZ (1) | DZ3225A1 (cs) |
| EA (1) | EA200200518A1 (cs) |
| EC (1) | ECSP003747A (cs) |
| HK (1) | HK1049107A1 (cs) |
| HU (1) | HUP0203152A3 (cs) |
| IL (1) | IL149367A0 (cs) |
| MA (1) | MA26841A1 (cs) |
| MX (1) | MXPA02004350A (cs) |
| NO (1) | NO20022057L (cs) |
| OA (1) | OA12076A (cs) |
| PE (1) | PE20011005A1 (cs) |
| PL (1) | PL355261A1 (cs) |
| SK (1) | SK7592002A3 (cs) |
| TR (1) | TR200201211T2 (cs) |
| TW (1) | TWI242431B (cs) |
| WO (1) | WO2001032127A2 (cs) |
| ZA (1) | ZA200203435B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL160271A0 (en) * | 2001-09-19 | 2004-07-25 | Altana Pharma Ag | Pharmaceutical compositions containing pde4-inhibitors and nsaid |
| CZ2004516A3 (cs) * | 2001-10-31 | 2004-08-18 | Merckápatentágmbh | Inhibitor fosfodiesterázy typu @Ź jeho kombinace s jinými drogami a jeho použití |
| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| TW200410923A (en) * | 2002-10-17 | 2004-07-01 | Ono Pharmaceutical Co | Therapeutic agent for chronic obstructive pulmonary disease |
| CN1767828A (zh) * | 2003-03-31 | 2006-05-03 | 协和发酵工业株式会社 | 医药组合物 |
| US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| EP1810692A1 (en) * | 2004-10-13 | 2007-07-25 | Kyowa Hakko Kogyo Co., Ltd. | Remedies/preventives for chronic skin disease |
| RU2008119322A (ru) * | 2005-10-19 | 2009-11-27 | Рэнбакси Лабораториз Лимитед (In) | Композиции ингибиторов фосфодиэстеразы iv типа |
| ES2702753T3 (es) | 2010-01-05 | 2019-03-05 | Microdose Therapeutx Inc | Dispositivo de inhalación |
| WO2015063669A1 (en) | 2013-10-30 | 2015-05-07 | Wockhardt Limited | Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995000139A1 (en) * | 1993-06-18 | 1995-01-05 | Smithkline Beecham Corporation | Compounds |
| DE4332041C2 (de) * | 1993-09-21 | 1997-12-11 | Rentschler Arzneimittel | Verwendung von Pentoxifyllin bei bestimmten Lungenerkrankungen |
| PE44995A1 (es) * | 1994-01-27 | 1995-12-18 | Schering Corp | Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias |
| SE9801368D0 (sv) * | 1998-04-20 | 1998-04-20 | Astra Ab | New use |
-
2000
- 2000-10-31 EC EC2000003747A patent/ECSP003747A/es unknown
- 2000-10-31 AR ARP000105742A patent/AR029189A1/es not_active Application Discontinuation
- 2000-11-01 KR KR1020027005609A patent/KR20020057988A/ko not_active Ceased
- 2000-11-01 HU HU0203152A patent/HUP0203152A3/hu unknown
- 2000-11-01 WO PCT/US2000/030113 patent/WO2001032127A2/en not_active Ceased
- 2000-11-01 DZ DZ003225A patent/DZ3225A1/fr active
- 2000-11-01 PL PL00355261A patent/PL355261A1/xx not_active Application Discontinuation
- 2000-11-01 AP APAP/P/2002/002496A patent/AP2002002496A0/en unknown
- 2000-11-01 JP JP2001534335A patent/JP2003513028A/ja active Pending
- 2000-11-01 MX MXPA02004350A patent/MXPA02004350A/es unknown
- 2000-11-01 BR BR0015270-6A patent/BR0015270A/pt not_active IP Right Cessation
- 2000-11-01 SK SK759-2002A patent/SK7592002A3/sk unknown
- 2000-11-01 CZ CZ20021512A patent/CZ20021512A3/cs unknown
- 2000-11-01 HK HK02109234.5A patent/HK1049107A1/zh unknown
- 2000-11-01 EA EA200200518A patent/EA200200518A1/ru unknown
- 2000-11-01 OA OA1200200124A patent/OA12076A/en unknown
- 2000-11-01 CN CN00815265A patent/CN1387404A/zh active Pending
- 2000-11-01 AU AU13575/01A patent/AU1357501A/en not_active Abandoned
- 2000-11-01 TR TR2002/01211T patent/TR200201211T2/xx unknown
- 2000-11-01 IL IL14936700A patent/IL149367A0/xx unknown
- 2000-11-01 CA CA002388333A patent/CA2388333A1/en not_active Abandoned
- 2000-11-01 EP EP00975533A patent/EP1225866A4/en not_active Withdrawn
- 2000-11-02 PE PE2000001168A patent/PE20011005A1/es not_active Application Discontinuation
- 2000-11-02 CO CO00083427A patent/CO5261512A1/es not_active Application Discontinuation
- 2000-11-22 TW TW089123039A patent/TWI242431B/zh not_active IP Right Cessation
-
2002
- 2002-04-30 NO NO20022057A patent/NO20022057L/no not_active Application Discontinuation
- 2002-04-30 ZA ZA200203435A patent/ZA200203435B/xx unknown
- 2002-05-02 MA MA26621A patent/MA26841A1/fr unknown
- 2002-05-29 BG BG106748A patent/BG106748A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02004350A (es) | 2002-11-07 |
| AP2002002496A0 (en) | 2002-06-30 |
| JP2003513028A (ja) | 2003-04-08 |
| NO20022057D0 (no) | 2002-04-30 |
| WO2001032127A2 (en) | 2001-05-10 |
| HK1049107A1 (zh) | 2003-05-02 |
| ECSP003747A (es) | 2002-05-23 |
| CN1387404A (zh) | 2002-12-25 |
| CA2388333A1 (en) | 2001-05-10 |
| HUP0203152A3 (en) | 2004-06-28 |
| IL149367A0 (en) | 2002-11-10 |
| BR0015270A (pt) | 2002-06-18 |
| AU1357501A (en) | 2001-05-14 |
| SK7592002A3 (en) | 2002-11-06 |
| HUP0203152A2 (hu) | 2003-01-28 |
| EP1225866A4 (en) | 2004-04-21 |
| TR200201211T2 (tr) | 2002-08-21 |
| DZ3225A1 (fr) | 2001-05-10 |
| NO20022057L (no) | 2002-06-27 |
| KR20020057988A (ko) | 2002-07-12 |
| BG106748A (en) | 2003-02-28 |
| ZA200203435B (en) | 2003-06-25 |
| MA26841A1 (fr) | 2004-12-20 |
| EP1225866A2 (en) | 2002-07-31 |
| AR029189A1 (es) | 2003-06-18 |
| PE20011005A1 (es) | 2001-09-28 |
| PL355261A1 (en) | 2004-04-05 |
| EA200200518A1 (ru) | 2002-10-31 |
| CO5261512A1 (es) | 2003-03-31 |
| TWI242431B (en) | 2005-11-01 |
| CZ20021512A3 (cs) | 2003-04-16 |
| WO2001032127A3 (en) | 2001-12-06 |
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