NO992526L - Cephalosporin derivatives - Google Patents

Cephalosporin derivatives

Info

Publication number
NO992526L
NO992526L NO992526A NO992526A NO992526L NO 992526 L NO992526 L NO 992526L NO 992526 A NO992526 A NO 992526A NO 992526 A NO992526 A NO 992526A NO 992526 L NO992526 L NO 992526L
Authority
NO
Norway
Prior art keywords
group
halogen
hydrogen
derivatives
alkyl group
Prior art date
Application number
NO992526A
Other languages
Norwegian (no)
Other versions
NO992526D0 (en
Inventor
Dane M Springer
Bing Y Luh
Andrea Stanley V D
Thomas W Hudyma
Oak K Kim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO992526D0 publication Critical patent/NO992526D0/en
Publication of NO992526L publication Critical patent/NO992526L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives cephem-derivater med den generelle formel V/? CH2-S-Q COOR1 hvor Q er en eventuelt substituert pyridiniumgruppe forbundet med svovelatomet via et ringkarbonatom; X er halogen; Y er hydrogen eller halogen; L1 er en furangruppe, en tiofengruppe, en C2-Ci0-alkylgruppe, eller en C2-Cio-alkylgruppe avbrutt av en eller flere grupper uavhengig valgt fra vinyl, S, SO, S02, S02NH, H eller xNxri/' H o n er O eller 1; A er C02H, P03H2, S03H eller tetrazol; og R1 er hydrogen eller en karboksyl-beskyttende gruppe; og farmasøytisk akseptable salter og/eller prodrugs derav. Derivatene er grampositive antibakterielle midler spesielt egnet til behandlingen av sykdommer forårsaket av methicillin-resistent Staphylococcus aureus (MRSA).Cephem derivatives of the general formula V /? CH2-S-Q COOR1 wherein Q is an optionally substituted pyridinium group connected to the sulfur atom via a ring carbon atom; X is halogen; Y is hydrogen or halogen; L1 is a furan group, a thiophene group, a C2-C10 alkyl group, or a C2-C10 alkyl group interrupted by one or more groups independently selected from vinyl, S, SO, SO2, SO2 NH, H or xNxri / H on is O or 1; A is CO 2 H, PO 3 H 2, SO 3 H or tetrazole; and R 1 is hydrogen or a carboxyl protecting group; and pharmaceutically acceptable salts and / or prodrugs thereof. The derivatives are gram-positive antibacterial agents particularly suitable for the treatment of diseases caused by methicillin-resistant Staphylococcus aureus (MRSA).

NO992526A 1996-11-27 1999-05-26 Cephalosporin derivatives NO992526L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3404696P 1996-11-27 1996-11-27
PCT/US1997/021785 WO1998023621A1 (en) 1996-11-27 1997-11-21 Cephalosporin derivatives

Publications (2)

Publication Number Publication Date
NO992526D0 NO992526D0 (en) 1999-05-26
NO992526L true NO992526L (en) 1999-05-26

Family

ID=21873971

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992526A NO992526L (en) 1996-11-27 1999-05-26 Cephalosporin derivatives

Country Status (17)

