NZ532779A - Method for treating diseases with omega interferon - Google Patents
Method for treating diseases with omega interferonInfo
- Publication number
- NZ532779A NZ532779A NZ532779A NZ53277902A NZ532779A NZ 532779 A NZ532779 A NZ 532779A NZ 532779 A NZ532779 A NZ 532779A NZ 53277902 A NZ53277902 A NZ 53277902A NZ 532779 A NZ532779 A NZ 532779A
- Authority
- NZ
- New Zealand
- Prior art keywords
- interferon
- use according
- omega interferon
- omega
- administered
- Prior art date
Links
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| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| OA12835A (fr) * | 2003-10-29 | 2006-09-15 | Koung Nee Bellet Anne Brigitte Dr | Interferon omega contre le VIH/SIDA, le cancer et asthme humain et veterinaire. |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| KR101106510B1 (ko) | 2006-05-30 | 2012-01-20 | 인타르시아 세라퓨틱스 인코포레이티드 | 투피스, 내부채널 삼투압 전달 시스템 유동 조절기 |
| EP2359808B1 (en) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Osmotic delivery systems and piston assemblies |
| WO2008133908A2 (en) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| RU2547990C2 (ru) | 2009-09-28 | 2015-04-10 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| RU2730996C2 (ru) | 2015-06-03 | 2020-08-26 | Интарсия Терапьютикс, Инк. | Системы установки и извлечения имплантата |
| KR102574993B1 (ko) | 2016-05-16 | 2023-09-06 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| JP7286542B2 (ja) | 2017-01-03 | 2023-06-05 | インターシア セラピューティクス，インコーポレイティド | Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法 |
| CN111973600B (zh) * | 2020-08-20 | 2021-11-16 | 华中农业大学 | 霉酚酸或其衍生物在制备犬瘟热病毒抑制剂中的用途 |
| WO2024015586A1 (en) * | 2022-07-15 | 2024-01-18 | Whitehead Institute For Biomedical Research | Compositions and methods for treating cancer with interferon-omega and analogs thereof |
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| US4211771A (en) * | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| EP0080879B1 (en) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| US5004689A (en) * | 1982-02-22 | 1991-04-02 | Biogen, Massachusetts | DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3220116A1 (de) * | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung |
| US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US4673405A (en) * | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
| US5231176A (en) * | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| US5120832A (en) * | 1984-08-27 | 1992-06-09 | Genentech, Inc. | Distinct family of human leukocyte interferons |
| FI90990C (fi) * | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| EP0205404B1 (en) * | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
| US4845196A (en) * | 1985-06-24 | 1989-07-04 | G. D. Searle & Co. | Modified interferon gammas |
| US4847079A (en) * | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| DE3607835A1 (de) * | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| ZA878295B (en) * | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
| CA1320905C (en) * | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| DE3642096A1 (de) * | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | Pferde-(gamma)-interferon |
| US4915954A (en) * | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
| US4917895A (en) * | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
| US4976966A (en) * | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
| US5906816A (en) * | 1995-03-16 | 1999-05-25 | University Of Florida | Method for treatment of autoimmune diseases |
| US5705363A (en) * | 1989-03-02 | 1998-01-06 | The Women's Research Institute | Recombinant production of human interferon τ polypeptides and nucleic acids |
| US5112614A (en) * | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5223266A (en) * | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
| US5120306A (en) * | 1990-03-21 | 1992-06-09 | Gosselin Leon F | Direct delivery of anti-inflammatories to the proximal small bowel |
| US5207752A (en) * | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
| US5324280A (en) * | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
| US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| IE920040A1 (en) * | 1991-01-09 | 1992-07-15 | Alza Corp | Bioerodible devices and compositions for diffusional release¹of agents |
