NO952018L - Substituerte 3-(aminoalkylamino)-1,2-benzisoksazoler og beslektede forbindelser - Google Patents

Substituerte 3-(aminoalkylamino)-1,2-benzisoksazoler og beslektede forbindelser

Info

Publication number
NO952018L
NO952018L NO952018A NO952018A NO952018L NO 952018 L NO952018 L NO 952018L NO 952018 A NO952018 A NO 952018A NO 952018 A NO952018 A NO 952018A NO 952018 L NO952018 L NO 952018L
Authority
NO
Norway
Prior art keywords
compounds
benzisoxazoles
aminoalkylamino
substituted
related compounds
Prior art date
Application number
NO952018A
Other languages
English (en)
Other versions
NO304980B1 (no
NO952018D0 (no
Inventor
Mark G Palermo
Gerard J O'malley
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/150,301 external-priority patent/US5494908A/en
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of NO952018D0 publication Critical patent/NO952018D0/no
Publication of NO952018L publication Critical patent/NO952018L/no
Publication of NO304980B1 publication Critical patent/NO304980B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO952018A 1992-11-23 1995-05-22 Substituerte 3-(aminoalkylamino)-1,2-benzisoksazoler og beslektede forbindelser, farmas°ytiske preparater inneholdende dem og deres anvendelse for fremstilling av legemidler NO304980B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98002192A 1992-11-23 1992-11-23
US08/150,301 US5494908A (en) 1992-11-23 1993-11-12 Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
PCT/US1993/011416 WO1994012495A1 (en) 1992-11-23 1993-11-22 Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds

Publications (3)

Publication Number Publication Date
NO952018D0 NO952018D0 (no) 1995-05-22
NO952018L true NO952018L (no) 1995-05-22
NO304980B1 NO304980B1 (no) 1999-03-15

Family

ID=26847521

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952018A NO304980B1 (no) 1992-11-23 1995-05-22 Substituerte 3-(aminoalkylamino)-1,2-benzisoksazoler og beslektede forbindelser, farmas°ytiske preparater inneholdende dem og deres anvendelse for fremstilling av legemidler

Country Status (14)

Country Link
US (2) US5580982A (no)
EP (1) EP0669920B1 (no)
JP (1) JP3462501B2 (no)
AT (1) ATE232529T1 (no)
AU (1) AU690529B2 (no)
CA (1) CA2149918A1 (no)
DE (1) DE69332691T2 (no)
DK (1) DK0669920T3 (no)
ES (1) ES2187518T3 (no)
FI (1) FI952481A0 (no)
MX (1) MX9307332A (no)
NO (1) NO304980B1 (no)
NZ (1) NZ258747A (no)
PT (1) PT669920E (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
JP4119126B2 (ja) * 2000-04-28 2008-07-16 アカディア ファーマシューティカルズ，インコーポレーテッド ムスカリン性アゴニスト
US8933236B2 (en) 2012-05-22 2015-01-13 Xenon Pharmaceuticals Inc. N-substituted benzamides and methods of use thereof
DE602005019913D1 (de) * 2004-11-29 2010-04-22 Warner Lambert Co Therapeutische pyrazoloä3,4-büpyridine und -indazole
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
AU2011216950A1 (en) * 2010-02-16 2012-08-23 Pfizer Inc. (R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors
MX2014005297A (es) 2011-10-31 2014-09-11 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y su uso como agentes terapeuticos.
WO2013064984A1 (en) 2011-10-31 2013-05-10 Xenon Pharmaceuticals Inc. Biaryl ether sulfonamides and their use as therapeutic agents
CN104797555B (zh) 2012-07-06 2017-12-22 基因泰克公司 N‑取代的苯甲酰胺及其使用方法
HK1213476A1 (zh) 2013-03-14 2016-07-08 基因泰克公司 取代的三唑並吡啶及其使用方法
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
WO2014144545A2 (en) * 2013-03-15 2014-09-18 Genentech, Inc. Substituted benzoxazoles and methods of use thereof
CR20160296A (es) 2013-11-27 2016-09-20 Genentech Inc Benzamidas sustituidas y métodos para usarlas
US10005724B2 (en) 2014-07-07 2018-06-26 Genentech, Inc. Therapeutic compounds and methods of use thereof
EP3297989A1 (en) 2015-05-22 2018-03-28 Genentech, Inc. Substituted benzamides and methods of use thereof
EP3341353A1 (en) 2015-08-27 2018-07-04 Genentech, Inc. Therapeutic compounds and methods of use thereof
RU2018115718A (ru) 2015-09-28 2019-10-28 Дженентек, Инк. Терапевтические соединения и способы их применения
MA43304A (fr) 2015-11-25 2018-10-03 Genentech Inc Benzamides substitués utiles en tant que bloqueurs de canaux sodiques
US10766858B2 (en) 2016-03-30 2020-09-08 Genentech, Inc. Substituted benzamides and methods of use thereof
CA3039853A1 (en) 2016-10-17 2018-04-26 Genentech, Inc. Therapeutic compounds and methods of use thereof
JP2020511511A (ja) 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
WO2019165290A1 (en) 2018-02-26 2019-08-29 Genentech, Inc. Pyridine-sulfonamide compounds and their use against pain and related conditions
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
JP7175481B2 (ja) * 2018-04-27 2022-11-21 国立大学法人大阪大学 ベンゾイソオキサゾール化合物
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
WO2021079962A1 (ja) * 2019-10-24 2021-04-29 国立大学法人大阪大学 難聴の予防および／または治療用医薬組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681382A (en) 1969-02-07 1972-08-01 Ciba Geigy Corp 3-aminoindazoles
US3725431A (en) 1970-09-23 1973-04-03 Ciba Geigy Corp 1-aralkyl-3-aminoindazoles
US4533731A (en) * 1982-03-17 1985-08-06 Asahi Kasei Kogyo Kabushiki Kaisha Aminoindazole derivatives
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
US5134236A (en) * 1987-08-07 1992-07-28 Hoechst-Roussel Pharmaceuticals Incorporated Phenylhydrazones as intermediates 1-phenyl-3-(1-piperazenyl)-1H-indazoles
EP0302423A3 (en) * 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
ATE231505T1 (de) * 1991-03-28 2003-02-15 Eisai Co Ltd Neue heterocyclische/cyclische amine

Also Published As

Publication number Publication date
FI952481A7 (fi) 1995-05-22
NO304980B1 (no) 1999-03-15
NO952018D0 (no) 1995-05-22
EP0669920A4 (en) 1995-10-25
AU5676594A (en) 1994-06-22
FI952481L (fi) 1995-05-22
AU690529B2 (en) 1998-04-30
ES2187518T3 (es) 2003-06-16
US6046203A (en) 2000-04-04
DE69332691T2 (de) 2003-12-18
US5580982A (en) 1996-12-03
PT669920E (pt) 2003-06-30
JPH08506094A (ja) 1996-07-02
EP0669920A1 (en) 1995-09-06
JP3462501B2 (ja) 2003-11-05
CA2149918A1 (en) 1994-06-09
FI952481A0 (fi) 1995-05-22
DE69332691D1 (de) 2003-03-20
ATE232529T1 (de) 2003-02-15
MX9307332A (es) 1994-07-29
DK0669920T3 (da) 2003-05-26
EP0669920B1 (en) 2003-02-12
NZ258747A (en) 1997-02-24

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Legal Events

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN MAY 2001