NO982754L - Fosfolipidderivater av fosfonokarboksylsyrer, fremstilling av slike derivater og anvendelse av derivatene som antivirusmedikamenter - Google Patents

Fosfolipidderivater av fosfonokarboksylsyrer, fremstilling av slike derivater og anvendelse av derivatene som antivirusmedikamenter

Info

Publication number
NO982754L
NO982754L NO982754A NO982754A NO982754L NO 982754 L NO982754 L NO 982754L NO 982754 A NO982754 A NO 982754A NO 982754 A NO982754 A NO 982754A NO 982754 L NO982754 L NO 982754L
Authority
NO
Norway
Prior art keywords
derivatives
preparation
phospholipid
antiviral drugs
phosphonocarboxylic acids
Prior art date
Application number
NO982754A
Other languages
English (en)
Norwegian (no)
Other versions
NO982754D0 (no
Inventor
Harald Zilch
Dieter Herrmann
Hans-Georg Opitz
Gerd Zimmermann
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1995147023 external-priority patent/DE19547023A1/de
Priority claimed from DE1996143416 external-priority patent/DE19643416A1/de
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO982754D0 publication Critical patent/NO982754D0/no
Publication of NO982754L publication Critical patent/NO982754L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075Esters with hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO982754A 1995-12-15 1998-06-15 Fosfolipidderivater av fosfonokarboksylsyrer, fremstilling av slike derivater og anvendelse av derivatene som antivirusmedikamenter NO982754L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1995147023 DE19547023A1 (de) 1995-12-15 1995-12-15 Neue Phospholipid-Derivate von Phosphonocarbonsäuren, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DE1996143416 DE19643416A1 (de) 1996-10-22 1996-10-22 Neue Phospholipid-Derivate von Phosphonocarbonsäuren, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
PCT/EP1996/005647 WO1997022613A1 (de) 1995-12-15 1996-12-16 Phospholipid-derivate von phosphonocarbonsäuren, deren herstellung sowie deren verwendung als antivirale arzneimittel

Publications (2)

Publication Number Publication Date
NO982754D0 NO982754D0 (no) 1998-06-15
NO982754L true NO982754L (no) 1998-08-13

Family

ID=26021319

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982754A NO982754L (no) 1995-12-15 1998-06-15 Fosfolipidderivater av fosfonokarboksylsyrer, fremstilling av slike derivater og anvendelse av derivatene som antivirusmedikamenter

Country Status (23)

Country Link
US (1) US6136797A (cs)
EP (1) EP0868425B1 (cs)
JP (1) JP2000515113A (cs)
KR (1) KR20000064374A (cs)
CN (1) CN1085672C (cs)
AR (1) AR005089A1 (cs)
AT (1) ATE278698T1 (cs)
AU (1) AU714236B2 (cs)
BR (1) BR9612133A (cs)
CA (1) CA2240366A1 (cs)
CZ (1) CZ291823B6 (cs)
DE (1) DE59611111D1 (cs)
ES (1) ES2230574T3 (cs)
HU (1) HUP0001534A3 (cs)
IL (1) IL124790A (cs)
NO (1) NO982754L (cs)
NZ (1) NZ325259A (cs)
PL (1) PL186402B1 (cs)
RU (1) RU2166508C2 (cs)
SK (1) SK75698A3 (cs)
TR (1) TR199801082T2 (cs)
TW (1) TW343975B (cs)
WO (1) WO1997022613A1 (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19547022A1 (de) * 1995-12-15 1997-06-19 Boehringer Mannheim Gmbh Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
US6835721B2 (en) * 1999-02-01 2004-12-28 Eisai Co., Ltd. Immunomodulatory compounds and methods of use thereof
US6551600B2 (en) * 1999-02-01 2003-04-22 Eisai Co., Ltd. Immunological adjuvant compounds compositions and methods of use thereof
US7915238B2 (en) * 1999-02-01 2011-03-29 Eisai R & D Management Co., Ltd. Immunomodulatory compounds and methods of use thereof
US20040006242A1 (en) 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
US6818057B2 (en) 1999-03-02 2004-11-16 Construction Research & Technology Gmbh Retarder for calcium sulfoaluminate cements
US20040172288A1 (en) * 2003-02-27 2004-09-02 Korn Lawrence D. Method for disseminating medical alert information
US7976852B2 (en) * 2005-04-26 2011-07-12 Eisai R&D Management Co., Ltd. Compositions and methods for cancer immunotherapy
US20070292418A1 (en) * 2005-04-26 2007-12-20 Eisai Co., Ltd. Compositions and methods for immunotherapy
CA2740726A1 (en) * 2008-11-06 2010-05-14 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
EP2876094A1 (en) 2014-04-03 2015-05-27 Basf Se Cement and calcium sulphate based binder composition
KR101658048B1 (ko) * 2014-06-25 2016-09-20 한국생명공학연구원 포스파티딜콜린 합성경로 관여 물질을 포함하는 항바이러스용 조성물
CA3105038A1 (en) 2018-06-26 2020-01-02 Tsrl, Inc. Metabolically stable prodrugs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444766A (en) * 1980-10-21 1984-04-24 Boehringer Mannheim Gmbh Sulfur-containing phospholipid compounds and therapeutic compositions
US5194654A (en) * 1989-11-22 1993-03-16 Vical, Inc. Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
DE3929217A1 (de) * 1989-09-02 1991-03-07 Boehringer Mannheim Gmbh Verwendung von phospholipid-derivaten als antivirale arzneimittel und neue phospholipide
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
DE19547022A1 (de) * 1995-12-15 1997-06-19 Boehringer Mannheim Gmbh Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Also Published As

Publication number Publication date
EP0868425B1 (de) 2004-10-06
KR20000064374A (ko) 2000-11-06
CZ291823B6 (cs) 2003-06-18
ES2230574T3 (es) 2005-05-01
BR9612133A (pt) 1999-07-13
TW343975B (en) 1998-11-01
HUP0001534A3 (en) 2002-08-28
IL124790A0 (en) 1999-01-26
PL327173A1 (en) 1998-11-23
DE59611111D1 (de) 2004-11-11
EP0868425A1 (de) 1998-10-07
TR199801082T2 (xx) 1998-09-21
US6136797A (en) 2000-10-24
CA2240366A1 (en) 1997-06-26
JP2000515113A (ja) 2000-11-14
RU2166508C2 (ru) 2001-05-10
ATE278698T1 (de) 2004-10-15
CN1209133A (zh) 1999-02-24
IL124790A (en) 2002-04-21
AR005089A1 (es) 1999-04-14
AU714236B2 (en) 1999-12-23
AU1373097A (en) 1997-07-14
SK75698A3 (en) 1999-03-12
NZ325259A (en) 2000-01-28
WO1997022613A1 (de) 1997-06-26
CZ181098A3 (cs) 1998-10-14
PL186402B1 (pl) 2004-01-30
NO982754D0 (no) 1998-06-15
HUP0001534A2 (hu) 2001-05-28
CN1085672C (zh) 2002-05-29

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