| US5443459A (en) * | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US5676942A (en) * | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| US5221278A (en) * | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| FR2690622B1 (fr) * | 1992-04-29 | 1995-01-20 | Chronotec | Système de pompe à perfusion ambulatoire programmable. |
| US5805688A (en) * | 1993-04-01 | 1998-09-08 | U.S. West Advanced Technologies, Inc. | Automated system and method for call handling |
| PT741577E (pt) * | 1994-03-07 | 2003-03-31 | Imperial College | Utilizacao do subtipo de interferao alfa 8 na preparacao de medicamentos para tratar infeccoes virais do figado |
| US5939286A (en) * | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
| US6129761A (en) * | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| NZ331186A (en) * | 1996-02-02 | 2000-04-28 | Alza Corp | Osmotically driven sustained delivery drug delivery capsule |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| WO1997033998A1 (en) * | 1996-03-14 | 1997-09-18 | The Immune Response Corporation | Targeted delivery of genes encoding interferon |
| US6204022B1 (en) * | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
| CN1203863C (zh) * | 1997-04-07 | 2005-06-01 | Iams公司 | 含可发酵纤维的宠物食品组合物的用途 |
| US6172046B1 (en) * | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| KR100568917B1 (ko) * | 1997-12-30 | 2006-04-07 | 알자 코포레이션 | 멤브레인 플러그를 갖는 익제 전달장치 |
| AU766597B2 (en) * | 1998-05-15 | 2003-10-16 | Schering Corporation | Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having chronic hepatitis C infection |
| TW586944B (en) * | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
| US6472512B1 (en) * | 1998-07-21 | 2002-10-29 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US7390637B2 (en) * | 1998-07-21 | 2008-06-24 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| WO2000040273A2 (en) * | 1999-01-08 | 2000-07-13 | Vical Incorporated | Treatment of viral diseases using an interferon omega expressing polynucleotide |
| US6833256B1 (en) * | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
| US6436091B1 (en) * | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US6875748B2 (en) * | 2000-04-21 | 2005-04-05 | Vical Incorporated | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
| IL155730A0 (en) * | 2000-11-03 | 2003-11-23 | Biomedicines Inc | Method for short-term and long-term drug dosimetry |
-
2002
- 2002-11-08 CA CA002466228A patent/CA2466228A1/en not_active Abandoned
- 2002-11-08 EP EP02805705A patent/EP1536839B1/en not_active Expired - Lifetime
- 2002-11-08 NZ NZ532779A patent/NZ532779A/en not_active IP Right Cessation
- 2002-11-08 AT AT02805705T patent/ATE481135T1/de active
- 2002-11-08 DE DE60237721T patent/DE60237721D1/de not_active Expired - Lifetime
- 2002-11-08 WO PCT/US2002/036025 patent/WO2003063573A2/en not_active Ceased
- 2002-11-08 AU AU2002365436A patent/AU2002365436B8/en not_active Ceased
- 2002-11-08 IL IL16188902A patent/IL161889A0/xx unknown
- 2002-11-08 US US10/290,790 patent/US20030143197A1/en not_active Abandoned
- 2002-11-08 CN CNB028245261A patent/CN100438870C/zh not_active Expired - Fee Related
- 2002-11-08 KR KR10-2004-7007037A patent/KR20040053291A/ko not_active Ceased
- 2002-11-08 JP JP2003563287A patent/JP2005516041A/ja active Pending
-
2004
- 2004-05-09 IL IL161889A patent/IL161889A/en not_active IP Right Cessation
-
2007
- 2007-06-07 US US11/811,415 patent/US20070248572A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1635886A (zh) | 2005-07-06 |
| WO2003063573A3 (en) | 2005-04-14 |
| EP1536839A4 (en) | 2009-03-11 |
| AU2002365436B2 (en) | 2008-01-24 |
| US20070248572A1 (en) | 2007-10-25 |
| WO2003063573A2 (en) | 2003-08-07 |
| ATE481135T1 (de) | 2010-10-15 |
| AU2002365436B8 (en) | 2008-04-03 |
| CA2466228A1 (en) | 2003-08-07 |
| IL161889A0 (en) | 2005-11-20 |
| US20030143197A1 (en) | 2003-07-31 |
| EP1536839A2 (en) | 2005-06-08 |
| IL161889A (en) | 2010-05-31 |
| DE60237721D1 (de) | 2010-10-28 |
| HK1084862A1 (zh) | 2006-08-11 |
| KR20040053291A (ko) | 2004-06-23 |
| EP1536839B1 (en) | 2010-09-15 |
| JP2005516041A (ja) | 2005-06-02 |
| CN100438870C (zh) | 2008-12-03 |
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| ASS | Change of ownership |
Owner name: INTARCIA THERAPEUTICS, INC, US Free format text: OLD OWNER(S): BIOMEDICINES, INC. |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
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| LAPS | Patent lapsed |