NZ593694A - Topically active steroids for use in radiation and chemotherapeutics injury - Google Patents
Topically active steroids for use in radiation and chemotherapeutics injuryInfo
- Publication number
- NZ593694A NZ593694A NZ593694A NZ59369409A NZ593694A NZ 593694 A NZ593694 A NZ 593694A NZ 593694 A NZ593694 A NZ 593694A NZ 59369409 A NZ59369409 A NZ 59369409A NZ 593694 A NZ593694 A NZ 593694A
- Authority
- NZ
- New Zealand
- Prior art keywords
- medicament
- radiation
- chemotherapeutics
- patient
- beclomethasone
- Prior art date
Links
- 230000006378 damage Effects 0.000 title abstract 3
- 230000005855 radiation Effects 0.000 title abstract 3
- 208000027418 Wounds and injury Diseases 0.000 title 1
- 208000014674 injury Diseases 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 abstract 2
- 229950000210 beclometasone dipropionate Drugs 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 241000792859 Enema Species 0.000 abstract 1
- OHYGPBKGZGRQKT-XGQKBEPLSA-N [(8s,9r,10s,11s,13s,14s,16s,17r)-9-chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CC)[C@@]1(C)C[C@@H]2O OHYGPBKGZGRQKT-XGQKBEPLSA-N 0.000 abstract 1
- 229940092705 beclomethasone Drugs 0.000 abstract 1
- 229940006003 beclomethasone 17-monopropionate Drugs 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 239000007920 enema Substances 0.000 abstract 1
- 229940095399 enema Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Marine Sciences & Fisheries (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12078508P | 2008-12-08 | 2008-12-08 | |
| PCT/US2009/067199 WO2010077681A1 (en) | 2008-12-08 | 2009-12-08 | Topically active steroids for use in radiation and chemotherapeutics injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ593694A true NZ593694A (en) | 2013-09-27 |
Family
ID=42310112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ593694A NZ593694A (en) | 2008-12-08 | 2009-12-08 | Topically active steroids for use in radiation and chemotherapeutics injury |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20100183749A1 (https=) |
| EP (2) | EP2373160B1 (https=) |
| JP (2) | JP5709266B2 (https=) |
| KR (2) | KR20110092351A (https=) |
| CN (2) | CN106692162A (https=) |
| AU (1) | AU2009333538B2 (https=) |
| CA (1) | CA2745930C (https=) |
| DK (2) | DK2902031T3 (https=) |
| IL (1) | IL213411A (https=) |
| NZ (1) | NZ593694A (https=) |
| SG (2) | SG10201704531XA (https=) |
| WO (1) | WO2010077681A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010039861A2 (en) | 2008-09-30 | 2010-04-08 | The Regents Of The University Of Michigan | Dendrimer conjugates |
| US9017644B2 (en) | 2008-11-07 | 2015-04-28 | The Regents Of The University Of Michigan | Methods of treating autoimmune disorders and/or inflammatory disorders |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| EP2393917B1 (en) | 2009-02-03 | 2016-04-06 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| WO2011059586A2 (en) | 2009-10-30 | 2011-05-19 | The Regents Of The University Of Michigan | Multifunctional small molecules |
| US9381187B2 (en) * | 2011-02-16 | 2016-07-05 | Paloma Pharmaceuticals, Inc. | Radiation countermeasure agents |
| WO2013085718A1 (en) | 2011-12-08 | 2013-06-13 | The Regents Of The University Of Michigan | Multifunctional small molecules |
| AU2013266069B2 (en) | 2012-05-25 | 2018-03-15 | Sloan Kettering Institute For Cancer Research | Methods for treating GI syndrome and graft versus host disease |
| WO2014025832A1 (en) * | 2012-08-06 | 2014-02-13 | University Of Southern California | Wnt modulators for the protection, mitigation and treatment of radiation injury |
| WO2014059068A1 (en) * | 2012-10-11 | 2014-04-17 | The Trustees Of The University Of Pennsylvania | Methods for the treatment and prevention of osteoporosis and bone-related disorders |
| WO2014134038A1 (en) * | 2013-02-28 | 2014-09-04 | The Regents Of The University Of Michigan | Compositions and methods relating to induction of intestinal stem cell homeogenesis and/or regeneration |
| AU2014318247B2 (en) * | 2013-09-13 | 2018-05-24 | Michael Abrams | Novel peptides and analogs for use in the treatment of oral mucositis |
| US11311598B2 (en) | 2013-09-13 | 2022-04-26 | Soligenix, Inc. | Peptides and analogs for use in the treatment of oral mucositis |
| US9439947B2 (en) | 2014-03-28 | 2016-09-13 | Albert Einstein College Of Medicine, Inc. | Therapy for radiation-induced lung injury |
| CN106794197A (zh) * | 2014-10-02 | 2017-05-31 | 西托索尔本茨公司 | 经胃肠施用的多孔消化道吸着剂聚合物用于预防或治疗辐射诱导的黏膜炎、食管炎、小肠炎、结肠炎和胃肠急性放射综合征的用途 |
| US20170007559A1 (en) * | 2015-07-12 | 2017-01-12 | The University Of Tennessee Research Foundation | Compositions and methods for protecting colonic epithelial barrier function |
