NO962127L - Isoksakinforbindelser som anti-innflammatoriske midler - Google Patents

Isoksakinforbindelser som anti-innflammatoriske midler

Info

Publication number
NO962127L
NO962127L NO962127A NO962127A NO962127L NO 962127 L NO962127 L NO 962127L NO 962127 A NO962127 A NO 962127A NO 962127 A NO962127 A NO 962127A NO 962127 L NO962127 L NO 962127L
Authority
NO
Norway
Prior art keywords
pct
date
compounds
pdeiv
sec
Prior art date
Application number
NO962127A
Other languages
English (en)
Other versions
NO962127D0 (no
Inventor
Edward F Kleinman
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO962127L publication Critical patent/NO962127L/no
Publication of NO962127D0 publication Critical patent/NO962127D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Denne oppfinnelse vedrører nye isokazolinforbindelser som er selektive inhibitorer for fosfodiesterase type IV (PDEIV). De nye isoksazolinforbindelser er anvendelige til inhibering av PDEIV og til behandling av AIDS, astma, artritt, bronkitt, kronisk opstruktiv lungesykdom, psoriasis, allergisk rhinitt, dermatitt, sjokk, atopisk dermatitt, reumatoid artritt og osteoartritt. Denne oppfinnelse vedrører også farmasøytiske blandinger anvendelige for disse.
NO962127A 1993-11-26 1996-05-24 Isoksakinforbindelser som anti-innflammatoriske midler NO962127D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15724893A 1993-11-26 1993-11-26
US26208694A 1994-06-17 1994-06-17
PCT/IB1994/000333 WO1995014681A1 (en) 1993-11-26 1994-10-26 Isoxazoline compounds as antiinflammatory agents

Publications (2)

Publication Number Publication Date
NO962127L true NO962127L (no) 1996-05-24
NO962127D0 NO962127D0 (no) 1996-05-24

Family

ID=26853945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962127A NO962127D0 (no) 1993-11-26 1996-05-24 Isoksakinforbindelser som anti-innflammatoriske midler

Country Status (24)

