NZ249165A - Mixture of sulphated oligosaccharides and pharmaceutical compositions - Google Patents

Mixture of sulphated oligosaccharides and pharmaceutical compositions

Info

Publication number
NZ249165A
NZ249165A NZ249165A NZ24916593A NZ249165A NZ 249165 A NZ249165 A NZ 249165A NZ 249165 A NZ249165 A NZ 249165A NZ 24916593 A NZ24916593 A NZ 24916593A NZ 249165 A NZ249165 A NZ 249165A
Authority
NZ
New Zealand
Prior art keywords
heparin
oligosaccharides
mixture
molecular weight
depolymerized
Prior art date
Application number
NZ249165A
Other languages
English (en)
Inventor
Andre Uzan
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NZ249165A publication Critical patent/NZ249165A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
NZ249165A 1992-02-07 1993-02-04 Mixture of sulphated oligosaccharides and pharmaceutical compositions NZ249165A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201383A FR2687158B1 (fr) 1992-02-07 1992-02-07 Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.

Publications (1)

Publication Number Publication Date
NZ249165A true NZ249165A (en) 1996-01-26

Family

ID=9426428

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ249165A NZ249165A (en) 1992-02-07 1993-02-04 Mixture of sulphated oligosaccharides and pharmaceutical compositions

Country Status (17)

Country Link
EP (1) EP0625166B1 (ko)
JP (1) JP3218039B2 (ko)
KR (1) KR950700334A (ko)
AT (1) ATE157991T1 (ko)
AU (1) AU671817B2 (ko)
CA (1) CA2126241C (ko)
DE (1) DE69313826T2 (ko)
DK (1) DK0625166T3 (ko)
ES (1) ES2109478T3 (ko)
FI (1) FI106034B (ko)
FR (1) FR2687158B1 (ko)
GR (1) GR3024695T3 (ko)
HU (1) HU214327B (ko)
MX (1) MX9300584A (ko)
NO (1) NO307466B1 (ko)
NZ (1) NZ249165A (ko)
WO (1) WO1993016112A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
EP0735050B1 (en) * 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Compositions for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU7753898A (en) * 1997-06-06 1998-12-21 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
EP2019843A2 (en) * 2006-05-25 2009-02-04 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CN103209997B (zh) * 2010-09-14 2016-03-16 国立大学法人宫崎大学 高纯度肝素及其制备方法
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945595A1 (de) * 1979-11-12 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur herstellung von niedermolekularem heparin bzw. seinen salzen
FR2622450B1 (fr) * 1987-11-03 1991-02-22 Sanofi Sa Association heparine/dermatane sulfate
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR2675806B1 (fr) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.

Also Published As

Publication number Publication date
FR2687158A1 (fr) 1993-08-13
MX9300584A (es) 1993-08-01
HU214327B (hu) 1998-03-02
ES2109478T3 (es) 1998-01-16
DK0625166T3 (da) 1998-02-02
CA2126241C (fr) 2004-06-22
DE69313826T2 (de) 1998-02-12
WO1993016112A1 (fr) 1993-08-19
NO942897D0 (ko) 1994-08-04
AU3505193A (en) 1993-09-03
JP3218039B2 (ja) 2001-10-15
ATE157991T1 (de) 1997-09-15
HUT67878A (en) 1995-05-29
CA2126241A1 (fr) 1993-08-19
FI943642A (fi) 1994-08-05
KR950700334A (ko) 1995-01-16
NO942897L (no) 1994-08-04
JPH07503496A (ja) 1995-04-13
NO307466B1 (no) 2000-04-10
FI106034B (fi) 2000-11-15
DE69313826D1 (de) 1997-10-16
EP0625166A1 (fr) 1994-11-23
EP0625166B1 (fr) 1997-09-10
GR3024695T3 (en) 1997-12-31
HU9401994D0 (en) 1994-09-28
FR2687158B1 (fr) 1995-06-30
FI943642A0 (fi) 1994-08-05
AU671817B2 (en) 1996-09-12

Similar Documents

Publication Publication Date Title
US5389618A (en) Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US4981955A (en) Depolymerization method of heparin
FI88046C (fi) Foerfarande foer framstaellning av hepariner med laog molekylvikt
US5280016A (en) Non-anticoagulant heparin derivatives
US4474770A (en) Oligosaccharides having anti-Xa activity, pharmaceutical compositions containing them and method of use
US5013724A (en) Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications
US5767269A (en) Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
CA2217054C (en) Compositions and methods for inhibiting thrombogenesis
USRE38743E1 (en) Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5922690A (en) Dermatan disulfate, an inhibitor of thrombin generation and activation
ZA200502787B (en) Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same.
US5849721A (en) Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
WO1998014481A9 (en) Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US5763427A (en) Compositions and methods for inhibiting thrombogenesis
EP0735050B1 (en) Compositions for inhibiting thrombogenesis
US5721357A (en) Preparation of sulfated polysaccharides for treatment or prevention of thromboses
AU671817B2 (en) Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof
Amar et al. Antithrombotic potencies of heparins in relation to their antifactor Xa and antithrombin activities: an experimental study in two models of thrombosis in the rabbit
USRE35770E (en) Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
NZ242431A (en) Mixture of sulphated oligosaccharides derived from depolymerised heparin, and pharmaceutical compositions
MXPA97008378A (en) Compounds and methods to prevent the trombogene