HUP9901345A2 - Új kinoxalin- és kinoxalinil-alkán-foszfonsavak - Google Patents
Új kinoxalin- és kinoxalinil-alkán-foszfonsavakInfo
- Publication number
- HUP9901345A2 HUP9901345A2 HU9901345A HUP9901345A HUP9901345A2 HU P9901345 A2 HUP9901345 A2 HU P9901345A2 HU 9901345 A HU9901345 A HU 9901345A HU P9901345 A HUP9901345 A HU P9901345A HU P9901345 A2 HUP9901345 A2 HU P9901345A2
- Authority
- HU
- Hungary
- Prior art keywords
- free
- aliphatic
- etherified
- mercaptans
- powder
- Prior art date
Links
- 239000000843 powder Substances 0.000 abstract 3
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 235000014787 Vitis vinifera Nutrition 0.000 abstract 1
- 240000006365 Vitis vinifera Species 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000946 synaptic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya (I) általánős képletű új kinőxőlin- vagykinőxalinil-alkán-főszfőnsavak - ahől R1 jelentése szabad vagy részlegesen észterezett főszfőnőcsőpőrt; R2 és R3 jelentése egymástól függetlenül hidrőgénatőm vagy alifáscsőpőrt; R4, R5 és R6 jelentése egymástól függetlenül hidrőgénatőm, alifásszénhidrőgéncsőpőrt, szabad vagy éterezett hidrőxilcsőpőrt, szabadvagy éterezett merkaptő- vagy őxidált szabad vagy éterezettmerkaptőcsőpőrt, adőtt esetben alifás csőpőrttal szűbsztitűált aminő-,nitrőcsőpőrt, szabad vagy észterezett vagy amidált karbőxilcsőpőrt,cianőcsőpőrt, szabad vagy amidált szűlfamőilcsőpőrt, halőgénatőm vagytriflűőr-metil-csőpőrt; és X jelentése kétértékű alifás csőpőrt - vagy aűtőmerjeik vagy sóik. Az (I) általánős képletű vegyületek NMDAantagőnista tűlajdőnságúak és az NMDA-szenzitív receptőrőkblőkkőlásával kapcsőlatős rendellenességek kezelésében alkalmazhatók. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH200995 | 1995-07-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901345A2 true HUP9901345A2 (hu) | 1999-08-30 |
| HUP9901345A3 HUP9901345A3 (en) | 2000-01-28 |
Family
ID=4223780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901345A HUP9901345A3 (en) | 1995-07-10 | 1996-07-01 | Novel quinoxaline- and quinoxalinylalkane-phosphonic acids |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0837864A1 (hu) |
| JP (1) | JPH11508902A (hu) |
| KR (1) | KR19990028839A (hu) |
| AU (1) | AU6516296A (hu) |
| BR (1) | BR9609644A (hu) |
| CA (1) | CA2224718A1 (hu) |
| CZ (1) | CZ5398A3 (hu) |
| HU (1) | HUP9901345A3 (hu) |
| IL (1) | IL122872A0 (hu) |
| NO (1) | NO980095L (hu) |
| PL (1) | PL324340A1 (hu) |
| SK (1) | SK2798A3 (hu) |
| TR (1) | TR199800022T1 (hu) |
| WO (1) | WO1997003079A1 (hu) |
| ZA (1) | ZA965800B (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3908790B2 (ja) * | 1996-10-24 | 2007-04-25 | ノバルティス アクチエンゲゼルシャフト | 置換アミノアルカンホスホン酸 |
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118675A (en) * | 1991-02-15 | 1992-06-02 | American Home Products Corporation | Quinoxaline phosphono-amino acids |
| IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1996
- 1996-07-01 SK SK27-98A patent/SK2798A3/sk unknown
- 1996-07-01 EP EP96924829A patent/EP0837864A1/en not_active Withdrawn
- 1996-07-01 AU AU65162/96A patent/AU6516296A/en not_active Abandoned
- 1996-07-01 PL PL96324340A patent/PL324340A1/xx unknown
- 1996-07-01 CA CA002224718A patent/CA2224718A1/en not_active Abandoned
- 1996-07-01 TR TR1998/00022T patent/TR199800022T1/xx unknown
- 1996-07-01 IL IL12287296A patent/IL122872A0/xx unknown
- 1996-07-01 CZ CZ9853A patent/CZ5398A3/cs unknown
- 1996-07-01 BR BR9609644A patent/BR9609644A/pt not_active Application Discontinuation
- 1996-07-01 HU HU9901345A patent/HUP9901345A3/hu unknown
- 1996-07-01 JP JP9505465A patent/JPH11508902A/ja active Pending
- 1996-07-01 WO PCT/EP1996/002866 patent/WO1997003079A1/en not_active Application Discontinuation
- 1996-07-01 KR KR1019980700140A patent/KR19990028839A/ko not_active Application Discontinuation
- 1996-07-09 ZA ZA965800A patent/ZA965800B/xx unknown
-
1998
- 1998-01-09 NO NO980095A patent/NO980095L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11508902A (ja) | 1999-08-03 |
| EP0837864A1 (en) | 1998-04-29 |
| PL324340A1 (en) | 1998-05-25 |
| KR19990028839A (ko) | 1999-04-15 |
| ZA965800B (en) | 1997-01-10 |
| TR199800022T1 (xx) | 1998-05-21 |
| SK2798A3 (en) | 1998-07-08 |
| HUP9901345A3 (en) | 2000-01-28 |
| IL122872A0 (en) | 1998-08-16 |
| CZ5398A3 (cs) | 1998-06-17 |
| WO1997003079A1 (en) | 1997-01-30 |
| CA2224718A1 (en) | 1997-01-30 |
| AU6516296A (en) | 1997-02-10 |
| BR9609644A (pt) | 1999-05-11 |
| NO980095D0 (no) | 1998-01-09 |
| NO980095L (no) | 1998-03-05 |
| MX9800332A (es) | 1998-07-31 |
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