NO954479L - Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdom - Google Patents

Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdom

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Publication number
NO954479L
NO954479L NO954479A NO954479A NO954479L NO 954479 L NO954479 L NO 954479L NO 954479 A NO954479 A NO 954479A NO 954479 A NO954479 A NO 954479A NO 954479 L NO954479 L NO 954479L
Authority
NO
Norway
Prior art keywords
optionally substituted
alkyl
hydrogen
alkynyl
independently selected
Prior art date
Application number
NO954479A
Other languages
English (en)
Other versions
NO954479D0 (no
Inventor
Basil Don Roufogalis
Colin Charles Duke
Qian Li
Original Assignee
Univ Sydney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sydney filed Critical Univ Sydney
Publication of NO954479D0 publication Critical patent/NO954479D0/no
Publication of NO954479L publication Critical patent/NO954479L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C07C39/16—Bis-(hydroxyphenyl) alkanes; Tris-(hydroxyphenyl)alkanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Anvendelse av en forbindelse av formelen (I), hvori Ar er et aromatisk ringsystem som omfatter en eller flere valgfritt substituerte fenylringer valgfritt lenket til eller sammensmeltet med en eller flere andre valgfritt substituerte fenylringer eller en eller flere 5- eller 6-leddede, valgfritt substituerte hetrosykliske ringer hvori heteroatomet er oksygen; og hvori ringsystemet omfatter 1-4 fenylringer og hvori Ar kan være lenket til et annet Ar via en gruppe X hvori Ar utvelges uavhengig; hvor X er valgfritt substituert C1.20alkylen, C2.20alkenyleng eller C2.20alkynylen; R er hydrogen; C].20alkenyl, C2.20alkynyl, C2.20alkanoyl, C2.20alkynoyl, hvorav hver enkelt kan være valgfritt substituert; Rj utvelges uavhengig og er hydrogen; valgfritt substituert C,.20alkyl, C2.12alkenyl, C2_I2alkynyl; -COOR' -NR'R', halogen, -OR1, -COR', -CONR'R', =O, -SR', -SO3R', -SO2NR'R', -SOR', -S02R', -N02, -CN, glykosid, silyl; hvor R1 uavhengig er hydrogen; alkyl, alkenyl eller alkynyl som hvor for seg og fritt er substituert; og hvor to R,-grupper kan være sluttet sammen; hvori de valgfrie substituenter er en eller flere som uavhengig utvelges fra Ci.10alkyl, C2.10alkenyl, C2.,0alkynyl; -COOR" -NR"R", halogen, -OR", -COR", -CONR"R", -SR", =O, -SO3R", -S02NR"R", -SOR", -SO2", -N02) -CN; hvori R" uavhengig er hydrogen, alkyl, alkenyl eller alkynyl; n = l, 2 eller 3; m = l, 2, 3 eller 4; eller et farmasøytisk akseptabelt derivat derav i fremstillingen av et medikament til inhiberingen av virkningen av Ca"+-ATPase enzymer. Visse forbindelser av formelen (I) og farmasøytiske 8-lavandulyl fravon-preparater er nye.
NO954479A 1993-06-03 1995-11-08 Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdom NO954479L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL918193 1993-06-03
PCT/AU1994/000297 WO1994028886A1 (en) 1993-06-03 1994-06-03 Use of natural products and related synthetic compounds for the treatment of cardiovascular disease

Publications (2)

Publication Number Publication Date
NO954479D0 NO954479D0 (no) 1995-11-08
NO954479L true NO954479L (no) 1996-02-02

Family

ID=3776946

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954479A NO954479L (no) 1993-06-03 1995-11-08 Anvendelse av naturlige produkter og relaterte syntetiske forbindelser til behandling av kardio-vaskulær sykdom

Country Status (16)

Country Link
US (2) US5741821A (no)
EP (1) EP0703780A4 (no)
JP (1) JPH09502163A (no)
KR (1) KR960702749A (no)
CN (1) CN1124922A (no)
BG (1) BG100166A (no)
BR (1) BR9406747A (no)
CA (1) CA2164317A1 (no)
CZ (1) CZ318795A3 (no)
FI (1) FI955786A (no)
HU (1) HUT74174A (no)
NO (1) NO954479L (no)
PL (1) PL311810A1 (no)
SI (1) SI9420037A (no)
SK (1) SK147995A3 (no)
WO (1) WO1994028886A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545131B1 (en) 1997-05-19 2003-04-08 The Johns Hopkins University Tissue specific prodrug
US6504014B1 (en) 1997-05-19 2003-01-07 The John Hopkins University Tissue specific prodrug
US6265540B1 (en) 1997-05-19 2001-07-24 The Johns Hopkins University School Of Medicine Tissue specific prodrug
US6538022B1 (en) * 1997-09-24 2003-03-25 Orion Corporation Compounds for deactivating phospholamban function on Ca-ATPase (phopholamban inhibitors)
RU2137472C1 (ru) 1998-10-12 1999-09-20 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН Лекарственный препарат "гистохром" для лечения острого инфаркта миокарда и ишемической болезни сердца
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
CA2369478A1 (en) * 1999-04-15 2000-10-26 Devgen Nv Compound screening methods
US7053042B1 (en) 1999-07-29 2006-05-30 Samuel Denmeade Activation of peptide prodrugs by hK2
AU2002213429A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
EP1206934A1 (en) * 2000-11-15 2002-05-22 B. Braun Melsungen Ag Blockade of sodium channels by phenol derivatives
KR100704299B1 (ko) * 2005-11-17 2007-04-09 한국생명공학연구원 신규한 퀴놀린계 화합물, 및 지네 추출물 또는 이로부터 분리된 화합물을 포함하는 심장순환계 질환의 예방 및 치료용 조성물
US9024273B2 (en) * 2010-04-20 2015-05-05 Varian Semiconductor Equipment Associates, Inc. Method to generate molecular ions from ions with a smaller atomic mass

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2321620A (en) * 1940-10-10 1943-06-15 Du Pont Phenolic compounds
DE3527862A1 (de) * 1985-08-02 1987-02-05 Bayer Ag Verfahren zur herstellung von bis-hydroxyphenyl-n-alkanen, neue bis-hydroxyphenyl-n-alkane und neue alkandione

Also Published As

Publication number Publication date
EP0703780A4 (en) 1998-01-07
WO1994028886A1 (en) 1994-12-22
HUT74174A (en) 1996-11-28
JPH09502163A (ja) 1997-03-04
HU9503441D0 (en) 1996-01-29
SK147995A3 (en) 1997-04-09
PL311810A1 (en) 1996-03-18
US5741821A (en) 1998-04-21
CZ318795A3 (en) 1996-06-12
NO954479D0 (no) 1995-11-08
KR960702749A (ko) 1996-05-23
BR9406747A (pt) 1996-04-02
SI9420037A (en) 1996-08-31
CN1124922A (zh) 1996-06-19
CA2164317A1 (en) 1994-12-22
FI955786A (fi) 1996-01-29
BG100166A (en) 1996-11-29
US5859067A (en) 1999-01-12
EP0703780A1 (en) 1996-04-03
FI955786A0 (fi) 1995-12-01

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