NZ565265A - Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity - Google Patents

Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity

Info

Publication number
NZ565265A
NZ565265A NZ565265A NZ56526506A NZ565265A NZ 565265 A NZ565265 A NZ 565265A NZ 565265 A NZ565265 A NZ 565265A NZ 56526506 A NZ56526506 A NZ 56526506A NZ 565265 A NZ565265 A NZ 565265A
Authority
NZ
New Zealand
Prior art keywords
exch
aminothiocolchicine
demethoxy
nmr
meoh
Prior art date
Application number
NZ565265A
Other languages
English (en)
Inventor
Gabriele Fontana
Ezio Bombardelli
Antonella Riva
Paolo Morazzoni
Donato Pocar
Maria Luisa Gelmi
Guido Pontremoli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NZ565265A publication Critical patent/NZ565265A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
NZ565265A 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity NZ565265A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001418A ITMI20051418A1 (it) 2005-07-22 2005-07-22 Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
PCT/EP2006/007108 WO2007009772A1 (en) 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity

Publications (1)

Publication Number Publication Date
NZ565265A true NZ565265A (en) 2010-01-29

Family

ID=37420844

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ565265A NZ565265A (en) 2005-07-22 2006-07-20 Thiocolchicoside analogues with myorelaxant and anti-inflammatory activity

Country Status (14)

Country Link
EP (1) EP1907405A1 (es)
JP (1) JP2009502755A (es)
KR (1) KR20080036585A (es)
CN (1) CN101228175A (es)
AU (1) AU2006271923A1 (es)
BR (1) BRPI0613680A2 (es)
CA (1) CA2615860A1 (es)
IL (1) IL188900A0 (es)
IT (1) ITMI20051418A1 (es)
MX (1) MX2008000968A (es)
NO (1) NO20080377L (es)
NZ (1) NZ565265A (es)
RU (1) RU2008102251A (es)
WO (1) WO2007009772A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8421747B2 (en) * 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
EP2435403A4 (en) * 2009-05-27 2015-04-01 Takeda Pharmaceuticals Usa Inc THIOCOLCHICINE DERIVATIVES AND MANUFACTURING AND USE METHOD THEREFOR
WO2011091114A2 (en) * 2010-01-22 2011-07-28 Mutual Pharmaceutical Company, Inc. Thiocolchicine and colchicine analogs, methods of making and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291550B1 (it) * 1997-04-11 1999-01-11 Indena Spa Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.

Also Published As

Publication number Publication date
CN101228175A (zh) 2008-07-23
JP2009502755A (ja) 2009-01-29
IL188900A0 (en) 2008-04-13
AU2006271923A1 (en) 2007-01-25
CA2615860A1 (en) 2007-01-25
BRPI0613680A2 (pt) 2011-01-25
NO20080377L (no) 2008-02-01
MX2008000968A (es) 2008-03-26
WO2007009772A1 (en) 2007-01-25
EP1907405A1 (en) 2008-04-09
RU2008102251A (ru) 2009-07-27
ITMI20051418A1 (it) 2007-01-23
KR20080036585A (ko) 2008-04-28

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Legal Events

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