OA09321A - Fused polycyclic compounds, compositions, methods of manufacture and their use as PAF antagonists, antihistamines and/or antiinflammatory agents. - Google Patents
Fused polycyclic compounds, compositions, methods of manufacture and their use as PAF antagonists, antihistamines and/or antiinflammatory agents.Info
- Publication number
- OA09321A OA09321A OA59878A OA59878A OA09321A OA 09321 A OA09321 A OA 09321A OA 59878 A OA59878 A OA 59878A OA 59878 A OA59878 A OA 59878A OA 09321 A OA09321 A OA 09321A
- Authority
- OA
- OAPI
- Prior art keywords
- antihistamines
- manufacture
- methods
- fused polycyclic
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18710588A | 1988-04-28 | 1988-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA09321A true OA09321A (en) | 1992-09-15 |
Family
ID=22687612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA59878A OA09321A (en) | 1988-04-28 | 1990-10-26 | Fused polycyclic compounds, compositions, methods of manufacture and their use as PAF antagonists, antihistamines and/or antiinflammatory agents. |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0339978B1 (fr) |
JP (1) | JP2511550B2 (fr) |
AT (1) | ATE141599T1 (fr) |
CA (1) | CA1341370C (fr) |
DE (1) | DE68926976T2 (fr) |
DK (1) | DK172717B1 (fr) |
ES (1) | ES2091195T3 (fr) |
FI (1) | FI96309C (fr) |
GR (1) | GR3021465T3 (fr) |
IL (1) | IL90102A (fr) |
MY (1) | MY106964A (fr) |
NO (1) | NO300972B1 (fr) |
NZ (1) | NZ228889A (fr) |
OA (1) | OA09321A (fr) |
SG (1) | SG44477A1 (fr) |
WO (1) | WO1989010363A1 (fr) |
ZA (1) | ZA893103B (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2038417A1 (fr) * | 1990-04-11 | 1991-10-12 | Yasuo Ito | Composes de piperidine, methode de preparation de ces composes, et une composition pharmaceutique qui en contient. |
US5470851A (en) * | 1990-06-27 | 1995-11-28 | Sankyo Company, Limited | Thiazolidinecarboxylic acid amide derivatives and their therapeutic uses |
US5393753A (en) * | 1990-10-10 | 1995-02-28 | Schering Corporation | Substituted imidazobenzazepines |
EP0552245A1 (fr) * | 1990-10-10 | 1993-07-28 | Schering Corporation | Composes de bis-benzo cyclohepta piperidylidene, piperidine et piperazine, compositions et procedes d'utilisation |
FR2668150B1 (fr) * | 1990-10-17 | 1994-11-18 | Theramex | Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant. |
GB9102997D0 (en) * | 1991-02-13 | 1991-03-27 | Pfizer Ltd | Therapeutic agents |
WO1992020681A1 (fr) * | 1991-05-23 | 1992-11-26 | Schering Corporation | Nouveaux composes de benzopyrido piperidylidene, compositions, procedes de preparation et d'utilisation |
EP0595989A1 (fr) * | 1991-07-23 | 1994-05-11 | Schering Corporation | Composes piperidylidene benzopyrido, compositions, leurs procedes de preparation et leurs utilisations |
NO924963L (no) * | 1991-12-27 | 1993-06-28 | Sankyo Co | Pyridyltiazolidinkarboksylsyreamid-derivater og fremgangsmaate til fremstilling derav |
JPH07505394A (ja) * | 1992-03-27 | 1995-06-15 | シェリング・コーポレーション | 橋渡しビスアリールカルビノール誘導体,組成物および使用法 |
ES2089815T3 (es) * | 1992-03-27 | 1996-10-01 | Schering Corp | Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso. |
ES2042421B1 (es) * | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina. |
US5674866A (en) * | 1993-07-13 | 1997-10-07 | Janssen Pharmaceutica N.V. | Antiallergic imidazoazepines |
US5661152A (en) * | 1993-10-15 | 1997-08-26 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5721236A (en) * | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
US6075025A (en) | 1993-10-15 | 2000-06-13 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6365588B1 (en) | 1993-10-15 | 2002-04-02 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5464840A (en) * | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5538986A (en) * | 1993-12-06 | 1996-07-23 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5684013A (en) * | 1995-03-24 | 1997-11-04 | Schering Corporation | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
US5891872A (en) * | 1995-04-07 | 1999-04-06 | Schering Corporation | Tricyclic compounds |
US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
WO1998043638A1 (fr) * | 1997-03-27 | 1998-10-08 | Kyowa Hakko Kogyo Co., Ltd. | Agent therapeutique pour maladies auto-immunes |
US6225322B1 (en) * | 1997-06-17 | 2001-05-01 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
CA2383222C (fr) | 1999-09-13 | 2008-11-18 | Bridge Pharma, Inc. | Isomeres de ketotifene optiquement actifs et metabolites therapeutiquement actifs |
EP2243778B1 (fr) | 2008-01-30 | 2014-10-29 | Nippon Zoki Pharmaceutical Co., Ltd. | Dérivé de piperidine |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL130095C (fr) * | 1962-08-31 | |||
US3491103A (en) * | 1963-12-19 | 1970-01-20 | Sandoz Ag | Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes |
FR91084E (fr) * | 1964-08-11 | 1968-04-05 | Sandoz Sa | Nouveaux benzo-cyclohepta-thiophènes et leur préparation |
US3458522A (en) * | 1967-05-17 | 1969-07-29 | Sandoz Ag | 4-piperidine substituted benzocycloheptaoxazoles and benzocycloheptathiazoles |
US3485846A (en) * | 1967-06-30 | 1969-12-23 | Eugene E Galantay | Benzocycloheptaimidazoles |
US3442903A (en) * | 1967-08-30 | 1969-05-06 | Sandoz Ag | Certain aminopropylidenebenzo(5,6)cyclohepta(1,2-d)thiazoles |
US3994915A (en) * | 1972-06-30 | 1976-11-30 | Sandoz, Inc. | Preparation of substituted oxazoles |
DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
US4173634A (en) * | 1979-02-23 | 1979-11-06 | E. R. Squibb & Sons, Inc. | Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents |
DE3135250A1 (de) * | 1981-09-05 | 1983-03-17 | Basf Ag, 6700 Ludwigshafen | Tricyclische thiazolyloxamate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
US4762843A (en) * | 1986-09-15 | 1988-08-09 | Warner-Lambert Company | Hetero [f] fused carbocyclic pyridines as dopaminergic agents |
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
AU609808B2 (en) * | 1987-04-09 | 1991-05-09 | E.I. Du Pont De Nemours And Company | Insecticidal substituted indazoles |
NZ224745A (en) * | 1987-05-29 | 1990-09-26 | Merrell Dow Pharma | Tricyclic oxazolone derivatives and pharmaceutical compositions |
-
1989
- 1989-04-26 CA CA000597848A patent/CA1341370C/fr not_active Expired - Fee Related
- 1989-04-26 WO PCT/US1989/001689 patent/WO1989010363A1/fr active IP Right Grant
- 1989-04-26 NZ NZ228889A patent/NZ228889A/xx unknown
- 1989-04-26 ES ES89304168T patent/ES2091195T3/es not_active Expired - Lifetime
- 1989-04-26 ZA ZA893103A patent/ZA893103B/xx unknown
- 1989-04-26 AT AT89304168T patent/ATE141599T1/de not_active IP Right Cessation
- 1989-04-26 EP EP89304168A patent/EP0339978B1/fr not_active Expired - Lifetime
- 1989-04-26 JP JP1504829A patent/JP2511550B2/ja not_active Expired - Lifetime
- 1989-04-26 MY MYPI89000539A patent/MY106964A/en unknown
- 1989-04-26 DE DE68926976T patent/DE68926976T2/de not_active Expired - Fee Related
- 1989-04-26 SG SG1996000742A patent/SG44477A1/en unknown
- 1989-04-26 EP EP89905353A patent/EP0412988A1/fr active Pending
- 1989-04-27 IL IL9010289A patent/IL90102A/en not_active IP Right Cessation
-
1990
- 1990-10-25 DK DK199002569A patent/DK172717B1/da active IP Right Grant
- 1990-10-26 FI FI905281A patent/FI96309C/fi not_active IP Right Cessation
- 1990-10-26 NO NO904666A patent/NO300972B1/no not_active IP Right Cessation
- 1990-10-26 OA OA59878A patent/OA09321A/xx unknown
-
1996
- 1996-10-24 GR GR960402820T patent/GR3021465T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU631795B2 (en) | 1992-12-10 |
ES2091195T3 (es) | 1996-11-01 |
IL90102A0 (en) | 1989-12-15 |
FI905281A0 (fi) | 1990-10-26 |
ATE141599T1 (de) | 1996-09-15 |
DE68926976D1 (de) | 1996-09-26 |
DK256990A (da) | 1990-12-17 |
WO1989010363A1 (fr) | 1989-11-02 |
AU3535689A (en) | 1989-11-24 |
EP0412988A1 (fr) | 1991-02-20 |
NO904666D0 (no) | 1990-10-26 |
SG44477A1 (en) | 1997-12-19 |
DE68926976T2 (de) | 1997-02-27 |
DK256990D0 (da) | 1990-10-25 |
NO904666L (no) | 1990-12-27 |
DK172717B1 (da) | 1999-06-14 |
EP0339978A1 (fr) | 1989-11-02 |
IL90102A (en) | 1994-07-31 |
NZ228889A (en) | 1991-09-25 |
ZA893103B (en) | 1989-12-27 |
NO300972B1 (no) | 1997-08-25 |
CA1341370C (fr) | 2002-06-18 |
FI96309B (fi) | 1996-02-29 |
MY106964A (en) | 1995-08-30 |
JPH03504855A (ja) | 1991-10-24 |
FI96309C (fi) | 1996-06-10 |
GR3021465T3 (en) | 1997-01-31 |
EP0339978B1 (fr) | 1996-08-21 |
JP2511550B2 (ja) | 1996-06-26 |
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