NZ537754A - Combination of VEGF receptor tyrosine kinase inhibitors for treatment of cancer - Google Patents
Combination of VEGF receptor tyrosine kinase inhibitors for treatment of cancerInfo
- Publication number
- NZ537754A NZ537754A NZ537754A NZ53775403A NZ537754A NZ 537754 A NZ537754 A NZ 537754A NZ 537754 A NZ537754 A NZ 537754A NZ 53775403 A NZ53775403 A NZ 53775403A NZ 537754 A NZ537754 A NZ 537754A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- treatment
- cancer
- tumour
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
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| GBGB0218526.2A GB0218526D0 (en) | 2002-08-09 | 2002-08-09 | Combination therapy |
| PCT/GB2003/003390 WO2004014426A1 (en) | 2002-08-09 | 2003-08-05 | Combination of vegf receptor tyrosine kinase inhibitors for treatment of cancer |
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| Publication Number | Publication Date |
|---|---|
| NZ537754A true NZ537754A (en) | 2008-02-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ537754A NZ537754A (en) | 2002-08-09 | 2003-08-05 | Combination of VEGF receptor tyrosine kinase inhibitors for treatment of cancer |
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| Country | Link |
|---|---|
| US (2) | US20050245549A1 (enExample) |
| EP (1) | EP1534338A1 (enExample) |
| JP (1) | JP2006500346A (enExample) |
| KR (1) | KR20050059060A (enExample) |
| CN (1) | CN100556456C (enExample) |
| BR (1) | BR0313117A (enExample) |
| CA (1) | CA2495489A1 (enExample) |
| GB (1) | GB0218526D0 (enExample) |
| IL (1) | IL166625A0 (enExample) |
| MX (1) | MXPA05001457A (enExample) |
| NO (1) | NO20050528L (enExample) |
| NZ (1) | NZ537754A (enExample) |
| WO (1) | WO2004014426A1 (enExample) |
| ZA (1) | ZA200501061B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376567C (zh) | 1999-11-05 | 2008-03-26 | 阿斯特拉曾尼卡有限公司 | 作为vegf抑制剂的喹唑啉衍生物 |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| US7160889B2 (en) | 2000-04-07 | 2007-01-09 | Astrazeneca Ab | Quinazoline compounds |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| CN1625555A (zh) | 2002-02-01 | 2005-06-08 | 阿斯特拉曾尼卡有限公司 | 喹唑啉化合物 |
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| US7462623B2 (en) | 2002-11-04 | 2008-12-09 | Astrazeneca Ab | Quinazoline derivatives as Src tyrosine kinase inhibitors |
| DK1592423T3 (da) * | 2003-02-13 | 2011-06-27 | Astrazeneca Ab | Kombinationsterapi af ZD6474 med 5-FU og/eller CPT-11 |
| GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| US20060167027A1 (en) * | 2003-07-10 | 2006-07-27 | Wedge Stephen R | Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| MX2007003505A (es) * | 2004-09-27 | 2007-05-10 | Astrazeneca Ab | Combinacion que comprende zd6474 e imatinib. |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| MX2007012662A (es) * | 2005-04-14 | 2008-04-04 | Wyeth Corp | Uso de un inhibidor de la cinasa del receptor del factor de crecimiento epidermico (egfr) en pacientes resistentes al gefitinib. |
| JP2009502960A (ja) * | 2005-07-27 | 2009-01-29 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | 膵臓癌の処置のためのゲムシタビンおよびチロシンキナーゼ阻害剤を含む組み合わせ |
| GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
| EP1948179A1 (en) | 2005-11-11 | 2008-07-30 | Boehringer Ingelheim International GmbH | Quinazoline derivatives for the treatment of cancer diseases |
| DE602006020621D1 (de) * | 2005-12-22 | 2011-04-21 | Astrazeneca Ab | Kombination von zd6474 und pemetrexed |
| US20070258976A1 (en) * | 2006-05-04 | 2007-11-08 | Ward Keith W | Combination Therapy for Diseases Involving Angiogenesis |
| BRPI0717586A2 (pt) * | 2006-09-18 | 2013-10-29 | Boehringer Ingelheim Int | Método para tratar câncer apresentando mutações do egfr |
