DE69839848D1 - Nicht identische gene und ihre anwendung in verbesserten molekularen adjuvanten - Google Patents

Nicht identische gene und ihre anwendung in verbesserten molekularen adjuvanten

Info

Publication number
DE69839848D1
DE69839848D1 DE69839848T DE69839848T DE69839848D1 DE 69839848 D1 DE69839848 D1 DE 69839848D1 DE 69839848 T DE69839848 T DE 69839848T DE 69839848 T DE69839848 T DE 69839848T DE 69839848 D1 DE69839848 D1 DE 69839848D1
Authority
DE
Germany
Prior art keywords
concatamer
encode
sequences
dna
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69839848T
Other languages
German (de)
English (en)
Inventor
Vivienne Frances Cox
Richard Anthony Godwin Smith
Pamela Jane Elizabeth Rowling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adprotech PLC
Original Assignee
Adprotech PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adprotech PLC filed Critical Adprotech PLC
Application granted granted Critical
Publication of DE69839848D1 publication Critical patent/DE69839848D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DE69839848T 1997-12-31 1998-12-30 Nicht identische gene und ihre anwendung in verbesserten molekularen adjuvanten Expired - Fee Related DE69839848D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9727512.7A GB9727512D0 (en) 1997-12-31 1997-12-31 Fuzzy genes and their application in molecular adjuvants
PCT/GB1998/003918 WO1999035260A1 (en) 1997-12-31 1998-12-30 Non-identical genes and their application in improved molec ular adjuvants

Publications (1)

Publication Number Publication Date
DE69839848D1 true DE69839848D1 (de) 2008-09-18

Family

ID=10824333

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839848T Expired - Fee Related DE69839848D1 (de) 1997-12-31 1998-12-30 Nicht identische gene und ihre anwendung in verbesserten molekularen adjuvanten

Country Status (10)

Country Link
US (1) US6770631B1 (https=)
EP (1) EP1042467B1 (https=)
JP (1) JP2002500042A (https=)
AT (1) ATE403721T1 (https=)
AU (1) AU757021B2 (https=)
CA (1) CA2317020A1 (https=)
DE (1) DE69839848D1 (https=)
GB (1) GB9727512D0 (https=)
NZ (1) NZ505827A (https=)
WO (1) WO1999035260A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0008582D0 (en) * 2000-04-08 2000-05-31 Adprotech Plc DNA immunization vectors
WO2001092295A2 (en) * 2000-05-30 2001-12-06 University Of Toronto Ligands for cd21 and compositions thereof for modulating immune responses
GB0025229D0 (en) * 2000-10-14 2000-11-29 Adprotech Ltd Veterinary immunisation vectors
DE60239386D1 (de) 2001-01-25 2011-04-21 Evolva Ltd Zellbibliothek
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
GB0204154D0 (en) * 2002-02-22 2002-04-10 Adprotech Ltd Cat immunisation vectors
CA2494971A1 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
US7664748B2 (en) * 2004-07-12 2010-02-16 John Eric Harrity Systems and methods for changing symbol sequences in documents
US8165823B2 (en) 2005-07-15 2012-04-24 Novartis Ag Pamps, pathogen associated molecular patterns

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641648A (en) * 1986-11-04 1997-06-24 Protein Polymer Technologies, Inc. Methods for preparing synthetic repetitive DNA
WO1988003533A1 (en) * 1986-11-04 1988-05-19 Syntro Corporation Construction of synthetic dna and its use in large polypeptide synthesis
US6018030A (en) * 1986-11-04 2000-01-25 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
JPH0829098B2 (ja) * 1988-01-05 1996-03-27 寳酒造株式会社 細胞接着活性ポリペプチド
AU3274793A (en) * 1991-12-12 1993-07-19 Hybritech Incorporated Enzymatic inverse polymerase chain reaction library mutagenesis
US5861285A (en) * 1994-09-16 1999-01-19 Tdk Corporation Fusion protein-bound magnetic particles for recombinant production and magnetic separation of polypeptides of interest
US5763733A (en) * 1994-10-13 1998-06-09 Enzon, Inc. Antigen-binding fusion proteins
GB9424631D0 (en) * 1994-12-06 1995-01-25 Lynxvale Ltd Modulating the immune response
DE19756975A1 (de) * 1997-12-20 1999-06-24 Hoechst Marion Roussel De Gmbh Bindungspartner für Inhibitoren von cyclinabhängigen Kinasen und ihre Verwendung zur Suche nach Inhibitoren, zur Diagnose oder zur Therapie einer Erkrankung

Also Published As

Publication number Publication date
CA2317020A1 (en) 1999-07-15
WO1999035260A1 (en) 1999-07-15
JP2002500042A (ja) 2002-01-08
AU1776299A (en) 1999-07-26
ATE403721T1 (de) 2008-08-15
NZ505827A (en) 2003-03-28
EP1042467B1 (en) 2008-08-06
AU757021B2 (en) 2003-01-30
EP1042467A1 (en) 2000-10-11
GB9727512D0 (en) 1998-02-25
US6770631B1 (en) 2004-08-03

Similar Documents

Publication Publication Date Title
FR19C1020I1 (fr) Nouvelles molecules b7-4 et leurs utilisations
DE69131580D1 (de) GDF-1 und UOG1 Proteine
ATE386800T1 (de) Immunogene chimäre umfassend nucleinsäuresequenzen, die signalsequenzpeptide des endoplasmatischen reticulums und mindestens ein anderes peptid codieren, deren verwendung in impfstoffen und zur behandlung von krankheiten
CY1106350T1 (el) Εμβολιο φυματιωσης
DE60235039D1 (de) Egvii-endoglucanase und dafür codierende nukleinsäuren
ATE366814T1 (de) Gl50 moleküle, sowie verwendungen derselben
WO2002012281A3 (en) Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen
DE69840230D1 (de) Polypeptide mit prolyldipeptidylaminopeptidase-aktivität und dafür kodierende nukleinsäuren
ATE403721T1 (de) Nicht identische gene und ihre anwendung in verbesserten molekularen adjuvanten
DE69837085D1 (de) Crsp-proteine (cystein-reiche, sekretierte proteine), die dafür kodierenden nukleinsäuren und ihre verwendungen
DK0892054T3 (da) Clostridium perfringens-vaccine
EP1015009A4 (en) GENETIC MATERIAL IN THE FORM OF MITIGATED IMMUNIZATION CASSETTES BASED ON LIVER DNA FOR GENETIC VACCINES
NO902251L (no) Fremstilling av gonoreiske p1-proteiner og vaksiner.
HUP0100267A2 (hu) Helicobacter pylori eredetű nukleinsav- és aminosav-szekvenciák és a megfelelő nukleinsavakat vagy peptideket tartalmazó vakcina-készítmények
WO2000012535A3 (en) Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof
NO930428L (no) Proteinstrukturen til plantetoksingelonin
ATE480554T1 (de) Rekombinanter leukotoxinimpfstoff aus fusobacterium necrophorum und dessen präparation
BR9815496A (pt) Vacinas de ácido nucléico que codificam proteìna gde vìrus sincicial respiratório
JP2002500042A5 (https=)
SE8801723D0 (sv) Fibronectin binding protein as well as its preparation
DK595187A (da) Minactivin og fremgangsmaade til fremstilling deraf
ATE470716T1 (de) 18480 humane proteinkinasemoleküle und ihre verwendungen
DK551786D0 (da) Rekombinant-dna-sekvens, der koder for aminosyresekvenser i et toksin, expressionssystem omfattende samme og vaertsceller transformeret hermed
ES2059801T3 (es) Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.
DK1233980T3 (da) Nukleinsyremolekyle, omfattende en nukleinsyresekvens, der koder for et hæmocyanin, og mindst en intronsekvens

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee