NZ543295A - DNA sequences for human angiogenesis genes - Google Patents
DNA sequences for human angiogenesis genesInfo
- Publication number
- NZ543295A NZ543295A NZ543295A NZ54329502A NZ543295A NZ 543295 A NZ543295 A NZ 543295A NZ 543295 A NZ543295 A NZ 543295A NZ 54329502 A NZ54329502 A NZ 54329502A NZ 543295 A NZ543295 A NZ 543295A
- Authority
- NZ
- New Zealand
- Prior art keywords
- polypeptide
- nucleic acid
- acid molecule
- angiogenesis
- expression
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title claims description 267
- 230000033115 angiogenesis Effects 0.000 title claims description 111
- 241000282414 Homo sapiens Species 0.000 title claims description 41
- 108091028043 Nucleic acid sequence Proteins 0.000 title claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 113
- 230000002491 angiogenic effect Effects 0.000 claims abstract description 110
- 238000000034 method Methods 0.000 claims abstract description 106
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 104
- 229920001184 polypeptide Polymers 0.000 claims abstract description 94
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 77
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 66
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 66
- 230000008569 process Effects 0.000 claims abstract description 34
- 210000004027 cell Anatomy 0.000 claims description 121
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 99
- 230000014509 gene expression Effects 0.000 claims description 83
- 208000035475 disorder Diseases 0.000 claims description 74
- 150000001875 compounds Chemical class 0.000 claims description 49
- 230000000692 anti-sense effect Effects 0.000 claims description 43
- 230000000694 effects Effects 0.000 claims description 37
- 239000012634 fragment Substances 0.000 claims description 37
- 239000013598 vector Substances 0.000 claims description 37
- 238000011282 treatment Methods 0.000 claims description 36
- 108020004414 DNA Proteins 0.000 claims description 26
- 201000010099 disease Diseases 0.000 claims description 25
- 238000009396 hybridization Methods 0.000 claims description 20
- 238000012216 screening Methods 0.000 claims description 20
- 238000003556 assay Methods 0.000 claims description 19
- 239000013604 expression vector Substances 0.000 claims description 18
- 238000003745 diagnosis Methods 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 239000000523 sample Substances 0.000 claims description 16
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 15
- 238000004458 analytical method Methods 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 230000027455 binding Effects 0.000 claims description 13
- 238000004393 prognosis Methods 0.000 claims description 13
- 201000001320 Atherosclerosis Diseases 0.000 claims description 11
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 11
- 201000004681 Psoriasis Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 10
- 241001465754 Metazoa Species 0.000 claims description 10
- 241000699670 Mus sp. Species 0.000 claims description 10
- 230000000302 ischemic effect Effects 0.000 claims description 10
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 10
- 239000000556 agonist Substances 0.000 claims description 9
- 239000005557 antagonist Substances 0.000 claims description 9
- 208000029078 coronary artery disease Diseases 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 9
- 108020004999 messenger RNA Proteins 0.000 claims description 9
- 210000005166 vasculature Anatomy 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000003247 decreasing effect Effects 0.000 claims description 8
- 239000002773 nucleotide Substances 0.000 claims description 8
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 230000002159 abnormal effect Effects 0.000 claims description 7
- 230000000295 complement effect Effects 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 230000008901 benefit Effects 0.000 claims description 6
- 238000012340 reverse transcriptase PCR Methods 0.000 claims description 5
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 4
- 241000700159 Rattus Species 0.000 claims description 4
- 230000005856 abnormality Effects 0.000 claims description 4
- 230000003197 catalytic effect Effects 0.000 claims description 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 241000282472 Canis lupus familiaris Species 0.000 claims description 3
- 241000283707 Capra Species 0.000 claims description 3
- 241000282693 Cercopithecidae Species 0.000 claims description 3
- 241000282326 Felis catus Species 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 3
- 210000005260 human cell Anatomy 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 241000972773 Aulopiformes Species 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- 241000700198 Cavia Species 0.000 claims description 2
- 241000699800 Cricetinae Species 0.000 claims description 2
- 108091027757 Deoxyribozyme Proteins 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 241000282579 Pan Species 0.000 claims description 2
- 241001494479 Pecora Species 0.000 claims description 2
- 241000282887 Suidae Species 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000003306 harvesting Methods 0.000 claims description 2
- 230000000704 physical effect Effects 0.000 claims description 2