| WO2008037996A1 (en) * | 2006-09-29 | 2008-04-03 | Astrazeneca Ab | Combination of zd6474 and bevacizumab for cancer therapy |
| PL2451445T3 (pl) | 2009-07-06 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| GB201516905D0 (en) * | 2015-09-24 | 2015-11-11 | Stratified Medical Ltd | Treatment of Neurodegenerative diseases |
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| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| AU2002223684A1 (en) * | 2000-11-22 | 2002-06-03 | Novartis Pharma Gmbh | Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| BR0309226A (pt) * | 2002-04-16 | 2005-02-09 | Astrazeneca Ab | Métodos para a produção de um efeito de danificação vascular em um animal de sangue quente, e para o tratamento de um câncer envolvendo um tumor sólido em um animal de sangue quente, composição farmacêutica, kit, e, usos de zd6126 ou de um seu sal farmaceuticamente aceitável, e de zd1839 ou de um seu sal farmaceuticamente aceitável |
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| US20050222183A1 (en) * | 2002-08-09 | 2005-10-06 | Wedge Stephen R | Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
| DK1592423T3 (da) * | 2003-02-13 | 2011-06-27 | Astrazeneca Ab | Kombinationsterapi af ZD6474 med 5-FU og/eller CPT-11 |
| GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| US20060167027A1 (en) * | 2003-07-10 | 2006-07-27 | Wedge Stephen R | Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0412074D0 (en) * | 2004-05-29 | 2004-06-30 | Astrazeneca Ab | Combination product |
| MX2007003505A (es) * | 2004-09-27 | 2007-05-10 | Astrazeneca Ab | Combinacion que comprende zd6474 e imatinib. |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| DE602006020621D1 (de) * | 2005-12-22 | 2011-04-21 | Astrazeneca Ab | Kombination von zd6474 und pemetrexed |
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2002
- 2002-08-09 GB GBGB0218526.2A patent/GB0218526D0/en not_active Ceased
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2003
- 2003-08-05 EP EP03784248A patent/EP1534338A1/en not_active Withdrawn
- 2003-08-05 KR KR1020057002187A patent/KR20050059060A/ko not_active Ceased
- 2003-08-05 NZ NZ537754A patent/NZ537754A/en not_active IP Right Cessation
- 2003-08-05 MX MXPA05001457A patent/MXPA05001457A/es active IP Right Grant
- 2003-08-05 BR BR0313117-3A patent/BR0313117A/pt not_active IP Right Cessation
- 2003-08-05 CA CA002495489A patent/CA2495489A1/en not_active Abandoned
- 2003-08-05 JP JP2004527018A patent/JP2006500346A/ja active Pending
- 2003-08-05 WO PCT/GB2003/003390 patent/WO2004014426A1/en not_active Ceased
- 2003-08-05 US US10/523,838 patent/US20050245549A1/en not_active Abandoned
- 2003-08-05 CN CNB038191105A patent/CN100556456C/zh not_active Expired - Fee Related
-
2005
- 2005-01-31 NO NO20050528A patent/NO20050528L/no not_active Application Discontinuation
- 2005-02-01 IL IL16662505A patent/IL166625A0/xx unknown
- 2005-02-04 ZA ZA200501061A patent/ZA200501061B/en unknown
-
2009
- 2009-07-13 US US12/501,593 patent/US20100130493A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2495489A1 (en) | 2004-02-19 |
| EP1534338A1 (en) | 2005-06-01 |
| MXPA05001457A (es) | 2005-06-06 |
| US20100130493A1 (en) | 2010-05-27 |
| WO2004014426A1 (en) | 2004-02-19 |
| US20050245549A1 (en) | 2005-11-03 |
| CN100556456C (zh) | 2009-11-04 |
| CN1674938A (zh) | 2005-09-28 |
| AU2003252976A1 (en) | 2004-02-25 |
| KR20050059060A (ko) | 2005-06-17 |
| NO20050528L (no) | 2005-05-03 |
| BR0313117A (pt) | 2005-07-05 |
| GB0218526D0 (en) | 2002-09-18 |
| JP2006500346A (ja) | 2006-01-05 |
| IL166625A0 (en) | 2006-01-15 |
| ZA200501061B (en) | 2007-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |