NO954479L - Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdom - Google Patents
Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdomInfo
- Publication number
- NO954479L NO954479L NO954479A NO954479A NO954479L NO 954479 L NO954479 L NO 954479L NO 954479 A NO954479 A NO 954479A NO 954479 A NO954479 A NO 954479A NO 954479 L NO954479 L NO 954479L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- alkynyl
- independently selected
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 229930014626 natural product Natural products 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 108091006112 ATPases Proteins 0.000 abstract 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
- C07C39/16—Bis-(hydroxyphenyl) alkanes; Tris-(hydroxyphenyl)alkanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anvendelse av en forbindelse av formelen (I), hvori Ar er et aromatisk ringsystem som omfatter en eller flere valgfritt substituerte fenylringer valgfritt lenket til eller sammensmeltet med en eller flere andre valgfritt substituerte fenylringer eller en eller flere 5- eller 6-leddede, valgfritt substituerte hetrosykliske ringer hvori heteroatomet er oksygen; og hvori ringsystemet omfatter 1-4 fenylringer og hvori Ar kan være lenket til et annet Ar via en gruppe X hvori Ar utvelges uavhengig; hvor X er valgfritt substituert C1.20alkylen, C2.20alkenyleng eller C2.20alkynylen; R er hydrogen; C].20alkenyl, C2.20alkynyl, C2.20alkanoyl, C2.20alkynoyl, hvorav hver enkelt kan være valgfritt substituert; Rj utvelges uavhengig og er hydrogen; valgfritt substituert C,.20alkyl, C2.12alkenyl, C2_I2alkynyl; -COOR' -NR'R', halogen, -OR1, -COR', -CONR'R', =O, -SR', -SO3R', -SO2NR'R', -SOR', -S02R', -N02, -CN, glykosid, silyl; hvor R1 uavhengig er hydrogen; alkyl, alkenyl eller alkynyl som hvor for seg og fritt er substituert; og hvor to R,-grupper kan være sluttet sammen; hvori de valgfrie substituenter er en eller flere som uavhengig utvelges fra Ci.10alkyl, C2.10alkenyl, C2.,0alkynyl; -COOR" -NR"R", halogen, -OR", -COR", -CONR"R", -SR", =O, -SO3R", -S02NR"R", -SOR", -SO2", -N02) -CN; hvori R" uavhengig er hydrogen, alkyl, alkenyl eller alkynyl; n = l, 2 eller 3; m = l, 2, 3 eller 4; eller et farmasøytisk akseptabelt derivat derav i fremstillingen av et medikament til inhiberingen av virkningen av Ca"+-ATPase enzymer. Visse forbindelser av formelen (I) og farmasøytiske 8-lavandulyl fravon-preparater er nye.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPL918193 | 1993-06-03 | ||
PCT/AU1994/000297 WO1994028886A1 (en) | 1993-06-03 | 1994-06-03 | Use of natural products and related synthetic compounds for the treatment of cardiovascular disease |
Publications (2)
Publication Number | Publication Date |
---|---|
NO954479D0 NO954479D0 (no) | 1995-11-08 |
NO954479L true NO954479L (no) | 1996-02-02 |
Family
ID=3776946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO954479A NO954479L (no) | 1993-06-03 | 1995-11-08 | Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdom |
Country Status (16)
Country | Link |
---|---|
US (2) | US5741821A (no) |
EP (1) | EP0703780A4 (no) |
JP (1) | JPH09502163A (no) |
KR (1) | KR960702749A (no) |
CN (1) | CN1124922A (no) |
BG (1) | BG100166A (no) |
BR (1) | BR9406747A (no) |
CA (1) | CA2164317A1 (no) |
CZ (1) | CZ318795A3 (no) |
FI (1) | FI955786A (no) |
HU (1) | HUT74174A (no) |
NO (1) | NO954479L (no) |
PL (1) | PL311810A1 (no) |
SI (1) | SI9420037A (no) |
SK (1) | SK147995A3 (no) |
WO (1) | WO1994028886A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998052966A1 (en) | 1997-05-19 | 1998-11-26 | The Johns Hopkins University School Of Medecine | Tissue specific prodrug |
US6545131B1 (en) | 1997-05-19 | 2003-04-08 | The Johns Hopkins University | Tissue specific prodrug |
US6504014B1 (en) | 1997-05-19 | 2003-01-07 | The John Hopkins University | Tissue specific prodrug |
US6538022B1 (en) * | 1997-09-24 | 2003-03-25 | Orion Corporation | Compounds for deactivating phospholamban function on Ca-ATPase (phopholamban inhibitors) |
RU2137472C1 (ru) | 1998-10-12 | 1999-09-20 | Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН | Лекарственный препарат "гистохром" для лечения острого инфаркта миокарда и ишемической болезни сердца |
US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
JP2002541859A (ja) * | 1999-04-15 | 2002-12-10 | デフヘン・ナムローゼ・フェンノートシャップ | 化合物スクリーニング方法 |
US7053042B1 (en) | 1999-07-29 | 2006-05-30 | Samuel Denmeade | Activation of peptide prodrugs by hK2 |
WO2002026728A2 (en) * | 2000-09-28 | 2002-04-04 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
WO2002026224A2 (en) * | 2000-09-28 | 2002-04-04 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
EP1206934A1 (en) * | 2000-11-15 | 2002-05-22 | B. Braun Melsungen Ag | Blockade of sodium channels by phenol derivatives |
KR100704299B1 (ko) * | 2005-11-17 | 2007-04-09 | 한국생명공학연구원 | 신규한 퀴놀린계 화합물, 및 지네 추출물 또는 이로부터 분리된 화합물을 포함하는 심장순환계 질환의 예방 및 치료용 조성물 |
US9024273B2 (en) * | 2010-04-20 | 2015-05-05 | Varian Semiconductor Equipment Associates, Inc. | Method to generate molecular ions from ions with a smaller atomic mass |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2321620A (en) * | 1940-10-10 | 1943-06-15 | Du Pont | Phenolic compounds |
DE3527862A1 (de) * | 1985-08-02 | 1987-02-05 | Bayer Ag | Verfahren zur herstellung von bis-hydroxyphenyl-n-alkanen, neue bis-hydroxyphenyl-n-alkane und neue alkandione |
-
1994
- 1994-06-03 US US08/553,714 patent/US5741821A/en not_active Expired - Fee Related
- 1994-06-03 CN CN94192317A patent/CN1124922A/zh active Pending
- 1994-06-03 JP JP7501103A patent/JPH09502163A/ja active Pending
- 1994-06-03 EP EP94916850A patent/EP0703780A4/en not_active Withdrawn
- 1994-06-03 PL PL94311810A patent/PL311810A1/xx unknown
- 1994-06-03 SI SI9420037A patent/SI9420037A/sl unknown
- 1994-06-03 SK SK1479-95A patent/SK147995A3/sk unknown
- 1994-06-03 CZ CZ953187A patent/CZ318795A3/cs unknown
- 1994-06-03 CA CA002164317A patent/CA2164317A1/en not_active Abandoned
- 1994-06-03 BR BR9406747A patent/BR9406747A/pt not_active Application Discontinuation
- 1994-06-03 HU HU9503441A patent/HUT74174A/hu unknown
- 1994-06-03 WO PCT/AU1994/000297 patent/WO1994028886A1/en not_active Application Discontinuation
-
1995
- 1995-11-08 NO NO954479A patent/NO954479L/no unknown
- 1995-11-24 BG BG100166A patent/BG100166A/xx unknown
- 1995-12-01 FI FI955786A patent/FI955786A/fi unknown
- 1995-12-02 KR KR1019950705432A patent/KR960702749A/ko not_active Application Discontinuation
-
1997
- 1997-11-12 US US08/969,145 patent/US5859067A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5859067A (en) | 1999-01-12 |
BR9406747A (pt) | 1996-04-02 |
NO954479D0 (no) | 1995-11-08 |
JPH09502163A (ja) | 1997-03-04 |
US5741821A (en) | 1998-04-21 |
EP0703780A1 (en) | 1996-04-03 |
EP0703780A4 (en) | 1998-01-07 |
CN1124922A (zh) | 1996-06-19 |
CA2164317A1 (en) | 1994-12-22 |
BG100166A (en) | 1996-11-29 |
KR960702749A (ko) | 1996-05-23 |
FI955786A0 (fi) | 1995-12-01 |
PL311810A1 (en) | 1996-03-18 |
CZ318795A3 (en) | 1996-06-12 |
SK147995A3 (en) | 1997-04-09 |
WO1994028886A1 (en) | 1994-12-22 |
HU9503441D0 (en) | 1996-01-29 |
HUT74174A (en) | 1996-11-28 |
SI9420037A (en) | 1996-08-31 |
FI955786A (fi) | 1996-01-29 |
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