- 230000006337 proteolytic cleavage Effects 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 235000019515 salmon Nutrition 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 2
- 229940038773 trisodium citrate Drugs 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- 101000829171 Hypocrea virens (strain Gv29-8 / FGSC 10586) Effector TSP1 Proteins 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 74
- 235000018102 proteins Nutrition 0.000 description 72
- 210000002889 endothelial cell Anatomy 0.000 description 45
- 239000002299 complementary DNA Substances 0.000 description 31
- 230000006870 function Effects 0.000 description 30
- 230000015572 biosynthetic process Effects 0.000 description 29
- 230000001105 regulatory effect Effects 0.000 description 23
- 210000003606 umbilical vein Anatomy 0.000 description 19
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 17
- 108091033319 polynucleotide Proteins 0.000 description 17
- 102000040430 polynucleotide Human genes 0.000 description 17
- 239000002157 polynucleotide Substances 0.000 description 17
- 210000001519 tissue Anatomy 0.000 description 16
- 238000012546 transfer Methods 0.000 description 16
- 230000001404 mediated effect Effects 0.000 description 15
- 108091060211 Expressed sequence tag Proteins 0.000 description 14
- 230000033228 biological regulation Effects 0.000 description 14
- 108050007852 Tumour necrosis factor Proteins 0.000 description 13
- 102000018594 Tumour necrosis factor Human genes 0.000 description 13
- 230000000638 stimulation Effects 0.000 description 13
- 238000013459 approach Methods 0.000 description 12
- 230000002018 overexpression Effects 0.000 description 11
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 10
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 10
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 10
- 150000001413 amino acids Chemical group 0.000 description 10
- 239000000512 collagen gel Substances 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 230000004044 response Effects 0.000 description 10
- 108020005196 Mitochondrial DNA Proteins 0.000 description 9
- 230000004663 cell proliferation Effects 0.000 description 9
- 230000012010 growth Effects 0.000 description 9
- 230000035772 mutation Effects 0.000 description 9
- 238000003752 polymerase chain reaction Methods 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 9
- 108010024212 E-Selectin Proteins 0.000 description 8
- 102100023471 E-selectin Human genes 0.000 description 8
- 238000013508 migration Methods 0.000 description 8
- 230000035755 proliferation Effects 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 102000008076 Angiogenic Proteins Human genes 0.000 description 7
- 108010074415 Angiogenic Proteins Proteins 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- 102000008186 Collagen Human genes 0.000 description 7
- 108020004635 Complementary DNA Proteins 0.000 description 7
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 7
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 229920001436 collagen Polymers 0.000 description 7
- 238000007877 drug screening Methods 0.000 description 7
- 238000010874 in vitro model Methods 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 230000005012 migration Effects 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 230000001177 retroviral effect Effects 0.000 description 7
- 241001430294 unidentified retrovirus Species 0.000 description 7
- 102000018898 GTPase-Activating Proteins Human genes 0.000 description 6
- 108091006094 GTPase-accelerating proteins Proteins 0.000 description 6
- 102100033300 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Human genes 0.000 description 6
- 101000926823 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Proteins 0.000 description 6
- 108020001507 fusion proteins Proteins 0.000 description 6
- 102000037865 fusion proteins Human genes 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 238000010363 gene targeting Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000001890 transfection Methods 0.000 description 6
- 108091026890 Coding region Proteins 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 241000699660 Mus musculus Species 0.000 description 5
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- 108010001441 Phosphopeptides Proteins 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 230000003915 cell function Effects 0.000 description 5
- 238000009510 drug design Methods 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 108010082117 matrigel Proteins 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000011830 transgenic mouse model Methods 0.000 description 5
- 241000701161 unidentified adenovirus Species 0.000 description 5
- 210000003934 vacuole Anatomy 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 108020004705 Codon Proteins 0.000 description 4
- 230000004568 DNA-binding Effects 0.000 description 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 4
- 108010067306 Fibronectins Proteins 0.000 description 4
- 102000016359 Fibronectins Human genes 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 230000012292 cell migration Effects 0.000 description 4
- 230000003399 chemotactic effect Effects 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 229940126864 fibroblast growth factor Drugs 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 238000002744 homologous recombination Methods 0.000 description 4
- 230000006801 homologous recombination Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 238000011813 knockout mouse model Methods 0.000 description 4
- 238000002493 microarray Methods 0.000 description 4
- 230000003278 mimic effect Effects 0.000 description 4
- 210000000287 oocyte Anatomy 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 230000010076 replication Effects 0.000 description 4
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 4
- 239000010754 BS 2869 Class F Substances 0.000 description 3
- 102100023973 Bax inhibitor 1 Human genes 0.000 description 3
- 102100032231 Caveolae-associated protein 2 Human genes 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 102100029145 DNA damage-inducible transcript 3 protein Human genes 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000030782 GTP binding Human genes 0.000 description 3
- 108091000058 GTP-Binding Proteins 0.000 description 3
- 102100035692 Importin subunit alpha-1 Human genes 0.000 description 3
- 238000000134 MTT assay Methods 0.000 description 3
- 231100000002 MTT assay Toxicity 0.000 description 3
- 108010021466 Mutant Proteins Proteins 0.000 description 3
- 102000008300 Mutant Proteins Human genes 0.000 description 3
- 108010038807 Oligopeptides Proteins 0.000 description 3
- 102000015636 Oligopeptides Human genes 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000010805 cDNA synthesis kit Methods 0.000 description 3
- 239000003184 complementary RNA Substances 0.000 description 3
- 230000009918 complex formation Effects 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 230000013020 embryo development Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 210000004602 germ cell Anatomy 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 238000000126 in silico method Methods 0.000 description 3
- 150000002484 inorganic compounds Chemical class 0.000 description 3
- 229910010272 inorganic material Inorganic materials 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000011987 methylation Effects 0.000 description 3
- 238000007069 methylation reaction Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- 238000007747 plating Methods 0.000 description 3
- 230000004853 protein function Effects 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 230000009261 transgenic effect Effects 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 238000001086 yeast two-hybrid system Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 description 2
- 102100034036 39S ribosomal protein L22, mitochondrial Human genes 0.000 description 2
- 101150096316 5 gene Proteins 0.000 description 2
- 102100021660 60S ribosomal protein L28 Human genes 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 2
- 108010085238 Actins Proteins 0.000 description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
- 206010001197 Adenocarcinoma of the cervix Diseases 0.000 description 2
- 208000034246 Adenocarcinoma of the cervix uteri Diseases 0.000 description 2
- 208000010370 Adenoviridae Infections Diseases 0.000 description 2
- 206010060931 Adenovirus infection Diseases 0.000 description 2
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 description 2
- 108020005544 Antisense RNA Proteins 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108050005259 Caveolae-associated protein 2 Proteins 0.000 description 2
- 102000000844 Cell Surface Receptors Human genes 0.000 description 2
- 108010001857 Cell Surface Receptors Proteins 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 102100038642 Cleavage and polyadenylation specificity factor subunit 2 Human genes 0.000 description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 102000006312 Cyclin D2 Human genes 0.000 description 2
- 108010058544 Cyclin D2 Proteins 0.000 description 2
- 102100025287 Cytochrome b Human genes 0.000 description 2
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 2
- 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 2
- 102100030801 Elongation factor 1-alpha 1 Human genes 0.000 description 2
- 102100032222 Emopamil-binding protein-like Human genes 0.000 description 2
- 102100031375 Endothelial lipase Human genes 0.000 description 2
- 208000036566 Erythroleukaemia Diseases 0.000 description 2
- 102100021699 Eukaryotic translation initiation factor 3 subunit B Human genes 0.000 description 2
- 101710109047 Eukaryotic translation initiation factor 3 subunit B Proteins 0.000 description 2
- 102100021062 Ferritin light chain Human genes 0.000 description 2
- 108091006027 G proteins Proteins 0.000 description 2
- 102000013446 GTP Phosphohydrolases Human genes 0.000 description 2
- 108091006109 GTPases Proteins 0.000 description 2
- 206010064571 Gene mutation Diseases 0.000 description 2
- 102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 2
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102100027421 Heat shock cognate 71 kDa protein Human genes 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 2
- 102100027703 Heterogeneous nuclear ribonucleoprotein H2 Human genes 0.000 description 2
- 101710203726 Heterogeneous nuclear ribonucleoprotein H2 Proteins 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 101000711436 Homo sapiens 39S ribosomal protein L22, mitochondrial Proteins 0.000 description 2
