NZ517359A - Hyaluronan as a cytotoxic agent, drug pre-sensitizer and chemo-sensitizer in the treatment of disease - Google Patents
Hyaluronan as a cytotoxic agent, drug pre-sensitizer and chemo-sensitizer in the treatment of diseaseInfo
- Publication number
- NZ517359A NZ517359A NZ517359A NZ51735901A NZ517359A NZ 517359 A NZ517359 A NZ 517359A NZ 517359 A NZ517359 A NZ 517359A NZ 51735901 A NZ51735901 A NZ 51735901A NZ 517359 A NZ517359 A NZ 517359A
- Authority
- NZ
- New Zealand
- Prior art keywords
- chemotherapeutic agent
- hyaluronan
- drug
- cells
- treatment
- Prior art date
Links
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ8795A AUPQ879500A0 (en) | 2000-07-14 | 2000-07-14 | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| PCT/AU2001/000849 WO2002005852A1 (en) | 2000-07-14 | 2001-07-13 | Hyaluronan as a cytotoxic agent, drug pre-sensitizer and chemo-sensitizer in the treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ517359A true NZ517359A (en) | 2003-11-28 |
Family
ID=3822859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ517359A NZ517359A (en) | 2000-07-14 | 2001-07-13 | Hyaluronan as a cytotoxic agent, drug pre-sensitizer and chemo-sensitizer in the treatment of disease |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20030180382A1 (enExample) |
| EP (1) | EP1301209A4 (enExample) |
| JP (2) | JP5548328B2 (enExample) |
| CN (1) | CN1388760A (enExample) |
| AU (1) | AUPQ879500A0 (enExample) |
| CA (1) | CA2382560C (enExample) |
| GB (1) | GB2368525B (enExample) |
| NZ (1) | NZ517359A (enExample) |
| WO (1) | WO2002005852A1 (enExample) |
| ZA (1) | ZA200201561B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000041730A1 (en) | 1999-01-13 | 2000-07-20 | Meditech Research Limited | A composition and method for the enhancement of the efficacy of drugs |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| CN1578677A (zh) * | 2001-08-27 | 2005-02-09 | 美迪泰克研究有限公司 | 改良的治疗方案 |
| CA2513143A1 (en) * | 2002-07-01 | 2004-01-08 | Tufts University | Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers |
| EP1912658B1 (en) * | 2005-07-27 | 2017-01-25 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| AU2006289651B2 (en) * | 2005-09-07 | 2012-07-26 | Alchemia Oncology Pty Limited | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
| JP2007153766A (ja) * | 2005-12-01 | 2007-06-21 | Toshitsu Kagaku Kenkyusho:Kk | Ｍａｐキナーゼキナーゼキナーゼ遺伝子の発現増強剤 |
| EP2078528B1 (en) | 2006-09-22 | 2013-08-14 | Kochi University | Radiation sensitizer or anti-cancer chemotherapy sensitizer |
| CA2713813C (en) * | 2008-01-30 | 2017-12-05 | University Of Kansas | Intralymphatic chemotherapy drug carriers |
| EP2649994B1 (de) * | 2011-01-31 | 2017-08-30 | LUCOLAS-M.D. Ltd. | Kombinationen von aromatase inhibitoren und antioxidanzien |
| US9316645B2 (en) | 2011-10-07 | 2016-04-19 | Brown University | Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging |
| US20130236504A1 (en) * | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
| WO2014015264A1 (en) | 2012-07-20 | 2014-01-23 | Brown University | Functionalized media and methods of making and using therefor |
| EP2712651A1 (en) | 2012-09-27 | 2014-04-02 | F. Hoffmann-La Roche AG | Venting device for use in ambulatory infusion system |
| EP2712650A1 (en) | 2012-09-27 | 2014-04-02 | F. Hoffmann-La Roche AG | Adapter and drug cartridge alignment device |
| WO2014126222A1 (ja) | 2013-02-15 | 2014-08-21 | 国立大学法人高知大学 | ハイドロゲルを担体として過酸化水素を徐放する腫瘍内局注用の放射線/化学療法増感剤 |
| CN109512825A (zh) * | 2018-12-29 | 2019-03-26 | 江苏靶标生物医药研究所有限公司 | 一种铂类化合物和透明质酸钠的组合物及其应用 |
| CN109528763A (zh) * | 2018-12-29 | 2019-03-29 | 江苏靶标生物医药研究所有限公司 | 顺铂与透明质酸钠的组合物 |
| AU2022220683A1 (en) * | 2021-02-11 | 2023-08-31 | Department Of Veterans Affairs | Methods for preventing cancer relapse |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA612307A (en) | 1961-01-10 | International Business Machines Corporation | Hydraulic drive tape handling system | |
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| IT1229075B (it) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico |
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| LU85582A1 (fr) | 1983-10-11 | 1985-06-04 | Fidia Spa | Fractions d'acide hyaluronique ayant une activite pharmaceutique,procedes pour leur preparation et compositions pharmaceutiques les contenant |
