NO307466B1 - Mixture of sulphated polysaccharides, their preparation, pharmaceutical preparations containing the saccharides and their use - Google Patents

Mixture of sulphated polysaccharides, their preparation, pharmaceutical preparations containing the saccharides and their use

Info

Publication number
NO307466B1
NO307466B1 NO942897A NO942897A NO307466B1 NO 307466 B1 NO307466 B1 NO 307466B1 NO 942897 A NO942897 A NO 942897A NO 942897 A NO942897 A NO 942897A NO 307466 B1 NO307466 B1 NO 307466B1
Authority
NO
Norway
Prior art keywords
mixture
saccharides
preparation
pharmaceutical preparations
preparations containing
Prior art date
Application number
NO942897A
Other languages
Norwegian (no)
Other versions
NO942897D0 (en
NO942897L (en
Inventor
Andre Uzan
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO942897D0 publication Critical patent/NO942897D0/no
Publication of NO942897L publication Critical patent/NO942897L/en
Publication of NO307466B1 publication Critical patent/NO307466B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A mixture of sulphated oligosaccharides which are components of heparin. At least 70 % has a molar mass of 5400-7800 daltons, and at least 5 % has a molar mass of over 6900 daltons.
NO942897A 1992-02-07 1994-08-04 Mixture of sulphated polysaccharides, their preparation, pharmaceutical preparations containing the saccharides and their use NO307466B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9201383A FR2687158B1 (en) 1992-02-07 1992-02-07 SULPHATE POLYSACCHARIDES, METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITION AND USE.
PCT/FR1993/000114 WO1993016112A1 (en) 1992-02-07 1993-02-04 Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof

Publications (3)

Publication Number Publication Date
NO942897D0 NO942897D0 (en) 1994-08-04
NO942897L NO942897L (en) 1994-08-04
NO307466B1 true NO307466B1 (en) 2000-04-10

Family

ID=9426428

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942897A NO307466B1 (en) 1992-02-07 1994-08-04 Mixture of sulphated polysaccharides, their preparation, pharmaceutical preparations containing the saccharides and their use

Country Status (17)

Country Link
EP (1) EP0625166B1 (en)
JP (1) JP3218039B2 (en)
KR (1) KR950700334A (en)
AT (1) ATE157991T1 (en)
AU (1) AU671817B2 (en)
CA (1) CA2126241C (en)
DE (1) DE69313826T2 (en)
DK (1) DK0625166T3 (en)
ES (1) ES2109478T3 (en)
FI (1) FI106034B (en)
FR (1) FR2687158B1 (en)
GR (1) GR3024695T3 (en)
HU (1) HU214327B (en)
MX (1) MX9300584A (en)
NO (1) NO307466B1 (en)
NZ (1) NZ249165A (en)
WO (1) WO1993016112A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
DE69623840D1 (en) * 1995-03-31 2002-10-31 Hamilton Civic Hospitals Res Composition for inhibiting the development of thrombosis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU7753898A (en) * 1997-06-06 1998-12-21 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
AU2003225724A1 (en) 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
CN101495517B (en) * 2006-05-25 2012-10-10 莫曼塔医药品有限公司 Low molecular weight heparin composition and uses thereof
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CA3020369C (en) * 2010-09-14 2019-11-26 University Of Miyazaki High purity heparin and production method therefor
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945595A1 (en) * 1979-11-12 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Low-molecular heparin prodn. from natural heparin - by ultrafiltration at PH 1-5.5
FR2622450B1 (en) * 1987-11-03 1991-02-22 Sanofi Sa HEPARIN / DERMATANE SULFATE ASSOCIATION
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
FR2663639B1 (en) * 1990-06-26 1994-03-18 Rhone Poulenc Sante LOW MOLECULAR WEIGHT POLYSACCHARIDE BLENDS PROCESS FOR PREPARATION AND USE.
FR2675806B1 (en) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa SULPHATE POLYSACCHARIDES, METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITION AND USE.

Also Published As

Publication number Publication date
ES2109478T3 (en) 1998-01-16
FR2687158B1 (en) 1995-06-30
NO942897D0 (en) 1994-08-04
WO1993016112A1 (en) 1993-08-19
NO942897L (en) 1994-08-04
GR3024695T3 (en) 1997-12-31
NZ249165A (en) 1996-01-26
JP3218039B2 (en) 2001-10-15
FR2687158A1 (en) 1993-08-13
HU214327B (en) 1998-03-02
CA2126241C (en) 2004-06-22
JPH07503496A (en) 1995-04-13
EP0625166A1 (en) 1994-11-23
DE69313826T2 (en) 1998-02-12
EP0625166B1 (en) 1997-09-10
HU9401994D0 (en) 1994-09-28
DK0625166T3 (en) 1998-02-02
CA2126241A1 (en) 1993-08-19
MX9300584A (en) 1993-08-01
FI943642A0 (en) 1994-08-05
FI943642A (en) 1994-08-05
HUT67878A (en) 1995-05-29
FI106034B (en) 2000-11-15
DE69313826D1 (en) 1997-10-16
AU3505193A (en) 1993-09-03
KR950700334A (en) 1995-01-16
ATE157991T1 (en) 1997-09-15
AU671817B2 (en) 1996-09-12

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