- 101000903937 Homo sapiens Bax inhibitor 1 Proteins 0.000 description 2
- 101000957590 Homo sapiens Cleavage and polyadenylation specificity factor subunit 2 Proteins 0.000 description 2
- 101000920078 Homo sapiens Elongation factor 1-alpha 1 Proteins 0.000 description 2
- 101000818390 Homo sapiens Ferritin light chain Proteins 0.000 description 2
- 101001080568 Homo sapiens Heat shock cognate 71 kDa protein Proteins 0.000 description 2
- 101000734646 Homo sapiens Programmed cell death protein 6 Proteins 0.000 description 2
- 101000919288 Homo sapiens Protein disulfide isomerase CRELD1 Proteins 0.000 description 2
- 101001092206 Homo sapiens Replication protein A 32 kDa subunit Proteins 0.000 description 2
- 101000707471 Homo sapiens Serine incorporator 3 Proteins 0.000 description 2
- 101000837344 Homo sapiens T-cell leukemia translocation-altered gene protein Proteins 0.000 description 2
- 101000802101 Homo sapiens mRNA decay activator protein ZFP36L2 Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 108060001621 Isoprenylcysteine carboxyl methyltransferase Proteins 0.000 description 2
- 102100025307 M-phase phosphoprotein 6 Human genes 0.000 description 2
- 206010028311 Muscle hypertrophy Diseases 0.000 description 2
- 108010067385 Myosin Light Chains Proteins 0.000 description 2
- 102000016349 Myosin Light Chains Human genes 0.000 description 2
- 102100028418 Nuclear transport factor 2 Human genes 0.000 description 2
- 101710159639 Nuclear transport factor 2 Proteins 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 102100026391 PHD finger protein 3 Human genes 0.000 description 2
- 101710151868 PHD finger protein 3 Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 102100024818 PRELI domain-containing protein 1, mitochondrial Human genes 0.000 description 2
- 108010004729 Phycoerythrin Proteins 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 102100034785 Programmed cell death protein 6 Human genes 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 102100031299 Proteasome activator complex subunit 2 Human genes 0.000 description 2
- 102100029371 Protein disulfide isomerase CRELD1 Human genes 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 2
- 102100035525 Replication protein A 32 kDa subunit Human genes 0.000 description 2
- 108700008625 Reporter Genes Proteins 0.000 description 2
- 208000005074 Retroviridae Infections Diseases 0.000 description 2
- 102000002278 Ribosomal Proteins Human genes 0.000 description 2
- 108010000605 Ribosomal Proteins Proteins 0.000 description 2
- 108050009586 Ribosomal protein L28 Proteins 0.000 description 2
- 102000010983 Ribosomal protein S13 Human genes 0.000 description 2
- 108050001197 Ribosomal protein S13 Proteins 0.000 description 2
- 102100031727 Serine incorporator 3 Human genes 0.000 description 2
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 102000016571 Sorting nexin-5 Human genes 0.000 description 2
- 108050006125 Sorting nexin-5 Proteins 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 102100023184 Stromal cell-derived factor 2 Human genes 0.000 description 2
- 101710088574 Stromal cell-derived factor 2 Proteins 0.000 description 2
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 description 2
- 102100028692 T-cell leukemia translocation-altered gene protein Human genes 0.000 description 2
- 241000700618 Vaccinia virus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000011589 adenoviridae infectious disease Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
- 230000001772 anti-angiogenic effect Effects 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000000423 cell based assay Methods 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000009087 cell motility Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 201000006662 cervical adenocarcinoma Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 201000010989 colorectal carcinoma Diseases 0.000 description 2
- 238000012875 competitive assay Methods 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000007876 drug discovery Methods 0.000 description 2
- 230000002900 effect on cell Effects 0.000 description 2
- 238000004520 electroporation Methods 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000010230 functional analysis Methods 0.000 description 2
- 230000030279 gene silencing Effects 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 108010011989 karyopherin alpha 2 Proteins 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 150000002611 lead compounds Chemical class 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 102100034703 mRNA decay activator protein ZFP36L2 Human genes 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000012042 muscle hypertrophy Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 230000026731 phosphorylation Effects 0.000 description 2
- 238000006366 phosphorylation reaction Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001323 posttranslational effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001023 pro-angiogenic effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000001236 prokaryotic cell Anatomy 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 102000029740 protein-S-isoprenylcysteine O-methyltransferase Human genes 0.000 description 2
