NZ200210A - Prostacyclin pgi2 derivatives and pharmaceutical compositions - Google Patents

Prostacyclin pgi2 derivatives and pharmaceutical compositions

Info

Publication number
NZ200210A
NZ200210A NZ200210A NZ20021082A NZ200210A NZ 200210 A NZ200210 A NZ 200210A NZ 200210 A NZ200210 A NZ 200210A NZ 20021082 A NZ20021082 A NZ 20021082A NZ 200210 A NZ200210 A NZ 200210A
Authority
NZ
New Zealand
Prior art keywords
formula
compounds
carbon atoms
compound
alkyl
Prior art date
Application number
NZ200210A
Other languages
English (en)
Inventor
L N Nysted
R Pappo
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NZ200210A publication Critical patent/NZ200210A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
NZ200210A 1981-04-02 1982-04-01 Prostacyclin pgi2 derivatives and pharmaceutical compositions NZ200210A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25053081A 1981-04-02 1981-04-02

Publications (1)

Publication Number Publication Date
NZ200210A true NZ200210A (en) 1985-10-11

Family

ID=22948130

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ200210A NZ200210A (en) 1981-04-02 1982-04-01 Prostacyclin pgi2 derivatives and pharmaceutical compositions

Country Status (12)

Country Link
EP (1) EP0062303B1 (fr)
JP (1) JPS57176978A (fr)
AU (1) AU549367B2 (fr)
CA (1) CA1215973A (fr)
DE (1) DE3267651D1 (fr)
DK (1) DK149682A (fr)
ES (1) ES8306997A1 (fr)
IE (1) IE52937B1 (fr)
NO (2) NO157329C (fr)
NZ (1) NZ200210A (fr)
PT (1) PT74691B (fr)
ZA (1) ZA822297B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation
JPS57200378A (en) * 1981-06-02 1982-12-08 Teijin Ltd Halogenated pgi2 and its preparation
US4670569A (en) * 1981-04-02 1987-06-02 G. D. Searle & Co. 5-fluoro-PGI2 compounds
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
US4579958A (en) * 1983-12-23 1986-04-01 G. D. Searle & Co. 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds
US4611065A (en) * 1985-01-25 1986-09-09 G. D. Searle & Co. Method for preparing 5-fluoroprostacyclins
US4616034A (en) * 1985-02-28 1986-10-07 G. D. Searle & Co. 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
WO1981001002A1 (fr) * 1979-10-10 1981-04-16 Univ Chicago Prostaglandines et prostacyclines substituees par le fluor
US4472428A (en) * 1980-12-09 1984-09-18 Teijin Limited Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore

Also Published As

Publication number Publication date
AU549367B2 (en) 1986-01-23
ES511067A0 (es) 1983-06-16
DK149682A (da) 1982-10-03
EP0062303B1 (fr) 1985-11-27
NO854442L (no) 1982-10-04
PT74691A (en) 1982-05-01
EP0062303A2 (fr) 1982-10-13
NO157329C (no) 1988-03-02
EP0062303A3 (en) 1982-11-10
NO821108L (no) 1982-10-04
ZA822297B (en) 1983-04-27
PT74691B (en) 1983-10-26
DE3267651D1 (en) 1986-01-09
IE52937B1 (en) 1988-04-13
ES8306997A1 (es) 1983-06-16
CA1215973A (fr) 1986-12-30
NO157329B (no) 1987-11-23
JPS57176978A (en) 1982-10-30
AU8225882A (en) 1982-10-07
IE820773L (en) 1982-10-02

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