Country Link
EP (1) EP0966472A1 (en)
JP (1) JP2001506607A (en)
KR (1) KR20000057283A (en)
CN (1) CN1238775A (en)
AR (1) AR010650A1 (en)
AU (1) AU734948B2 (en)
BR (1) BR9713350A (en)
CA (1) CA2272717A1 (en)
CZ (1) CZ185399A3 (en)
HU (1) HUP9903621A3 (en)
IL (1) IL129437A0 (en)
NO (1) NO992526L (en)
NZ (1) NZ335892A (en)
PL (1) PL334558A1 (en)
TW (1) TW414796B (en)
WO (1) WO1998023621A1 (en)
ZA (1) ZA9710662B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265394B1 (en) * 1997-07-31 2001-07-24 Bristol-Myers Squibb Company Bis quaternary MRSA cephem derivatives
KR20020085181A (en) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 Novel cephalosporin antibiotics and process for preparing same
KR20020085180A (en) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 Novel cephalosporin antibiotics and process for preparing same
KR20020085176A (en) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 Novel cephalosporin antibiotics and process for preparing same
KR20020085178A (en) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 Novel cephalosporin antibiotics and process for preparing same
KR20030071311A (en) * 2002-02-28 2003-09-03 주식회사 엘지생명과학 Novel cephalosporin compounds and process for preparing the same
MX2013013211A (en) * 2011-05-18 2014-02-20 Syngenta Participations Ag Insecticidal compounds based on arylthioacetamide derivatives.
CN105131018B (en) * 2015-09-23 2017-12-26 浙江华方药业股份有限公司 A kind of preparation method of ceftezole acid
CN114957056A (en) * 2021-02-20 2022-08-30 帕潘纳(北京)科技有限公司 Process for preparing methyl 3-methyl-2-chloro-4-methylsulfonylbenzoate and intermediates thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3345366A (en) * 1967-02-15 1967-10-03 American Cyanamid Co Substituted 7-acetylamino cephalosporanic acids
US4148997A (en) * 1977-11-07 1979-04-10 Yeda Research And Development Co., Ltd. 7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives
US5567698A (en) * 1995-02-15 1996-10-22 Bristol-Myers Squibb Company Pyridinium thiomethyl substituted chepholosporin derivatives
US5620969A (en) * 1995-04-25 1997-04-15 Bristol-Myers Squibb Company Cephalosporin derviatives
AU1278197A (en) * 1995-12-20 1997-07-14 Bristol-Myers Squibb Company Cephalosporin derivatives

Also Published As

Publication number Publication date
EP0966472A1 (en) 1999-12-29
KR20000057283A (en) 2000-09-15
CN1238775A (en) 1999-12-15
HUP9903621A3 (en) 2001-05-28
AU734948B2 (en) 2001-06-28
CA2272717A1 (en) 1998-06-04
IL129437A0 (en) 2000-02-17
BR9713350A (en) 2000-01-25
NZ335892A (en) 2001-07-27
AR010650A1 (en) 2000-06-28
WO1998023621A1 (en) 1998-06-04
CZ185399A3 (en) 1999-08-11
HUP9903621A2 (en) 2000-04-28
TW414796B (en) 2000-12-11
ZA9710662B (en) 1999-05-26
NO992526D0 (en) 1999-05-26
PL334558A1 (en) 2000-03-13
EP0966472A4 (en) 1999-12-29
JP2001506607A (en) 2001-05-22
AU5365298A (en) 1998-06-22

Similar Documents

Publication Publication Date Title
DE69331089T2 (en) Beta-lactam and cepham compounds and their manufacture
NO992526L (en) Cephalosporin derivatives
GB1526978A (en) 3-thiosubstituted cephalosporin antibiotics
FI864825A (en) CEFALOSPORINDERIVAT.
IE832266L (en) Carbapenene antibiotics
EP0376724A3 (en) Cephalosporin compounds
FI924934A0 (en) THIRD PHTHALAZINER FOR SOME INHOLDER AND ETHER-ELLER THIOETER GRUPPERING I 1-STAELLNING OCH FOERFARANDE FOER DERAS FRAMSTAELLNING
EP0214600A3 (en) Cephalosporin derivatives
ES455404A1 (en) Therapeutic compounds containing beta -lactams
SE7709071L (en) OLIVANIC ACID ESTERS
PH25378A (en) Novel aminoalkyl-substituted heterocyclic ssulfur coumpounds
DE3787030D1 (en) 1-CARBOXY-1-VINYLOXYIMINOAMINOTHIAZOLE-CEPHALOSPORINE DERIVATIVES AND THE PRODUCTION THEREOF.
NO171502C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE THIADIAZOLYLACETAMIDE CEFEM DERIVATIVES
ES2123728T3 (en) DERIVATIVES OF PYRROLLO-PYRAZINE ACTIVITY 5-HT3.
ATE206426T1 (en) CARBAPENEM DERIVATIVES
ES8405399A1 (en) Carbapenem antibiotics
ES8507150A1 (en) Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection.
CA2155837A1 (en) Benzopyrans as potassium channel openers
SE7709646L (en) ANTIBACTERIAL AGENTS
SE8504538D0 (en) CARBAPENEM ANTIBIOTICS
RU99113359A (en) DERIVATIVES OF CEFALOSPORIN
SE8104308L (en) NEW ASSOCIATIONS WITH ANTIBIOTIC EFFECT
DK366982A (en) CEPHALOSPORINE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION
TH7294B (en) Carboxylkina Mido Cephalosporin

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application