CA2495489A1 - Combination of vegf receptor tyrosine kinase inhibitors for treatment of cancer - Google Patents
Combination of vegf receptor tyrosine kinase inhibitors for treatment of cancer Download PDFInfo
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- CA2495489A1 CA2495489A1 CA002495489A CA2495489A CA2495489A1 CA 2495489 A1 CA2495489 A1 CA 2495489A1 CA 002495489 A CA002495489 A CA 002495489A CA 2495489 A CA2495489 A CA 2495489A CA 2495489 A1 CA2495489 A1 CA 2495489A1
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- pharmaceutically acceptable
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- cancer
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
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Landscapes
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| GB0218526.2 | 2002-08-09 | ||
| GBGB0218526.2A GB0218526D0 (en) | 2002-08-09 | 2002-08-09 | Combination therapy |
| PCT/GB2003/003390 WO2004014426A1 (en) | 2002-08-09 | 2003-08-05 | Combination of vegf receptor tyrosine kinase inhibitors for treatment of cancer |
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| CA2495489A1 true CA2495489A1 (en) | 2004-02-19 |
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| CA (1) | CA2495489A1 (enExample) |
| GB (1) | GB0218526D0 (enExample) |
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| NZ (1) | NZ537754A (enExample) |
| WO (1) | WO2004014426A1 (enExample) |
| ZA (1) | ZA200501061B (enExample) |
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| EP1676845B1 (en) | 1999-11-05 | 2008-06-11 | AstraZeneca AB | New quinazoline derivatives |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| EP1274692B1 (en) | 2000-04-07 | 2006-08-02 | AstraZeneca AB | Quinazoline compounds |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| NZ534171A (en) | 2002-02-01 | 2007-06-29 | Astrazeneca Ab | Quinazoline compounds for the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
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| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| NZ539408A (en) | 2002-11-04 | 2007-09-28 | Astrazeneca Ab | Quinazoline derivatives as SRC tyrosine kinase inhibitors for treating solid tumours |
| CA2514227C (en) * | 2003-02-13 | 2011-08-09 | Astrazeneca Ab | Combination therapy of zd6474 with 5-fu or/and cpt-11 |
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| JP2008536847A (ja) * | 2005-04-14 | 2008-09-11 | ワイス | ゲフィニチブ耐性患者における上皮増殖因子レセプター（ｅｇｆｒ）キナーゼインヒビターの使用 |
| WO2007014335A2 (en) * | 2005-07-27 | 2007-02-01 | The University Of Texas System | Combinations comprising gemcitabine and tyrosine kinase inhibitors for the treatment of pancreatic cancer |
| GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
| CA2629244C (en) | 2005-11-11 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| EP1971338B8 (en) * | 2005-12-22 | 2011-09-21 | AstraZeneca AB | Combination of zd6474 and pemetrexed |
| US20070258976A1 (en) * | 2006-05-04 | 2007-11-08 | Ward Keith W | Combination Therapy for Diseases Involving Angiogenesis |
| SI2068880T1 (sl) * | 2006-09-18 | 2012-08-31 | Boehringer Ingelheim Int | Postopek za zdravljenje raka, ki vsebuje mutacije EGFR |
| US20100092466A1 (en) * | 2006-09-29 | 2010-04-15 | Anderson Joseph Ryan | Combination of zd6474 and bevacizumab for cancer therapy |
| DK2451445T3 (da) | 2009-07-06 | 2019-06-24 | Boehringer Ingelheim Int | Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| GB201516905D0 (en) * | 2015-09-24 | 2015-11-11 | Stratified Medical Ltd | Treatment of Neurodegenerative diseases |
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| EP1339458B1 (en) * | 2000-11-22 | 2007-08-15 | Novartis AG | Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| DE60311788T2 (de) * | 2002-04-16 | 2007-11-22 | Astrazeneca Ab | Kombinationstherapie zur behandlung von krebs |
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- 2003-08-05 CA CA002495489A patent/CA2495489A1/en not_active Abandoned
- 2003-08-05 MX MXPA05001457A patent/MXPA05001457A/es active IP Right Grant
- 2003-08-05 CN CNB038191105A patent/CN100556456C/zh not_active Expired - Fee Related
-
2005
- 2005-01-31 NO NO20050528A patent/NO20050528L/no not_active Application Discontinuation
- 2005-02-01 IL IL16662505A patent/IL166625A0/xx unknown
- 2005-02-04 ZA ZA200501061A patent/ZA200501061B/en unknown
-
2009
- 2009-07-13 US US12/501,593 patent/US20100130493A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1534338A1 (en) | 2005-06-01 |
| US20100130493A1 (en) | 2010-05-27 |
| NZ537754A (en) | 2008-02-29 |
| BR0313117A (pt) | 2005-07-05 |
| IL166625A0 (en) | 2006-01-15 |
| WO2004014426A1 (en) | 2004-02-19 |
| MXPA05001457A (es) | 2005-06-06 |
| AU2003252976A1 (en) | 2004-02-25 |
| ZA200501061B (en) | 2007-01-31 |
| KR20050059060A (ko) | 2005-06-17 |
| US20050245549A1 (en) | 2005-11-03 |
| NO20050528L (no) | 2005-05-03 |
| JP2006500346A (ja) | 2006-01-05 |
| GB0218526D0 (en) | 2002-09-18 |
| CN100556456C (zh) | 2009-11-04 |
| CN1674938A (zh) | 2005-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |