ATE232529T1 - Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungen - Google Patents
Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungenInfo
- Publication number
- ATE232529T1 ATE232529T1 AT94902374T AT94902374T ATE232529T1 AT E232529 T1 ATE232529 T1 AT E232529T1 AT 94902374 T AT94902374 T AT 94902374T AT 94902374 T AT94902374 T AT 94902374T AT E232529 T1 ATE232529 T1 AT E232529T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- benzisoxazoles
- aminoalkylamino
- substituted
- related compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98002192A | 1992-11-23 | 1992-11-23 | |
US08/150,301 US5494908A (en) | 1992-11-23 | 1993-11-12 | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
PCT/US1993/011416 WO1994012495A1 (en) | 1992-11-23 | 1993-11-22 | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE232529T1 true ATE232529T1 (de) | 2003-02-15 |
Family
ID=26847521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94902374T ATE232529T1 (de) | 1992-11-23 | 1993-11-22 | Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungen |
Country Status (14)
Country | Link |
---|---|
US (2) | US5580982A (de) |
EP (1) | EP0669920B1 (de) |
JP (1) | JP3462501B2 (de) |
AT (1) | ATE232529T1 (de) |
AU (1) | AU690529B2 (de) |
CA (1) | CA2149918A1 (de) |
DE (1) | DE69332691T2 (de) |
DK (1) | DK0669920T3 (de) |
ES (1) | ES2187518T3 (de) |
FI (1) | FI952481A (de) |
MX (1) | MX9307332A (de) |
NO (1) | NO304980B1 (de) |
NZ (1) | NZ258747A (de) |
PT (1) | PT669920E (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
TW200505900A (en) * | 2000-04-28 | 2005-02-16 | Acadia Pharm Inc | Muscarinic agonists |
BRPI0518693A2 (pt) * | 2004-11-29 | 2008-12-02 | Warner Lambert Co | pirazol [3,4-b]piridinas e indazàis terapÊuticos, bem como composiÇço farmacÊutica e uso dos mesmos |
DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
MX2012008721A (es) * | 2010-02-16 | 2012-08-17 | Pfizer | (r)-4-((4-((4-(tetrahidrofuran-3-iloxi)benzo[d]isoxazol-3-iloxi)m etil) tetrahidro-2h-piran-4-ol, un agonista pacial de receptores 5-ht4. |
ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
CA2855019A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
US8952169B2 (en) | 2012-05-22 | 2015-02-10 | Xenon Pharmaceuticals Inc. | N-substituted benzamides and methods of use thereof |
WO2014008458A2 (en) | 2012-07-06 | 2014-01-09 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
KR20150131233A (ko) | 2013-03-14 | 2015-11-24 | 제넨테크, 인크. | 치환된 트리아졸로피리딘 및 이의 사용 방법 |
CN105492430B (zh) * | 2013-03-15 | 2017-10-10 | 基因泰克公司 | 取代的苯并噁唑及其使用方法 |
WO2014144545A2 (en) * | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
JP6383418B2 (ja) | 2013-11-27 | 2018-08-29 | ジェネンテック, インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
US10005724B2 (en) | 2014-07-07 | 2018-06-26 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
JP2018520107A (ja) | 2015-05-22 | 2018-07-26 | ジェネンテック, インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
CN108137477A (zh) | 2015-08-27 | 2018-06-08 | 基因泰克公司 | 治疗化合物及其使用方法 |
MX2018003828A (es) | 2015-09-28 | 2018-06-22 | Genentech Inc | Compuestos terapeuticos y sus metodos de uso. |
CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
CN109071426A (zh) | 2016-03-30 | 2018-12-21 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