| WO2017119988A2 (en) * | 2015-12-10 | 2017-07-13 | Memorial Sloan Kettering Cancer Center | Radioprotection by wnt activation |
| CN107753932A (zh) * | 2016-08-22 | 2018-03-06 | 中国辐射防护研究院 | Kgf在制备治疗或预防放射性肠炎药物中的用途 |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4661509A (en) * | 1982-09-28 | 1987-04-28 | Gordon Arnold Z | Methods for treating leukopenia |
| US5252333A (en) * | 1987-04-27 | 1993-10-12 | Scotia Holdings Plc | Lithium salt-containing pharmaceutical compositions |
| US6077692A (en) * | 1995-02-14 | 2000-06-20 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US20030144202A1 (en) * | 1996-10-15 | 2003-07-31 | Amgen Inc. | Uses of keratinocyte growth factor-2 |
| WO2001024812A1 (en) * | 1999-10-06 | 2001-04-12 | N.V. Nutricia | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
| US20020086857A1 (en) * | 2000-09-15 | 2002-07-04 | Mcdonald George B. | Method of long-term treatment of graft-versus-host disease using topical active corticosterioids |
| US7544348B2 (en) * | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| AU2002254205B2 (en) * | 2001-03-15 | 2007-05-10 | Enteron Pharmaceuticals, Inc. | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
| JP2008526773A (ja) * | 2004-12-30 | 2008-07-24 | ドール バイオファーマ、インコーポレイテッド | ベクロメタゾンジプロピオネート及びプレドニゾンでの、移植片対宿主病及び白血病の治療 |
| JP4839436B2 (ja) * | 2005-11-02 | 2011-12-21 | 国立大学法人徳島大学 | 消化管粘膜保護剤、カベオリン遺伝子発現促進剤及び抗ストレス剤 |
| US20070293458A1 (en) | 2006-06-16 | 2007-12-20 | Ip-6 Research Inc. | Prevention of nuclear, solar, and other radiation-induced tissue damage |
| WO2008101215A1 (en) * | 2007-02-16 | 2008-08-21 | Varian Medical Systems Technologies, Inc. | Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo |
| US20090149433A1 (en) * | 2007-11-13 | 2009-06-11 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
-
2009
- 2009-12-08 SG SG10201704531XA patent/SG10201704531XA/en unknown
- 2009-12-08 CN CN201710119024.2A patent/CN106692162A/zh active Pending
- 2009-12-08 CA CA2745930A patent/CA2745930C/en active Active
- 2009-12-08 SG SG2011041332A patent/SG171997A1/en unknown
- 2009-12-08 EP EP09836727.9A patent/EP2373160B1/en not_active Not-in-force
- 2009-12-08 AU AU2009333538A patent/AU2009333538B2/en not_active Ceased
- 2009-12-08 WO PCT/US2009/067199 patent/WO2010077681A1/en not_active Ceased
- 2009-12-08 US US12/633,631 patent/US20100183749A1/en not_active Abandoned
- 2009-12-08 CN CN2009801562821A patent/CN102307466A/zh active Pending
- 2009-12-08 DK DK15158919.9T patent/DK2902031T3/en active
- 2009-12-08 NZ NZ593694A patent/NZ593694A/xx not_active IP Right Cessation
- 2009-12-08 JP JP2011539796A patent/JP5709266B2/ja not_active Expired - Fee Related
- 2009-12-08 EP EP15158919.9A patent/EP2902031B1/en not_active Not-in-force
- 2009-12-08 DK DK09836727.9T patent/DK2373160T3/en active
- 2009-12-08 KR KR1020117015534A patent/KR20110092351A/ko not_active Ceased
- 2009-12-08 KR KR1020167036277A patent/KR101783577B1/ko not_active Expired - Fee Related
-
2011
- 2011-06-06 IL IL213411A patent/IL213411A/en active IP Right Grant
-
2014
- 2014-11-25 JP JP2014237466A patent/JP5905562B2/ja not_active Expired - Fee Related
-
2017
- 2017-04-24 US US15/495,798 patent/US20170333448A1/en not_active Abandoned
-
2019
- 2019-06-21 US US16/448,526 patent/US20200155571A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5905562B2 (ja) | 2016-04-20 |
| EP2373160B1 (en) | 2017-10-25 |
| EP2902031A1 (en) | 2015-08-05 |
| DK2373160T3 (en) | 2018-01-02 |
| CA2745930A1 (en) | 2010-07-08 |
| SG10201704531XA (en) | 2017-07-28 |
| EP2902031B1 (en) | 2018-10-24 |
| US20200155571A1 (en) | 2020-05-21 |
| KR101783577B1 (ko) | 2017-09-29 |
| WO2010077681A1 (en) | 2010-07-08 |
| IL213411A0 (en) | 2011-07-31 |
| JP2015038155A (ja) | 2015-02-26 |
| CN102307466A (zh) | 2012-01-04 |
| CN106692162A (zh) | 2017-05-24 |
| SG171997A1 (en) | 2011-07-28 |
| US20170333448A1 (en) | 2017-11-23 |
| HK1207582A1 (en) | 2016-02-05 |
| DK2902031T3 (en) | 2019-01-14 |
| EP2373160A4 (en) | 2012-06-13 |
| CA2745930C (en) | 2017-05-02 |
| KR20170001735A (ko) | 2017-01-04 |
| EP2373160A1 (en) | 2011-10-12 |
| IL213411A (en) | 2016-12-29 |
| JP5709266B2 (ja) | 2015-04-30 |
| JP2012511034A (ja) | 2012-05-17 |
| KR20110092351A (ko) | 2011-08-17 |
| AU2009333538B2 (en) | 2014-09-11 |
| AU2009333538A1 (en) | 2011-07-14 |
| US20100183749A1 (en) | 2010-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: SOLIGENIX, INC., US Free format text: OLD OWNER(S): SOLIGENIX, INC.; ROBERT N BREY; GEORGE B MCDONALD; CHRISTOPHER SCHABER |
|
| S883 | Correction of error according to section 88(3) (mistake in register caused on part of patentee or applicant) |
Free format text: CORRECTION TO APPLICANT (71) CHAIN OF TITLE AND INVENTORS (72) |
|
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