AR021770A1 - El uso de derivados de arilciclohexilamina contra desordenes del sistema nervioso central - Google Patents
El uso de derivados de arilciclohexilamina contra desordenes del sistema nervioso centralInfo
- Publication number
- AR021770A1 AR021770A1 ARP990104079A ARP990104079A AR021770A1 AR 021770 A1 AR021770 A1 AR 021770A1 AR P990104079 A ARP990104079 A AR P990104079A AR P990104079 A ARP990104079 A AR P990104079A AR 021770 A1 AR021770 A1 AR 021770A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- arilciclohexylamine
- nervous system
- central nervous
- derivatives against
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Uso de compuestos de la formula (1) en donde Ar1 representa fenilo, naftilo o tetrahidronaftilo, opcionalmente sustituidos por hidroxi, alcoxi-inferior,nitro, amino o metanosulfonamida; Ar2 representa fenilo, naftilo tetrahidronaftilo, opcionalmentesustituidos por alquil-inferior o halogeno; X representa C,CH,C(OH) o N;Y representa -CH2-,-CH u O,Z es -CH2-, -CH(CH3)- o -C(CH3)2; R1 representa hidrogeno, alquil-inferior o acetilo; A representa C=O o -(CHR2)n-, endonde R2 representa hidrogeno, alquil-inferior o alquil inferior-hidroxi; B representa -(CH2)n-, O, -CH(OH)(CH2)n, -CH(CH2OH)(CH2)n-, -(CH2)n CH(OH)- o-CH(CH2OH)-;--- puede representar un enlace y n representa 0-4 y las sales de adicion de ácido aceptables farmacéuticamente para laelaboracion de medicamentosque representen indicaciones terapéuticas para bloqueadores específicos de subtipos de receptores NMDA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98115484 | 1998-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021770A1 true AR021770A1 (es) | 2002-08-07 |
Family
ID=8232474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990104079A AR021770A1 (es) | 1998-08-18 | 1999-08-13 | El uso de derivados de arilciclohexilamina contra desordenes del sistema nervioso central |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6184236B1 (es) |
| JP (1) | JP3455142B2 (es) |
| KR (1) | KR100341194B1 (es) |
| CN (1) | CN1141936C (es) |
| AR (1) | AR021770A1 (es) |
| AT (1) | ATE326219T1 (es) |
| AU (1) | AU756408B2 (es) |
| BR (1) | BR9903779A (es) |
| CA (1) | CA2280455A1 (es) |
| DE (1) | DE69931316D1 (es) |
| HR (1) | HRP990256A2 (es) |
| HU (1) | HUP9902737A3 (es) |
| ID (1) | ID23107A (es) |
| IL (1) | IL131399A0 (es) |
| MA (1) | MA26677A1 (es) |
| MY (1) | MY133133A (es) |
| NO (1) | NO993948L (es) |
| NZ (1) | NZ337243A (es) |
| PE (1) | PE20000955A1 (es) |
| PL (1) | PL334949A1 (es) |
| SG (1) | SG82014A1 (es) |
| TR (1) | TR199902015A2 (es) |
| YU (1) | YU38699A (es) |
| ZA (1) | ZA995212B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE301642T1 (de) * | 2000-06-06 | 2005-08-15 | Warner Lambert Co | Bicyclische cyclohexylamine und ihre verwendung als nmda-rezeptor antagonisten |
| US7375136B2 (en) * | 2001-03-08 | 2008-05-20 | Emory University | pH-dependent NMDA receptor antagonists |
| DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
| US20070004805A1 (en) * | 2005-07-01 | 2007-01-04 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
| AU2008272964A1 (en) | 2007-06-29 | 2009-01-08 | Emory University | NMDA receptor antagonists for neuroprotection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4032766A1 (de) | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
