NZ204213A - Ar-substituted 2,3,3a,4,5,9a-hexahydro-1h-benz(f)isoindoles and pharmaceutical compositions - Google Patents

Ar-substituted 2,3,3a,4,5,9a-hexahydro-1h-benz(f)isoindoles and pharmaceutical compositions

Info

Publication number
NZ204213A
NZ204213A NZ204213A NZ20421383A NZ204213A NZ 204213 A NZ204213 A NZ 204213A NZ 204213 A NZ204213 A NZ 204213A NZ 20421383 A NZ20421383 A NZ 20421383A NZ 204213 A NZ204213 A NZ 204213A
Authority
NZ
New Zealand
Prior art keywords
hydrogen
compound
tetrahydro
carbon atoms
loweralkyl
Prior art date
Application number
NZ204213A
Other languages
English (en)
Inventor
Bernardis J F De
W J Mcclellan
D J Kerkman
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NZ204213A publication Critical patent/NZ204213A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ204213A 1982-06-01 1983-05-12 Ar-substituted 2,3,3a,4,5,9a-hexahydro-1h-benz(f)isoindoles and pharmaceutical compositions NZ204213A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38363182A 1982-06-01 1982-06-01

Publications (1)

Publication Number Publication Date
NZ204213A true NZ204213A (en) 1986-06-11

Family

ID=23514004

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ204213A NZ204213A (en) 1982-06-01 1983-05-12 Ar-substituted 2,3,3a,4,5,9a-hexahydro-1h-benz(f)isoindoles and pharmaceutical compositions

Country Status (10)

Country Link
EP (1) EP0095666B1 (enExample)
JP (1) JPS58225064A (enExample)
KR (1) KR900001193B1 (enExample)
AT (1) ATE40115T1 (enExample)
AU (1) AU560459B2 (enExample)
CA (1) CA1215376A (enExample)
DE (1) DE3378978D1 (enExample)
ES (1) ES8503329A1 (enExample)
NZ (1) NZ204213A (enExample)
ZA (1) ZA833494B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622405A (en) * 1984-07-25 1986-11-11 Abbott Laboratories 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension
KR910700251A (ko) * 1988-12-15 1991-03-14 원본미기재 5-ht 선택제
GR1001059B (el) * 1988-12-15 1993-04-28 Abbott Lab Μεθοδος παραγωγης εκλεκτικων παραγοντων 5-ητ.
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
US5792767A (en) * 1995-01-27 1998-08-11 Abbott Laboratories Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists
NZ335711A (en) * 1996-12-06 2000-10-27 Abbott Lab Substituted benzopyranopyrrole and benzopyranopyridine derivatives
US5891882A (en) * 1996-12-06 1999-04-06 Abbott Laboratories Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166570A (en) * 1963-02-15 1965-01-19 American Home Prod Derivatives of benzo[e] isoindoline and their preparation
EP0003757B1 (de) * 1978-02-08 1981-10-14 Ciba-Geigy Ag Tricyclische Imidylderivate und Verfahren zu ihrer Herstellung
US4282240A (en) * 1979-11-23 1981-08-04 Merck & Co., Inc. Amino substituted tetrahydrobenzindoles

Also Published As

Publication number Publication date
DE3378978D1 (de) 1989-02-23
KR840005096A (ko) 1984-11-03
EP0095666B1 (en) 1989-01-18
ES522875A0 (es) 1985-02-16
EP0095666A3 (en) 1985-01-16
EP0095666A2 (en) 1983-12-07
ATE40115T1 (de) 1989-02-15
JPH0443064B2 (enExample) 1992-07-15
KR900001193B1 (ko) 1990-02-28
ES8503329A1 (es) 1985-02-16
AU560459B2 (en) 1987-04-09
AU1445283A (en) 1983-12-08
CA1215376A (en) 1986-12-16
ZA833494B (en) 1984-02-29
JPS58225064A (ja) 1983-12-27

Similar Documents

Publication Publication Date Title
WO1993012786A1 (en) Indolinone derivatives
US3975532A (en) Hexahydro-1H-furo(3,4-c) pyrrole compounds for treating pain
CA2325587A1 (en) Imidazolone anorectic agents: ii. phenyl derivatives
JPS59176275A (ja) 置換された４−アミノメチレン−クロマン類及び−クロメン類
EP0626954A1 (en) Benzocycloheptenes, benzoxepines and benzothiepines
NZ204213A (en) Ar-substituted 2,3,3a,4,5,9a-hexahydro-1h-benz(f)isoindoles and pharmaceutical compositions
JPS6222986B2 (enExample)
US4942163A (en) 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
US4500543A (en) Substituted 1-aminomethyl-phthalans
US4618683A (en) Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives
Cannon et al. Congeners of the. alpha. conformer of dopamine derived from octahydrobenz [h] isoquinoline
US4473586A (en) Aminoalkyl dihydronaphthalenes
US4340595A (en) Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one and pharmaceutical formulations containing the said compounds
US5541217A (en) 4-arylcyclopenta[c]pyrrole analgesics
EP0170093B1 (en) 1,2,3,3a,8,8a-hexahydro-indeno-(1,2-c)pyrrdes
EP0229510B1 (en) Sulfinyl and sulfonyl substituted-3-benzazepines
US4707483A (en) 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
US4622405A (en) 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension
KR100453981B1 (ko) 아미노피롤린 화합물, 이의 제조 방법 및 이를 함유하는약제 조성물
Cannon et al. 1-(Aminomethyl)-6, 7-dihydroxytetralin derivatives: synthesis and assessment of dopamine-like effects
US4824839A (en) Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders
JPS62238271A (ja) １−フエニル−３−ベンズアゼピン類
CA1286675C (en) Adrenergic compounds
KR820000198B1 (ko) 아릴-알킬아민의 제조 방법
KR820000199B1 (ko) 아릴-알킬아민의 제조 방법