NO963655L - Nye aminosyrederivater, fremgangsmåte for fremstilling av dem og farmasöytiske blandinger som inneholder dem - Google Patents

Nye aminosyrederivater, fremgangsmåte for fremstilling av dem og farmasöytiske blandinger som inneholder dem

Info

Publication number
NO963655L
NO963655L NO963655A NO963655A NO963655L NO 963655 L NO963655 L NO 963655L NO 963655 A NO963655 A NO 963655A NO 963655 A NO963655 A NO 963655A NO 963655 L NO963655 L NO 963655L
Authority
NO
Norway
Prior art keywords
preparation
amino acid
acid derivatives
pharmaceutical compositions
compositions containing
Prior art date
Application number
NO963655A
Other languages
English (en)
Other versions
NO963655D0 (no
Inventor
Franz Esser
Gerd Schnorrenberg
Horst Dollinger
Birgit Jung
Erich Buerger
Georg Speck
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944406885 external-priority patent/DE4406885A1/de
Priority claimed from DE4406884A external-priority patent/DE4406884A1/de
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of NO963655D0 publication Critical patent/NO963655D0/no
Publication of NO963655L publication Critical patent/NO963655L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen vedrører nye aminosyrederivater med den generelle formel l Ri-C-A-R2 (l) og deres farmasøytisk akseptable salter, hvori gruppen R2 er og R1, A, G, Y, Z og m har de i beskrivelsen angitte betydninger, samt deres fremstilling og anvendelse. De nye forbindelser er verdifulle neurikinin (tachykinin)- antagonister.
NO963655A 1994-03-03 1996-09-02 Nye aminosyrederivater, fremgangsmåte for fremstilling av dem og farmasöytiske blandinger som inneholder dem NO963655L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19944406885 DE4406885A1 (de) 1994-03-03 1994-03-03 Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4406884A DE4406884A1 (de) 1994-03-03 1994-03-03 Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
PCT/EP1995/000760 WO1995023810A1 (de) 1994-03-03 1995-03-02 Aminosäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen

Publications (2)

Publication Number Publication Date
NO963655D0 NO963655D0 (no) 1996-09-02
NO963655L true NO963655L (no) 1996-11-01

Family

ID=25934302

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963655A NO963655L (no) 1994-03-03 1996-09-02 Nye aminosyrederivater, fremgangsmåte for fremstilling av dem og farmasöytiske blandinger som inneholder dem

Country Status (18)

Country Link
US (1) US5712397A (no)
EP (1) EP0802922B1 (no)
JP (1) JP2801087B2 (no)
KR (1) KR970701727A (no)
CN (1) CN1142228A (no)
AT (1) ATE206135T1 (no)
AU (1) AU1812795A (no)
CA (1) CA2182396A1 (no)
CZ (1) CZ254296A3 (no)
DE (1) DE59509647D1 (no)
FI (1) FI963440A (no)
HU (1) HUT75527A (no)
MX (1) MX9603272A (no)
NO (1) NO963655L (no)
NZ (1) NZ281240A (no)
PE (1) PE45195A1 (no)
PL (1) PL316114A1 (no)
WO (1) WO1995023810A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) * 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
IL141063A (en) * 1998-08-07 2005-06-19 Applied Research Systems Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility
JP2005504029A (ja) * 2001-07-20 2005-02-10 ファイザー・プロダクツ・インク 犬の好ましくない行動を改善するためのｎｋ−１受容体アンタゴニストの使用
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
WO1993001169A2 (en) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
ATE186548T1 (de) * 1992-09-03 1999-11-15 Boehringer Ingelheim Pharma Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen

Also Published As

Publication number Publication date
MX9603272A (es) 1997-03-29
ATE206135T1 (de) 2001-10-15
EP0802922A1 (de) 1997-10-29
PE45195A1 (es) 1996-01-17
NZ281240A (en) 1997-09-22
FI963440A0 (fi) 1996-09-03
JPH09505317A (ja) 1997-05-27
EP0802922B1 (de) 2001-09-26
FI963440A (fi) 1996-09-03
DE59509647D1 (de) 2001-10-31
AU1812795A (en) 1995-09-18
HUT75527A (en) 1997-05-28
WO1995023810A1 (de) 1995-09-08
KR970701727A (ko) 1997-04-12
NO963655D0 (no) 1996-09-02
CN1142228A (zh) 1997-02-05
US5712397A (en) 1998-01-27
CA2182396A1 (en) 1995-09-08
PL316114A1 (en) 1996-12-23
JP2801087B2 (ja) 1998-09-21
CZ254296A3 (en) 1997-06-11
HU9602402D0 (en) 1996-10-28

Similar Documents

Publication Publication Date Title
FI941987A (fi) Uudet aminohappojohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät farmaseuttiset koostumukset
CA2234610A1 (en) New amino acid derivatives, processes for preparing them and pharmaceutical compositions containing these compounds
BG100946A (en) New amino acid derivatives, method for their preparation and pharmaceutical compositions containing them
DK0894084T3 (da) Kanelsyrederivater og deres anvendelse som integrinantagonister
IL112716A0 (en) Ureido derivatives of naphthalenephosphonic acid, their preparation and pharmaceutical compositions containing them
CA2218096A1 (en) New arylglycinamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
ATE36699T1 (de) Chinonderivate, verfahren zu ihrer herstellung, ihre verwendung und pharmazeutische zusammensetzung.
NO963655L (no) Nye aminosyrederivater, fremgangsmåte for fremstilling av dem og farmasöytiske blandinger som inneholder dem
YU8197A (sh) Novi derivati arilglicinamida, postupci za njihovo pripremanje i farmaceutski preparati koji sadreže ova jedinjenja
SE9103022D0 (sv) Nya 5h-bensodiazepinderivat, farmaceutiska kompositioner innehaallande desamma samt foerfarande foer framstaellning av dessa
DE69417907D1 (de) Anthracyclin-disaccharide, verfahren zu ihrer herstellung, und diese enthaltende arzneimittel
ATE63114T1 (de) Piperazinderivate, verfahren zu ihrer herstellung und diese als wirkstoffe enthaltende pharmazeutische zusammensetzungen.
UY26971A1 (es) Nuevos antagonistas de neuroquinina, procedimiento para su preparación y composiciones farmacéuticas que contienen estos compuestos
SE8206230L (sv) Nya cykliska iminderivat, sett for deras framstellning och farmaceutiska beredningar innehallande dem
ECSP951512A (es) Antagonistas de neuroquinina