NZ202472A - Heterocyclic derivatives and pharmaceutical compositions - Google Patents

Heterocyclic derivatives and pharmaceutical compositions

Info

Publication number
NZ202472A
NZ202472A NZ202472A NZ20247282A NZ202472A NZ 202472 A NZ202472 A NZ 202472A NZ 202472 A NZ202472 A NZ 202472A NZ 20247282 A NZ20247282 A NZ 20247282A NZ 202472 A NZ202472 A NZ 202472A
Authority
NZ
New Zealand
Prior art keywords
compound
hydrogen
alkyl
stated above
meanings stated
Prior art date
Application number
NZ202472A
Other languages
English (en)
Inventor
D Brown
R B Hargreaves
B J Mcloughlin
S D Mills
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of NZ202472A publication Critical patent/NZ202472A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/21—Radicals derived from sulfur analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ202472A 1981-11-12 1982-11-11 Heterocyclic derivatives and pharmaceutical compositions NZ202472A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8134175 1981-11-12

Publications (1)

Publication Number Publication Date
NZ202472A true NZ202472A (en) 1985-11-08

Family

ID=10525836

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ202472A NZ202472A (en) 1981-11-12 1982-11-11 Heterocyclic derivatives and pharmaceutical compositions

Country Status (14)

Country Link
US (3) US4495185A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0080296A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5890567A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU563867B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1199028A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK500382A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES517332A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI823894L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR77365B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL67185A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO823767L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ202472A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT75827B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA828304B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4616014A (en) * 1981-10-22 1986-10-07 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
US4495185A (en) * 1981-11-12 1985-01-22 Imperial Chemical Industries, Plc 1,2,4-Triazin-3(2H) ones
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
JPS5962578A (ja) * 1982-10-04 1984-04-10 Mitsui Toatsu Chem Inc オキサジアジン誘導体およびそれを含有する医薬組成物
GB8310435D0 (en) * 1983-04-18 1983-05-25 Fujisawa Pharmaceutical Co Triazine derivatives
JPS59196874A (ja) * 1983-04-22 1984-11-08 Fujisawa Pharmaceut Co Ltd トリアジン誘導体
JPS61106574A (ja) * 1984-10-29 1986-05-24 Yoshitomi Pharmaceut Ind Ltd オキサ（またはチア）ジアジン誘導体
US4782066A (en) * 1985-04-19 1988-11-01 Uniroyal Chemical Company, Inc. Substituted oxadiazinone miticidal compositions and use
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
HU209473B (en) * 1990-12-22 1994-06-28 Egyt Gyogyszervegyeszeti Gyar Process for production of fodder-additives, premixes and fodders containing n-thiobenzoil-morpholine derivatives with weight-gain increasing action
HU212783B (en) * 1990-12-22 1996-11-28 Egyt Gyogyszervegyeszeti Gyar Process for producing new thiobenzoyl morpholide derivatives and weight increasing agents comprising such compounds
FR2671551B1 (fr) * 1991-01-15 1993-03-12 Adir Nouveaux composes de structure aryl triazinique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4134893A1 (de) * 1991-10-23 1993-04-29 Merck Patent Gmbh Thiadiazinone
US5446163A (en) * 1992-10-02 1995-08-29 Reilly Industries, Inc. Preparation of hydrazones, dihydrothiadiazoles and triazinones
DE4239540A1 (de) * 1992-11-25 1994-05-26 Asta Medica Ag Neue heterocyclische Verbindungen mit antiasthmatischer/antiallergischer, entzündungshemmender, positiv inotroper und blutdrucksenkender Wirkung
DE4310699A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Thiadiazinone
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
WO2019025554A1 (en) 2017-08-04 2019-02-07 Bayer Aktiengesellschaft 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3 (2H) -ONE DERIVATIVES AS INHIBITORS OF PDE3A AND PDE3B FOR THE TREATMENT OF CANCER
WO2020157188A1 (en) 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
AR117929A1 (es) * 2019-02-01 2021-09-01 Bayer Ag Compuestos de 1,2,4-triazin-3(2h)-ona
WO2020157189A1 (en) 2019-02-01 2020-08-06 Bayer Aktiengesellschaft 1,2,4-triazin-6(1h)-one compounds for the treatment of hyperproliferative diseases
WO2020157201A1 (en) 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Oxadiazinone compounds for the treatment of hyperproliferative diseases
CN117903077B (zh) * 2023-01-13 2024-09-03 上海超阳药业有限公司 二氢噁二嗪酮化合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3377345A (en) * 1966-09-23 1968-04-09 Dow Chemical Co Substituted 3, 4, 5, 6-tetrahydro-2h-1, 3, 4-oxadiazin-2-one compounds and method ofpreparation thereof
US3946010A (en) * 1975-04-09 1976-03-23 E. R. Squibb & Sons, Inc. 3-Phenyl-2,5-dihydro-as-triazin-6 (1H)-ones
US4097671A (en) * 1975-08-28 1978-06-27 General Electric Company Dihydrooxadiazinones and method for making
US4105848A (en) * 1976-12-27 1978-08-08 General Electric Company Process for the production of dihydrooxadiazinone compounds
EP0052442B1 (en) * 1980-11-14 1985-09-11 Imperial Chemical Industries Plc Heterocyclic compounds
US4495185A (en) * 1981-11-12 1985-01-22 Imperial Chemical Industries, Plc 1,2,4-Triazin-3(2H) ones
US4489074A (en) * 1982-11-12 1984-12-18 Imperial Chemical Industries, Plc 1,3,4-Thiadiazin-2-ones
JPH072947B2 (ja) * 1985-06-27 1995-01-18 松下電子工業株式会社 螢光体

