NO980095L - Nye quinoxalin- og quinoxalinylalkan-forfonsyrer - Google Patents
Nye quinoxalin- og quinoxalinylalkan-forfonsyrerInfo
- Publication number
- NO980095L NO980095L NO980095A NO980095A NO980095L NO 980095 L NO980095 L NO 980095L NO 980095 A NO980095 A NO 980095A NO 980095 A NO980095 A NO 980095A NO 980095 L NO980095 L NO 980095L
- Authority
- NO
- Norway
- Prior art keywords
- free
- quinoxalinyl
- esterified
- alkane
- aliphatic
- Prior art date
Links
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 title abstract 4
- -1 quinoxalinyl alkane Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
- IVHVNMLJNASKHW-UHFFFAOYSA-M Chlorphonium chloride Chemical compound [Cl-].CCCC[P+](CCCC)(CCCC)CC1=CC=C(Cl)C=C1Cl IVHVNMLJNASKHW-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Quinoksalin- og quinoksalinylalkan-fosfonsyrer med formel I (I). der R, er fri eller forestret karboksy eller fri eller delvis forestret fosfon, R2 og R3 er hver uavhengig av hverandre hydrogen eller et alifatisk radikal, radikalene R,, R5 og R^ er hver uavhengig av hverandre hydrogen, et alifatisk hydrokarbonradikal, fri eller foretret hydroksy, fri eller foretret merkapto eller oksydert fri eller foretret merkapto, usubstitu- ert eller alifatisk substituert amin, nitro, fri eller forestret eller amidert karboksy, cyano, fri eller amidert sulfamoyl, halogen eller trifluormetyl og X er et toverdig alifatisk radi- kal, og deres tautomerer og/eller salter har NMDA-antagonistiske egenskaper og kan bli anvendt i behandling av patologiske tilstander som er responsive for blokkering av NMDA-sensitive reseptorer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH200995 | 1995-07-10 | ||
| PCT/EP1996/002866 WO1997003079A1 (en) | 1995-07-10 | 1996-07-01 | Novel quinoxaline- and quinoxalinylalkane-phosphonic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO980095D0 NO980095D0 (no) | 1998-01-09 |
| NO980095L true NO980095L (no) | 1998-03-05 |
Family
ID=4223780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO980095A NO980095L (no) | 1995-07-10 | 1998-01-09 | Nye quinoxalin- og quinoxalinylalkan-forfonsyrer |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0837864A1 (no) |
| JP (1) | JPH11508902A (no) |
| KR (1) | KR19990028839A (no) |
| AU (1) | AU6516296A (no) |
| BR (1) | BR9609644A (no) |
| CA (1) | CA2224718A1 (no) |
| CZ (1) | CZ5398A3 (no) |
| HU (1) | HUP9901345A3 (no) |
| IL (1) | IL122872A0 (no) |
| NO (1) | NO980095L (no) |
| PL (1) | PL324340A1 (no) |
| SK (1) | SK2798A3 (no) |
| TR (1) | TR199800022T1 (no) |
| WO (1) | WO1997003079A1 (no) |
| ZA (1) | ZA965800B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3908790B2 (ja) * | 1996-10-24 | 2007-04-25 | ノバルティス アクチエンゲゼルシャフト | 置換アミノアルカンホスホン酸 |
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118675A (en) * | 1991-02-15 | 1992-06-02 | American Home Products Corporation | Quinoxaline phosphono-amino acids |
| IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1996
- 1996-07-01 SK SK27-98A patent/SK2798A3/sk unknown
- 1996-07-01 EP EP96924829A patent/EP0837864A1/en not_active Withdrawn
- 1996-07-01 AU AU65162/96A patent/AU6516296A/en not_active Abandoned
- 1996-07-01 PL PL96324340A patent/PL324340A1/xx unknown
- 1996-07-01 CA CA002224718A patent/CA2224718A1/en not_active Abandoned
- 1996-07-01 TR TR1998/00022T patent/TR199800022T1/xx unknown
- 1996-07-01 IL IL12287296A patent/IL122872A0/xx unknown
