NO963483L - Nye indolderivater som er anvendbare for å behandle östrogen-relaterte neoplasmer og forstyrrelser - Google Patents
Nye indolderivater som er anvendbare for å behandle östrogen-relaterte neoplasmer og forstyrrelserInfo
- Publication number
- NO963483L NO963483L NO963483A NO963483A NO963483L NO 963483 L NO963483 L NO 963483L NO 963483 A NO963483 A NO 963483A NO 963483 A NO963483 A NO 963483A NO 963483 L NO963483 L NO 963483L
- Authority
- NO
- Norway
- Prior art keywords
- indole derivatives
- derivatives useful
- disorders
- neoplasms
- treating estrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Foreliggende oppfinnelse angår !nye indolderivater av formel (I) (CH2)p-C-N-(CHi)n-C---N som er anvendbare ved nedregulering av østrogenreseptorekspresjon. ; Også innbefattet er metoder for behandling av neoplasmer eller for regulering av veksten av en neo- plasme i en pasient angrepet av en neoplastisk sykdom, spesielt østrogen-avhengige neoplasmer slik som de som er assosiert med bryst-, ovarie-og cervikalt vev. En annen utførelsesform av foreliggende oppfinnelse er en metode for pro- fylaktisk behandling av en pasient med risiko for å utvikle en neo- plastisk sykdomstilstand. Også tilveiebragt er en metode for behandling av autoimmune sykdommer. Også innbefattet er farmasøytiske preparater av de nye indol- derivater.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20005794A | 1994-02-22 | 1994-02-22 | |
US36204694A | 1994-12-22 | 1994-12-22 | |
PCT/US1995/001372 WO1995022524A1 (en) | 1994-02-22 | 1995-01-31 | Novel indole derivatives useful to treat estrogen-related neoplasms and disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
NO963483D0 NO963483D0 (no) | 1996-08-21 |
NO963483L true NO963483L (no) | 1996-10-22 |
Family
ID=26895427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO963483A NO963483L (no) | 1994-02-22 | 1996-08-21 | Nye indolderivater som er anvendbare for å behandle östrogen-relaterte neoplasmer og forstyrrelser |
Country Status (17)
Country | Link |
---|---|
US (1) | US5877202A (no) |
EP (1) | EP0746544B1 (no) |
JP (1) | JP3536258B2 (no) |
KR (1) | KR100362864B1 (no) |
CN (1) | CN1141627A (no) |
AT (1) | ATE170839T1 (no) |
AU (1) | AU680740B2 (no) |
CA (1) | CA2183731C (no) |
DE (1) | DE69504637T2 (no) |
DK (1) | DK0746544T3 (no) |
ES (1) | ES2122555T3 (no) |
FI (1) | FI963272A (no) |
HU (1) | HUT76133A (no) |
IL (1) | IL112700A0 (no) |
NO (1) | NO963483L (no) |
NZ (1) | NZ281431A (no) |
WO (1) | WO1995022524A1 (no) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5880137A (en) * | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
AU6015098A (en) * | 1997-02-24 | 1998-09-09 | Cornell Research Foundation Inc. | Method of screening agents as candidates for drugs or sources of drugs |
US6150395A (en) | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
AU3894299A (en) * | 1998-05-15 | 1999-12-06 | American Home Products Corporation | Compositions comprising 2-phenyl-indole compounds and estrogen formulations |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
EP1212335B1 (en) * | 1999-09-13 | 2006-01-18 | Wyeth | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1- 4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
CA2424222A1 (en) * | 2000-10-02 | 2002-04-11 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US20030130199A1 (en) * | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
FR2842526B1 (fr) | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments |
US7414067B2 (en) * | 2003-03-27 | 2008-08-19 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
CA2562783A1 (en) | 2004-04-26 | 2005-12-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
US8765488B2 (en) | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
CN101360422B (zh) | 2005-11-23 | 2013-10-23 | 得克萨斯大学体系董事会 | 致癌Ras特异性细胞毒化合物及其使用方法 |
WO2011047156A1 (en) | 2009-10-15 | 2011-04-21 | Hercules Technology Management Co V, Inc. | Sepiapterin reductase inhibitors for the treatment of pain |
US9523105B2 (en) | 2010-08-30 | 2016-12-20 | Arzeda Corporation | Fermentation route for the production of levulinic acid, levulinate esters and valerolactone and derivatives thereof |
EP2768499A4 (en) | 2011-10-17 | 2015-08-26 | Univ Vanderbilt | INDOMETACIN ANALOGUES FOR THE TREATMENT OF CANCER PROSTATE RESISTANT TO CASTRATION |
AU2013202982C1 (en) * | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
WO2013131235A1 (zh) * | 2012-03-05 | 2013-09-12 | 大连理工大学 | 一类以萘为母体的双光子荧光探针、其制备方法及应用 |
TW202222786A (zh) | 2016-02-01 | 2022-06-16 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
US10815247B2 (en) * | 2016-12-28 | 2020-10-27 | Promega Corporation | Functionalized NANOLUC inhibitors |
EP4334285A1 (en) * | 2021-05-05 | 2024-03-13 | Kare Chemical Technologies Inc. | Catalytic tryptamine processes and precursors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1482845A (fr) * | 1964-12-31 | 1967-06-02 | Merck & Co Inc | Composés de l'indol |
ATE118207T1 (de) * | 1989-12-04 | 1995-02-15 | Searle & Co | Heterozyklische acylaminodiol-beta-aminosäure- derivate. |
JPH05504968A (ja) * | 1990-03-07 | 1993-07-29 | ローン―プーラン・ロレ・ソシエテ・アノニム | グリシンアミド誘導体、その製造及びそれを含む医薬品 |
US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
EP0639567A1 (en) * | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
JPH0835029A (ja) * | 1994-07-19 | 1996-02-06 | Toyota Motor Corp | 高強度高延性鋳造アルミニウム合金およびその製造方法 |
-
1995
- 1995-01-31 NZ NZ281431A patent/NZ281431A/en unknown
- 1995-01-31 AT AT95910164T patent/ATE170839T1/de not_active IP Right Cessation
- 1995-01-31 DK DK95910164T patent/DK0746544T3/da active
- 1995-01-31 HU HU9602299A patent/HUT76133A/hu unknown
- 1995-01-31 DE DE69504637T patent/DE69504637T2/de not_active Expired - Lifetime
- 1995-01-31 ES ES95910164T patent/ES2122555T3/es not_active Expired - Lifetime
- 1995-01-31 KR KR1019960704579A patent/KR100362864B1/ko not_active IP Right Cessation
- 1995-01-31 AU AU18373/95A patent/AU680740B2/en not_active Ceased
- 1995-01-31 JP JP52182295A patent/JP3536258B2/ja not_active Expired - Lifetime
- 1995-01-31 CA CA002183731A patent/CA2183731C/en not_active Expired - Lifetime
- 1995-01-31 EP EP95910164A patent/EP0746544B1/en not_active Expired - Lifetime
- 1995-01-31 CN CN95191750A patent/CN1141627A/zh active Pending
- 1995-01-31 WO PCT/US1995/001372 patent/WO1995022524A1/en active IP Right Grant
- 1995-02-20 IL IL11270095A patent/IL112700A0/xx unknown
-
1996
- 1996-01-31 US US08/594,505 patent/US5877202A/en not_active Expired - Lifetime
- 1996-08-21 FI FI963272A patent/FI963272A/fi unknown
- 1996-08-21 NO NO963483A patent/NO963483L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0746544B1 (en) | 1998-09-09 |
IL112700A0 (en) | 1995-05-26 |
