OA10375A - Interleukin-15 - Google Patents

Interleukin-15 Download PDF

Info

Publication number
OA10375A
OA10375A OA60897A OA60897A OA10375A OA 10375 A OA10375 A OA 10375A OA 60897 A OA60897 A OA 60897A OA 60897 A OA60897 A OA 60897A OA 10375 A OA10375 A OA 10375A
Authority
OA
OAPI
Prior art keywords
polypeptide
host cell
dna
leu
ser
Prior art date
Application number
OA60897A
Other languages
English (en)
Inventor
Kenneth H Grabstein
Dirk M Anderson
June R Eisenman
Charles Rauch
Victor Fung
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT94915781T priority Critical patent/ATE196315T1/de
Priority to PT94915781T priority patent/PT772624E/pt
Priority to DE69425906T priority patent/DE69425906T2/de
Priority to PCT/US1994/003793 priority patent/WO1995027722A1/en
Priority to JP7526299A priority patent/JPH09512165A/ja
Priority to AU67673/94A priority patent/AU680909B2/en
Priority to DK94915781T priority patent/DK0772624T3/da
Priority to CA002186747A priority patent/CA2186747C/en
Priority to ES94915781T priority patent/ES2151927T3/es
Priority to EP94915781A priority patent/EP0772624B1/en
Priority to NZ266264A priority patent/NZ266264A/en
Priority claimed from ZA942636A external-priority patent/ZA942636B/xx
Priority to ZA942636A priority patent/ZA942636B/xx
Priority to FI963828A priority patent/FI117054B/fi
Priority to OA60897A priority patent/OA10375A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Priority to NO19964141A priority patent/NO318435B1/no
Priority to GR20000402710T priority patent/GR3035019T3/el
Publication of OA10375A publication Critical patent/OA10375A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
OA60897A 1994-04-06 1996-09-27 Interleukin-15 OA10375A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EP94915781A EP0772624B1 (en) 1994-04-06 1994-04-06 Interleukin-15
ES94915781T ES2151927T3 (es) 1994-04-06 1994-04-06 Interleuquina-15.
PCT/US1994/003793 WO1995027722A1 (en) 1994-04-06 1994-04-06 Interleukin-15
JP7526299A JPH09512165A (ja) 1994-04-06 1994-04-06 インターロイキン１５
AU67673/94A AU680909B2 (en) 1994-04-06 1994-04-06 Interleukin-15
DK94915781T DK0772624T3 (da) 1994-04-06 1994-04-06 Interleukin-15
CA002186747A CA2186747C (en) 1994-04-06 1994-04-06 Interleukin-15
AT94915781T ATE196315T1 (de) 1994-04-06 1994-04-06 Interleukin-15
DE69425906T DE69425906T2 (de) 1994-04-06 1994-04-06 Interleukin-15
PT94915781T PT772624E (pt) 1994-04-06 1994-04-06 Interleucina-15
NZ266264A NZ266264A (en) 1994-04-06 1994-04-06 Mammalian epithelium-derived t-cell factor called interleukin-15
ZA942636A ZA942636B (en) 1994-04-06 1994-04-18 Interleukin-15
FI963828A FI117054B (fi) 1994-04-06 1996-09-25 Interleukiini-15:n valmistusmenetelmä ja sitä koodaava DNA-sekvenssi
OA60897A OA10375A (en) 1994-04-06 1996-09-27 Interleukin-15
NO19964141A NO318435B1 (no) 1994-04-06 1996-09-30 Isolert DNA-sekvens fra IL-15, isolert DNA-sekvens som koder for et forloperpolypeptid til det biologisk aktive IL-15 polypeptid, rekombinant ekspresjonsvektor, vertcelle, fremgangsmate for fremstilling av et IL-15 polypeptid, isolert biologisk aktivt IL-15 polypeptidpreparat, farmasoytisk preparat for stimmulering av proliferasjon av T-lymfocytter, samt anvendelse av et polypeptid ifolge oppfinnelsen for fremstilling av et middel for behandling eller forebyggelse av spesifikt angitte sykdommer.
GR20000402710T GR3035019T3 (en) 1994-04-06 2000-12-06 Interleukin-15

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ266264A NZ266264A (en) 1994-04-06 1994-04-06 Mammalian epithelium-derived t-cell factor called interleukin-15
PCT/US1994/003793 WO1995027722A1 (en) 1994-04-06 1994-04-06 Interleukin-15
ZA942636A ZA942636B (en) 1994-04-06 1994-04-18 Interleukin-15
OA60897A OA10375A (en) 1994-04-06 1996-09-27 Interleukin-15

Publications (1)

Publication Number Publication Date
OA10375A true OA10375A (en) 2001-11-16

Family

ID=33314371

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60897A OA10375A (en) 1994-04-06 1996-09-27 Interleukin-15

Country Status (11)

Country Link
EP (1) EP0772624B1 (pt)
AT (1) ATE196315T1 (pt)
CA (1) CA2186747C (pt)
DE (1) DE69425906T2 (pt)
DK (1) DK0772624T3 (pt)
ES (1) ES2151927T3 (pt)
GR (1) GR3035019T3 (pt)
NZ (1) NZ266264A (pt)
OA (1) OA10375A (pt)
PT (1) PT772624E (pt)
WO (1) WO1995027722A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU700250B2 (en) * 1995-04-02 1998-12-24 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for curing thrombocytopenia
WO1997014433A1 (en) 1995-10-17 1997-04-24 Wayne State University Chicken interleukin-15 and uses thereof
US6509313B1 (en) 1996-02-28 2003-01-21 Cornell Research Foundation, Inc. Stimulation of immune response with low doses of cytokines
CA2252557A1 (en) * 1996-04-26 1997-11-06 Beth Israel Deaconess Medical Center, Inc. Antagonists of interleukin-15
US6451308B1 (en) 1996-04-26 2002-09-17 Beth Israel Deaconess Medical Center Antagonists of interleukin-15
DK0927254T3 (da) * 1996-04-26 2005-10-03 Beth Israel Hospital Interleukin-15-antagonister
US6087172A (en) * 1997-10-31 2000-07-11 Hisamitsu Pharmaceutical Co., Inc. Ribozymes targeted to human IL-15 mRNA
US5985663A (en) * 1998-11-25 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of interleukin-15 expression
AU3373300A (en) * 1999-02-24 2000-09-14 Wistar Institute Of Anatomy And Biology, The Method of modifying cytotoxic cells and uses thereof
US6828147B1 (en) 1999-02-24 2004-12-07 The Wistar Institute Of Anatomy And Biology Method of modifying cytotoxic cells and uses thereof
US6797263B2 (en) 2000-05-12 2004-09-28 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for achieving immune suppression
CU23093A1 (es) * 2002-10-09 2005-10-19 Ct Ingenieria Genetica Biotech Composición vacunal que comprende interleucina-15 (il-15)
CN100427597C (zh) * 2003-11-26 2008-10-22 中国医学科学院基础医学研究所 可用于生产人重组白细胞介素-15的原核表达工程菌及纯化方法
CU23472A1 (es) 2004-09-17 2009-12-17 Ct Ingenieria Genetica Biotech Péptido antagonista de la interleucina-15
EP1809321B1 (en) * 2004-10-08 2012-03-14 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Adoptive immunotherapy with enhanced t lymphocyte survival
MX2007014474A (es) 2005-05-17 2008-02-07 Univ Connecticut Composiciones y metodos para inmunomodulacion en un organismo.
EP1777294A1 (en) 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
NZ569541A (en) 2006-01-13 2012-05-25 Us Gov Health & Human Serv Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
CN108948177B (zh) 2007-05-11 2022-04-22 阿尔托生物科学有限公司 融合分子与il-15变异体
ES2466916T3 (es) 2007-06-27 2014-06-11 Admune Therapeutics Llc Complejos de IL-15 e IL-15R alfa y usos de los mismos
WO2009135031A1 (en) 2008-04-30 2009-11-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Substituted il-15
AU2010282280B2 (en) 2009-08-14 2016-06-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of IL-15 to increase thymic output and to treat lymphopenia
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
ES2651170T3 (es) 2010-09-21 2018-01-24 Altor Bioscience Corporation Moléculas de fusión solubles multímeras de IL-15 y métodos para elaborar y usar las mismas
EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
US10351824B2 (en) 2011-12-12 2019-07-16 Cell Medica Limited Process of expanding T cells
ES2748652T3 (es) 2012-02-09 2020-03-17 Baylor College Medicine Mezclas pep para generar CTL multivíricos con amplia especificidad
DK2986312T3 (da) 2013-04-19 2022-02-14 Cytune Pharma Cytokinafledt behandling med reduceret vaskulært lækagesyndrom
EP2915569A1 (en) 2014-03-03 2015-09-09 Cytune Pharma IL-15/IL-15Ralpha based conjugates purification method
MA39711A (fr) 2014-04-03 2015-10-08 Nektar Therapeutics Conjugués d'une fraction d'il-15 et d'un polymère
MX2017000116A (es) 2014-06-30 2017-05-30 Altor Bioscience Corp Moleculas basadas en il-15 y metodos para su uso.
JP6999941B2 (ja) 2015-09-18 2022-02-10 ベイラー カレッジ オブ メディスン 病原体からの免疫原性抗原同定および臨床的有効性との相関
WO2017218533A1 (en) 2016-06-13 2017-12-21 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
AU2017345791B2 (en) 2016-10-21 2020-10-22 Altor Bioscience Corporation Multimeric IL-15-based molecules
CA3059634A1 (en) 2017-04-13 2018-10-18 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
KR102008429B1 (ko) 2017-06-30 2019-08-07 아주대학교산학협력단 인터루킨-15/인터루킨-15 수용체 알파-Fc 복합체를 포함하는 염증질환 치료 또는 예방용 조성물
CA3074826A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
CA3116138A1 (en) 2018-10-17 2020-04-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
US20220195396A1 (en) * 2020-12-03 2022-06-23 Century Therapeutics, Inc. Genetically Engineered Cells and Uses Thereof
WO2023086772A1 (en) 2021-11-12 2023-05-19 Xencor, Inc. Bispecific antibodies that bind to b7h3 and nkg2d
WO2024102636A1 (en) 2022-11-07 2024-05-16 Xencor, Inc. Bispecific antibodies that bind to b7h3 and mica/b

Also Published As

Publication number Publication date
EP0772624B1 (en) 2000-09-13
ATE196315T1 (de) 2000-09-15
EP0772624A1 (en) 1997-05-14
GR3035019T3 (en) 2001-03-30
CA2186747A1 (en) 1995-10-19
WO1995027722A1 (en) 1995-10-19
NZ266264A (en) 1997-01-29
PT772624E (pt) 2001-03-30
DK0772624T3 (da) 2000-11-13
ES2151927T3 (es) 2001-01-16
EP0772624A4 (en) 1997-07-02
DE69425906D1 (en) 2000-10-19
CA2186747C (en) 2009-01-27
DE69425906T2 (de) 2001-03-29

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