OA10079A - Anti-cd4 antibody homologs useful in prophylaxis and treatment of aids arc and hiv infection - Google Patents
Anti-cd4 antibody homologs useful in prophylaxis and treatment of aids arc and hiv infection Download PDFInfo
- Publication number
- OA10079A OA10079A OA60249A OA60249A OA10079A OA 10079 A OA10079 A OA 10079A OA 60249 A OA60249 A OA 60249A OA 60249 A OA60249 A OA 60249A OA 10079 A OA10079 A OA 10079A
- Authority
- OA
- OAPI
- Prior art keywords
- antibody
- seq
- ser
- human
- leu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61854290A | 1990-11-27 | 1990-11-27 | |
PCT/US1991/008843 WO1992009305A1 (en) | 1990-11-27 | 1991-11-27 | Anti cd-4 antibodies blocking hiv-induced syncytia |
Publications (1)
Publication Number | Publication Date |
---|---|
OA10079A true OA10079A (en) | 1996-12-18 |
Family
ID=24478147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA60249A OA10079A (en) | 1990-11-27 | 1992-07-27 | Anti-cd4 antibody homologs useful in prophylaxis and treatment of aids arc and hiv infection |
Country Status (13)
Country | Link |
---|---|
US (1) | US5871732A (da) |
EP (1) | EP0512112B1 (da) |
JP (5) | JPH05505112A (da) |
AT (1) | ATE153536T1 (da) |
AU (1) | AU662891B2 (da) |
CA (1) | CA2073031C (da) |
DE (1) | DE69126301T2 (da) |
DK (1) | DK0512112T3 (da) |
ES (1) | ES2101834T3 (da) |
GR (1) | GR3024274T3 (da) |
HK (1) | HK1007686A1 (da) |
OA (1) | OA10079A (da) |
WO (1) | WO1992009305A1 (da) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5651970A (en) * | 1993-03-19 | 1997-07-29 | Allen; Allen D. | Method for inhibiting disease associated with the human immunodeficiency virus through the use of monoclonal antibodies directed against anti-self cytotoxic T-lymphocytes or their lytics |
DE4435950A1 (de) * | 1994-10-07 | 1996-04-11 | Hoechst Ag | Copolymerisate mit cyclischen oder polycyclischen Monomeren mit einer speziellen Isomerenverteilung und deren Einsatz in Beschichtungsmitteln |
US5961976A (en) * | 1996-06-03 | 1999-10-05 | United Biomedical, Inc. | Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV |
WO1998058966A1 (en) * | 1997-06-24 | 1998-12-30 | Norman Godin | A composition for specific immunoprotection and method for obtaining said composition |
US6420545B1 (en) * | 1999-05-24 | 2002-07-16 | The Trustees Of The University Of Pennsylvania | CD4-independent HIV envelope proteins as vaccines and therapeutics |
EP1212407A4 (en) * | 1999-09-03 | 2003-04-02 | Human Genome Sciences Inc | POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES OF THE IMMUNOGLOBULIN SUPERFAMILY |
AU2265701A (en) * | 1999-12-16 | 2001-06-25 | Tanox, Inc. | Anti-hiv-1 conjugates for treatment of hiv disease |
BR0314711A (pt) * | 2002-09-27 | 2005-07-26 | Tanox Inc | Composições sinérgicas para a prevenção e tratamento da sìndrome da imunodeficiência adquirida |
EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
WO2007094983A2 (en) * | 2006-02-03 | 2007-08-23 | Tanox, Inc. | Methods and compositions for the inhibition of hiv infection of t cells |
CA2658474A1 (en) * | 2006-08-17 | 2008-02-21 | F.Hoffmann-La Roche Ag | A conjugate of an antibody against ccr5 and an antifusogenic peptide |
TW200817438A (en) | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
CL2008000707A1 (es) | 2007-03-13 | 2008-09-22 | Hoffmann La Roche | Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion. |
TW200902547A (en) | 2007-04-27 | 2009-01-16 | Genentech Inc | Potent, stable and non-immunosuppressive anti-CD4 antibodies |
US20090022720A1 (en) * | 2007-07-20 | 2009-01-22 | Stephan Fischer | Conjugate of an antibody against CD4 and antifusogenic peptides |
ES2569217T3 (es) * | 2008-03-13 | 2016-05-09 | Biotest Ag | Agente para tratar enfermedades |
BRPI0909179A2 (pt) * | 2008-03-13 | 2015-08-25 | Biotest Ag | Composição farmacêutica, e, método de tratamento de uma doença autoimune. |
WO2009121690A1 (en) * | 2008-03-13 | 2009-10-08 | Biotest Ag | Agent for treating disease |
US8637466B2 (en) | 2008-08-11 | 2014-01-28 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
CN102215867B (zh) * | 2008-09-29 | 2017-04-19 | 生物测试股份公司 | 疾病治疗用组合物 |
EP2246364A1 (en) * | 2009-04-29 | 2010-11-03 | Pierre Fabre Médicament | Anti CXCR4 antibodies for the treatment of HIV |
GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
DK2691530T3 (da) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | Cmv-glycoproteiner og rekombinante vektorer |
CN102321653B (zh) * | 2011-07-18 | 2013-11-20 | 清华大学 | 人鼠嵌合型cd4质粒及其多抗在抑制hiv感染中的应用 |
EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
WO2014100139A1 (en) | 2012-12-18 | 2014-06-26 | The Rockefeller University | Glycan-modified anti-cd4 antibodies for hiv prevention and therapy |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
CA2961464A1 (en) | 2014-09-16 | 2016-03-24 | Ubi Ip Holdings | Treatment and functional cure of hiv infection by monoclonal antibodies to cd4 mediating competitive hiv entry inhibition |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
JP6568239B2 (ja) | 2015-06-01 | 2019-08-28 | メディジーン イミュノテラピーズ ゲーエムベーハー | T細胞受容体ライブラリ |
US11292838B2 (en) | 2015-06-01 | 2022-04-05 | Medigene Immunotherapies Gmbh | Method for generating antibodies against T cell receptor |
US9925258B2 (en) | 2015-10-02 | 2018-03-27 | International Aids Vaccine Initiative | Replication-competent VSV-HIV Env vaccines |
CA3009542C (en) | 2015-12-23 | 2023-08-29 | Medigene Immunotherapies Gmbh | Novel generation of antigen-specific tcrs |
CA3033728A1 (en) | 2016-08-13 | 2018-02-22 | Ubi Ip Holdings | Treatment and sustained virologic remission of hiv infection by antibodies to cd4 in haart stabilized patients |
CN112175087B (zh) * | 2019-07-02 | 2022-05-13 | 深圳市迈加瑞生物技术有限公司 | 一种抗CD4和TGFβ的双特异性抗体、其药物组合及其用途 |
US12012451B2 (en) * | 2019-08-19 | 2024-06-18 | The Rockefeller University | Engineering pH-dependent antigen binding activity into anti-HIV antibodies with improved pharmacokinetics |
WO2021062546A1 (en) * | 2019-10-01 | 2021-04-08 | Taimed Biologics Inc. | Use of ibalizumab for the treatment of hiv-2 infection |
CN112500491B (zh) | 2020-12-18 | 2022-04-08 | 深圳市迈加瑞生物技术有限公司 | 一种特异性中和辅助性T细胞TGF-β信号的双特异性抗体、其药物组合及其用途 |
EP4381081A1 (en) | 2021-08-04 | 2024-06-12 | Sana Biotechnology, Inc. | Use of cd4-targeted viral vectors |
WO2023114949A1 (en) | 2021-12-16 | 2023-06-22 | Sana Biotechnology, Inc. | Methods and systems of particle production |
WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
WO2023150647A1 (en) | 2022-02-02 | 2023-08-10 | Sana Biotechnology, Inc. | Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
WO2024064838A1 (en) | 2022-09-21 | 2024-03-28 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
WO2024112867A1 (en) | 2022-11-23 | 2024-05-30 | University Of Georgia Research Foundation, Inc. | Compositions and methods of use thereof for increasing immune responses |
WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4515895A (en) * | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to human helper T cells |
US4652447A (en) * | 1979-04-26 | 1987-03-24 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human helper T cells |
US4381295A (en) * | 1979-04-26 | 1983-04-26 | Ortho Pharmaceutical Corporation | Monoclonal antibody to human helper T cells and methods of preparing same |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4653020A (en) * | 1983-10-17 | 1987-03-24 | International Business Machines Corporation | Display of multiple data windows in a multi-tasking system |
NZ215865A (en) * | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
JPH02501192A (ja) * | 1987-09-04 | 1990-04-26 | バイオジェン インコーポレイテッド | 可溶性t4蛋白を製造するためのdna配列、組換dna分子および方法 |
US4908203A (en) * | 1987-09-09 | 1990-03-13 | Johnson & Johnson | Method for inducing HIV neutralizing antibodies using an internal image idiotope |
WO1989009782A1 (en) * | 1987-10-14 | 1989-10-19 | United States Of America, Represented By The Secre | New anti-receptor peptides and therapeutic agents |
WO1990004978A1 (en) * | 1988-11-01 | 1990-05-17 | Becton Dickinson And Company | Method of directing immune response to a viral binding site |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
-
1991
- 1991-11-27 ES ES92903295T patent/ES2101834T3/es not_active Expired - Lifetime
- 1991-11-27 DE DE69126301T patent/DE69126301T2/de not_active Expired - Lifetime
- 1991-11-27 WO PCT/US1991/008843 patent/WO1992009305A1/en active IP Right Grant
- 1991-11-27 AT AT92903295T patent/ATE153536T1/de not_active IP Right Cessation
- 1991-11-27 DK DK92903295.1T patent/DK0512112T3/da active
- 1991-11-27 JP JP92503666A patent/JPH05505112A/ja not_active Withdrawn
- 1991-11-27 US US07/916,098 patent/US5871732A/en not_active Expired - Lifetime
- 1991-11-27 EP EP92903295A patent/EP0512112B1/en not_active Expired - Lifetime
- 1991-11-27 CA CA002073031A patent/CA2073031C/en not_active Expired - Lifetime
- 1991-11-27 AU AU91543/91A patent/AU662891B2/en not_active Expired
-
1992
- 1992-07-27 OA OA60249A patent/OA10079A/en unknown
-
1997
- 1997-07-30 GR GR970401923T patent/GR3024274T3/el unknown
-
1998
- 1998-06-26 HK HK98107033A patent/HK1007686A1/xx not_active IP Right Cessation
-
2002
- 2002-03-08 JP JP2002064584A patent/JP2002356499A/ja not_active Withdrawn
-
2004
- 2004-03-04 JP JP2004061381A patent/JP2005041859A/ja not_active Withdrawn
-
2007
- 2007-01-22 JP JP2007012058A patent/JP2007151556A/ja not_active Withdrawn
- 2007-01-22 JP JP2007012057A patent/JP4642035B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2101834T3 (es) | 1997-07-16 |
JP2007175055A (ja) | 2007-07-12 |
DE69126301T2 (de) | 1998-01-02 |
JPH05505112A (ja) | 1993-08-05 |
US5871732A (en) | 1999-02-16 |
JP4642035B2 (ja) | 2011-03-02 |
JP2005041859A (ja) | 2005-02-17 |
WO1992009305A1 (en) | 1992-06-11 |
EP0512112B1 (en) | 1997-05-28 |
AU9154391A (en) | 1992-06-25 |
JP2002356499A (ja) | 2002-12-13 |
GR3024274T3 (en) | 1997-10-31 |
AU662891B2 (en) | 1995-09-21 |
HK1007686A1 (en) | 1999-04-23 |
JP2007151556A (ja) | 2007-06-21 |
CA2073031C (en) | 2002-10-01 |
CA2073031A1 (en) | 1992-05-28 |
ATE153536T1 (de) | 1997-06-15 |
EP0512112A1 (en) | 1992-11-11 |
DE69126301D1 (de) | 1997-07-03 |
DK0512112T3 (da) | 1997-09-29 |
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