NZ537015A - Anti-tumour polycyclic carboxamides with cytotoxicity - Google Patents

Info

Publication number

NZ537015A

NZ537015A NZ537015A NZ53701503A NZ537015A NZ 537015 A NZ537015 A NZ 537015A NZ 537015 A NZ537015 A NZ 537015A NZ 53701503 A NZ53701503 A NZ 53701503A NZ 537015 A NZ537015 A NZ 537015A

Authority

NZ

New Zealand

Prior art keywords

formula

compound

optionally substituted

nmr

pct

Prior art date

2002-05-15

Links

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• Global Dossier
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• -1 polycyclic carboxamides Chemical class 0.000 title claims abstract description 52
• 230000000259 anti-tumor effect Effects 0.000 title claims description 8
• 230000003013 cytotoxicity Effects 0.000 title abstract description 5
• 231100000135 cytotoxicity Toxicity 0.000 title abstract description 5
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 53
• 238000000034 method Methods 0.000 claims abstract description 32
• 238000011282 treatment Methods 0.000 claims abstract description 28
• 238000002360 preparation method Methods 0.000 claims abstract description 26
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
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• 230000001413 cellular effect Effects 0.000 claims abstract description 12
• 230000002062 proliferating effect Effects 0.000 claims abstract description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
• 230000008569 process Effects 0.000 claims abstract description 11
• 238000011321 prophylaxis Methods 0.000 claims abstract description 6
• 150000001875 compounds Chemical class 0.000 claims description 132
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 88
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 57
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 52
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 50
• 239000002253 acid Substances 0.000 claims description 45
• 238000006243 chemical reaction Methods 0.000 claims description 29
• 239000000203 mixture Substances 0.000 claims description 26
• 125000000623 heterocyclic group Chemical group 0.000 claims description 21
• 230000000694 effects Effects 0.000 claims description 20
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• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 18
• 150000001408 amides Chemical class 0.000 claims description 17
• 229910052799 carbon Inorganic materials 0.000 claims description 17
• 150000003839 salts Chemical class 0.000 claims description 16
• 229910052757 nitrogen Inorganic materials 0.000 claims description 15
• 125000000217 alkyl group Chemical group 0.000 claims description 13
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 13
• 229920006395 saturated elastomer Polymers 0.000 claims description 13
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
• 150000001412 amines Chemical class 0.000 claims description 11
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• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 5
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