- 230000007420 reactivation Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000007423 screening assay Methods 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000037314 wound repair Effects 0.000 description 2
- 238000002424 x-ray crystallography Methods 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- 108020004465 16S ribosomal RNA Proteins 0.000 description 1
- 101150066375 35 gene Proteins 0.000 description 1
- 108010079721 ATP synthase subunit 6 Proteins 0.000 description 1
- 102100021921 ATP synthase subunit a Human genes 0.000 description 1
- 102100023388 ATP-dependent RNA helicase DHX15 Human genes 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 101710159080 Aconitate hydratase A Proteins 0.000 description 1
- 101710159078 Aconitate hydratase B Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 101710168921 Amyloid beta precursor like protein 2 Proteins 0.000 description 1
- 108010031677 Anaphase-Promoting Complex-Cyclosome Proteins 0.000 description 1
- 102000005446 Anaphase-Promoting Complex-Cyclosome Human genes 0.000 description 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 108010014885 Arginine-tRNA ligase Proteins 0.000 description 1
- 200000000007 Arterial disease Diseases 0.000 description 1
- 108010002913 Asialoglycoproteins Proteins 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 101710113263 Bax inhibitor 1 Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108050009021 Bromodomains Proteins 0.000 description 1
- 102000001805 Bromodomains Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 102100025580 Calmodulin-1 Human genes 0.000 description 1
- 101710164735 Calmodulin-1 Proteins 0.000 description 1
- 101800001318 Capsid protein VP4 Proteins 0.000 description 1
- 102000011068 Cdc42 Human genes 0.000 description 1
- 108050001278 Cdc42 Proteins 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 108700010070 Codon Usage Proteins 0.000 description 1
- 108020004394 Complementary RNA Proteins 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 108091029523 CpG island Proteins 0.000 description 1
- 108010051219 Cre recombinase Proteins 0.000 description 1
- 102100026398 Cyclic AMP-responsive element-binding protein 3 Human genes 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- 102000003849 Cytochrome P450 Human genes 0.000 description 1
- 108010075028 Cytochromes b Proteins 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 102000011724 DNA Repair Enzymes Human genes 0.000 description 1
- 108010076525 DNA Repair Enzymes Proteins 0.000 description 1
- 101710156077 DNA damage-inducible transcript 3 protein Proteins 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 102100034109 DnaJ homolog subfamily C member 13 Human genes 0.000 description 1
- 101000965024 Drosophila melanogaster Acetylcholine receptor subunit alpha-like 1 Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101710094225 Emopamil-binding protein-like Proteins 0.000 description 1
- 101710087274 Endothelial lipase Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 102100029055 Exostosin-1 Human genes 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102100039788 GTPase NRas Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 101710092774 Glyoxalase 1 Proteins 0.000 description 1
- 102100032564 Golgin subfamily A member 2 Human genes 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102100023737 GrpE protein homolog 1, mitochondrial Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 102100027704 Histone-lysine N-methyltransferase SETD7 Human genes 0.000 description 1
- 101710159508 Histone-lysine N-methyltransferase SETD7 Proteins 0.000 description 1
- 101000779382 Homo sapiens A-kinase anchor protein 12 Proteins 0.000 description 1
- 101000907886 Homo sapiens ATP-dependent RNA helicase DHX15 Proteins 0.000 description 1
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 description 1
- 101000855520 Homo sapiens Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 1
- 101000858267 Homo sapiens Cytochrome b Proteins 0.000 description 1
- 101000870239 Homo sapiens DnaJ homolog subfamily C member 13 Proteins 0.000 description 1
- 101000941275 Homo sapiens Endothelial lipase Proteins 0.000 description 1
- 101000918311 Homo sapiens Exostosin-1 Proteins 0.000 description 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 1
- 101001014629 Homo sapiens Golgin subfamily A member 2 Proteins 0.000 description 1
- 101000829489 Homo sapiens GrpE protein homolog 1, mitochondrial Proteins 0.000 description 1
- 101001001331 Homo sapiens Importin subunit alpha-1 Proteins 0.000 description 1
- 101001134694 Homo sapiens LIM domain and actin-binding protein 1 Proteins 0.000 description 1
- 101001054848 Homo sapiens Leucine zipper protein 1 Proteins 0.000 description 1
- 101000577058 Homo sapiens M-phase phosphoprotein 6 Proteins 0.000 description 1
- 101000687425 Homo sapiens PRELI domain-containing protein 1, mitochondrial Proteins 0.000 description 1
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 description 1
- 101000705759 Homo sapiens Proteasome activator complex subunit 2 Proteins 0.000 description 1
- 101000734537 Homo sapiens Pyridoxal-dependent decarboxylase domain-containing protein 1 Proteins 0.000 description 1
- 101000727821 Homo sapiens RING1 and YY1-binding protein Proteins 0.000 description 1
- 101000701334 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-1 Proteins 0.000 description 1
- 101000804921 Homo sapiens X-ray repair cross-complementing protein 5 Proteins 0.000 description 1
- 108091010040 Host cell factor Proteins 0.000 description 1
- 102000031927 Host cell factor Human genes 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 102100033339 LIM domain and actin-binding protein 1 Human genes 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 102100026915 Leucine zipper protein 1 Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 101710126849 M-phase phosphoprotein 6 Proteins 0.000 description 1
- 101150024363 MT-ND4 gene Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100300543 Mus musculus Qki gene Proteins 0.000 description 1
- 102100038625 NADH-ubiquinone oxidoreductase chain 1 Human genes 0.000 description 1
- 101710106575 NADH-ubiquinone oxidoreductase chain 1 Proteins 0.000 description 1
- 102100021506 NADH-ubiquinone oxidoreductase chain 4 Human genes 0.000 description 1
- 101150100316 ND4 gene Proteins 0.000 description 1
- 108091061960 Naked DNA Proteins 0.000 description 1
- 101710095545 PRELI domain-containing protein 1, mitochondrial Proteins 0.000 description 1
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 1
- 102000005891 Pancreatic ribonuclease Human genes 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 108010068204 Peptide Elongation Factors Proteins 0.000 description 1
- 102000002508 Peptide Elongation Factors Human genes 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 102000019200 Poly(A)-Binding Protein I Human genes 0.000 description 1
- 108010012887 Poly(A)-Binding Protein I Proteins 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 102100036134 Probable arginine-tRNA ligase, mitochondrial Human genes 0.000 description 1
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 description 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 1
- 101710103684 Proteasome activator complex subunit 2 Proteins 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- 102100025670 Protein S100-A13 Human genes 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 102100034759 Pyridoxal-dependent decarboxylase domain-containing protein 1 Human genes 0.000 description 1
- 102100029760 RING1 and YY1-binding protein Human genes 0.000 description 1
- 102000009572 RNA Polymerase II Human genes 0.000 description 1
- 108010009460 RNA Polymerase II Proteins 0.000 description 1
- 102000015097 RNA Splicing Factors Human genes 0.000 description 1
- 108010039259 RNA Splicing Factors Proteins 0.000 description 1
- 102000028391 RNA cap binding Human genes 0.000 description 1
- 108091000106 RNA cap binding Proteins 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 102000044126 RNA-Binding Proteins Human genes 0.000 description 1
- 101710105008 RNA-binding protein Proteins 0.000 description 1
- 101000658294 Rattus norvegicus Thioredoxin-like protein 1 Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102100027609 Rho-related GTP-binding protein RhoD Human genes 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 101100517535 Scyliorhinus canicula MTND4 gene Proteins 0.000 description 1
- 108090000184 Selectins Proteins 0.000 description 1
- 102000003800 Selectins Human genes 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 102100030458 Sodium/potassium-transporting ATPase subunit alpha-1 Human genes 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 108010046075 Thymosin Proteins 0.000 description 1
- 102000007501 Thymosin Human genes 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 108010057666 Transcription Factor CHOP Proteins 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 101000862137 Trichoderma koningii Glyceraldehyde-3-phosphate dehydrogenase 1 Proteins 0.000 description 1
- 102100033782 UDP-galactose translocator Human genes 0.000 description 1
- 108010075920 UDP-galactose translocator Proteins 0.000 description 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001766 X chromosome Anatomy 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 102100036973 X-ray repair cross-complementing protein 5 Human genes 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- CESGKXMBHGUQTB-VONOSFMSSA-N [(1S,2S,6R,10S,11R,13S,14R,15R)-1,6,14-trihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate Chemical compound C1=C(CO)C[C@]2(O)C(=O)C(C)=C[C@H]2[C@@]2(O)[C@H](C)[C@@H](O)[C@@]3(OC(=O)CCCCCCCCCCCCC)C(C)(C)[C@H]3[C@@H]21 CESGKXMBHGUQTB-VONOSFMSSA-N 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 238000003016 alphascreen Methods 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 208000028922 artery disease Diseases 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008619 cell matrix interaction Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000021953 cytokinesis Effects 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 231100001129 embryonic lethality Toxicity 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 238000005558 fluorometry Methods 0.000 description 1
- 238000002825 functional assay Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000012226 gene silencing method Methods 0.000 description 1
- 238000003167 genetic complementation Methods 0.000 description 1
- 230000008303 genetic mechanism Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 108091006093 heterotrimeric G proteins Proteins 0.000 description 1