Country Link
US (1) US5716967A (no)
EP (1) EP0730588B1 (no)
JP (1) JP2802547B2 (no)
KR (1) KR0182324B1 (no)
CN (1) CN1046274C (no)
AT (1) ATE154932T1 (no)
AU (1) AU687452B2 (no)
BR (1) BR9408174A (no)
CA (1) CA2176255C (no)
CO (1) CO4180606A1 (no)
CZ (1) CZ283564B6 (no)
DE (1) DE69404044T2 (no)
DK (1) DK0730588T3 (no)
EG (1) EG20693A (no)
ES (1) ES2104424T3 (no)
FI (1) FI945557A (no)
GR (1) GR3024133T3 (no)
HU (1) HUT76784A (no)
IL (1) IL111670A (no)
NO (1) NO962127D0 (no)
NZ (1) NZ274244A (no)
PE (1) PE33495A1 (no)
PL (1) PL314605A1 (no)
WO (1) WO1995014681A1 (no)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
US5869511A (en) * 1994-03-09 1999-02-09 Pfizer Inc. Isoxazoline compounds as inhibitors of TNF release
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
US6245774B1 (en) * 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412573D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
US7491740B2 (en) * 2001-06-08 2009-02-17 Cytokine Pharmasciences, Inc. Isoxazoline compounds having MIF antagonist activity
EP0934307B1 (en) 1996-06-19 2011-04-27 Aventis Pharma Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
EP0946523A1 (en) 1996-12-23 1999-10-06 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
US6022977A (en) * 1997-03-26 2000-02-08 Dupont Pharmaceuticals Company Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
DZ3019A1 (fr) * 1999-03-01 2005-05-20 Smithkline Beecham Corp Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd.
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
ATE320800T1 (de) 1999-08-21 2006-04-15 Altana Pharma Ag Synergistische kombination von roflumilast und salmeterol
CN1137888C (zh) * 1999-09-17 2004-02-11 株式会社Lgci 半胱氨酰天冬氨酸蛋白酶抑制剂
KR100399361B1 (ko) 1999-11-04 2003-09-26 주식회사 엘지생명과학 캐스파제 억제제 함유 치료제 조성물
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
DE19953024A1 (de) * 1999-11-04 2001-05-10 Merck Patent Gmbh Isoxazolderivate als Phosphodiesterase VII-Hemmer
GB2362101A (en) * 2000-05-12 2001-11-14 Astrazeneca Ab Treatment of chronic obstructive pulmonary disease
EP1389468A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS PROMOTING THE GUISON OF A BONE FRACTURE
KR20040007583A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 연골 질환의 재생치료용 조성물
AU2002312933B2 (en) * 2001-05-29 2007-12-06 Schering Ag CDK inhibiting pyrimidines, production thereof and their use as medicaments
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
AU2003301903A1 (en) * 2002-11-06 2004-06-03 Bristol-Myers Squibb Company Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
AU2004268847A1 (en) * 2003-08-29 2005-03-10 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-IV
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
WO2005051931A2 (en) * 2003-11-26 2005-06-09 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
CN102532048B (zh) 2004-03-05 2015-06-24 日产化学工业株式会社 异噁唑啉取代苯甲酰胺化合物的制备中间体
EP1727542A4 (en) * 2004-03-26 2009-08-05 Cytokine Pharmasciences Inc COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE FOR INHIBITING MACROPHAGE MIGRATION INHIBITION FACTOR
US20080009535A1 (en) * 2004-08-30 2008-01-10 Sarala Balachandran Inhibitors of phosphodiesterase type-IV
SE0402591D0 (sv) * 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
ES2370788T3 (es) * 2005-02-07 2011-12-22 Aerocrine Ab Controlar flujo de aliento exhalado durante análisis.
WO2006097273A1 (en) * 2005-03-15 2006-09-21 Ganial Immunotherapeutics Inc. Compounds having immunomodulator activity
PL1889198T3 (pl) 2005-04-28 2015-04-30 Proteus Digital Health Inc System farmakologiczno-informatyczny
EP1879884B1 (en) * 2005-05-03 2010-08-25 Ranbaxy Laboratories Limited Azole-based phosphodiesterase inhibitors
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2643199A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
WO2008030651A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20100029728A1 (en) * 2006-09-22 2010-02-04 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP3366698A1 (en) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylate cyclase c agonists
MX350825B (es) 2011-03-31 2017-09-22 Bayer Ip Gmbh 3-fenilisoxazolin-5-carboxamidas y 3-fenilisoxazolin-5-tioamidas de accion herbicida y fungicida.
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US20150064221A1 (en) 2012-04-17 2015-03-05 Niranjan Y. Sardesai Compounds having immunomudulator activity
KR101977920B1 (ko) * 2012-09-25 2019-05-13 바이엘 크롭사이언스 악티엔게젤샤프트 제초 작용을 가지는 3-페닐이속사졸린 유도체
WO2014081752A1 (en) * 2012-11-20 2014-05-30 Biogen Idec Ma Inc. S1p and/or atx modulating agents
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CN103381157A (zh) * 2013-07-04 2013-11-06 丁圣雨 Chukrasone B在治疗慢性阻塞性肺疾病的药物中的应用
CN105979959B (zh) 2013-08-09 2021-11-30 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
CN106573924B (zh) * 2014-04-22 2019-06-25 诺华股份有限公司 作为LpxC抑制剂的异噁唑啉异羟肟酸衍生物
PL3638665T3 (pl) 2017-06-13 2021-12-27 Bayer Aktiengesellschaft Chwastobójczo skuteczne 3-fenyloizoksazolino-5-karboksyamidy kwasów i estrów tetrahydro- i dihydrofuranokarboksylowych
HUE056695T2 (hu) 2017-06-13 2022-03-28 Bayer Ag Tetrahidro- és dihidrofurán-karbonsav-amidok gyomirtó 3-fenilizoxazolin-5-karboxamidjai
JP7198519B2 (ja) 2017-08-17 2023-01-04 バイエル・アクチエンゲゼルシヤフト シクロペンチルカルボン酸類及びエステル類の除草活性３－フェニル－５－トリフルオロメチルイソオキサゾリン－５－カルボキサミド類
PL3743411T3 (pl) 2018-01-25 2023-03-13 Bayer Aktiengesellschaft Herbicydowo czynne 3-fenyloizoksazolino-5-karboksyamidy z pochodnych kwasów cyklopentenylokarboksylowych
CA3133025A1 (en) 2019-03-12 2020-09-17 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenyl carboxylic acid esters
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55104273A (en) * 1979-02-05 1980-08-09 Sankyo Co Ltd 4-phenylisoxazole derivative and its preparation
JPS62103070A (ja) * 1985-10-29 1987-05-13 Mitsui Toatsu Chem Inc イソオキサゾリン誘導体および植物生長調節剤
US4731382A (en) * 1986-12-29 1988-03-15 Bristol-Myers Company Lipoxygenase inhibitory phenylalkanohydroxamic acids
US4861798A (en) * 1986-12-29 1989-08-29 Bristol-Myers Company Lipoxygenase inhibitory compounds
FR2639636B1 (fr) * 1988-11-30 1994-03-04 Novapharme Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant
US5258397A (en) * 1988-11-30 1993-11-02 Novapharme 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions
IL92915A0 (en) * 1989-01-05 1990-09-17 Ciba Geigy Ag Certain pyrrolylphenyl-substituted hydroxamic acid derivatives
DE3939010A1 (de) * 1989-11-25 1991-05-29 Hoechst Ag Isoxazoline, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschuetzende mittel
JP2787602B2 (ja) * 1990-01-24 1998-08-20 大鵬薬品工業株式会社 イソキサゾリン誘導体
EP0451790A1 (de) * 1990-04-12 1991-10-16 Hoechst Aktiengesellschaft 3,5-disubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu deren Herstellung, diese enthaltende Mittel und ihre Verwendung
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
US5140047A (en) * 1991-05-03 1992-08-18 Smithkline Beecham Corporation Lipoxygenase inhibitors
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
WO1994018158A1 (en) * 1993-02-15 1994-08-18 Pfizer Inc. Spiroalkylhydroxyureas for use as lipoxygenase inhibitors

