FR2980365B1 - NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT. - Google Patents

NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT.

Info

Publication number
FR2980365B1
FR2980365B1 FR1158565A FR1158565A FR2980365B1 FR 2980365 B1 FR2980365 B1 FR 2980365B1 FR 1158565 A FR1158565 A FR 1158565A FR 1158565 A FR1158565 A FR 1158565A FR 2980365 B1 FR2980365 B1 FR 2980365B1
Authority
FR
France
Prior art keywords
nanoemulsions
preparation
contrast agent
contrast
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1158565A
Other languages
French (fr)
Other versions
FR2980365A1 (en
Inventor
Caroline Robic
Samy Chadel
Veronique Schmitt
Calderon Fernando Leal
Marc Port
Olivier Lambert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Priority to FR1158565A priority Critical patent/FR2980365B1/en
Priority to PCT/EP2012/068984 priority patent/WO2013045504A1/en
Publication of FR2980365A1 publication Critical patent/FR2980365A1/en
Application granted granted Critical
Publication of FR2980365B1 publication Critical patent/FR2980365B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1809—Micelles, e.g. phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
FR1158565A 2011-09-26 2011-09-26 NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT. Active FR2980365B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR1158565A FR2980365B1 (en) 2011-09-26 2011-09-26 NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT.
PCT/EP2012/068984 WO2013045504A1 (en) 2011-09-26 2012-09-26 Perfluorinated nanoemulsions, method for preparing same, and use thereof as a contrast agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1158565A FR2980365B1 (en) 2011-09-26 2011-09-26 NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT.

Publications (2)

Publication Number Publication Date
FR2980365A1 FR2980365A1 (en) 2013-03-29
FR2980365B1 true FR2980365B1 (en) 2016-02-12

Family

ID=46934583

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1158565A Active FR2980365B1 (en) 2011-09-26 2011-09-26 NANOEMULSIONS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS A CONTRAST AGENT.

Country Status (2)

Country Link
FR (1) FR2980365B1 (en)
WO (1) WO2013045504A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11406722B2 (en) 2017-03-16 2022-08-09 The Board Of Regents Of The University Of Texas System Nanodroplets with improved properties
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof
CN114369647A (en) * 2021-12-31 2022-04-19 深圳麦科田生物医疗技术股份有限公司 Water-in-oil droplet for micro-droplet digital PCR and application thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927623A (en) 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US5077036A (en) 1986-01-14 1991-12-31 Alliance Pharmaceutical Corp. Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5114703A (en) 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5304325A (en) 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5403575A (en) 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5958371A (en) 1995-06-08 1999-09-28 Barnes-Jewish Hospital Site specific binding system, nuclear imaging compositions and methods
US5733526A (en) * 1995-12-14 1998-03-31 Alliance Pharmaceutical Corp. Hydrocarbon oil/fluorochemical preparations and methods of use
US6676963B1 (en) 2000-10-27 2004-01-13 Barnes-Jewish Hospital Ligand-targeted emulsions carrying bioactive agents
CN101249269A (en) 2002-01-24 2008-08-27 巴内斯－朱威胥医院 Integrin targeted imaging agents
FR2883562B1 (en) * 2005-03-24 2009-02-27 Guerbet Sa LIPOPHILIC CHELATES AND THEIR USE IN IMAGING
US20090263329A1 (en) * 2006-02-24 2009-10-22 Washington University Cell labeling with perfluorocarbon nanoparticles for magnetic resonance imaging and spectroscopy
WO2007112100A2 (en) * 2006-03-24 2007-10-04 The University Of Utah Research Foundation Highly fluorinated oils and surfactants and methods of making and using same
KR101005561B1 (en) * 2008-06-21 2011-01-05 한국생명공학연구원 The multimodal imaging method using nano-emulsion consisted of optical nano-particles and perfluorocarbons

Also Published As

Publication number Publication date
WO2013045504A1 (en) 2013-04-04
FR2980365A1 (en) 2013-03-29

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