DE69504637D1 (de) | 1998-10-15 |
US5877202A (en) | 1999-03-02 |
KR100362864B1 (ko) | 2003-04-16 |
FI963272A0 (fi) | 1996-08-21 |
EP0746544A1 (en) | 1996-12-11 |
NZ281431A (en) | 1997-09-22 |
DK0746544T3 (da) | 1999-06-07 |
AU1837395A (en) | 1995-09-04 |
AU680740B2 (en) | 1997-08-07 |
JP3536258B2 (ja) | 2004-06-07 |
CA2183731C (en) | 2000-03-21 |
ES2122555T3 (es) | 1998-12-16 |
NO963483D0 (no) | 1996-08-21 |
JPH09509169A (ja) | 1997-09-16 |
HUT76133A (en) | 1997-06-30 |
ATE170839T1 (de) | 1998-09-15 |
CA2183731A1 (en) | 1995-08-24 |
CN1141627A (zh) | 1997-01-29 |
DE69504637T2 (de) | 1999-05-06 |
WO1995022524A1 (en) | 1995-08-24 |
FI963272A (fi) | 1996-08-21 |
HU9602299D0 (en) | 1996-10-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO963483L (no) | Nye indolderivater som er anvendbare for å behandle östrogen-relaterte neoplasmer og forstyrrelser | |
Kadakia et al. | The effect of hormones on the voice | |
NO985975L (no) | Blandinger og fremgangsmÕter for frembringelse av farmakologisk aktive preparater og anvendelser derav | |
ATE228003T1 (de) | Verwendung von cntf (ciliary neurotrophic factor) rezeptoraktivatoren fur behandlung von fettleibigkeit | |
DE69521620D1 (de) | Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom | |
TR200103104T2 (tr) | Glukortikoid alıcı modülatörleri | |
NO981203L (no) | Selektive <beta>3 -adrenergiske agonister | |
NO20055919L (no) | 3-Subtituerte,5,6-Diaryl-Pyrazin-2-Karboksamid og 2-Sulfonamidderivater som CB1-Modulatorar | |
PT101087A (pt) | Derivados de indole | |
DE69820632D1 (de) | 2-phenyl-substituierte 1-(n-phenylaminoalkyl)-piperazin-derivate | |
NO994901L (no) | Behandling av sentralnerveforstyrrelser ved selektive östrogenreseptormodulatorer | |
NO20033821L (no) | Anvendelse av GABA A inverse agonister i kombinasjon med nikotinreseptordelagonister, östrogen, selektive östrogenmodulatorer, ellervitamin E for behandling av kognitive forstyrrelser | |
EA200401078A1 (ru) | Применение фитоэстрогенсодержащих экстрактов, селективно модулирующих бета-рецептор эстрогена | |
ATE260653T1 (de) | Verwendung von naaladase inhibitoren zur behandlung von angstzuständen und gedächtnisstörungen | |
ATE171873T1 (de) | Antiglucocorticoidsteroide zur behandlung von angststörungen | |
DE69725879D1 (de) | VERWENDUNG VON p-AMINOPHENOLDERIVATEN ZUR HERSTELLUNG VON PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN | |
DK1525215T3 (da) | Modulatorer for receptoren for progesteron med forhöjet anti-gonadotrop aktivitet til fertilitetskontrol hos kvinder og ved terapi til erstatning af hormoner | |
NZ512923A (en) | Potent sulfatase inhibitors that are metabolically stable, selective and devoid of estrogenic activity | |
DE60042446D1 (de) | Verwendung von antagonisten der 5-ht3-rezeptoren zur behandlung von muskuloeskeletalen erkrankungen | |
BR0309032A (pt) | Método para tratar sintomas vasomotores, a menopausa, deficiências hormonais em um paciente, e para tratar um paciente que sofre de sintomas vasomotores | |
NO980375L (no) | Humant MP52 Arg protein | |
ATE293994T1 (de) | Multivalente rekombinante antikörper zur behandlung von hrv infektionen | |
HUP0100742A2 (hu) | Cikloprop[14,15]-ösztriol származékok alkalmazása a központi idegrendszerben az ösztrogénhiány pótlására szolgáló gyógyszerkészítmények előállítására | |
RU94000387A (ru) | Способ лечения врожденного вывиха надколенника |