NZ568652A - Commercial process for making forskolin and its derivatives - Google Patents
Commercial process for making forskolin and its derivativesInfo
- Publication number
- NZ568652A NZ568652A NZ568652A NZ56865207A NZ568652A NZ 568652 A NZ568652 A NZ 568652A NZ 568652 A NZ568652 A NZ 568652A NZ 56865207 A NZ56865207 A NZ 56865207A NZ 568652 A NZ568652 A NZ 568652A
- Authority
- NZ
- New Zealand
- Prior art keywords
- forskolin
- isoforskolin
- ethanol
- extract
- deacetylforskolin
- Prior art date
Links
- 238000010960 commercial process Methods 0.000 title claims abstract description 19
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 title claims description 128
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 title claims description 63
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 title claims description 60
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 85
- CLOQVZCSBYBUPB-KGGHGJDLSA-N [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-6-yl] acetate Chemical compound O[C@H]([C@@]12C)CCC(C)(C)[C@@H]1[C@H](OC(=O)C)[C@H](O)[C@]1(C)[C@]2(O)C(=O)C[C@](C)(C=C)O1 CLOQVZCSBYBUPB-KGGHGJDLSA-N 0.000 claims abstract description 71
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- SBMKZIAQTQIEHN-NRADYMPXSA-N Coleonol C Natural products [H][C@@]12[C@H](OC(C)=O)[C@@H](O)[C@@]3(C)O[C@@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](C)CCC2(C)C)C=C SBMKZIAQTQIEHN-NRADYMPXSA-N 0.000 claims abstract description 35
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract description 33
- WPDITXOBNLYZHH-UHFFFAOYSA-N desacetylforskolin Natural products O1C(C)(C=C)CC(=O)C2(O)C3(C)C(O)CCC(C)(C)C3C(O)C(O)C21C WPDITXOBNLYZHH-UHFFFAOYSA-N 0.000 claims abstract description 23
- WDJJFDJQYGLZPA-CGPDBNODSA-N (3R,4aS,5S,6S,6aS,10S,10aS,10bR)-3-ethenyl-5,6,10-trihydroxy-3,4a,7,7,10a-pentamethyl-2,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromen-1-one Chemical compound O1[C@@](C)(C=C)CC(=O)[C@@H]2[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](O)[C@]21C WDJJFDJQYGLZPA-CGPDBNODSA-N 0.000 claims abstract description 22
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims abstract description 20
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- SUZLHDUTVMZSEV-WESICCPUSA-N (3R,4aR,5S,6S,6aS,10S,10aS,10bS)-3-ethenyl-6,10-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate Chemical compound O=C([C@@H]12)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C SUZLHDUTVMZSEV-WESICCPUSA-N 0.000 claims description 6
- PXYAFNGUEZPJBI-OAUGPMCWSA-N [(3r,4ar,5s,6s,6as,10as,10bs)-3-ethenyl-6,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-5-yl] acetate Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)CCCC1(C)C PXYAFNGUEZPJBI-OAUGPMCWSA-N 0.000 claims description 6
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
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| NZ552997A NZ552997A (en) | 2006-02-07 | 2007-02-02 | Composition for physiological increase of male and female hormones with diterpene forskolin and its derivatives |
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| NZ568652A true NZ568652A (en) | 2009-12-24 |
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| NZ552997A NZ552997A (en) | 2006-02-07 | 2007-02-02 | Composition for physiological increase of male and female hormones with diterpene forskolin and its derivatives |
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| CN101843366A (zh) * | 2010-04-29 | 2010-09-29 | 云南省玉溪市溶剂厂有限公司 | 一种含有异佛司可林的烟用增塑剂及其制作方法 |
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| US8865762B2 (en) * | 2009-07-17 | 2014-10-21 | Korea Research Institute Of Bioscience And Biotechnology | Method for the treatment of bone diseases comprising colforsin daropate |
| CN105693684B (zh) * | 2016-01-22 | 2018-10-09 | 昆明医科大学 | 一种异佛司可林的制备方法 |
| CN107929785A (zh) * | 2017-12-16 | 2018-04-20 | 蒋央芳 | 一种精油及其制备方法 |
| US20230346956A1 (en) * | 2020-01-23 | 2023-11-02 | SciPharm S.à.r.l | Complex of 7-deacetylforskolin and pvp |
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| JPH11313637A (ja) * | 1998-05-07 | 1999-11-16 | Sanpo Kk | コレウス・フォルスコリ根を用いた新規食品 |
| JP4432069B2 (ja) * | 2002-09-03 | 2010-03-17 | ビーエイチエヌ株式会社 | 肥満抑制剤 |
| US6960300B2 (en) * | 2003-09-08 | 2005-11-01 | Sami Labs Limited | Process for preparing water soluble diterpenes and their applications |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843366A (zh) * | 2010-04-29 | 2010-09-29 | 云南省玉溪市溶剂厂有限公司 | 一种含有异佛司可林的烟用增塑剂及其制作方法 |
| CN101843366B (zh) * | 2010-04-29 | 2012-01-04 | 云南省玉溪市溶剂厂有限公司 | 一种含有异佛司可林的烟用增塑剂及其制作方法 |
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|---|---|
| NZ552997A (en) | 2008-09-26 |
| JP2007210988A (ja) | 2007-08-23 |
| AU2007200442A1 (en) | 2007-08-23 |
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