- 102000034345 heterotrimeric G proteins Human genes 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 210000000688 human artificial chromosome Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000012405 in silico analysis Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000008611 intercellular interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000007852 inverse PCR Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000012917 library technology Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000010232 migration assay Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 238000000302 molecular modelling Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000013152 negative regulation of cell migration Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 230000006916 protein interaction Effects 0.000 description 1
- 238000000455 protein structure prediction Methods 0.000 description 1
- 230000018883 protein targeting Effects 0.000 description 1
- 230000025220 protein targeting to vacuole Effects 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 102000016914 ras Proteins Human genes 0.000 description 1
- 108010014186 ras Proteins Proteins 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 102000007268 rho GTP-Binding Proteins Human genes 0.000 description 1
- 108010033674 rho GTP-Binding Proteins Proteins 0.000 description 1
- 229940101201 ringl Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 210000003518 stress fiber Anatomy 0.000 description 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 238000012090 tissue culture technique Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005029 transcription elongation Effects 0.000 description 1
- 108091006106 transcriptional activators Proteins 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR7974A AUPR797401A0 (en) | 2001-09-27 | 2001-09-27 | Dna sequences for human angiogenesis genes ii |
| AUPR7973A AUPR797301A0 (en) | 2001-09-27 | 2001-09-27 | Dna sequences for human angiogenesis genes i |
| AUPR8210A AUPR821001A0 (en) | 2001-10-11 | 2001-10-11 | Dna sequences for human angiogenesis gene iv |
| AUPR8532A AUPR853201A0 (en) | 2001-10-29 | 2001-10-29 | Dna sequences for human angiogenesis genes vi |
| AUPR8838A AUPR883801A0 (en) | 2001-11-13 | 2001-11-13 | Dna sequences for human angiogenesis genes v |
| AU2002951032A AU2002951032A0 (en) | 2002-08-28 | 2002-08-28 | Dna sequence for a human angiogenesis gene vii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ543295A true NZ543295A (en) | 2008-04-30 |
Family
ID=27542986
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ543295A NZ543295A (en) | 2001-09-27 | 2002-09-19 | DNA sequences for human angiogenesis genes |
| NZ554534A NZ554534A (en) | 2001-09-27 | 2002-09-19 | DNA sequences for human angiogenesis genes |
| NZ531570A NZ531570A (en) | 2001-09-27 | 2002-09-19 | DNA sequences for human angiogenesis genes |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ554534A NZ554534A (en) | 2001-09-27 | 2002-09-19 | DNA sequences for human angiogenesis genes |
| NZ531570A NZ531570A (en) | 2001-09-27 | 2002-09-19 | DNA sequences for human angiogenesis genes |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20050112574A1 (https=) |
| EP (1) | EP1430126A4 (https=) |
| JP (2) | JP4486815B2 (https=) |
| CA (1) | CA2461372C (https=) |
| NZ (3) | NZ543295A (https=) |
| WO (1) | WO2003027285A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1430126A4 (en) * | 2001-09-27 | 2006-01-11 | Bionomics Ltd | DNA SEQUENCES FOR THE HUMAN GENES OF ANGIOGENESIS |
| AU2003901511A0 (en) * | 2003-03-28 | 2003-04-17 | Bionomics Limited | Nucleic acid molecules associated with angiogenesis II |
| WO2005014854A1 (en) * | 2003-08-08 | 2005-02-17 | Licentia, Ltd. | Materials and methods for colorectal cancer screening, diagnosis, and therapy |
| JP2005073621A (ja) * | 2003-09-01 | 2005-03-24 | Japan Science & Technology Agency | 脳腫瘍マーカーと脳腫瘍の診断方法 |
| US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
| JP4685369B2 (ja) * | 2004-04-30 | 2011-05-18 | 独立行政法人科学技術振興機構 | 関節リウマチ診断用試薬 |
| CA2576228A1 (en) | 2004-08-09 | 2006-02-16 | Bionomics Limited | Compositions and methods for angiogenesis-related molecules and treatments |
| AU2005270734B2 (en) * | 2004-08-09 | 2011-03-24 | Bionomics Limited | Compositions and methods for angiogenesis-related molecules and treatments |
| US20080032926A1 (en) * | 2004-08-10 | 2008-02-07 | Yoshikazu Naito | Knockout Non-Human Animal |
| FR2884258A1 (fr) * | 2005-04-07 | 2006-10-13 | Pharmamens Sarl | Mesure de l'activite specifique de la glyoxalase i comme nouvel outil diagnostic/pronostic dans la pathologie du diabete et des processus du vieillissement |
| US20090035312A1 (en) * | 2005-09-30 | 2009-02-05 | Universiteit Maastricht | Tumor angiogenesis associated genes and a method for their identification |
| CN101583714A (zh) * | 2006-11-09 | 2009-11-18 | 优尼拜尔斯金股份有限公司 | 增殖性疾病治疗中钠-钾ATP酶α1或α3亚单位的靶向作用 |
| US20100168382A1 (en) * | 2007-06-12 | 2010-07-01 | Vladimir Berezin | Neuroplastin derived peptides |
| KR20090020897A (ko) | 2007-08-24 | 2009-02-27 | 삼성전자주식회사 | 외부기기의 제어명령에 따라 제어되는 무선 영상시스템,무선 영상수신기 및 무선 영상시스템 제어방법 |
| WO2009079762A1 (en) | 2007-12-21 | 2009-07-02 | Genesis Group Inc. | Diagnostic test for cardiomyopathy |
