NO963496L - Injiserbare emulsjoner inneholdende antifungale derivater - Google Patents

Injiserbare emulsjoner inneholdende antifungale derivater

Info

Publication number
NO963496L
NO963496L NO963496A NO963496A NO963496L NO 963496 L NO963496 L NO 963496L NO 963496 A NO963496 A NO 963496A NO 963496 A NO963496 A NO 963496A NO 963496 L NO963496 L NO 963496L
Authority
NO
Norway
Prior art keywords
group
water
hydrogen atom
emulsions containing
containing antifungal
Prior art date
Application number
NO963496A
Other languages
English (en)
Inventor
Jun Sato
Akiko Watanabe
Susumu Iwasa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO963496L publication Critical patent/NO963496L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Injlserbar olje-l-vann-emulsjonssammensetnlng omfat- tende en antlfungal trlazolforblndelse med den følgende formel (I) OR< RI -CH2-C¿C-A l l Ar R2 (D hvor Ar står for en substituert fenylgruppe; R1 og R2 står uavhengig for et hydrogenatom eller en lavere alkylgruppe, eller R1 og R2 kan sammen danne en lavere alkylengruppe; R4 står for et hydrogenatom eller en acylgruppe; og A står for en eventuelt substituert cykllsk amldgruppe bundet via et nltrogenatom, eller et salt derav. Oppleseligheten til trlazolforblndelsen med dårlig vannoppløsellghet og fettoppløsellghet kan bil betydelig øket ved dlspergerlng l vann ved anvendelse av en oljekomponent (f.eks. et trlglyserld av fett- syrer) og en eraulgator (f.eks. et fosfollpld).
NO963496A 1994-02-25 1996-08-22 Injiserbare emulsjoner inneholdende antifungale derivater NO963496L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2847494 1994-02-25
PCT/JP1995/000260 WO1995022973A1 (en) 1994-02-25 1995-02-23 Injectable emulsions containing antifungal triazole derivatives

Publications (1)

Publication Number Publication Date
NO963496L true NO963496L (no) 1996-08-22

Family

ID=12249651

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963496A NO963496L (no) 1994-02-25 1996-08-22 Injiserbare emulsjoner inneholdende antifungale derivater

Country Status (11)

Country Link
US (1) US5814324A (no)
EP (1) EP0746318A1 (no)
CN (1) CN1141588A (no)
AU (1) AU682580B2 (no)
CA (1) CA2182698A1 (no)
FI (1) FI963297A (no)
HU (1) HUT74735A (no)
NO (1) NO963496L (no)
NZ (1) NZ281327A (no)
WO (1) WO1995022973A1 (no)
ZA (1) ZA951578B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2150533A1 (en) * 1994-05-31 1995-12-01 Katsumi Itoh Production of optically active triazole compounds and their intermediates
TW318841B (no) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
DE69923300T2 (de) 1998-03-09 2006-01-05 Takeda Pharmaceutical Co. Ltd. Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
NZ511792A (en) 1998-11-20 2003-08-29 Skyepharma Canada Inc Dispersible phospholipid stabilized microparticles
ATE345122T1 (de) * 2000-02-04 2006-12-15 Takeda Pharmaceutical Stabile emulsionszubereitungen
US7960416B2 (en) * 2001-08-03 2011-06-14 Takeda Pharmaceutical Company Limited Stable emulsion composition
CA2618655C (en) 2005-07-18 2015-12-22 University Of Massachusetts Lowell Compositions and methods for making and using nanoemulsions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
BRPI0719732A2 (pt) 2006-12-01 2017-05-16 Anterios Inc nanopartículas de peptídeo e usos para as mesmas
BRPI0719756A2 (pt) 2006-12-01 2014-01-21 Anterios Inc Nanopartículas de entidades anfifílicas
KR20100050443A (ko) 2007-05-31 2010-05-13 안테리오스, 인코퍼레이티드 핵산 나노입자 및 이의 용도
US11311496B2 (en) 2016-11-21 2022-04-26 Eirion Therapeutics, Inc. Transdermal delivery of large agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384545A (en) * 1965-03-09 1968-05-21 Hoffmann La Roche Injectable aqueous emulsions of fat soluble vitamins
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
DE3623376A1 (de) * 1986-07-11 1988-01-21 Behringwerke Ag Pharmazeutische formulierung und verfahren zu deren herstellung
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
JP3074731B2 (ja) * 1989-12-01 2000-08-07 日本新薬株式会社 脂肪乳剤
US5326789A (en) * 1989-12-11 1994-07-05 Isp Investments Inc. Water-based microemulsions of a triazole fungicide
TW218017B (no) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
CA2182698A1 (en) 1995-08-31
WO1995022973A1 (en) 1995-08-31
CN1141588A (zh) 1997-01-29
HUT74735A (en) 1997-02-28
FI963297A (fi) 1996-10-18
ZA951578B (en) 1995-12-12
EP0746318A1 (en) 1996-12-11
HU9602334D0 (en) 1996-10-28
FI963297A0 (fi) 1996-08-23
AU682580B2 (en) 1997-10-09
AU1823495A (en) 1995-09-11
MX9603630A (es) 1998-07-31
US5814324A (en) 1998-09-29
NZ281327A (en) 1997-07-27

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