NZ595492A - Improved Process for the Preparation of Lenalidomide - Google Patents
Improved Process for the Preparation of LenalidomideInfo
- Publication number
- NZ595492A NZ595492A NZ595492A NZ59549210A NZ595492A NZ 595492 A NZ595492 A NZ 595492A NZ 595492 A NZ595492 A NZ 595492A NZ 59549210 A NZ59549210 A NZ 59549210A NZ 595492 A NZ595492 A NZ 595492A
- Authority
- NZ
- New Zealand
- Prior art keywords
- lenalidomide
- isoindol
- dione
- piperidine
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Optical Communication System (AREA)
- Lighting Device Outwards From Vehicle And Optical Signal (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN383KO2009 | 2009-03-02 | ||
| IN463KO2009 | 2009-03-16 | ||
| PCT/GB2010/050352 WO2010100476A2 (en) | 2009-03-02 | 2010-03-01 | Improved process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ595492A true NZ595492A (en) | 2013-07-26 |
Family
ID=54290149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ595492A NZ595492A (en) | 2009-03-02 | 2010-03-01 | Improved Process for the Preparation of Lenalidomide |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8946265B2 (https=) |
| EP (1) | EP2403845B1 (https=) |
| JP (1) | JP5727944B2 (https=) |
| CN (1) | CN102414196A (https=) |
| AU (1) | AU2010220204B2 (https=) |
| CA (1) | CA2753241C (https=) |
| CY (1) | CY1115376T1 (https=) |
| DK (1) | DK2403845T3 (https=) |
| ES (1) | ES2487215T3 (https=) |
| HR (1) | HRP20140686T1 (https=) |
| NZ (1) | NZ595492A (https=) |
| PL (1) | PL2403845T3 (https=) |
| PT (1) | PT2403845E (https=) |
| SI (1) | SI2403845T1 (https=) |
| SM (1) | SMT201400100B (https=) |
| WO (1) | WO2010100476A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| TWI475014B (zh) * | 2009-09-17 | 2015-03-01 | Scinopharm Taiwan Ltd | 固體形態的３－（４－胺基－１－側氧基－１，３－二氫－異吲哚－２－基）－哌啶－２，６－二酮及其製造方法 |
| WO2011064574A1 (en) | 2009-11-24 | 2011-06-03 | Generics [Uk] Limited | Hplc method for detecting lenalidomide |
| US8877932B2 (en) | 2010-03-08 | 2014-11-04 | Natco Pharma Limited | Anhydrous lenalidomide form-I |
| KR20130050952A (ko) | 2010-06-16 | 2013-05-16 | 브루스 챈들러 메이 | 인플루엔자, 감기 및 염증의 치료에서 레보세티리진 및 몬테루카스트의 용도 |
| WO2013005229A1 (en) * | 2011-07-05 | 2013-01-10 | Hetero Research Foundation | Process for lenalidomide |
| CA2842316A1 (en) | 2011-07-19 | 2013-01-24 | Amplio Pharma, Llc | Urea cocrystal of 3-(4-amin0-1-0x0-1,3 dihydro-isoindol-2-yl)piperidine-2,6-dione |
| CN102838586A (zh) * | 2012-09-20 | 2012-12-26 | 重庆泰濠制药有限公司 | 一种制备来那度胺的方法 |
| ES2654093T3 (es) * | 2013-03-13 | 2018-02-12 | Inflammatory Response Research, Inc. | Uso de levocetirizina y montelukast en el tratamiento de trastornos autoinmunes |
| RU2672871C2 (ru) | 2013-03-13 | 2018-11-20 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцетиризина и монтелукаста при лечении травматических повреждений |
| CA2901413A1 (en) | 2013-03-13 | 2014-10-09 | Bruce Chandler May | Use of levocetirizine and montelukast in the treatment of vasculitis |
| US9808450B2 (en) | 2013-03-26 | 2017-11-07 | Celgene Corporation | Solid forms comprising 3-(4-amino-1-OXO-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione and a coformer, compositions and methods of use thereof |
| CN103601717A (zh) * | 2013-10-09 | 2014-02-26 | 湖南华腾制药有限公司 | 一种来那度胺的新型制备方法 |
| LV14985B (lv) | 2013-10-14 | 2015-06-20 | Latvijas Organiskās Sintēzes Institūts | Lenalidomīda iegūšanas process |
| EP3137450A2 (en) * | 2014-04-26 | 2017-03-08 | Shilpa Medicare Limited | Crystalline lenalidomide process |
| US10392364B2 (en) | 2014-08-11 | 2019-08-27 | Avra Laboratories Pvt. Ltd. | Process for synthesis of lenalidomide |
| KR102516638B1 (ko) * | 2014-08-19 | 2023-04-03 | 신톤 비.브이. | 레날리도마이드의 결정형 a의 제조 방법 |
| JP2017526728A (ja) | 2014-09-15 | 2017-09-14 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト |
| EA036205B1 (ru) * | 2015-12-22 | 2020-10-14 | Синтон Б.В. | Фармацевтическая композиция, содержащая аморфный леналидомид и антиоксидант |
| US10899793B2 (en) | 2016-05-27 | 2021-01-26 | Regents Of The University Of Minnesota | Melanocortin ligands and methods of use thereof |
| US11124541B2 (en) | 2016-10-18 | 2021-09-21 | Regents Of The University Of Minnesota | Chimeric melanocortin ligands and methods of use thereof |
| JP2020535192A (ja) * | 2017-09-27 | 2020-12-03 | バイオコン・リミテッド | レナリドミドの結晶形 |