CA3039853A1 (en) | 2016-10-17 | 2018-04-26 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
CN110546148A (zh) | 2017-03-24 | 2019-12-06 | 基因泰克公司 | 作为钠通道抑制剂的4-哌啶-n-(嘧啶-4-基)色满-7-磺酰胺衍生物 |
WO2019165290A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
JP2021519788A (ja) | 2018-03-30 | 2021-08-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物 |
JP7175481B2 (ja) * | 2018-04-27 | 2022-11-21 | 国立大学法人大阪大学 | ベンゾイソオキサゾール化合物 |
WO2021079962A1 (ja) * | 2019-10-24 | 2021-04-29 | 国立大学法人大阪大学 | 難聴の予防および/または治療用医薬組成物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3381617D1 (de) * | 1982-03-17 | 1990-07-05 | Asahi Chemical Ind | Indazol-derivate. |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
US4999356A (en) * | 1987-08-07 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-phenyl-3-(1-piperazinyl)-1H-indazoles |
US5134236A (en) * | 1987-08-07 | 1992-07-28 | Hoechst-Roussel Pharmaceuticals Incorporated | Phenylhydrazones as intermediates 1-phenyl-3-(1-piperazenyl)-1H-indazoles |
EP0302423A3 (de) * | 1987-08-07 | 1991-01-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-Phenyl-3-(1-piperazinyl)-1H-Indazole, Verfahren und Zwischenprodukte zu deren Herstellung und deren Anwendung als Arzneimittel |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
EP0646115B1 (de) * | 1991-03-28 | 2003-01-22 | Eisai Co., Ltd. | Neue heterocyclische/cyclische amine |
-
1993
- 1993-11-22 DK DK94902374T patent/DK0669920T3/da active
- 1993-11-22 PT PT94902374T patent/PT669920E/pt unknown
- 1993-11-22 NZ NZ258747A patent/NZ258747A/en unknown
- 1993-11-22 DE DE69332691T patent/DE69332691T2/de not_active Expired - Fee Related
- 1993-11-22 CA CA002149918A patent/CA2149918A1/en not_active Abandoned
- 1993-11-22 ES ES94902374T patent/ES2187518T3/es not_active Expired - Lifetime
- 1993-11-22 JP JP51335294A patent/JP3462501B2/ja not_active Expired - Fee Related
- 1993-11-22 EP EP94902374A patent/EP0669920B1/de not_active Expired - Lifetime
- 1993-11-22 AU AU56765/94A patent/AU690529B2/en not_active Ceased
- 1993-11-22 AT AT94902374T patent/ATE232529T1/de not_active IP Right Cessation
- 1993-11-23 MX MX9307332A patent/MX9307332A/es not_active Application Discontinuation
-
1995
- 1995-05-22 NO NO952018A patent/NO304980B1/no not_active IP Right Cessation
- 1995-05-22 FI FI952481A patent/FI952481A/fi not_active IP Right Cessation
- 1995-06-06 US US08/470,520 patent/US5580982A/en not_active Expired - Lifetime
- 1995-06-06 US US08/471,197 patent/US6046203A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NO952018L (no) | 1995-05-22 |
US6046203A (en) | 2000-04-04 |
DE69332691D1 (de) | 2003-03-20 |
JPH08506094A (ja) | 1996-07-02 |
NO304980B1 (no) | 1999-03-15 |
JP3462501B2 (ja) | 2003-11-05 |
US5580982A (en) | 1996-12-03 |
FI952481A0 (fi) | 1995-05-22 |
FI952481A (fi) | 1995-05-22 |
AU690529B2 (en) | 1998-04-30 |
MX9307332A (es) | 1994-07-29 |
DE69332691T2 (de) | 2003-12-18 |
DK0669920T3 (da) | 2003-05-26 |
PT669920E (pt) | 2003-06-30 |
NO952018D0 (no) | 1995-05-22 |
CA2149918A1 (en) | 1994-06-09 |
EP0669920A4 (de) | 1995-10-25 |
EP0669920A1 (de) | 1995-09-06 |
EP0669920B1 (de) | 2003-02-12 |
ES2187518T3 (es) | 2003-06-16 |
AU5676594A (en) | 1994-06-22 |
NZ258747A (en) | 1997-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |