NZ735011A - 1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders - Google Patents

1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders

Info

Publication number
NZ735011A
NZ735011A NZ735011A NZ73501116A NZ735011A NZ 735011 A NZ735011 A NZ 735011A NZ 735011 A NZ735011 A NZ 735011A NZ 73501116 A NZ73501116 A NZ 73501116A NZ 735011 A NZ735011 A NZ 735011A
Authority
NZ
New Zealand
Prior art keywords
compounds
isochromanyl
heterocyclyl
analogs
cns disorders
Prior art date
Application number
NZ735011A
Other languages
English (en)
Inventor
Taleen G Hanania
Vadim Alexandrov
Linghong Xie
Philip Glyn Jones
Kerry L Spear
Noel Aaron Powell
Original Assignee
Sunovion Pharmaceuticals Inc
Pgi Drug Discovery Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunovion Pharmaceuticals Inc, Pgi Drug Discovery Llc filed Critical Sunovion Pharmaceuticals Inc
Publication of NZ735011A publication Critical patent/NZ735011A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ735011A 2015-02-11 2016-02-11 1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders NZ735011A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562115064P 2015-02-11 2015-02-11
PCT/US2016/017539 WO2016130796A1 (en) 2015-02-11 2016-02-11 1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders

Publications (1)

Publication Number Publication Date
NZ735011A true NZ735011A (en) 2023-07-28

Family

ID=55456908

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ735011A NZ735011A (en) 2015-02-11 2016-02-11 1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders

Country Status (22)

Country Link
US (4) US9856238B2 (OSRAM)
EP (2) EP3256466B9 (OSRAM)
JP (3) JP6657241B2 (OSRAM)
KR (1) KR102601972B1 (OSRAM)
CN (2) CN111925360B (OSRAM)
AU (1) AU2016219253C1 (OSRAM)
CA (1) CA2976095C (OSRAM)
CY (1) CY1125198T1 (OSRAM)
DK (1) DK3256466T3 (OSRAM)
EA (1) EA201791804A1 (OSRAM)
ES (2) ES2967643T3 (OSRAM)
HU (1) HUE058698T2 (OSRAM)
IL (1) IL253914B (OSRAM)
MX (2) MX392664B (OSRAM)
MY (1) MY188160A (OSRAM)
NZ (1) NZ735011A (OSRAM)
PH (1) PH12017501422A1 (OSRAM)
PL (1) PL3256466T3 (OSRAM)
PT (1) PT3256466T (OSRAM)
SG (2) SG11201706515QA (OSRAM)
UA (1) UA122222C2 (OSRAM)
WO (1) WO2016130796A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3256476T3 (pl) * 2015-02-11 2019-05-31 Pgi Drug Discovery Llc Związki i analogi fuzyjnego dihydro-4h-pirazolo[5,1-c][1,4]oksazynylu w leczeniu zaburzeń oun
DK3256466T3 (da) * 2015-02-11 2022-05-02 Sunovion Pharmaceuticals Inc 1-heterocyclyl-isochromanylforbindelser og analoger til behandling af cns-forstyrrelser
CN110087687A (zh) 2016-07-29 2019-08-02 赛诺维信制药公司 化合物、组合物及其用途
CA3032302A1 (en) 2016-07-29 2018-02-01 Taleen G. Hanania Compounds and compositions and uses thereof
EP3645120B1 (en) 2017-06-30 2024-12-11 Chase Therapeutics Corporation Nk-1 antagonist compositions and methods for use in treating depression
CN111183138A (zh) 2017-08-02 2020-05-19 赛诺维信制药公司 异色满化合物以及用途
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
US12077546B2 (en) 2021-04-10 2024-09-03 Sumitomo Pharma Co., Ltd. Bicyclic pyridine derivative

Family Cites Families (17)

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US3438995A (en) 1968-01-08 1969-04-15 Melville Sahyun Diazaheterocyclic substituted benz-oxaheterocyclic compounds
US4963568A (en) 1989-05-31 1990-10-16 Abbott Laboratories Dopamine agonists
US5621133A (en) 1989-05-31 1997-04-15 Deninno; Michael P. Dopamine agonists
IE73232B1 (en) * 1990-05-25 1997-05-21 Akzo Nv Isochromane derivatives
US5238939A (en) * 1990-05-25 1993-08-24 Akzo N.V. Isochromane derivatives
WO2000000487A1 (en) 1998-06-30 2000-01-06 Eli Lilly And Company 5-ht1f agonists
SE9902267D0 (sv) * 1999-06-16 1999-06-16 Astra Ab New compounds
MXPA04004368A (es) * 2001-11-08 2004-08-11 Sepracor Inc Metodos para tratar depresion y otros transtornos del sistema nervioso central utilizando desmetil-y didesmetil-metabolitos del citalopram enantiomericamente enriquecidos.
EP1831203A1 (en) * 2004-12-21 2007-09-12 F. Hoffmann-Roche AG Chroman derivatives and uses thereof in the treatment of cns disorders
RU2007139541A (ru) 2005-04-22 2009-05-27 Вайет (Us) Производные хромана и хромена и их применение
KR20080090545A (ko) * 2006-01-27 2008-10-08 에프. 호프만-라 로슈 아게 Cns 장애 치료용 2-이미다졸의 용도
KR101103118B1 (ko) 2007-11-02 2012-01-04 동아제약주식회사 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물
SG10201401661RA (en) * 2009-12-04 2014-07-30 Sunovion Pharmaceuticals Inc Multicycle compounds and pharmaceutical compositions useful for the treatment of neurological disorders
WO2012122340A1 (en) 2011-03-10 2012-09-13 Boehringer Ingelheim International Gmbh Soluble guanylate cyclase activators
AR090557A1 (es) * 2012-04-02 2014-11-19 Orion Corp DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2
JP6359560B2 (ja) * 2012-12-31 2018-07-18 サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. 複素環式化合物及びその使用方法
DK3256466T3 (da) * 2015-02-11 2022-05-02 Sunovion Pharmaceuticals Inc 1-heterocyclyl-isochromanylforbindelser og analoger til behandling af cns-forstyrrelser

Also Published As

Publication number Publication date
AU2016219253B2 (en) 2020-10-01
MX2017010363A (es) 2018-05-04
JP7023994B2 (ja) 2022-02-22
HUE058698T2 (hu) 2022-09-28
EA201791804A1 (ru) 2018-02-28
EP4046995C0 (en) 2023-09-13
US9856238B2 (en) 2018-01-02
US10336732B2 (en) 2019-07-02
US20170001987A1 (en) 2017-01-05
MX2020001157A (es) 2022-05-27
CN107531674A (zh) 2018-01-02
US20180093974A1 (en) 2018-04-05
ES2911910T9 (es) 2022-08-12
EP4046995B1 (en) 2023-09-13
EP4046995A1 (en) 2022-08-24
IL253914B (en) 2021-09-30
CA2976095A1 (en) 2016-08-18
MX392664B (es) 2025-03-24
US20190389845A1 (en) 2019-12-26
US20220185799A1 (en) 2022-06-16
MX371404B (es) 2020-01-29
CA2976095C (en) 2023-10-17
JP6657241B2 (ja) 2020-03-04
JP2020079282A (ja) 2020-05-28
SG11201706515QA (en) 2017-09-28
CN111925360B (zh) 2024-03-22
MY188160A (en) 2021-11-24
PT3256466T (pt) 2022-05-10
KR20170129730A (ko) 2017-11-27
SG10201806809QA (en) 2018-09-27
CN111925360A (zh) 2020-11-13
AU2016219253A1 (en) 2017-09-21
BR112017017354A2 (pt) 2018-04-10
EP3256466B9 (en) 2022-07-27
PL3256466T3 (pl) 2022-05-23
UA122222C2 (uk) 2020-10-12
EP3256466A1 (en) 2017-12-20
EP3256466B1 (en) 2022-04-06
KR102601972B1 (ko) 2023-11-13
DK3256466T3 (da) 2022-05-02
ES2911910T3 (es) 2022-05-23
CY1125198T1 (el) 2024-12-13
WO2016130796A1 (en) 2016-08-18
CN107531674B (zh) 2020-07-31
US11192885B2 (en) 2021-12-07
AU2016219253C1 (en) 2022-12-08
JP2018505205A (ja) 2018-02-22
PH12017501422A1 (en) 2018-03-19
IL253914A0 (en) 2017-10-31
ES2967643T3 (es) 2024-05-03
JP2022065050A (ja) 2022-04-26

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Effective date: 20240117

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