NZ586552A - Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same - Google Patents
Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the sameInfo
- Publication number
- NZ586552A NZ586552A NZ586552A NZ58655209A NZ586552A NZ 586552 A NZ586552 A NZ 586552A NZ 586552 A NZ586552 A NZ 586552A NZ 58655209 A NZ58655209 A NZ 58655209A NZ 586552 A NZ586552 A NZ 586552A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dioxo
- dihydro
- quinazolin
- propyl
- butyl
- Prior art date
Links
- SDQJTWBNWQABLE-UHFFFAOYSA-N 1h-quinazoline-2,4-dione Chemical class C1=CC=C2C(=O)NC(=O)NC2=C1 SDQJTWBNWQABLE-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 238000011282 treatment Methods 0.000 title abstract description 12
- 239000000203 mixture Substances 0.000 title abstract description 9
- 208000019736 Cranial nerve disease Diseases 0.000 title abstract description 5
- 208000014826 cranial nerve neuropathy Diseases 0.000 title abstract description 3
- 238000011321 prophylaxis Methods 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 151
- 150000003839 salts Chemical class 0.000 claims abstract description 51
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 123
- 125000006308 propyl amino group Chemical group 0.000 claims description 51
- -1 hydroxy, methoxy, ethoxy Chemical group 0.000 claims description 49
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 29
- 125000006309 butyl amino group Chemical group 0.000 claims description 23
- 238000006243 chemical reaction Methods 0.000 claims description 22
- 210000002569 neuron Anatomy 0.000 claims description 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- LFKDJXLFVYVEFG-UHFFFAOYSA-N tert-butyl carbamate Chemical compound CC(C)(C)OC(N)=O LFKDJXLFVYVEFG-UHFFFAOYSA-N 0.000 claims description 15
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- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 claims description 7
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- 125000001245 hexylamino group Chemical group [H]N([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 6
- MLAJKFBHELLQJC-UHFFFAOYSA-N 3-[4-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]butyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCCCCN1C(=O)C2=CC=CC=C2NC1=O MLAJKFBHELLQJC-UHFFFAOYSA-N 0.000 claims description 5
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- 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 4
- JBZGLYIWQCCGSY-UHFFFAOYSA-N 3-[2-[3-[2-(2,4-dioxo-1h-quinazolin-3-yl)ethylamino]propylamino]ethyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCNCCCNCCN1C(=O)C2=CC=CC=C2NC1=O JBZGLYIWQCCGSY-UHFFFAOYSA-N 0.000 claims description 3
- HAXIGGFPEXYILL-UHFFFAOYSA-N 3-[3-[4-[3-(2,5-dioxopyrrolidin-1-yl)propylamino]butylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound O=C1CCC(=O)N1CCCNCCCCNCCCN1C(=O)C2=CC=CC=C2NC1=O HAXIGGFPEXYILL-UHFFFAOYSA-N 0.000 claims description 3
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- JWAZCOLPZRXAMX-UHFFFAOYSA-N 1-hexyl-3-[3-[4-[3-(1-hexyl-2,4-dioxoquinazolin-3-yl)propylamino]butylamino]propyl]quinazoline-2,4-dione Chemical compound O=C1N(CCCCCC)C2=CC=CC=C2C(=O)N1CCCNCCCCNCCCN1C(=O)C2=CC=CC=C2N(CCCCCC)C1=O JWAZCOLPZRXAMX-UHFFFAOYSA-N 0.000 claims description 2
- KKARFJXBDDKSOI-UHFFFAOYSA-N 3-[3-[2-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]ethylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCCNCCCN1C(=O)C2=CC=CC=C2NC1=O KKARFJXBDDKSOI-UHFFFAOYSA-N 0.000 claims description 2
- BBVXOMSJMHOIQX-UHFFFAOYSA-N 3-[3-[4-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]but-2-enylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCC=CCNCCCN1C(=O)C2=CC=CC=C2NC1=O BBVXOMSJMHOIQX-UHFFFAOYSA-N 0.000 claims description 2
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- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 2
- TWLLPUMZVVGILS-UHFFFAOYSA-N Ethyl 2-aminobenzoate Chemical compound CCOC(=O)C1=CC=CC=C1N TWLLPUMZVVGILS-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20080009390 | 2008-01-30 | ||
| PCT/KR2009/000083 WO2009096667A2 (fr) | 2008-01-30 | 2009-01-08 | Nouveau dérivé de quinazoline-2,4-dione et compositions médicales pour la prophylaxie et le traitement de la maladie du nerf crânien contenant ledit dérivé |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ586552A true NZ586552A (en) | 2012-06-29 |
Family