- 1996-07-01 CZ CZ9853A patent/CZ5398A3/cs unknown
- 1996-07-01 BR BR9609644A patent/BR9609644A/pt not_active Application Discontinuation
- 1996-07-01 HU HU9901345A patent/HUP9901345A3/hu unknown
- 1996-07-01 JP JP9505465A patent/JPH11508902A/ja active Pending
- 1996-07-01 WO PCT/EP1996/002866 patent/WO1997003079A1/en not_active Application Discontinuation
- 1996-07-01 KR KR1019980700140A patent/KR19990028839A/ko not_active Application Discontinuation
- 1996-07-09 ZA ZA965800A patent/ZA965800B/xx unknown
-
1998
- 1998-01-09 NO NO980095A patent/NO980095L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11508902A (ja) | 1999-08-03 |
| EP0837864A1 (en) | 1998-04-29 |
| PL324340A1 (en) | 1998-05-25 |
| KR19990028839A (ko) | 1999-04-15 |
| ZA965800B (en) | 1997-01-10 |
| TR199800022T1 (xx) | 1998-05-21 |
| SK2798A3 (en) | 1998-07-08 |
| HUP9901345A3 (en) | 2000-01-28 |
| IL122872A0 (en) | 1998-08-16 |
| CZ5398A3 (cs) | 1998-06-17 |
| HUP9901345A2 (hu) | 1999-08-30 |
| WO1997003079A1 (en) | 1997-01-30 |
| CA2224718A1 (en) | 1997-01-30 |
| AU6516296A (en) | 1997-02-10 |
| BR9609644A (pt) | 1999-05-11 |
| NO980095D0 (no) | 1998-01-09 |
| MX9800332A (es) | 1998-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ID21927A (id) | Asam aminoalkanafosfonat tersubstitusi | |
| MY103021A (en) | Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors | |
| ATE233256T1 (de) | 2-pyrimidinamin derivaten und verfahrens zu deren herstellung | |
| DK0526488T3 (da) | Benzylphosphonsyre-tyrosinkinaseinhibitorer | |
| ES2039369T3 (es) | Un procedimiento para la produccion de nuevos derivados de acido picolinico. | |
| ATE168101T1 (de) | Arylpyridazinone | |
| DE69922703D1 (de) | Ureido-thiobuttersäurederivate als ppar-agonisten | |
| NO955326L (no) | Isokinolinderivater, fremgangsmåte for deres fremstilling og terapeutiske anvendelse | |
| DE3577580D1 (de) | Mittel und verfahren zum nachweis von redox-systemen. | |
| BR0005005A (pt) | Aditivo de polìmero para um meio de banho alcalino de eletrogalvanização de zinco ou liga de zinco, meio de banho alcalino de zinco ou liga de zinco, processo para eletrogalvanizar zinco e/ou ligas de zinco em um substrato condutivo, e uso do polìmero | |
| NO980095L (no) | Nye quinoxalin- og quinoxalinylalkan-forfonsyrer | |
| ZA982137B (en) | Cycloalkylalkanecarboxamides and their preparation and use. | |
| ATE104965T1 (de) | Chinolinderivate, ihre herstellung und verwendung. | |
| DK227085A (da) | 1-halogen-1-azolyl-2,2-diaryl-ethan-derivater, salte og metalkomplekser deraf samt deres fremstilling og anvendelse | |
| ATE163402T1 (de) | Substituierte ortho- ethenylphenylessigsäurederivate | |
| KR930702269A (ko) | 포스포리파제 a2저해 물질 | |
| TR199903159T2 (xx) | Yeni �-Amino ve �-Azido karbonik asit t�revleri. | |
| DK373985D0 (da) | Substituerede pyridazinoner samt deres fremstilling og anvendelse | |
| EP0222578A3 (en) | Use of cyclic somatostatin analogues in the treatment of immediate hypersensitivity diseases | |
| ES486050A1 (es) | Procedimiento de preparacion de ditiocarbamatos | |
| ES8800913A1 (es) | Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno | |
| IE35122L (en) | Aminopropionic acid derivatives | |
| NO943791L (no) | 1,2-dihydro-2-okso-3-metylsulfonylaminometylpyridin | |
| YU30696A (sh) | Postupak za pripremanje supstituisanih 8-hidroksihinolina | |
| ES2010505B3 (es) | Procedimiento de preparacion de acidos alcanoicos. |