| DE59204456D1 (de) | 1991-03-14 | 1996-01-11 | Basf Ag | Substituierte N-Phenylpiperidine und Arzneimittel daraus. |
| DE4117904A1 (de) | 1991-05-31 | 1992-12-03 | Basf Ag | Substituierte n-phenylpiperidine |
| DE69628051T2 (de) * | 1995-10-26 | 2004-02-26 | Mitsubishi Pharma Corp. | Phenylethanolamin-verbindungen und ihre anwendung als beta3 agonisten, verfahren zu ihrer herstellung und zwischenprodukte ihrer herstellung |
-
1999
- 1999-08-09 DE DE69931316T patent/DE69931316D1/de not_active Expired - Lifetime
- 1999-08-09 AT AT99115114T patent/ATE326219T1/de not_active IP Right Cessation
- 1999-08-09 US US09/370,602 patent/US6184236B1/en not_active Expired - Fee Related
- 1999-08-13 PE PE1999000826A patent/PE20000955A1/es not_active Application Discontinuation
- 1999-08-13 AR ARP990104079A patent/AR021770A1/es not_active Application Discontinuation
- 1999-08-13 IL IL13139999A patent/IL131399A0/xx unknown
- 1999-08-13 NZ NZ337243A patent/NZ337243A/xx unknown
- 1999-08-13 CA CA002280455A patent/CA2280455A1/en not_active Abandoned
- 1999-08-16 HU HU9902737A patent/HUP9902737A3/hu unknown
- 1999-08-16 YU YU38699A patent/YU38699A/sh unknown
- 1999-08-16 SG SG9903973A patent/SG82014A1/en unknown
- 1999-08-16 ZA ZA9905212A patent/ZA995212B/xx unknown
- 1999-08-16 MY MYPI99003508A patent/MY133133A/en unknown
- 1999-08-16 ID IDP990791A patent/ID23107A/id unknown
- 1999-08-16 JP JP22965899A patent/JP3455142B2/ja not_active Expired - Fee Related
- 1999-08-17 KR KR1019990033814A patent/KR100341194B1/ko not_active IP Right Cessation
- 1999-08-17 PL PL99334949A patent/PL334949A1/xx not_active Application Discontinuation
- 1999-08-17 BR BR9903779-3A patent/BR9903779A/pt not_active IP Right Cessation
- 1999-08-17 NO NO993948A patent/NO993948L/no unknown
- 1999-08-17 AU AU44537/99A patent/AU756408B2/en not_active Ceased
- 1999-08-17 CN CNB991179110A patent/CN1141936C/zh not_active Expired - Fee Related
- 1999-08-17 MA MA25736A patent/MA26677A1/fr unknown
- 1999-08-18 TR TR1999/02015A patent/TR199902015A2/xx unknown
- 1999-08-18 HR HR98115484.2A patent/HRP990256A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9903779A (pt) | 2000-09-19 |
| KR100341194B1 (ko) | 2002-06-20 |
| MA26677A1 (fr) | 2004-12-20 |
| YU38699A (sh) | 2002-03-18 |
| NO993948D0 (no) | 1999-08-17 |
| NO993948L (no) | 2000-02-21 |
| CN1248439A (zh) | 2000-03-29 |
| US6184236B1 (en) | 2001-02-06 |
| HUP9902737A3 (en) | 2001-01-29 |
| ATE326219T1 (de) | 2006-06-15 |
| SG82014A1 (en) | 2001-07-24 |
| HUP9902737A2 (hu) | 2000-06-28 |
| TR199902015A3 (tr) | 2000-03-21 |
| ZA995212B (en) | 2000-02-18 |
| HRP990256A2 (en) | 2000-04-30 |
| HU9902737D0 (en) | 1999-10-28 |
| MY133133A (en) | 2007-10-31 |
| ID23107A (id) | 2000-02-24 |
| AU4453799A (en) | 2000-05-04 |
| CN1141936C (zh) | 2004-03-17 |
| DE69931316D1 (de) | 2006-06-22 |
| JP3455142B2 (ja) | 2003-10-14 |
| PL334949A1 (en) | 2000-02-28 |
| JP2000109429A (ja) | 2000-04-18 |
| NZ337243A (en) | 2000-12-22 |
| TR199902015A2 (xx) | 2000-03-21 |
| CA2280455A1 (en) | 2000-02-18 |
| IL131399A0 (en) | 2001-01-28 |
| PE20000955A1 (es) | 2000-09-28 |
| KR20000017343A (ko) | 2000-03-25 |
| AU756408B2 (en) | 2003-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |