OA09322A - Improved emulsions of highly fluorinated organic compounds. - Google Patents

Improved emulsions of highly fluorinated organic compounds.

Info

Publication number
OA09322A
OA09322A OA59880A OA59880A OA09322A OA 09322 A OA09322 A OA 09322A OA 59880 A OA59880 A OA 59880A OA 59880 A OA59880 A OA 59880A OA 09322 A OA09322 A OA 09322A
Authority
OA
OAPI
Prior art keywords
highly fluorinated
fluorinated organic
organic compounds
emulsions
improved emulsions
Prior art date
Application number
OA59880A
Inventor
Robert J Kaufman
Thomas J Richard
Original Assignee
Hemagen Pfc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemagen Pfc filed Critical Hemagen Pfc
Publication of OA09322A publication Critical patent/OA09322A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
OA59880A 1988-04-29 1990-10-29 Improved emulsions of highly fluorinated organic compounds. OA09322A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/187,854 US5171755A (en) 1988-04-29 1988-04-29 Emulsions of highly fluorinated organic compounds

Publications (1)

Publication Number Publication Date
OA09322A true OA09322A (en) 1992-09-15

Family

ID=22690763

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59880A OA09322A (en) 1988-04-29 1990-10-29 Improved emulsions of highly fluorinated organic compounds.

Country Status (16)

Country Link
US (3) US5171755A (en)
EP (1) EP0449825B1 (en)
JP (1) JPH0798745B2 (en)
KR (1) KR940002658B1 (en)
CN (1) CN1042794C (en)
AT (1) ATE112958T1 (en)
AU (1) AU629832B2 (en)
CA (1) CA1336494C (en)
DE (1) DE68918952T2 (en)
DK (1) DK172973B1 (en)
IE (1) IE65288B1 (en)
IL (1) IL90009A0 (en)
NZ (1) NZ228686A (en)
OA (1) OA09322A (en)
WO (1) WO1989010118A1 (en)
ZA (1) ZA892924B (en)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514720A (en) * 1986-07-09 1996-05-07 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
DE68928349T2 (en) * 1989-07-05 1998-05-07 Alliance Pharma Fluorocarbon emulsions with saturated phospholipid emulsifiers
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
FR2679150A1 (en) * 1991-07-17 1993-01-22 Atta PREPARATIONS CONSISTING OF A FLUOROCARBIDE OR HIGHLY FLUORINE COMPOUND AND A LIPOPHILIC-FLUOROPHILIC ORGANIC COMPOUND, AND THEIR USES.
RU2114637C1 (en) * 1991-09-17 1998-07-10 Сонус Фармасьютикалз, Инк. Biologically compatible contrast medium and method for producing ultrasonic images
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
MX9205298A (en) 1991-09-17 1993-05-01 Steven Carl Quay GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5295953A (en) * 1992-05-26 1994-03-22 Hemagen/Pfc Method and apparatus for extracorporeal separation of fluorochemicals from whole blood of a patient
US5628930A (en) * 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
US5420359A (en) * 1992-12-11 1995-05-30 Minnesota Mining And Manufacturing Company Chlorofluoroether compositions and preparation thereof
AU5539294A (en) * 1992-12-24 1994-07-19 Hemagen/Pfc Fluorocarbon emulsions
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
SG52198A1 (en) * 1993-01-25 1998-09-28 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US20030068362A1 (en) * 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US5525324A (en) * 1993-08-06 1996-06-11 Block; Ronald E. Organic silicon contrast agents and methods of use
PL182223B1 (en) 1993-12-15 2001-11-30 Bracco Research Sa Usg contrast medium
US5658962A (en) 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
CA2152765A1 (en) 1994-06-30 1995-12-31 Jeroen Elisabeth-Joseph Knops Methods for treating a physiological disorder associated with beta amyloid peptide
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
DE19529921C2 (en) * 1995-08-01 1997-09-25 Schering Ag Use of MRI contrast media for ventilation imaging of the lungs
AU7298196A (en) * 1995-10-25 1997-05-15 Janssen Pharmaceutica N.V. Infusions of neuroprotectants and perfluorochemicals
US5733526A (en) * 1995-12-14 1998-03-31 Alliance Pharmaceutical Corp. Hydrocarbon oil/fluorochemical preparations and methods of use
WO1997025978A1 (en) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Method of obtaining perfluorocarbon emulsions for medical purposes
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
NZ331460A (en) * 1996-03-05 1998-12-23 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
ES2189974T3 (en) 1996-09-11 2003-07-16 Imarx Pharmaceutical Corp IMPROVED PROCEDURES FOR OBTAINING DIAGNOSTIC IMAGES USING A CONTRAST AGENT AND A VASODILATATOR.
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
AU5161298A (en) * 1996-11-25 1998-06-22 Imarx Pharmaceutical Corp. Perfluorinated-ether compositions as diagnostic contrast agents
DE19701037A1 (en) * 1997-01-15 1998-07-16 Sanguibiotech Ag Hemoglobins provided with protective ligands of the oxygen binding sites as artificial oxygen carriers for direct biological-medical use and processes for their production
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US20020039594A1 (en) * 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
JPH113349A (en) * 1997-06-11 1999-01-06 Fujitsu Ltd Data protecting system, data preparing device and data processing device
US5980936A (en) * 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US7220401B2 (en) * 1999-09-24 2007-05-22 Barnes-Jewish Hospital Blood clot-targeted nanoparticles
BR0100091A (en) 2000-01-18 2001-08-28 Implant Innovations Inc Preparation cover to create an accurate permanent pin to support a final prosthesis and method for creating it
KR100372555B1 (en) * 2000-04-20 2003-02-17 주식회사 도도화장품 Method of producing a cosmetic
US6676963B1 (en) 2000-10-27 2004-01-13 Barnes-Jewish Hospital Ligand-targeted emulsions carrying bioactive agents
BR0307206A (en) 2002-01-24 2004-12-21 Barnes Jewish Hospital Integrin-directed Imaging Agents
EP1365068B1 (en) * 2002-05-10 2008-05-07 The Procter & Gamble Company Embossed tissue having loosened surface fibers and method for its production
RU2259819C1 (en) * 2004-03-01 2005-09-10 Кузнецова Ирина Николаевна Emulsion of perfluoroorganic compounds of medicinal indication and method for its obtaining
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1768558A4 (en) 2004-06-09 2009-11-25 Kereos Inc Lipohilic derivatives of chelate monoamides
EP2019667A4 (en) * 2006-04-27 2012-08-22 Barnes Jewish Hospital Detection and imaging of target tissue
DE602007003135D1 (en) 2006-05-18 2009-12-24 Mitsubishi Gas Chemical Co Process for the preparation of xylylenediamine
DE102006040450B3 (en) * 2006-08-24 2008-04-24 Coty Prestige Lancaster Group Gmbh Use of a composition for skin treatment after X-irradiation
WO2009049089A1 (en) 2007-10-09 2009-04-16 Washington University In St. Louis Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
CN101868180A (en) 2007-10-09 2010-10-20 圣路易斯华盛顿州立大学 Particles for imaging
EP2512452B1 (en) 2009-12-17 2018-09-19 The Washington University Antithrombotic nanoparticle
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
AU2011239414A1 (en) 2010-04-15 2012-11-08 The Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
FR2980364B1 (en) 2011-09-26 2018-08-31 Guerbet NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS
FR2980365B1 (en) 2011-09-26 2016-02-12 Guerbet Sa NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT.
WO2013116691A1 (en) 2012-02-02 2013-08-08 The Washington University Methods for improving muscle strength
EP2783703A1 (en) * 2013-03-25 2014-10-01 B. Braun Melsungen AG Semifluorocarbon compound containing contrast agent
RU2544849C1 (en) * 2014-01-09 2015-03-20 Общество с ограниченной ответственностью "Химический завод фторсолей" Method of purifying perfluorodecalin
CN107206111B (en) 2014-12-31 2021-04-27 蓝瑟斯医学影像公司 Lipid-encapsulated gas microsphere compositions and related methods
CN105248412A (en) * 2015-10-30 2016-01-20 暨南大学 Application of emulsified perfluorocarbon liquid in preparation of lung preserving fluid
US10213448B2 (en) 2016-03-25 2019-02-26 Novazoi Theranostics Ethanolamine-based lipid biosynthetic compounds, method of making and use thereof
CN109641068B (en) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 Method and device for preparing ultrasonic contrast agent
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
CN108849861A (en) * 2018-09-30 2018-11-23 南京麦荻泉生物科技有限公司 One kind containing fluorocarbon emulsion type organ preservative fluid
WO2024046999A1 (en) * 2022-08-31 2024-03-07 Johann Wolfgang Goethe-Universität Frankfurt am Main Lecithin-modified nanoscale oxygen carriers (lenox)