| US8651916B2 (en) * | 2010-01-18 | 2014-02-18 | Disney Enterprises, Inc. | System and method for generating realistic eyes |
| US20120309034A1 (en) * | 2010-02-12 | 2012-12-06 | Nitto Boseki Co., Ltd. | METHOD FOR MEASURING IMMUNITY OF COMPLEX OF Ku86 AND AUTOANTIBODY THEREOF, KIT USED THEREFOR, AND METHOD FOR DETERMINING CANCER USING SAME |
| BR112013004161B1 (pt) | 2010-08-24 | 2021-03-09 | Asahi Kasei Chemicals Corporation | método e aparelho para reduzir óxidos de nitrogênio em motor de combustão interna |
| WO2012064975A1 (en) | 2010-11-12 | 2012-05-18 | Gen9, Inc. | Protein arrays and methods of using and making the same |
| LT2944693T (lt) | 2011-08-26 | 2019-08-26 | Gen9, Inc. | Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai |
| US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
| CA2871505C (en) | 2012-04-24 | 2021-10-12 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| WO2016168694A1 (en) * | 2015-04-15 | 2016-10-20 | Ohio State Innovation Foundation | Engineered calmodulin for treatment of ryanopathies |
| US11311606B2 (en) * | 2018-03-13 | 2022-04-26 | Georgetown University | Enhancing chemotherapy in medulloblastoma and glioblastoma with high basal p53 levels |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| AUPM425294A0 (en) * | 1994-03-04 | 1994-03-31 | Australian National University, The | In-vitro angiogenesis assay |
| EP1248798A2 (en) * | 1999-08-18 | 2002-10-16 | Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. | Human dna sequences |
| FR2798674B1 (fr) * | 1999-09-21 | 2004-01-30 | Mahmood Salman Al | Procede d'identification de nouveaux genes impliques dans la regulation de l'angiogenese, etude de ces genes et leur utilisation a des fins therapeutiques |
| CA2389751A1 (en) * | 1999-11-01 | 2001-05-10 | Curagen Corporation | Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same |
| EP1430126A4 (en) * | 2001-09-27 | 2006-01-11 | Bionomics Ltd | DNA SEQUENCES FOR THE HUMAN GENES OF ANGIOGENESIS |
| EP1470247A2 (en) * | 2001-11-05 | 2004-10-27 | Deutsches Krebsforschungszentrum | Novel genetic markers for leukemias |
-
2002
- 2002-09-19 EP EP02762158A patent/EP1430126A4/en not_active Withdrawn
- 2002-09-19 US US10/489,740 patent/US20050112574A1/en not_active Abandoned
- 2002-09-19 NZ NZ543295A patent/NZ543295A/en not_active IP Right Cessation
- 2002-09-19 JP JP2003530854A patent/JP4486815B2/ja not_active Expired - Fee Related
- 2002-09-19 NZ NZ554534A patent/NZ554534A/en not_active IP Right Cessation
- 2002-09-19 CA CA2461372A patent/CA2461372C/en not_active Expired - Fee Related
- 2002-09-19 WO PCT/AU2002/001282 patent/WO2003027285A1/en not_active Ceased
- 2002-09-19 NZ NZ531570A patent/NZ531570A/xx not_active IP Right Cessation
-
2008
- 2008-01-17 US US12/009,242 patent/US20080292614A1/en not_active Abandoned
-
2010
- 2010-02-23 JP JP2010037197A patent/JP2010187671A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2461372A1 (en) | 2003-04-03 |
| CA2461372C (en) | 2014-01-07 |
| NZ531570A (en) | 2006-03-31 |
| EP1430126A1 (en) | 2004-06-23 |
| US20050112574A1 (en) | 2005-05-26 |
| EP1430126A4 (en) | 2006-01-11 |
| NZ554534A (en) | 2008-10-31 |
| JP4486815B2 (ja) | 2010-06-23 |
| WO2003027285A1 (en) | 2003-04-03 |
| US20080292614A1 (en) | 2008-11-27 |
| JP2005505274A (ja) | 2005-02-24 |
| JP2010187671A (ja) | 2010-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20080292614A1 (en) | DNA sequences for human angiogenesis genes | |
| US6566325B2 (en) | 49 human secreted proteins | |
| JP2001502894A (ja) | ドメイン死アゴニストと相互作用するｂｈ３ | |
| WO2002064775A1 (en) | Identification of genes involved in the tumourigenic process | |
| CA2445532A1 (en) | Breast cancer-associated genes and uses thereof | |
| JP2002525067A (ja) | レプチン誘導遺伝子 | |
| CA2341705A1 (en) | Sequences characteristic of hypoxia-regulated gene transcription | |
| US20040009541A1 (en) | Novel carcinoma-related genes and polypeptides and methods of use thereof | |
| JP2002516577A (ja) | 哺乳動物ｃｈｋ１エフェクター細胞周期チェックポイントタンパク質キナーゼ物質及び方法 | |
| JP2006524492A (ja) | 血管形成に関連する核酸分子を同定するための方法 | |
| US20020107373A1 (en) | 49937, 49931, and 49933, novel human transporter family members and uses thereof | |
| AU2002328200B2 (en) | DNA sequences for human angiogenesis genes | |
| JP2007523608A (ja) | サイクリックａｍｐ応答エレメントアクティベータータンパク質およびそれに関連する使用 | |
| US20040225118A1 (en) | 31 human secreted proteins | |
| US6361954B1 (en) | Methods of immunoassay for human CDC6 | |
| AU2008201496A1 (en) | DNA sequences for human angiogenesis genes | |
| AU2002328200A1 (en) | DNA sequences for human angiogenesis genes | |
| US7462447B2 (en) | Methods for evaluating susceptibility to a bone homeostasis disorder | |
| WO2005024024A1 (en) | Mutations in the nedd4 gene family in epilepsy and other cns disorders | |
| CA2486583C (en) | Marker molecules associated with lung tumors | |
| JP2003503069A (ja) | 新規キナーゼおよびその使用 | |
| US20020045217A1 (en) | Novel tumor suppressor encoding nucleic acid, PTX1, and methods of use thereof | |
| JP2002171977A (ja) | 新規なヒトｓｈ２蛋白質 | |
| EP1001966A1 (en) | A senescence gene and its use in the treatment of cancer and other diseases | |
| AU2001288346A1 (en) | Novel tumor suppressor encoding nucleic acid, PTX1, and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 SEP 2016 BY CPA GLOBAL Effective date: 20150807 |
|
| LAPS | Patent lapsed |