NZ202510A - Antihypertensive compositions based on certain 7,8-dihydroxy-1-(4-hydroxyphenyl)-1,2,4,5-tetrahydro-3h-3-benzazepines and a beta-adrenergic blocker - Google Patents
Antihypertensive compositions based on certain 7,8-dihydroxy-1-(4-hydroxyphenyl)-1,2,4,5-tetrahydro-3h-3-benzazepines and a beta-adrenergic blockerInfo
- Publication number
- NZ202510A NZ202510A NZ202510A NZ20251082A NZ202510A NZ 202510 A NZ202510 A NZ 202510A NZ 202510 A NZ202510 A NZ 202510A NZ 20251082 A NZ20251082 A NZ 20251082A NZ 202510 A NZ202510 A NZ 202510A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dihydroxy
- tetrahydro
- hydroxyphenyl
- benzazepine
- chloro
- Prior art date
Links
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- UAORFCGRZIGNCI-UHFFFAOYSA-N nifenalol Chemical compound CC(C)NCC(O)C1=CC=C([N+]([O-])=O)C=C1 UAORFCGRZIGNCI-UHFFFAOYSA-N 0.000 description 1
- 229950000096 nifenalol Drugs 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229960004570 oxprenolol Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229960001749 practolol Drugs 0.000 description 1
- DURULFYMVIFBIR-UHFFFAOYSA-N practolol Chemical compound CC(C)NCC(O)COC1=CC=C(NC(C)=O)C=C1 DURULFYMVIFBIR-UHFFFAOYSA-N 0.000 description 1
- 229950002322 prizidilol Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000013878 renal filtration Effects 0.000 description 1
- 229940124550 renal vasodilator Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229950000245 toliprolol Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 239000002996 urinary tract agent Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP81110252A EP0081006B1 (en) | 1981-12-08 | 1981-12-08 | Pharmaceutical compositions comprising 7,8-dihydroxy-1(hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine derivatives and a beta-adrenergic blocking compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ202510A true NZ202510A (en) | 1985-09-13 |
Family
ID=8188060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ202510A NZ202510A (en) | 1981-12-08 | 1982-11-16 | Antihypertensive compositions based on certain 7,8-dihydroxy-1-(4-hydroxyphenyl)-1,2,4,5-tetrahydro-3h-3-benzazepines and a beta-adrenergic blocker |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4469690A (enExample) |
| EP (1) | EP0081006B1 (enExample) |
| JP (1) | JPS58105921A (enExample) |
| AT (1) | ATE15762T1 (enExample) |
| AU (1) | AU550892B2 (enExample) |
| CA (1) | CA1183777A (enExample) |
| DE (1) | DE3172458D1 (enExample) |
| GR (1) | GR77842B (enExample) |
| HK (1) | HK11489A (enExample) |
| HU (1) | HU187804B (enExample) |
| IL (1) | IL67310A (enExample) |
| MY (1) | MY8700934A (enExample) |
| NZ (1) | NZ202510A (enExample) |
| PH (1) | PH22073A (enExample) |
| PT (1) | PT75915B (enExample) |
| SG (1) | SG61188G (enExample) |
| ZA (1) | ZA829004B (enExample) |
| ZW (1) | ZW25482A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0365134A1 (en) * | 1988-09-16 | 1990-04-25 | Smithkline Beecham Corporation | Synergistic compositions of renal dopaminergic agent and angiotensin converting enzyme inhibitors |
| CA2056405A1 (en) * | 1990-04-06 | 1991-10-07 | Mitsumasa Shino | Solid oral preparation containing catechol compound |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US7022342B2 (en) | 2002-03-28 | 2006-04-04 | Andrx Corporation, Inc. | Controlled release oral dosage form of beta-adrenergic blocking agents |
| CN102379684B (zh) | 2005-04-28 | 2014-11-19 | 普罗透斯数字保健公司 | 药物信息系统 |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| EP2398500B1 (en) | 2009-02-20 | 2019-03-13 | 2-BBB Medicines B.V. | Glutathione-based drug delivery system |
| ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
| DE2638716A1 (de) * | 1976-08-27 | 1978-03-02 | Ici Gmbh | Antihypertensiva |
| US4160765A (en) * | 1976-11-17 | 1979-07-10 | Smithkline Corporation | Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds |
| US4171359A (en) * | 1978-04-12 | 1979-10-16 | Smithkline Corporation | Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4265889A (en) * | 1978-05-05 | 1981-05-05 | Smithkline Corporation | 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4192297A (en) * | 1978-05-25 | 1980-03-11 | Leopold Labrecque | Therapeutic feet bathing device |
| DE2850078A1 (de) * | 1978-11-18 | 1980-05-29 | Basf Ag | Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons |
| EP0022330B1 (en) * | 1979-07-10 | 1983-12-21 | Smithkline Beckman Corporation | Synergistic antihypertensive compositions |
-
1981
- 1981-12-08 EP EP81110252A patent/EP0081006B1/en not_active Expired
- 1981-12-08 AT AT81110252T patent/ATE15762T1/de not_active IP Right Cessation
- 1981-12-08 DE DE8181110252T patent/DE3172458D1/de not_active Expired
-
1982
- 1982-11-16 US US06/442,051 patent/US4469690A/en not_active Expired - Fee Related
- 1982-11-16 NZ NZ202510A patent/NZ202510A/en unknown
- 1982-11-17 CA CA000415758A patent/CA1183777A/en not_active Expired
- 1982-11-19 IL IL67310A patent/IL67310A/xx unknown
- 1982-11-24 AU AU90844/82A patent/AU550892B2/en not_active Ceased
- 1982-11-25 PH PH28197A patent/PH22073A/en unknown
- 1982-11-29 PT PT75915A patent/PT75915B/pt unknown
- 1982-12-01 ZW ZW254/82A patent/ZW25482A1/xx unknown
- 1982-12-07 JP JP57215355A patent/JPS58105921A/ja active Pending
- 1982-12-07 ZA ZA829004A patent/ZA829004B/xx unknown
- 1982-12-07 GR GR70010A patent/GR77842B/el unknown
- 1982-12-08 HU HU823958A patent/HU187804B/hu not_active IP Right Cessation
-
1987
- 1987-12-30 MY MY934/87A patent/MY8700934A/xx unknown
-
1988
- 1988-09-26 SG SG611/88A patent/SG61188G/en unknown
-
1989
- 1989-02-09 HK HK114/89A patent/HK11489A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE15762T1 (de) | 1985-10-15 |
| HU187804B (en) | 1986-02-28 |
| EP0081006A1 (en) | 1983-06-15 |
| US4469690A (en) | 1984-09-04 |
| DE3172458D1 (en) | 1985-10-31 |
| MY8700934A (en) | 1987-12-31 |
| AU9084482A (en) | 1983-06-16 |
| IL67310A (en) | 1988-09-30 |
| EP0081006B1 (en) | 1985-09-25 |
| ZW25482A1 (en) | 1983-02-23 |
| PH22073A (en) | 1988-05-20 |
| PT75915B (en) | 1985-11-15 |
| JPS58105921A (ja) | 1983-06-24 |
| SG61188G (en) | 1989-07-07 |
| PT75915A (en) | 1982-12-01 |
| CA1183777A (en) | 1985-03-12 |
| GR77842B (enExample) | 1984-09-25 |
| ZA829004B (en) | 1983-09-28 |
| HK11489A (en) | 1989-02-17 |
| AU550892B2 (en) | 1986-04-10 |
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