| JPS6117A (ja) * | 1984-06-11 | 1986-01-06 | Seikagaku Kogyo Co Ltd | ムコ多糖系癌転移抑制剤 |
| CA1227427A (en) | 1984-08-16 | 1987-09-29 | Albert Landsberger | Therapeutic agent for the use in cancer treatment |
| JPS6191986U (enExample) | 1984-11-24 | 1986-06-14 | ||
| US5532341A (en) * | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
| US5202431A (en) * | 1985-07-08 | 1993-04-13 | Fidia, S.P.A. | Partial esters of hyaluronic acid |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US4665107A (en) * | 1986-03-21 | 1987-05-12 | Koh-I-Noor Rapidograph, Inc. | Pigment encapsulated latex aqueous colorant dispersions |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5128450A (en) * | 1989-06-30 | 1992-07-07 | Urdal David L | Nonglycosylated human interleukin-3 analog proteins |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5095037B1 (en) * | 1989-12-21 | 1995-12-19 | Nissho Kk | Combined anti-inflammatory agent |
| CA2061566C (en) | 1992-02-20 | 2002-07-09 | Rudolf E. Falk | Treatment of disease employing hyaluronic acid and nsaids |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| US5733891A (en) * | 1990-10-18 | 1998-03-31 | Shiseido Co., Ltd. | Compound for medicinal ingredient and hyaluronic acid and process for producing the same |
| US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| AU643141B2 (en) * | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| CA2122519C (en) * | 1994-04-29 | 2001-02-20 | Rudolf Edgar Dr. Falk | Cancer treatment and metastasis prevention |
| US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| WO1998017320A1 (en) | 1991-07-03 | 1998-04-30 | Hyal Pharmaceutical Corporation | Use of hyaluronan in gene therapy |
| CA2076465C (en) * | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
| US5287123A (en) * | 1992-05-01 | 1994-02-15 | Hewlett-Packard Company | Preheat roller for thermal ink-jet printer |
| JPH08508240A (ja) | 1993-01-12 | 1996-09-03 | ジョージ グリスティーナ，アンソニー | 受動免疫の直接的濃厚伝達のための方法および組成物 |
| CA2089621A1 (en) * | 1993-02-16 | 1994-08-17 | Rudolf Edgar Falk | Formulations containing hyaluronic acid |
| CA2094203A1 (en) | 1993-04-16 | 1994-10-17 | Derek A. Willoughby | Inhibition of angiogenesis |
| US5847002A (en) * | 1993-04-16 | 1998-12-08 | Hyal Pharmaceutical Corporation | Compositions, for inhibition, control and regression of angiogenesis, containing hyaluronic acid and NSAID |
| US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| ITPD940054A1 (it) * | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| AU2479695A (en) | 1994-05-09 | 1995-11-29 | Hadasit Medical Research Services & Development Company Ltd | Prevention of tumor metastasis |
| EP0778776A1 (en) | 1994-08-30 | 1997-06-18 | Hyal Pharmaceutical Corporation | Hyaluronic acid and derivatives for modulation of cellular activity |
| AU718451B2 (en) * | 1995-09-14 | 2000-04-13 | Bristol-Myers Squibb Company | Insulin-like growth factor binding protein 3 (IGF-BP3) in treatment of P53-related tumors |
| WO1997010841A1 (en) * | 1995-09-18 | 1997-03-27 | The Trustees Of Columbia University In The City Of New York | Antiangiogenic properties of endothelial-monocyte activating polypeptide ii |
| US5968972A (en) * | 1995-10-26 | 1999-10-19 | Baker Norton Pharmaceuticals, Inc. | Method for increasing the oral bioactivity of pharmaceutical agents |
| AU727001B2 (en) | 1995-12-01 | 2000-11-30 | Jagotec Ag | Targeting of dosages of medicine and therapeutic agents and other glycosaminoglycans (GAGS) |
| US5776925A (en) * | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
| EP0787716B1 (en) * | 1996-01-31 | 1999-12-08 | Nisshin Flour Milling Co., Ltd. | Isoprene derivatives |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
| CA2175282A1 (en) * | 1996-04-29 | 1997-10-30 | Rudolf Edgar Falk | Use of forms of hyaluronic acid (ha) for the treatment of cancer |
| CA2189916C (en) * | 1996-11-08 | 2001-01-16 | Parkash S. Gill | A new regime for paclitaxel in kaposi's sarcoma patients |
| IT1286510B1 (it) | 1996-11-29 | 1998-07-15 | Cooperativa Centro Ricerche Po | Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono |
| EP0891775A4 (en) * | 1996-12-27 | 2002-07-24 | Seikagaku Kogyo Co Ltd | MEDICINE FOR URBAN BLADDER DISORDERS |
| ES2189166T3 (es) * | 1997-04-04 | 2003-07-01 | Fidia Advanced Biopolymers Srl | Compuestos del acido hialuronico n-sulfatado, sus derivados y proceso para su preparacion. |
| CA2208924A1 (en) | 1997-07-09 | 1999-01-09 | Hyal Pharmaceutical Corporation | Sparing paclitaxel by the use of hyaluronan |
| US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| GB9727524D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
| US20020015724A1 (en) * | 1998-08-10 | 2002-02-07 | Chunlin Yang | Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing |
| EP1117835A4 (en) | 1998-10-02 | 2005-03-09 | Genzyme Corp | PREVENTION OF ADHERENCES |
| IT1303735B1 (it) * | 1998-11-11 | 2001-02-23 | Falorni Italia Farmaceutici S | Acidi ialuronici reticolati e loro usi medici. |
| WO2000041730A1 (en) * | 1999-01-13 | 2000-07-20 | Meditech Research Limited | A composition and method for the enhancement of the efficacy of drugs |
| EP1044977B1 (en) * | 1999-03-09 | 2002-05-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Camptothecin derivatives having antitumor activity |
| IT1306643B1 (it) * | 1999-04-08 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica |
| SE9904121D0 (sv) | 1999-11-15 | 1999-11-15 | Gustaf Jederstroem | Hydrophobe biomolecular structure |
| WO2001047561A1 (en) * | 1999-12-28 | 2001-07-05 | Bioniche Life Sciences Inc. | Hyaluronic acid in the treatment of cancer |
| US6749865B2 (en) * | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| AUPQ879500A0 (en) | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| US6620927B2 (en) * | 2001-02-22 | 2003-09-16 | Anika Therapeutics, Inc. | Thiol-modified hyaluronan |
| CN1578677A (zh) * | 2001-08-27 | 2005-02-09 | 美迪泰克研究有限公司 | 改良的治疗方案 |
| CA2476451A1 (en) * | 2002-02-15 | 2003-08-28 | Research Development Foundation | Hyaluronic acid mediated adenoviral transduction |
| JP2004262777A (ja) | 2003-02-27 | 2004-09-24 | Shiseido Co Ltd | アセチル化ヒアルロン酸含有眼用医薬組成物 |
| WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
| EP1912658B1 (en) * | 2005-07-27 | 2017-01-25 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| AU2006289651B2 (en) | 2005-09-07 | 2012-07-26 | Alchemia Oncology Pty Limited | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
-
2000
- 2000-07-14 AU AUPQ8795A patent/AUPQ879500A0/en not_active Abandoned
-
2001
- 2001-07-13 NZ NZ517359A patent/NZ517359A/en not_active IP Right Cessation
- 2001-07-13 EP EP01951219A patent/EP1301209A4/en not_active Ceased
- 2001-07-13 US US10/088,774 patent/US20030180382A1/en not_active Abandoned
- 2001-07-13 JP JP2002511783A patent/JP5548328B2/ja not_active Expired - Fee Related
- 2001-07-13 GB GB0204331A patent/GB2368525B/en not_active Expired - Fee Related
- 2001-07-13 WO PCT/AU2001/000849 patent/WO2002005852A1/en not_active Ceased
- 2001-07-13 CN CN01802357A patent/CN1388760A/zh active Pending
- 2001-07-13 CA CA2382560A patent/CA2382560C/en not_active Expired - Fee Related
-
2002
- 2002-02-25 ZA ZA200201561A patent/ZA200201561B/en unknown
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2005
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2006
- 2006-05-01 US US11/415,612 patent/US8388993B2/en not_active Expired - Fee Related
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2012
- 2012-05-30 JP JP2012123354A patent/JP2012162569A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002005852A1 (en) | 2002-01-24 |
| JP2012162569A (ja) | 2012-08-30 |
| CA2382560C (en) | 2011-05-10 |
| JP5548328B2 (ja) | 2014-07-16 |
| US8388993B2 (en) | 2013-03-05 |
| GB0204331D0 (en) | 2002-04-10 |
| AUPQ879500A0 (en) | 2000-08-10 |
| US8287894B2 (en) | 2012-10-16 |
| US20060263395A1 (en) | 2006-11-23 |
| GB2368525B (en) | 2004-08-11 |
| CN1388760A (zh) | 2003-01-01 |
| EP1301209A1 (en) | 2003-04-16 |
| ZA200201561B (en) | 2003-11-25 |
| US20050267069A1 (en) | 2005-12-01 |
| CA2382560A1 (en) | 2002-01-24 |
| GB2368525A (en) | 2002-05-08 |
| JP2004502789A (ja) | 2004-01-29 |
| EP1301209A4 (en) | 2005-11-09 |
| US20030180382A1 (en) | 2003-09-25 |
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