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2055083A (en) * 1932-07-13 1936-09-22 Winthrop Chem Co Inc Pharmaceutical preparation
GB1256162A (en) * 1968-08-16 1971-12-08 Braun Fa B Improvements in and relating to liquid products for intravenous administration
US3958014A (en) * 1970-09-05 1976-05-18 The Green Cross Corporation Process for preparing injection-purpose fluorocarbon emulsion capable of carrying oxygen
US3975512A (en) * 1970-12-21 1976-08-17 University Of Illinois Foundation Non-toxic brominated perfluorocarbons radiopaque agents
US3823091A (en) * 1971-05-19 1974-07-09 Green Cross Corp Stable emulsion of fluorocarbon particles
US3942527A (en) * 1972-03-14 1976-03-09 Exxon Research & Engineering Co. Blood oxygenation process
US3778381A (en) * 1972-04-24 1973-12-11 Allied Chem Fluorocarbon microemulsions
US3914294A (en) * 1972-06-01 1975-10-21 Squibb & Sons Inc 3,5-Disubstituted-2,4,6-triiodobenzoic acids
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
JPS5331209B2 (en) * 1973-10-05 1978-09-01
FR2249657B1 (en) * 1973-11-07 1977-04-15 Ugine Kuhlmann
JPS5126213A (en) * 1974-08-21 1976-03-04 Tanabe Seiyaku Co JOHOSEIBIRYUSHISEIZAINO SEIHO
US4073879A (en) * 1974-08-26 1978-02-14 University Of Illinois Foundation Brominated perfluorocarbon radiopaque agents
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
US4110474A (en) * 1977-08-26 1978-08-29 Suntech, Inc. Tetramethylpentane blood substitutes
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
JPS55100312A (en) * 1979-01-25 1980-07-31 Toshiro Wada Contrast medium for blood vessel
US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
WO1981000002A1 (en) * 1979-06-25 1981-01-08 Suntech Use of perfluorocarbon as burn treatment
US4657532A (en) * 1985-07-19 1987-04-14 Thomas Jefferson University Intra-peritoneal perfusion of oxygenated fluorocarbon
CA1181011A (en) * 1980-05-27 1985-01-15 Robert P. Geyer Perfluorinated n,n-dimethyl cyclohexylmethylamine and emulsions containing the same
FR2515198A1 (en) * 1981-10-22 1983-04-29 Centre Nat Rech Scient AQUEOUS MICROEMULSIONS OF FLUOROCARBONS INDUFINIMENTALLY STABLE AT A DATA TEMPERATURE, PROCESS FOR OBTAINING AND APPLICATION AS OXYGEN TRANSPORTERS
US4569784A (en) * 1980-11-17 1986-02-11 Adamantech, Inc. Preparation of a gel having gas transporting capability
JPS5924132B2 (en) * 1980-12-02 1984-06-07 株式会社 林原生物化学研究所 Manufacturing method for nutritional supplement emulsion
JPS57188514A (en) * 1981-05-12 1982-11-19 Green Cross Corp:The Fluorine compound emulsion
US4395393A (en) * 1981-08-10 1983-07-26 Basf Wyandotte Corporation Artificial blood emulsifiers
JPS5832829A (en) * 1981-08-22 1983-02-25 Green Cross Corp:The Contrast medium for blood vessel
US4591599A (en) * 1981-11-27 1986-05-27 The Green Cross Corporation Perfluoropyrrolizines and emulsions thereof useful as blood substitutes
CA1187882A (en) * 1981-11-27 1985-05-28 Kazumasa Yokoyama Perfluoro compound and emulsion thereof
US4599343A (en) * 1981-11-27 1986-07-08 The Green Cross Corporation Perfluoroindolizines and emulsions thereof useful as blood substitutes
JPS5892680A (en) * 1981-11-27 1983-06-02 Green Cross Corp:The Perfluorobicyclo compound
JPS58170782A (en) * 1982-01-22 1983-10-07 アイ・エス・シ−・ケミカルズ・リミテツド Perfluorinated heterocyclic compound and emulsion containing same
US4446154A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4490351A (en) * 1982-03-15 1984-12-25 Children's Hospital Medical Center Methods of treating disorders of an eye with liquid perfluorocarbons
US4461717A (en) * 1982-03-19 1984-07-24 Sun Tech, Inc. Stable gas-carrying compositions
US4452818A (en) * 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US4397870A (en) * 1982-07-27 1983-08-09 The University Of Pennsylvania Process for prolonging retention of emulsion particles in the bloodstream
US4497829A (en) * 1982-07-27 1985-02-05 The University Of Pennsylvania Process for preparing perfluorochemical emulsion artificial blood
US4542147A (en) * 1982-08-07 1985-09-17 The Green Cross Corporation Perfluoro-1-azatricyclic amine compound
JPS5939870A (en) * 1982-08-30 1984-03-05 Green Cross Corp:The Fluorocarbon emulsion preparation
JPS5946218A (en) * 1982-09-09 1984-03-15 Green Cross Corp:The Fluorocarbon emulsion preparation
US4534978A (en) * 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
JPS59130812A (en) * 1983-01-14 1984-07-27 Green Cross Corp:The Adminiculum for chemotherapy of cancer
JPS59130813A (en) * 1983-01-14 1984-07-27 Green Cross Corp:The Adminiculum for chemotherapy of cancer
EP0138969A1 (en) * 1983-03-17 1985-05-02 University Patents, Inc. Method for inhibiting the growth of anaerobes
JPS59193814A (en) * 1983-04-20 1984-11-02 Ajinomoto Co Inc Fat emulsion containing amino acid
US4519576A (en) * 1983-12-15 1985-05-28 Winegeart Mitchell E Oil well safety valve for use with drill pipe
CA1257828A (en) * 1984-04-16 1989-07-25 William Mccormick Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation
CA1257131A (en) * 1984-07-27 1989-07-11 John Y. Park Total parenteral and enteral nutrition composition
IT1186704B (en) * 1985-04-04 1987-12-16 Motefluos Spa PERFLUORCALCANI AND ALOPERFLUOROALCANI, THEIR PRECURSORS AND THEIR SYNTHESIS PROCESS
SE8505047L (en) * 1985-10-25 1987-04-26 Nutritional Int Res Inst fat emulsion
SE8505048L (en) * 1985-10-25 1987-04-26 Nutritional Int Res Inst NUTRITION EMULSION WITH ACID TRANSPORTING PROPERTIES
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US5080885A (en) * 1986-01-14 1992-01-14 Alliance Pharmaceutical Corp. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
ES2054658T3 (en) * 1986-01-24 1994-08-16 Childrens Hosp Medical Center METHOD FOR THE PREPARATION OF A PHYSIOLOGICALLY ACCEPTABLE EMULSION.
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides

Also Published As

Publication number Publication date
WO1989010118A1 (en) 1989-11-02
IL90009A0 (en) 1989-12-15
NZ228686A (en) 1994-09-27
IE891396L (en) 1989-10-29
US5171755A (en) 1992-12-15
US5350571A (en) 1994-09-27
CA1336494C (en) 1995-08-01
CN1038022A (en) 1989-12-20
JPH0798745B2 (en) 1995-10-25
IE65288B1 (en) 1995-10-18
ATE112958T1 (en) 1994-11-15
KR900700085A (en) 1990-08-11
DK258590A (en) 1990-10-29
DK258590D0 (en) 1990-10-26
DE68918952D1 (en) 1994-11-24
ZA892924B (en) 1989-12-27
CN1042794C (en) 1999-04-07
JPH03502693A (en) 1991-06-20
DK172973B1 (en) 1999-10-25
US5407962A (en) 1995-04-18
AU3566489A (en) 1989-11-24
KR940002658B1 (en) 1994-03-28
DE68918952T2 (en) 1995-03-16
AU629832B2 (en) 1992-10-15
EP0449825B1 (en) 1994-10-19
EP0449825A1 (en) 1991-10-09

Similar Documents

Publication Publication Date Title
ZA892924B (en) Emulsions of highly fluorinated organic compounds
BG28977A3 (en) Fungicide means and method for fungus fighting
AU8011882A (en) Working chamber for offshore structures
IT8523129A0 (en) PROCEDURE FOR LAUNCHING LARGE UNDERWATER PIPELINES FROM THE LAND, PARTICULARLY FOR INTAKE WORKS.
AU8137887A (en) Pesticidal formulations
HUT50580A (en) Ulv-composition of artropodicide activity
JPS52103002A (en) Long-noise vertical pump
JPS534007A (en) Fuel composition
FI896048A0 (en) 5-FLUORMETHYL-1,2,4-TRIAZOLO / 1,5-A / PYRIMIDINE-2-SULPHONAMIDER, FORMULATED FOR FRAMSTAELLNING AND COMPOSITIONS FOR THE FORMATION OF A HERBICIDER.
JPS537671A (en) 3-phenylhydantoin derivatives, their preparation and nonmedical fungicides containing the same
JPS532468A (en) 2,2-bis(3,4-epoxy-5-oxotetrahydropyrane)-ethers and method of preparing the same
BG28978A3 (en) Fungicide means and method for fighting the fungus
JPS527882A (en) Water repellent, oil repellent agents
JPS5228483A (en) Method of treating floating oil
JPS522986A (en) Semi submerged boat
JPS52116904A (en) Centrifugal pump
EP0114389A3 (en) Substituted arylglyoxal derivatives
ES2077064T3 (en) PREPARATION OF PHENYL HYDROQUINONE.
JPS5214589A (en) Fluoride-containing high-molecular water and oil repellent agents
WO1981000733A1 (en) Support structure for offshore platforms
JPS5349792A (en) Offshore platform
JPS545995A (en) Thiazoropyrimidine compounds and herbicides containing the same as active constituents
JPS52103011A (en) Jet pump for shallow well
JPS53145023A (en) Stationary induction device
IE782438L (en) Offshore working platform.