| WO2019138424A1 (en) * | 2018-01-11 | 2019-07-18 | Natco Pharma Limited | Stable pharmaceutical compositions comprising lenalidomide |
| US11332499B2 (en) | 2018-08-16 | 2022-05-17 | Regents Of The University Of Minnesota | Cyclic peptides and methods of use thereof |
| CN111196800B (zh) * | 2018-11-19 | 2022-10-11 | 欣凯医药化工中间体（上海）有限公司 | 一种制备来那度胺的方法 |
| EP4153178A4 (en) | 2020-05-19 | 2024-06-05 | Irr, Inc. | Levocetirizine and montelukast in the treatment of sepsis and symptoms thereof |
| WO2022144924A1 (en) * | 2021-01-04 | 2022-07-07 | Avra Laboratories Pvt. Ltd. | An improved process for synthesis of lenalidomide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| EP1797068B1 (en) * | 2004-09-03 | 2013-10-09 | Celgene Corporation | Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines |
| EP2136896B1 (en) | 2007-04-16 | 2015-01-21 | Momenta Pharmaceuticals, Inc. | Multi-dimensional chromatographic methods for separating n-glycans |
| CA2709262A1 (en) | 2007-12-14 | 2009-06-25 | Generics [Uk] Limited | New hplc method |
| AU2009223014A1 (en) | 2008-03-11 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| EP2364305A1 (en) | 2008-11-03 | 2011-09-14 | Generics (UK) Limited | A crystalline form of lenalidomide and a process for its preparation |
| WO2011064574A1 (en) | 2009-11-24 | 2011-06-03 | Generics [Uk] Limited | Hplc method for detecting lenalidomide |
-
2010
- 2010-03-01 CN CN2010800195527A patent/CN102414196A/zh active Pending
- 2010-03-01 WO PCT/GB2010/050352 patent/WO2010100476A2/en not_active Ceased
- 2010-03-01 ES ES10707950.1T patent/ES2487215T3/es active Active
- 2010-03-01 PL PL10707950T patent/PL2403845T3/pl unknown
- 2010-03-01 NZ NZ595492A patent/NZ595492A/xx not_active IP Right Cessation
- 2010-03-01 SI SI201030679T patent/SI2403845T1/sl unknown
- 2010-03-01 AU AU2010220204A patent/AU2010220204B2/en not_active Ceased
- 2010-03-01 DK DK10707950.1T patent/DK2403845T3/da active
- 2010-03-01 PT PT107079501T patent/PT2403845E/pt unknown
- 2010-03-01 JP JP2011552515A patent/JP5727944B2/ja not_active Expired - Fee Related
- 2010-03-01 CA CA2753241A patent/CA2753241C/en active Active
- 2010-03-01 HR HRP20140686AT patent/HRP20140686T1/hr unknown
- 2010-03-01 EP EP10707950.1A patent/EP2403845B1/en active Active
- 2010-03-01 US US13/254,249 patent/US8946265B2/en active Active
-
2014
- 2014-07-24 CY CY20141100562T patent/CY1115376T1/el unknown
- 2014-07-28 SM SM201400100T patent/SMT201400100B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2403845E (pt) | 2014-08-04 |
| EP2403845A2 (en) | 2012-01-11 |
| JP2012519207A (ja) | 2012-08-23 |
| SI2403845T1 (sl) | 2014-09-30 |
| CN102414196A (zh) | 2012-04-11 |
| HRP20140686T1 (hr) | 2014-09-26 |
| AU2010220204B2 (en) | 2015-10-08 |
| DK2403845T3 (da) | 2014-08-04 |
| ES2487215T3 (es) | 2014-08-20 |
| US8946265B2 (en) | 2015-02-03 |
| CY1115376T1 (el) | 2017-01-04 |
| SMT201400100B (it) | 2014-11-10 |
| CA2753241C (en) | 2015-06-16 |
| WO2010100476A3 (en) | 2011-06-16 |
| JP5727944B2 (ja) | 2015-06-03 |
| AU2010220204A1 (en) | 2011-10-20 |
| US20120071509A1 (en) | 2012-03-22 |
| CA2753241A1 (en) | 2010-09-10 |
| EP2403845B1 (en) | 2014-04-30 |
| PL2403845T3 (pl) | 2014-09-30 |
| WO2010100476A2 (en) | 2010-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 MAR 2017 BY DENNEMEYER SA Effective date: 20140214 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2018 BY RENEWALS TEAM Effective date: 20170325 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2019 BY RENEWALS TEAM Effective date: 20180210 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2020 BY RENEWALS TEAM Effective date: 20190105 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2021 BY RENEWALS TEAM Effective date: 20200224 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2022 BY IPAN GMBH Effective date: 20210218 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2023 BY IPAN GMBH Effective date: 20220215 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2024 BY IPAN GMBH Effective date: 20230215 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2025 BY IPAN GMBH Effective date: 20240216 |
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| ASS | Change of ownership |
Owner name: TIANISH LABORATORIES PRIVATE LIMITED, IN Effective date: 20250417 |
|
| LAPS | Patent lapsed |