NZ337243A - Use of aryl-cyclohexylamine derivatives as NMDA (N-methyl-D-aspartate) receptor subtype selective blockers against CNS disorders - Google Patents

Use of aryl-cyclohexylamine derivatives as NMDA (N-methyl-D-aspartate) receptor subtype selective blockers against CNS disorders

Info

Publication number
NZ337243A
NZ337243A NZ337243A NZ33724399A NZ337243A NZ 337243 A NZ337243 A NZ 337243A NZ 337243 A NZ337243 A NZ 337243A NZ 33724399 A NZ33724399 A NZ 33724399A NZ 337243 A NZ337243 A NZ 337243A
Authority
NZ
New Zealand
Prior art keywords
receptor subtype
nmda
aspartate
aryl
methyl
Prior art date
Application number
NZ337243A
Other languages
English (en)
Inventor
Alexander Alanine
Bernd Buttelmann
Neidhart Marie-Paule Heitz
Emmanuel Pinard
Rene Wyler
Original Assignee
F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F filed Critical F
Publication of NZ337243A publication Critical patent/NZ337243A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
NZ337243A 1998-08-18 1999-08-13 Use of aryl-cyclohexylamine derivatives as NMDA (N-methyl-D-aspartate) receptor subtype selective blockers against CNS disorders NZ337243A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98115484 1998-08-18

Publications (1)

Publication Number Publication Date
NZ337243A true NZ337243A (en) 2000-12-22

Family

ID=8232474

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ337243A NZ337243A (en) 1998-08-18 1999-08-13 Use of aryl-cyclohexylamine derivatives as NMDA (N-methyl-D-aspartate) receptor subtype selective blockers against CNS disorders

Country Status (24)

Country Link
US (1) US6184236B1 (de)
JP (1) JP3455142B2 (de)
KR (1) KR100341194B1 (de)
CN (1) CN1141936C (de)
AR (1) AR021770A1 (de)
AT (1) ATE326219T1 (de)
AU (1) AU756408B2 (de)
BR (1) BR9903779A (de)
CA (1) CA2280455A1 (de)
DE (1) DE69931316D1 (de)
HR (1) HRP990256A2 (de)
HU (1) HUP9902737A3 (de)
ID (1) ID23107A (de)
IL (1) IL131399A0 (de)
MA (1) MA26677A1 (de)
MY (1) MY133133A (de)
NO (1) NO993948L (de)
NZ (1) NZ337243A (de)
PE (1) PE20000955A1 (de)
PL (1) PL334949A1 (de)
SG (1) SG82014A1 (de)
TR (1) TR199902015A2 (de)
YU (1) YU38699A (de)
ZA (1) ZA995212B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE301642T1 (de) * 2000-06-06 2005-08-15 Warner Lambert Co Bicyclische cyclohexylamine und ihre verwendung als nmda-rezeptor antagonisten
US7375136B2 (en) * 2001-03-08 2008-05-20 Emory University pH-dependent NMDA receptor antagonists
DE10153345A1 (de) * 2001-10-29 2003-05-08 Gruenenthal Gmbh Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen
US20070004805A1 (en) * 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
AU2008272964A1 (en) 2007-06-29 2009-01-08 Emory University NMDA receptor antagonists for neuroprotection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4032766A1 (de) 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
DE59204456D1 (de) 1991-03-14 1996-01-11 Basf Ag Substituierte N-Phenylpiperidine und Arzneimittel daraus.
DE4117904A1 (de) 1991-05-31 1992-12-03 Basf Ag Substituierte n-phenylpiperidine
DE69628051T2 (de) * 1995-10-26 2004-02-26 Mitsubishi Pharma Corp. Phenylethanolamin-verbindungen und ihre anwendung als beta3 agonisten, verfahren zu ihrer herstellung und zwischenprodukte ihrer herstellung

Also Published As

Publication number Publication date
BR9903779A (pt) 2000-09-19
KR100341194B1 (ko) 2002-06-20
MA26677A1 (fr) 2004-12-20
YU38699A (sh) 2002-03-18
NO993948D0 (no) 1999-08-17
NO993948L (no) 2000-02-21
AR021770A1 (es) 2002-08-07
CN1248439A (zh) 2000-03-29
US6184236B1 (en) 2001-02-06
HUP9902737A3 (en) 2001-01-29
ATE326219T1 (de) 2006-06-15
SG82014A1 (en) 2001-07-24
HUP9902737A2 (hu) 2000-06-28
TR199902015A3 (tr) 2000-03-21
ZA995212B (en) 2000-02-18
HRP990256A2 (en) 2000-04-30
HU9902737D0 (en) 1999-10-28
MY133133A (en) 2007-10-31
ID23107A (id) 2000-02-24
AU4453799A (en) 2000-05-04
CN1141936C (zh) 2004-03-17
DE69931316D1 (de) 2006-06-22
JP3455142B2 (ja) 2003-10-14
PL334949A1 (en) 2000-02-28
JP2000109429A (ja) 2000-04-18
TR199902015A2 (xx) 2000-03-21
CA2280455A1 (en) 2000-02-18
IL131399A0 (en) 2001-01-28
PE20000955A1 (es) 2000-09-28
KR20000017343A (ko) 2000-03-25
AU756408B2 (en) 2003-01-09

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