Also Published As

Publication number Publication date
EP0080296A1 (en) 1983-06-01
FI823894A7 (fi) 1983-05-13
PT75827B (en) 1985-11-12
ES8404339A1 (es) 1984-04-16
AU9038882A (en) 1983-05-19
DK500382A (da) 1983-05-13
US4584298A (en) 1986-04-22
IL67185A0 (en) 1983-03-31
US4495185A (en) 1985-01-22
PT75827A (en) 1982-12-01
US4694005A (en) 1987-09-15
AU563867B2 (en) 1987-07-23
JPS5890567A (ja) 1983-05-30
ES517332A0 (es) 1984-04-16
FI823894A0 (fi) 1982-11-12
NO823767L (no) 1983-05-13
FI823894L (fi) 1983-05-13
GR77365B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-09-11
ZA828304B (en) 1983-09-28
CA1199028A (en) 1986-01-07

Similar Documents

Publication Publication Date Title
US4495185A (en) 1,2,4-Triazin-3(2H) ones
US4503054A (en) 6-Aryl-1,2,4-triazin-6-ones which possess cardiotonic properties
CA1199027A (en) Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
US4489074A (en) 1,3,4-Thiadiazin-2-ones
EP0462264A1 (fr) Derives heterocycliques, leur procede de preparation et leur application therapeutique comme antagonistes du paf.
FI72971B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4h-1,2,4-triazolderivat.
US4493835A (en) 1,3,4-Thiadiazines
HU176533B (en) Process for preparing o-alkylated hydroxylamines
US4139538A (en) Oxazolidinones as therapeutic agents
EP0086564B1 (en) Alkanolamine derivatives
CA1138457A (en) 2-hydroxy-5-(1-hydroxy-2- piperazinylethyl)benzoic acid derivatives
SK281387B6 (sk) Deriváty kyseliny hydroxímovej, farmaceutický prostriedok, ktorý ich obsahuje, spôsob ich prípravy a medziprodukty na ich prípravu
US3929783A (en) 1-Substituted-4-phenyl-4H-{8 1,2,4{9 triazolo{8 3,4-C{9 {8 1,4{9 {0 benzothiazines or benzoxazines
US4268511A (en) 3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therapeutic applications
US4179442A (en) 4-(Alpha-hydroxy-isopropyl)-5-phenyl-oxazolidin-2-one
PL153857B1 (en) Procedure for the production of new derivatives of alkanolamine
US3560490A (en) Trifluoromethyl furan derivatives
US5446163A (en) Preparation of hydrazones, dihydrothiadiazoles and triazinones
Bettarini et al. Synthesis and acaricidal activity of 3‐aryl‐5‐arylmethyl‐1, 3, 4‐oxa (thia) diazol‐2 (3h)‐ones