AU3505193A - Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof - Google Patents

Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof

Info

Publication number
AU3505193A
AU3505193A AU35051/93A AU3505193A AU3505193A AU 3505193 A AU3505193 A AU 3505193A AU 35051/93 A AU35051/93 A AU 35051/93A AU 3505193 A AU3505193 A AU 3505193A AU 3505193 A AU3505193 A AU 3505193A
Authority
AU
Australia
Prior art keywords
preparation
pharmaceutical composition
sulphated polysaccharides
sulphated
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU35051/93A
Other versions
AU671817B2 (en
Inventor
Andre Uzan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of AU3505193A publication Critical patent/AU3505193A/en
Application granted granted Critical
Publication of AU671817B2 publication Critical patent/AU671817B2/en
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Request to Amend Deed and Register Assignors: RHONE-POULENC RORER S.A.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A mixture of sulphated oligosaccharides which are components of heparin. At least 70 % has a molar mass of 5400-7800 daltons, and at least 5 % has a molar mass of over 6900 daltons.
AU35051/93A 1992-02-07 1993-02-04 Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof Expired AU671817B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9201383 1992-02-07
FR9201383A FR2687158B1 (en) 1992-02-07 1992-02-07 SULPHATE POLYSACCHARIDES, METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITION AND USE.
PCT/FR1993/000114 WO1993016112A1 (en) 1992-02-07 1993-02-04 Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof

Publications (2)

Publication Number Publication Date
AU3505193A true AU3505193A (en) 1993-09-03
AU671817B2 AU671817B2 (en) 1996-09-12

Family

ID=9426428

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35051/93A Expired AU671817B2 (en) 1992-02-07 1993-02-04 Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof

Country Status (17)

Country Link
EP (1) EP0625166B1 (en)
JP (1) JP3218039B2 (en)
KR (1) KR950700334A (en)
AT (1) ATE157991T1 (en)
AU (1) AU671817B2 (en)
CA (1) CA2126241C (en)
DE (1) DE69313826T2 (en)
DK (1) DK0625166T3 (en)
ES (1) ES2109478T3 (en)
FI (1) FI106034B (en)
FR (1) FR2687158B1 (en)
GR (1) GR3024695T3 (en)
HU (1) HU214327B (en)
MX (1) MX9300584A (en)
NO (1) NO307466B1 (en)
NZ (1) NZ249165A (en)
WO (1) WO1993016112A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
GB2299998B (en) * 1995-03-31 1997-03-26 Hamilton Civic Hospitals Res Compositions for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU7753898A (en) * 1997-06-06 1998-12-21 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
AU2003225724A1 (en) 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
AU2007267561B2 (en) * 2006-05-25 2012-05-17 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
KR101794877B1 (en) * 2010-09-14 2017-11-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 High purity heparin and production method therefor
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945595A1 (en) * 1979-11-12 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Low-molecular heparin prodn. from natural heparin - by ultrafiltration at PH 1-5.5
FR2622450B1 (en) * 1987-11-03 1991-02-22 Sanofi Sa HEPARIN / DERMATANE SULFATE ASSOCIATION
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
FR2663639B1 (en) * 1990-06-26 1994-03-18 Rhone Poulenc Sante LOW MOLECULAR WEIGHT POLYSACCHARIDE BLENDS PROCESS FOR PREPARATION AND USE.
FR2675806B1 (en) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa SULPHATE POLYSACCHARIDES, METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITION AND USE.

Also Published As

Publication number Publication date
JPH07503496A (en) 1995-04-13
HU9401994D0 (en) 1994-09-28
DE69313826T2 (en) 1998-02-12
AU671817B2 (en) 1996-09-12
CA2126241A1 (en) 1993-08-19
EP0625166A1 (en) 1994-11-23
NO942897L (en) 1994-08-04
NO307466B1 (en) 2000-04-10
NO942897D0 (en) 1994-08-04
MX9300584A (en) 1993-08-01
FI943642A (en) 1994-08-05
ATE157991T1 (en) 1997-09-15
HUT67878A (en) 1995-05-29
WO1993016112A1 (en) 1993-08-19
EP0625166B1 (en) 1997-09-10
CA2126241C (en) 2004-06-22
DK0625166T3 (en) 1998-02-02
KR950700334A (en) 1995-01-16
FI106034B (en) 2000-11-15
ES2109478T3 (en) 1998-01-16
FI943642A0 (en) 1994-08-05
NZ249165A (en) 1996-01-26
HU214327B (en) 1998-03-02
FR2687158B1 (en) 1995-06-30
DE69313826D1 (en) 1997-10-16
GR3024695T3 (en) 1997-12-31
FR2687158A1 (en) 1993-08-13
JP3218039B2 (en) 2001-10-15

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