Also Published As

Publication number Publication date
FI945557A (fi) 1995-05-27
DK0730588T3 (da) 1997-12-08
BR9408174A (pt) 1997-05-27
HU9601412D0 (en) 1996-07-29
GR3024133T3 (en) 1997-10-31
IL111670A (en) 1998-08-16
EP0730588A1 (en) 1996-09-11
DE69404044D1 (de) 1997-08-07
CN1136314A (zh) 1996-11-20
DE69404044T2 (de) 1997-10-16
NO962127D0 (no) 1996-05-24
CZ283564B6 (cs) 1998-05-13
CA2176255A1 (en) 1995-06-01
CZ151096A3 (en) 1997-01-15
EG20693A (en) 1999-11-30
HUT76784A (en) 1997-11-28
CO4180606A1 (es) 1995-06-07
KR960705795A (ko) 1996-11-08
IL111670A0 (en) 1995-01-24
FI945557A0 (fi) 1994-11-25
ES2104424T3 (es) 1997-10-01
PE33495A1 (es) 1995-10-27
EP0730588B1 (en) 1997-07-02
JP2802547B2 (ja) 1998-09-24
AU687452B2 (en) 1998-02-26
ATE154932T1 (de) 1997-07-15
AU7821894A (en) 1995-06-13
CN1046274C (zh) 1999-11-10
JPH09500147A (ja) 1997-01-07
CA2176255C (en) 1999-02-23
PL314605A1 (en) 1996-09-16
KR0182324B1 (ko) 1999-05-01
WO1995014681A1 (en) 1995-06-01
US5716967A (en) 1998-02-10
NZ274244A (en) 1997-09-22

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