ES8507150A1 - Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection. - Google Patents

Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection.

Info

Publication number
ES8507150A1
ES8507150A1 ES532996A ES532996A ES8507150A1 ES 8507150 A1 ES8507150 A1 ES 8507150A1 ES 532996 A ES532996 A ES 532996A ES 532996 A ES532996 A ES 532996A ES 8507150 A1 ES8507150 A1 ES 8507150A1
Authority
ES
Spain
Prior art keywords
group
substituted
optionally
cephalosporin derivatives
prophylactic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532996A
Other languages
Spanish (es)
Other versions
ES532996A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Publication of ES532996A0 publication Critical patent/ES532996A0/en
Publication of ES8507150A1 publication Critical patent/ES8507150A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60J—WINDOWS, WINDSCREENS, NON-FIXED ROOFS, DOORS, OR SIMILAR DEVICES FOR VEHICLES; REMOVABLE EXTERNAL PROTECTIVE COVERINGS SPECIALLY ADAPTED FOR VEHICLES
    • B60J10/00—Sealing arrangements
    • B60J10/20—Sealing arrangements characterised by the shape
    • B60J10/24—Sealing arrangements characterised by the shape having tubular parts
    • B60J10/248—Sealing arrangements characterised by the shape having tubular parts having two or more tubular cavities, e.g. formed by partition walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60J—WINDOWS, WINDSCREENS, NON-FIXED ROOFS, DOORS, OR SIMILAR DEVICES FOR VEHICLES; REMOVABLE EXTERNAL PROTECTIVE COVERINGS SPECIALLY ADAPTED FOR VEHICLES
    • B60J10/00—Sealing arrangements
    • B60J10/80—Sealing arrangements specially adapted for opening panels, e.g. doors
    • B60J10/86—Sealing arrangements specially adapted for opening panels, e.g. doors arranged on the opening panel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Abstract

1. A cephalosporin derivatives of the general formula < IMAGE > (I) wherein R1 is an alpha -, beta - or gamma -amino acid residue (bonded by the ester linkage), which may optionally be substituted by one or two lower alkyl groups at the amino group thereof, R2 is an 1-alkanoyloxyalkyl, 1-alkoxycarbonyloxyalkyl, phthalidyl or 5-methyl-1,3-dioxolen-2-on-4-ylmethyl group, R3 is a carbamoyloxymethyl group, which may optionally be substituted by one or two lower alkyl groups, or a heterocyclothiomethyl group, which may optionally be substituted by one or more appropriate substituents, and R4 is a hydrogen atom or a hydroxy group, or its non-toxic salt are found to be useful as orally administrable antibiotics having broad antimicrobial activities against both gram-positive and gram-negative bacteria.
ES532996A 1982-11-10 1984-05-31 Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection. Expired ES8507150A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1982/000437 WO1984001949A1 (en) 1982-11-10 1982-11-10 Cephalosporin derivatives, process and their preparation, and prophylactic and treating agent against bacterial infection

Publications (2)

Publication Number Publication Date
ES532996A0 ES532996A0 (en) 1985-08-16
ES8507150A1 true ES8507150A1 (en) 1985-08-16

Family

ID=13762361

Family Applications (3)

Application Number Title Priority Date Filing Date
ES526561A Expired ES8504821A1 (en) 1982-11-10 1983-10-19 Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection.
ES532996A Expired ES8507150A1 (en) 1982-11-10 1984-05-31 Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection.
ES532997A Granted ES532997A0 (en) 1982-11-10 1984-05-31 A METHOD OF PRODUCING CEPHALOSPORIN DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES526561A Expired ES8504821A1 (en) 1982-11-10 1983-10-19 Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES532997A Granted ES532997A0 (en) 1982-11-10 1984-05-31 A METHOD OF PRODUCING CEPHALOSPORIN DERIVATIVES

Country Status (18)

Country Link
US (1) US4605651A (en)
EP (1) EP0108942B1 (en)
JP (1) JPS59116292A (en)
KR (1) KR900007200B1 (en)
AT (1) ATE32724T1 (en)
AU (1) AU568094B2 (en)
CA (1) CA1239928A (en)
CY (1) CY1512A (en)
DE (1) DE3375787D1 (en)
DK (1) DK481883A (en)
ES (3) ES8504821A1 (en)
FI (1) FI75348C (en)
HK (1) HK39390A (en)
NO (1) NO162240C (en)
NZ (1) NZ206019A (en)
SU (2) SU1322983A3 (en)
WO (1) WO1984001949A1 (en)
ZA (1) ZA837635B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034975A (en) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk Production of cephalosporin
JPS6034978A (en) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and its preparation
DK401088A (en) * 1987-07-21 1989-01-22 Kyoto Pharma Ind CEPHALOSPOR CONNECTION, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION CONTAINING IT
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
JP4323968B2 (en) * 2004-01-14 2009-09-02 株式会社日立コミュニケーションテクノロジー Timing adjustment method for wireless communication device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229453A (en) * 1968-01-30 1971-04-21
US3701775A (en) * 1970-11-25 1972-10-31 Smith Kline French Lab Esters of mandeloylaminocephalosporanic acids
IL38099A (en) * 1970-12-17 1976-01-30 Smith Kline French Lab 3-heterocyclyl thiomethylcephalosporins
US3812116A (en) * 1971-07-02 1974-05-21 Fujisawa Pharmaceutical Co 7-acylated 3-substituted cephalosporin compounds
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
GB1492393A (en) * 1974-02-21 1977-11-16 Beecham Group Ltd Cephalosporin esters
US4107433A (en) * 1974-02-21 1978-08-15 Beecham Group Limited Phthalidyl ester of 3-carbomoyloxy cephalosporin derivatives
CH606001A5 (en) * 1974-05-13 1978-10-13 Ciba Geigy Ag
US3933808A (en) * 1974-05-20 1976-01-20 Eli Lilly And Company Cephalosporin esters
US4172196A (en) * 1974-09-03 1979-10-23 Bristol-Myers Company Certain 7-α-substituted-α-hydroxyacetamido-3-(1-carboxymethyltetrazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acids
JPS5283877A (en) * 1976-01-01 1977-07-13 Lilly Co Eli Cephalospoline esters
MA18686A1 (en) * 1978-07-07 1980-10-01 Ciba Geigy Ag AMINOTHIAZOLIC COMPOUNDS
JPS57193489A (en) * 1981-05-21 1982-11-27 Fujisawa Pharmaceut Co Ltd Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation

Also Published As

Publication number Publication date
JPS59116292A (en) 1984-07-05
CA1239928A (en) 1988-08-02
HK39390A (en) 1990-06-01
AU2019983A (en) 1984-05-17
EP0108942A2 (en) 1984-05-23
ES532996A0 (en) 1985-08-16
ES526561A0 (en) 1985-04-16
DE3375787D1 (en) 1988-04-07
ES8504821A1 (en) 1985-04-16
KR900007200B1 (en) 1990-10-05
ES8507151A1 (en) 1985-08-16
SU1309912A3 (en) 1987-05-07
EP0108942A3 (en) 1985-05-15
NO162240B (en) 1989-08-21
NO833807L (en) 1984-05-11
US4605651A (en) 1986-08-12
EP0108942B1 (en) 1988-03-02
CY1512A (en) 1990-08-03
DK481883D0 (en) 1983-10-20
DK481883A (en) 1984-05-11
ATE32724T1 (en) 1988-03-15
FI75348C (en) 1988-06-09
FI833839A (en) 1984-05-11
FI75348B (en) 1988-02-29
AU568094B2 (en) 1987-12-17
FI833839A0 (en) 1983-10-20
NO162240C (en) 1989-11-29
SU1322983A3 (en) 1987-07-07
WO1984001949A1 (en) 1984-05-24
ES532997A0 (en) 1985-08-16
NZ206019A (en) 1986-06-11
KR840006667A (en) 1984-12-01
ZA837635B (en) 1984-11-28

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506