NZ527208A - Concatemers of differentially expressed multiple genes - Google Patents
Concatemers of differentially expressed multiple genesInfo
- Publication number
- NZ527208A NZ527208A NZ527208A NZ52720802A NZ527208A NZ 527208 A NZ527208 A NZ 527208A NZ 527208 A NZ527208 A NZ 527208A NZ 52720802 A NZ52720802 A NZ 52720802A NZ 527208 A NZ527208 A NZ 527208A
- Authority
- NZ
- New Zealand
- Prior art keywords
- vector
- concatemer
- denotes
- promoter
- cell
- Prior art date
Links
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
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- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| DKPA200100127 | 2001-01-25 | ||
| US30102201P | 2001-06-27 | 2001-06-27 | |
| PCT/DK2002/000055 WO2002059296A2 (en) | 2001-01-25 | 2002-01-25 | Concatemers of differentially expressed multiple genes |
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| NZ527208A true NZ527208A (en) | 2005-05-27 |
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| NZ527208A NZ527208A (en) | 2001-01-25 | 2002-01-25 | Concatemers of differentially expressed multiple genes |
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| DE (1) | DE60222857T2 (https=) |
| NZ (1) | NZ527208A (https=) |
| WO (1) | WO2002059296A2 (https=) |
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| US7193128B2 (en) | 1997-06-03 | 2007-03-20 | Chromatin, Inc. | Methods for generating or increasing revenues from crops |
| US7119250B2 (en) | 1997-06-03 | 2006-10-10 | The University Of Chicago | Plant centromere compositions |
| US7227057B2 (en) | 1997-06-03 | 2007-06-05 | Chromatin, Inc. | Plant centromere compositions |
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
| AU2003247270A1 (en) * | 2002-08-01 | 2004-03-03 | Evolva Ltd | Methods of mixing large numbers of heterologous genes |
| NZ554824A (en) | 2004-10-22 | 2010-10-29 | Revivicor Inc | Porcines that lack endogenous antibody chains and express exogenous immunoglobulins |
| EP2348827B1 (en) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunocompromised ungulates |
| EP2456894A4 (en) | 2009-07-23 | 2013-09-25 | Chromatin Inc | CENTROMER SEQUENCES AND SORGHUM MINI-CHROMOSOMES |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| JP6295512B2 (ja) * | 2012-03-15 | 2018-03-20 | 株式会社豊田中央研究所 | 酵母における外来遺伝子の発現産物の生産方法、酵母における発現調節剤及びその利用 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
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| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
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| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12595501B2 (en) * | 2019-06-13 | 2026-04-07 | Global Life Sciences Solutions Usa Llc | Expression of products from nucleic acid concatemers |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| CN116312618B (zh) * | 2023-03-27 | 2025-09-16 | 中科南京智能技术研究院 | 一种说话人识别方法及系统 |
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| US5316922A (en) * | 1992-04-15 | 1994-05-31 | The United States Of America As Represented By Department Of Health And Human Services | Method for indentifying and expressing proteins that recognize and adhere to specific probes |
| US6242211B1 (en) * | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
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2002
- 2002-01-25 EP EP02709978A patent/EP1360308B1/en not_active Expired - Lifetime
- 2002-01-25 CA CA2474161A patent/CA2474161C/en not_active Expired - Fee Related
- 2002-01-25 DE DE60222857T patent/DE60222857T2/de not_active Expired - Lifetime
- 2002-01-25 AT AT02709978T patent/ATE375394T1/de active
- 2002-01-25 NZ NZ527208A patent/NZ527208A/en not_active IP Right Cessation
- 2002-01-25 WO PCT/DK2002/000055 patent/WO2002059296A2/en not_active Ceased
- 2002-01-25 AU AU2002227882A patent/AU2002227882B2/en not_active Ceased
- 2002-01-25 JP JP2002559583A patent/JP2004525623A/ja not_active Withdrawn
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| EP1360308B1 (en) | 2007-10-10 |
| EP1360308A2 (en) | 2003-11-12 |
| WO2002059296A8 (en) | 2004-04-15 |
| AU2002227882C9 (en) | 2002-08-06 |
| WO2002059296A3 (en) | 2003-05-01 |
| WO2002059296A2 (en) | 2002-08-01 |
| JP2004525623A (ja) | 2004-08-26 |
| CA2474161C (en) | 2012-03-27 |
| ATE375394T1 (de) | 2007-10-15 |
| DE60222857T2 (de) | 2008-07-17 |
| AU2002227882B2 (en) | 2007-06-28 |
| DE60222857D1 (de) | 2007-11-22 |
| JP2010057519A (ja) | 2010-03-18 |
| AU2002227882C1 (en) | 2002-08-06 |
| CA2474161A1 (en) | 2002-08-01 |
| JP5001346B2 (ja) | 2012-08-15 |
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