NZ778579A - Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies - Google Patents

Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies

Info

Publication number
NZ778579A
NZ778579A NZ778579A NZ77857920A NZ778579A NZ 778579 A NZ778579 A NZ 778579A NZ 778579 A NZ778579 A NZ 778579A NZ 77857920 A NZ77857920 A NZ 77857920A NZ 778579 A NZ778579 A NZ 778579A
Authority
NZ
New Zealand
Prior art keywords
egfr
combination therapies
bispecific anti
met antibodies
patient stratification
Prior art date
Application number
NZ778579A
Other languages
English (en)
Inventor
Sheri Moores
Smruthi Vijayaraghavan
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of NZ778579A publication Critical patent/NZ778579A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ778579A 2019-02-26 2020-02-24 Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies NZ778579A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962810716P 2019-02-26 2019-02-26
US201962930190P 2019-11-04 2019-11-04
PCT/IB2020/051559 WO2020174370A2 (en) 2019-02-26 2020-02-24 Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies

Publications (1)

Publication Number Publication Date
NZ778579A true NZ778579A (en) 2026-03-27

Family

ID=72142314

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ778579A NZ778579A (en) 2019-02-26 2020-02-24 Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies

Country Status (16)

Country Link
US (3) US11459391B2 (enExample)
EP (1) EP3931224A4 (enExample)
JP (3) JP7703448B2 (enExample)
KR (1) KR20210132117A (enExample)
CN (1) CN113840842A (enExample)
AU (1) AU2020229467A1 (enExample)
BR (1) BR112021016149A2 (enExample)
CA (1) CA3131654A1 (enExample)
IL (1) IL285718A (enExample)
JO (1) JOP20210233A1 (enExample)
MA (1) MA55089A (enExample)
MX (1) MX2021010265A (enExample)
NZ (1) NZ778579A (enExample)
PH (1) PH12021552030A1 (enExample)
SG (1) SG11202108311RA (enExample)
WO (1) WO2020174370A2 (enExample)

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EP3956035A4 (en) * 2019-04-17 2023-01-25 Board of Regents, The University of Texas System ANTI-CANCER LINKS WITH TYROSINE KINASE RESISTANT EGFR MUTATIONS
MX2021013955A (es) * 2019-05-14 2022-03-11 Janssen Biotech Inc Terapias de combinación con anticuerpos anti-egfr/c-met biespecíficos e inhibidores de tirosina quinasa de egfr de 3.a generación.
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US11879013B2 (en) * 2019-05-14 2024-01-23 Janssen Biotech, Inc. Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
JP7783182B2 (ja) * 2020-02-12 2025-12-09 ヤンセン バイオテツク，インコーポレーテツド ｃ－ＭＥＴエクソン１４スキッピング変異を有する患者の治療
CN116194141A (zh) 2020-08-25 2023-05-30 詹森生物科技公司 具有egfr突变的非小细胞肺癌的治疗
BR112023018278A2 (pt) * 2021-03-09 2023-10-31 Janssen Biotech Inc Tratamento de cânceres sem mutações de ativação de egfr
EP4372001A4 (en) * 2021-07-14 2025-02-12 Jiangsu Hengrui Pharmaceuticals Co., Ltd. ANTIGEN-BINDING MOLECULE SPECIFICALLY BINDING TO HGFR AND EGFR, AND PHARMACEUTICAL USE THEREOF
CN118043075A (zh) * 2021-07-29 2024-05-14 得克萨斯州大学系统董事会 用于治疗kras突变体癌症的方法和组合物
KR102793991B1 (ko) 2021-10-06 2025-04-09 주식회사 엘지에너지솔루션 태양광 시스템과 연계하는 에너지 저장 시스템 및 에너지 저장 시스템의 제어 방법
US20230183360A1 (en) * 2021-12-09 2023-06-15 Janssen Biotech, Inc. Use of Amivantamab to Treat Colorectal Cancer
WO2024189544A1 (en) * 2023-03-13 2024-09-19 Janssen Biotech, Inc. Combination therapies with bi-specific anti-egfr/c-met antibodies and anti-pd-1 antibodies
KR20260005269A (ko) * 2023-04-24 2026-01-09 치아타이 티안큉 파마수티컬 그룹 주식회사 c-Met를 표적으로 하는 다중 특이성 항체
CN119700964A (zh) * 2023-09-28 2025-03-28 上海翰森生物医药科技有限公司 一种双特异性抗体在制备治疗癌症的药物中的用途

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Also Published As

Publication number Publication date
SG11202108311RA (en) 2021-09-29
PH12021552030A1 (en) 2022-08-15
JP2025084739A (ja) 2025-06-03
EP3931224A4 (en) 2023-03-01
US20200270351A1 (en) 2020-08-27
BR112021016149A2 (pt) 2021-10-13
JP7703448B2 (ja) 2025-07-07
US20250236675A1 (en) 2025-07-24
IL285718A (en) 2021-10-31
US12215161B2 (en) 2025-02-04
CA3131654A1 (en) 2020-09-03
MA55089A (fr) 2022-01-05
US11459391B2 (en) 2022-10-04
US20230130600A1 (en) 2023-04-27
WO2020174370A2 (en) 2020-09-03
AU2020229467A1 (en) 2021-08-12
WO2020174370A3 (en) 2020-12-03
EP3931224A2 (en) 2022-01-05
JP2022521610A (ja) 2022-04-11
CN113840842A (zh) 2021-12-24
JP2024153659A (ja) 2024-10-29
MX2021010265A (es) 2021-09-23
JOP20210233A1 (ar) 2023-01-30
KR20210132117A (ko) 2021-11-03

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