NZ505827A - Concatamers of non-identical genes for the same polypeptide and their application in vaccines - Google Patents
Concatamers of non-identical genes for the same polypeptide and their application in vaccinesInfo
- Publication number
- NZ505827A NZ505827A NZ505827A NZ50582798A NZ505827A NZ 505827 A NZ505827 A NZ 505827A NZ 505827 A NZ505827 A NZ 505827A NZ 50582798 A NZ50582798 A NZ 50582798A NZ 505827 A NZ505827 A NZ 505827A
- Authority
- NZ
- New Zealand
- Prior art keywords
- concatamer
- encode
- nucleic acid
- acid sequence
- sequences
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 6
- 102100032768 Complement receptor type 2 Human genes 0.000 abstract 3
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 108020004705 Codon Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 101710143772 Complement receptor type 2 Proteins 0.000 abstract 1
- 108010041986 DNA Vaccines Proteins 0.000 abstract 1
- 229940021995 DNA vaccine Drugs 0.000 abstract 1
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9727512.7A GB9727512D0 (en) | 1997-12-31 | 1997-12-31 | Fuzzy genes and their application in molecular adjuvants |
| PCT/GB1998/003918 WO1999035260A1 (en) | 1997-12-31 | 1998-12-30 | Non-identical genes and their application in improved molec ular adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ505827A true NZ505827A (en) | 2003-03-28 |
Family
ID=10824333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ505827A NZ505827A (en) | 1997-12-31 | 1998-12-30 | Concatamers of non-identical genes for the same polypeptide and their application in vaccines |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6770631B1 (https=) |
| EP (1) | EP1042467B1 (https=) |
| JP (1) | JP2002500042A (https=) |
| AT (1) | ATE403721T1 (https=) |
| AU (1) | AU757021B2 (https=) |
| CA (1) | CA2317020A1 (https=) |
| DE (1) | DE69839848D1 (https=) |
| GB (1) | GB9727512D0 (https=) |
| NZ (1) | NZ505827A (https=) |
| WO (1) | WO1999035260A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0008582D0 (en) * | 2000-04-08 | 2000-05-31 | Adprotech Plc | DNA immunization vectors |
| WO2001092295A2 (en) * | 2000-05-30 | 2001-12-06 | University Of Toronto | Ligands for cd21 and compositions thereof for modulating immune responses |
| GB0025229D0 (en) * | 2000-10-14 | 2000-11-29 | Adprotech Ltd | Veterinary immunisation vectors |
| DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| GB0204154D0 (en) * | 2002-02-22 | 2002-04-10 | Adprotech Ltd | Cat immunisation vectors |
| CA2494971A1 (en) * | 2002-08-14 | 2004-02-26 | Avidis Sa | Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use |
| US7664748B2 (en) * | 2004-07-12 | 2010-02-16 | John Eric Harrity | Systems and methods for changing symbol sequences in documents |
| US8165823B2 (en) | 2005-07-15 | 2012-04-24 | Novartis Ag | Pamps, pathogen associated molecular patterns |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641648A (en) * | 1986-11-04 | 1997-06-24 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
| WO1988003533A1 (en) * | 1986-11-04 | 1988-05-19 | Syntro Corporation | Construction of synthetic dna and its use in large polypeptide synthesis |
| US6018030A (en) * | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| JPH0829098B2 (ja) * | 1988-01-05 | 1996-03-27 | 寳酒造株式会社 | 細胞接着活性ポリペプチド |
| AU3274793A (en) * | 1991-12-12 | 1993-07-19 | Hybritech Incorporated | Enzymatic inverse polymerase chain reaction library mutagenesis |
| US5861285A (en) * | 1994-09-16 | 1999-01-19 | Tdk Corporation | Fusion protein-bound magnetic particles for recombinant production and magnetic separation of polypeptides of interest |
| US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
| GB9424631D0 (en) * | 1994-12-06 | 1995-01-25 | Lynxvale Ltd | Modulating the immune response |
| DE19756975A1 (de) * | 1997-12-20 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Bindungspartner für Inhibitoren von cyclinabhängigen Kinasen und ihre Verwendung zur Suche nach Inhibitoren, zur Diagnose oder zur Therapie einer Erkrankung |
-
1997
- 1997-12-31 GB GBGB9727512.7A patent/GB9727512D0/en not_active Ceased
-
1998
- 1998-12-30 DE DE69839848T patent/DE69839848D1/de not_active Expired - Fee Related
- 1998-12-30 WO PCT/GB1998/003918 patent/WO1999035260A1/en not_active Ceased
- 1998-12-30 JP JP2000527645A patent/JP2002500042A/ja active Pending
- 1998-12-30 AT AT98962638T patent/ATE403721T1/de not_active IP Right Cessation
- 1998-12-30 CA CA002317020A patent/CA2317020A1/en not_active Abandoned
- 1998-12-30 EP EP98962638A patent/EP1042467B1/en not_active Expired - Lifetime
- 1998-12-30 US US09/582,761 patent/US6770631B1/en not_active Expired - Fee Related
- 1998-12-30 NZ NZ505827A patent/NZ505827A/xx unknown
- 1998-12-30 AU AU17762/99A patent/AU757021B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2317020A1 (en) | 1999-07-15 |
| WO1999035260A1 (en) | 1999-07-15 |
| JP2002500042A (ja) | 2002-01-08 |
| AU1776299A (en) | 1999-07-26 |
| ATE403721T1 (de) | 2008-08-15 |
| EP1042467B1 (en) | 2008-08-06 |
| DE69839848D1 (de) | 2008-09-18 |
| AU757021B2 (en) | 2003-01-30 |
| EP1042467A1 (en) | 2000-10-11 |
| GB9727512D0 (en) | 1998-02-25 |
| US6770631B1 (en) | 2004-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed |