NO990912L - Terapeutiske kombinasjoner av PAR-antagonister og RXR-agonister og bruken derav - Google Patents

Terapeutiske kombinasjoner av PAR-antagonister og RXR-agonister og bruken derav

Info

Publication number
NO990912L
NO990912L NO990912A NO990912A NO990912L NO 990912 L NO990912 L NO 990912L NO 990912 A NO990912 A NO 990912A NO 990912 A NO990912 A NO 990912A NO 990912 L NO990912 L NO 990912L
Authority
NO
Norway
Prior art keywords
antagonist
rar
therapeutic combinations
rxr agonists
antagonists
Prior art date
Application number
NO990912A
Other languages
English (en)
Norwegian (no)
Other versions
NO990912D0 (no
Inventor
Pierre Chambon
Hinrich Gronemeyer
Peter R Reczek
Jacek Ostrowski
Original Assignee
Inst Nat Sante Rech Med
Centre Nat Rech Scient
Univ Pasteur
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Centre Nat Rech Scient, Univ Pasteur, Bristol Myers Squibb Co filed Critical Inst Nat Sante Rech Med
Publication of NO990912D0 publication Critical patent/NO990912D0/no
Publication of NO990912L publication Critical patent/NO990912L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
NO990912A 1996-08-28 1999-02-25 Terapeutiske kombinasjoner av PAR-antagonister og RXR-agonister og bruken derav NO990912L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2477296P 1996-08-28 1996-08-28
PCT/US1997/015155 WO1998008546A2 (fr) 1996-08-28 1997-08-28 Combinaisons therapeutiques d'antagonistes de rar et d'agonistes de rxr

Publications (2)

Publication Number Publication Date
NO990912D0 NO990912D0 (no) 1999-02-25
NO990912L true NO990912L (no) 1999-04-27

Family

ID=21822317

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990912A NO990912L (no) 1996-08-28 1999-02-25 Terapeutiske kombinasjoner av PAR-antagonister og RXR-agonister og bruken derav

Country Status (11)

Country Link
US (2) US6130230A (fr)
EP (1) EP0928200B1 (fr)
JP (1) JP2001500486A (fr)
AT (1) ATE236654T1 (fr)
AU (1) AU731060B2 (fr)
CA (1) CA2263817A1 (fr)
DE (1) DE69720745T2 (fr)
ES (1) ES2196361T3 (fr)
IL (1) IL128723A0 (fr)
NO (1) NO990912L (fr)
WO (1) WO1998008546A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344653A1 (fr) 1998-09-29 2000-04-06 Gamida Cell Ltd. Procedes de regulation de la proliferation et de la differentiation de cellules souches et precurseurs
CA2254429A1 (fr) * 1998-11-19 2000-05-19 Tully Michael Underhill Compositions favorisant la chondrogenese
WO2000061233A2 (fr) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methodes et compositions de traitement et de prevention de maladies pulmonaires
US6436993B1 (en) * 1999-07-13 2002-08-20 The Salk Institute For Biological Studies Use of RAR antagonists as modulators of hormone mediated processes
CA2402413A1 (fr) * 2000-03-14 2001-09-20 The University Of Western Ontario Compositions et procedes exercant un effet sur l'osteogenese
AU4866201A (en) * 2000-04-13 2001-10-30 Pierre Chambon Compositions and methods for use in modulating immune system function
EP1348033A2 (fr) 2000-05-26 2003-10-01 Board of Trustees of the University of Illinois Reactifs et methodes destines a l'identification et a la modulation de l'expression de genes regules par les retinoides
WO2002022113A2 (fr) 2000-09-13 2002-03-21 Bristol-Myers Squibb Company Antagonistes vis-a-vis du recepteur d'acide retinoique, tenant lieu de promoteurs de l'angiogenese
WO2002100827A2 (fr) * 2001-06-11 2002-12-19 Ludwig Institute For Cancer Research Procede pour augmenter la survie de cellules secretant de la dopamine
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (fr) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methodes de developpement de cellules souches et de cellules precurseurs, populations de cellules multipliees obtenues a l'aide de ces methodes
US20040097587A1 (en) * 2002-03-27 2004-05-20 Arbiser Jack L Compositions and methods of treatment of ulcerating diseases, burns, and related conditions
JP4473491B2 (ja) * 2002-05-28 2010-06-02 株式会社資生堂 毛穴縮小剤
US20050054731A1 (en) * 2003-09-08 2005-03-10 Franco Folli Multi-system therapy for diabetes, the metabolic syndrome and obesity
US20050112123A1 (en) * 2003-10-06 2005-05-26 Vaughan Michael R. Methods of treating proteinuria
GB2411115A (en) * 2004-02-19 2005-08-24 Medical Res Council Retinoic acid antagonists for the treatment of oesophageal disorders
WO2006030442A2 (fr) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methodes de culture ex vivo de cellules souches et de precurseur par co-culture avec des cellules mesenchymales
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
EP2181710A1 (fr) * 2008-10-28 2010-05-05 Phenex Pharmaceuticals AG Ligands pour la modulation de l'activité du récepteur gamma orphelin (NR1F3)
EP2329817A1 (fr) * 2009-09-04 2011-06-08 Ernst-Moritz-Arndt-Universität Greifswald Antagonistes du récepteur de l'acide rétinoïque, inhibiteurs de miR-10a et inhibiteurs des répresseurs HOXB1 et/ou HOXB3 pour le traitement du cancer du pancréas
BR112013033309B1 (pt) 2011-06-24 2022-07-05 Gri Bio, Inc Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i
US20150064273A1 (en) 2012-02-13 2015-03-05 Gamida-Cell Ltd. Mesenchymal Stem Cells Conditioned Medium and Methods of Generating and Using the Same
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9963439B2 (en) 2013-08-20 2018-05-08 University Of Washington Through Its Center For Commercialization Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase
PL3380086T3 (pl) 2015-11-25 2022-02-21 Io Therapeutics, Inc. Oporne na cyp26 agonisty selektywne względem rar-alfa w leczeniu nowotworu
EP3468600A4 (fr) 2016-06-10 2019-11-13 IO Therapeutics, Inc. Composés rétinoïdes et rexinoïdes sélectifs du récepteur et modulateurs immunitaires pour l'immunothérapie du cancer
KR20200029544A (ko) 2017-07-13 2020-03-18 아이오 테라퓨틱스, 인크. 암 면역요법을 위해 면역 조절제와 조합된 면역조절 레티노이드 및 렉시노이드 화합물
SG11202001479RA (en) 2017-08-31 2020-03-30 Io Therapeutics Inc Rar selective agonists in combination with immune modulators for cancer immunotherapy
US12115140B2 (en) * 2020-07-31 2024-10-15 The Trustees Of Columbia University In The City Of New York Method of treating adenoid cystic carcinoma

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016658A1 (fr) 1991-03-18 1992-10-01 The Salk Institute For Biological Studies Compositions a elements de reaction et dosages les incorporant
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5399586A (en) * 1993-03-11 1995-03-21 Allergan, Inc. Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity
EP0659045A4 (fr) * 1993-05-18 1997-02-26 Inst Nat Sante Rech Med Souris produite par genie genetique et comportant des modifications dans les genes codant les proteines du recepteur de l'acide retinoique.
US5702914A (en) * 1994-12-21 1997-12-30 The Salk Institute For Biological Studies Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements
CA2210248A1 (fr) 1995-01-13 1996-07-18 Ronald M. Evans Regulation allosterique de recepteurs d'hormones nucleaires
US5747661A (en) * 1995-01-13 1998-05-05 Howard Hughes Medical Institute Retinoid-inducible response elements
US5559248A (en) * 1995-04-05 1996-09-24 Bristol-Myers Squibb Co. Retinoid-like heterocycles
US6025388A (en) * 1995-04-26 2000-02-15 Allergan Sales, Inc. Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids
US5906920A (en) 1995-08-29 1999-05-25 The Salk Institute For Biological Studies Methods for the detection of ligands for retinoid X receptors
AU5727998A (en) 1996-12-31 1998-07-31 Salk Institute For Biological Studies, The Treatment of liposarcomas using a combination of thiazolidinediones and retinoidx receptor selective agonists
CA2276288A1 (fr) 1996-12-31 1998-07-09 Laszlo Nagy Traitement des etats pathologiques generes par la proliferation cellulaire neoplasique au moyen d'activateurs ppar-gamma et compositions utiles a cet effet
US6387673B1 (en) 1997-05-01 2002-05-14 The Salk Institute For Biological Studies Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds

Also Published As

Publication number Publication date
WO1998008546A8 (fr) 2001-04-19
WO1998008546A3 (fr) 1998-04-23
ATE236654T1 (de) 2003-04-15
ES2196361T3 (es) 2003-12-16
AU731060B2 (en) 2001-03-22
AU4167497A (en) 1998-03-19
DE69720745D1 (de) 2003-05-15
JP2001500486A (ja) 2001-01-16
US6130230A (en) 2000-10-10
DE69720745T2 (de) 2004-02-26
US6653322B1 (en) 2003-11-25
CA2263817A1 (fr) 1998-03-05
EP0928200A2 (fr) 1999-07-14
NO990912D0 (no) 1999-02-25
WO1998008546A2 (fr) 1998-03-05
IL128723A0 (en) 2000-01-31
EP0928200B1 (fr) 2003-04-09

Similar Documents

Publication Publication Date Title
NO990912L (no) Terapeutiske kombinasjoner av PAR-antagonister og RXR-agonister og bruken derav
DE69925024D1 (de) Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
ATE258067T1 (de) Kombinationspräparat zur behandlung der parkinsonschen krankheit, das selektive nmda- antagonisten enthält
ATE355374T1 (de) Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
SE9803710D0 (sv) Use of certain drugs for treating nerve root injury
DE60316779D1 (de) Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen
DE60216830D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
EA199900137A1 (ru) Замещенные пиридины в качестве избирательных ингибиторов циклооксигеназы-2
DE60134453D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von ZNS und anderen Krankheiten
DE60331537D1 (de) Kombinationen zur behandlung von multiplem myelom
BR0008847A (pt) Composições analgésicas que compreendemcompostos antiepilépticos, e métodos de uso dasmesmas
CY1118924T1 (el) Μεθοδος για θεραπεια της πρωτοπαθους αϋπνιας
AP2001002129A0 (en) 5HT1 receptor agonists and metoclopramide for the treatment of migrane.
EA200200132A1 (ru) СЕЛЕКТИВНЫЕ АНТАГОНИСТЫ РЕЦЕПТОРА iGluRДЛЯ ЛЕЧЕНИЯ МИГРЕНИ
ES2165990T3 (es) Thip para el tratamiento de trastornos del sueño.
YU2603A (sh) Nova kombinacija (5ht2) agonista i (5ht6) antagonista serotonina kao farmaceutska kombinacija
DK0415613T3 (da) Anvendelse af sertralin til behandling af præmatur ejakulation
TWI367751B (en) Pharmaceutical composition comprising rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction
EA199800717A1 (ru) Способ лечения заболеваний млекопитающих и цвиттерионная композиция
CA2156481A1 (fr) Compositions antagonistes du recepteur 5-ht2, utiles pour le traitement des troubles veineux
IT1269185B (it) Associazione dotata di effetto sinergico che ha un effetto antagonista dei recettori nk1 e nk2
HUP9903679A2 (hu) Olanzapin alkalmazása bipoláris zavar kezelésére szolgáló gyógyszerkészítmények előállítására
DK0768083T3 (da) Anvendelse af sertralin til at behandle patienter med post myocardisk infarkt
ATE268170T1 (de) Verwendung von bernsteisäure oder deren salze zur behandlung von insulinresistenz
ATE248607T1 (de) Aminotetralin derivate zur therapie der kardiovaskulären erkrankungen

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application