NZ528999A - An assay for detecting inhibitors of the enzyme myeloperoxidase and as a diagnostic test - Google Patents

An assay for detecting inhibitors of the enzyme myeloperoxidase and as a diagnostic test

Info

Publication number
NZ528999A
NZ528999A NZ528999A NZ52899902A NZ528999A NZ 528999 A NZ528999 A NZ 528999A NZ 528999 A NZ528999 A NZ 528999A NZ 52899902 A NZ52899902 A NZ 52899902A NZ 528999 A NZ528999 A NZ 528999A
Authority
NZ
New Zealand
Prior art keywords
myeloperoxidase
assay
mpo
hydrogen peroxide
taurine
Prior art date
Application number
NZ528999A
Other languages
English (en)
Inventor
Anthony Kettle
Original Assignee
Astrazeneca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE2001/001014 external-priority patent/WO2001085146A1/en
Priority claimed from SE0103766A external-priority patent/SE0103766D0/xx
Application filed by Astrazeneca filed Critical Astrazeneca
Publication of NZ528999A publication Critical patent/NZ528999A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NZ528999A 2001-05-08 2002-05-06 An assay for detecting inhibitors of the enzyme myeloperoxidase and as a diagnostic test NZ528999A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/SE2001/001014 WO2001085146A1 (en) 2000-05-12 2001-05-08 Pharmaceutical compounds for treating copd
SE0103766A SE0103766D0 (sv) 2001-11-09 2001-11-09 Novel assay
PCT/SE2002/000877 WO2002090575A1 (en) 2001-05-08 2002-05-06 An assay for detecting inhibitors of the enzyme mueloperokidase

Publications (1)

Publication Number Publication Date
NZ528999A true NZ528999A (en) 2005-04-29

Family

ID=26655416

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ528999A NZ528999A (en) 2001-05-08 2002-05-06 An assay for detecting inhibitors of the enzyme myeloperoxidase and as a diagnostic test

Country Status (12)

Country Link
EP (1) EP1387893B1 (da)
JP (1) JP4095446B2 (da)
CN (1) CN1228452C (da)
AT (1) ATE346951T1 (da)
AU (1) AU2002258327B2 (da)
CA (1) CA2446039A1 (da)
DE (1) DE60216442T2 (da)
DK (1) DK1387893T3 (da)
ES (1) ES2275865T3 (da)
IL (1) IL158462A0 (da)
NZ (1) NZ528999A (da)
WO (1) WO2002090575A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
US7195891B2 (en) 2004-08-11 2007-03-27 General Atomics Methods and compositions of enzymatic cycling based assays for myeloperoxidase
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
EA027324B1 (ru) 2011-11-11 2017-07-31 Пфайзер Инк. 2-тиопиримидиноны
PE20180503A1 (es) 2015-05-05 2018-03-09 Pfizer 2-tiopirimidinonas
CN105891182B (zh) * 2016-06-17 2018-05-29 云南圣清环境监测科技有限公司 一种对过氧化氢酶定量的方法
CN106908601B (zh) * 2017-03-06 2019-02-12 海格德生物科技（深圳）有限公司 人髓过氧化物酶活性及总量检测试剂盒及检测方法和制备方法
CN109975282A (zh) * 2019-04-04 2019-07-05 华侨大学 一种基于酶催化碘化钾氧化显色检测过氧化氢含量的分光光度法
CN114509429A (zh) * 2021-12-20 2022-05-17 苏州百源基因技术有限公司 一种尿碘检测试剂盒及其使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976823A (en) * 1997-03-19 1999-11-02 Integrated Biomedical Technology, Inc. Low range total available chlorine test strip

Also Published As

Publication number Publication date
JP4095446B2 (ja) 2008-06-04
JP2004525646A (ja) 2004-08-26
IL158462A0 (en) 2004-05-12
DE60216442T2 (de) 2007-09-27
CN1228452C (zh) 2005-11-23
CN1507495A (zh) 2004-06-23
CA2446039A1 (en) 2002-11-14
AU2002258327B2 (en) 2007-03-01
DE60216442D1 (de) 2007-01-11
EP1387893A1 (en) 2004-02-11
WO2002090575A1 (en) 2002-11-14
DK1387893T3 (da) 2007-02-19
EP1387893B1 (en) 2006-11-29
ATE346951T1 (de) 2006-12-15
ES2275865T3 (es) 2007-06-16

Similar Documents

Publication Publication Date Title
Fernandes et al. In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal anti-inflammatory indole, pyrrole, and oxazole derivative drugs
Kettle et al. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs
Costa et al. Inhibition of human neutrophil oxidative burst by pyrazolone derivatives
Pi et al. A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits
Eiserich et al. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
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Jantschko et al. Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design
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Wasil et al. Biologically-significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs
EP1387893B1 (en) An assay for detecting inhibitors of the enzyme myeloperokidase
Dad et al. Haloacetic acid water disinfection byproducts affect pyruvate dehydrogenase activity and disrupt cellular metabolism
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Vakhrusheva et al. Enzymatic and bactericidal activity of myeloperoxidase in conditions of halogenative stress
Patnaik et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO)
Klebanoff et al. Inhibition of peroxidase-catalyzed reactions by deferoxamine
Galijasevic et al. Potential role of tryptophan and chloride in the inhibition of human myeloperoxidase
de Carvalho Bertozo et al. Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase
Yuasa et al. Methylene blue and ascorbate interfere with the accurate determination of the kinetic properties of IDO2
Camp et al. Hypochlorous acid facilitates inducible nitric oxide synthase subunit dissociation: The link between heme destruction, disturbance of the zinc-tetrathiolate center, and the prevention by melatonin
Kettle et al. Do neutrophils produce ozone? An appraisal of current evidence
Wroczyński et al. Aromatic aldehydes as fluorogenic indicators for human aldehyde dehydrogenases and oxidases: substrate and isozyme specificityPresented as a poster at the VIIIth International Symposium on Luminescence Spectrometry in Biomedical Analysis, Las Palmas de Gran Canaria, Spain, May 1998.

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