ID=40913386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ586552A NZ586552A (en) | 2008-01-30 | 2009-01-08 | Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8404696B2 (fr) |
| EP (1) | EP2239257B1 (fr) |
| JP (1) | JP5291124B2 (fr) |
| KR (1) | KR101075435B1 (fr) |
| CN (1) | CN101925585B (fr) |
| AR (1) | AR074372A1 (fr) |
| AU (1) | AU2009209811B2 (fr) |
| BR (1) | BRPI0906996B1 (fr) |
| CA (1) | CA2712819C (fr) |
| CO (1) | CO6290762A2 (fr) |
| DK (1) | DK2239257T3 (fr) |
| EA (1) | EA018142B1 (fr) |
| ES (1) | ES2387539T3 (fr) |
| HK (1) | HK1149263A1 (fr) |
| IL (1) | IL206738A (fr) |
| MY (1) | MY153733A (fr) |
| NZ (1) | NZ586552A (fr) |
| PL (1) | PL2239257T3 (fr) |
| PT (1) | PT2239257E (fr) |
| WO (1) | WO2009096667A2 (fr) |
| ZA (1) | ZA201004546B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY153733A (en) | 2008-01-30 | 2015-03-13 | Shin Poong Pharmaceutical Co | Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same |
| US8337902B2 (en) * | 2008-09-25 | 2012-12-25 | Wisconsin Alumni Research Foundation | Degradation of prion protein and reduced prion infectivity by earthworm homogenates |
| CN103517890B (zh) * | 2011-05-02 | 2016-08-17 | 弗纳技术股份有限公司 | 乙苯生产方法 |
| JP6002331B2 (ja) * | 2014-01-20 | 2016-10-05 | Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 | カテコールアミン産生促進剤、カテコールアミンの欠乏に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物 |
| JP7203495B2 (ja) * | 2015-06-15 | 2023-01-13 | コーニンクレッカ フィリップス エヌ ヴェ | 改善されたノズル設計を具備する口腔清掃装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9400680D0 (en) * | 1994-01-14 | 1994-03-09 | Sandoz Ltd | Improvements in or relating to organic compounds |
| SK284108B6 (sk) | 1996-05-15 | 2004-09-08 | Pfizer Inc. | 2,3-Disubstituované 4(3H)-chinazolinóny, ich použitie a farmaceutické kompozície s ich obsahom |
| US6060479A (en) | 1997-06-09 | 2000-05-09 | Pfizer Inc | Quinazoline-4-one AMPA antagonists |
| KR20010100004A (ko) * | 1999-11-01 | 2001-11-09 | 도리이 신이치로 | 키마제 억제 물질을 함유하여 이루어진 혈관 지질 침착방지제 |
| MXPA02005989A (es) * | 2000-01-24 | 2002-10-23 | Warner Lambert Co | Agentes antibacteriales de 3-aminoquinazolin-2,4-diona. |
| CA2444148A1 (fr) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Composes de pyrimidine en tant qu'agents anti-ictogeniques et/ou anti-epileptiques |
| DE10201240A1 (de) * | 2002-01-15 | 2003-07-24 | Bayer Ag | Substituierte Alkyluracile und ihre Verwendung |
| GB0416730D0 (en) * | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| TWI396543B (zh) * | 2005-05-12 | 2013-05-21 | Sankyo Co | 取代丙烯醯胺衍生物及含有它之醫藥組成物 |
| WO2008112715A2 (fr) | 2007-03-12 | 2008-09-18 | Vm Discovery Inc. | Nouveaux agents modulateurs des canaux d'ions calcium |
| MY153733A (en) | 2008-01-30 | 2015-03-13 | Shin Poong Pharmaceutical Co | Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same |
-
2009
- 2009-01-08 MY MYPI2010003123A patent/MY153733A/en unknown
- 2009-01-08 CA CA2712819A patent/CA2712819C/fr active Active
- 2009-01-08 KR KR1020090001655A patent/KR101075435B1/ko active IP Right Grant
- 2009-01-08 EP EP09705187A patent/EP2239257B1/fr active Active
- 2009-01-08 US US12/863,332 patent/US8404696B2/en active Active
- 2009-01-08 PT PT09705187T patent/PT2239257E/pt unknown
- 2009-01-08 PL PL09705187T patent/PL2239257T3/pl unknown
- 2009-01-08 EA EA201070898A patent/EA018142B1/ru not_active IP Right Cessation
- 2009-01-08 ES ES09705187T patent/ES2387539T3/es active Active
- 2009-01-08 AU AU2009209811A patent/AU2009209811B2/en active Active
- 2009-01-08 NZ NZ586552A patent/NZ586552A/en unknown
- 2009-01-08 WO PCT/KR2009/000083 patent/WO2009096667A2/fr active Application Filing
- 2009-01-08 JP JP2010544881A patent/JP5291124B2/ja active Active
- 2009-01-08 DK DK09705187.4T patent/DK2239257T3/da active
- 2009-01-08 BR BRPI0906996-8A patent/BRPI0906996B1/pt active IP Right Grant
- 2009-01-08 CN CN2009801032365A patent/CN101925585B/zh active Active
- 2009-11-19 AR ARP090104459A patent/AR074372A1/es active IP Right Grant
-
2010
- 2010-06-28 ZA ZA2010/04546A patent/ZA201004546B/en unknown
- 2010-06-30 IL IL206738A patent/IL206738A/en active IP Right Grant
- 2010-07-29 CO CO10092621A patent/CO6290762A2/es active IP Right Grant
-
2011
- 2011-04-06 HK HK11103446.1A patent/HK1149263A1/xx unknown
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2012
- 2012-12-11 US US13/710,543 patent/US9290480B2/en active Active
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