ATE232529T1 - Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungen - Google Patents

Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungen

Info

Publication number
ATE232529T1
ATE232529T1 AT94902374T AT94902374T ATE232529T1 AT E232529 T1 ATE232529 T1 AT E232529T1 AT 94902374 T AT94902374 T AT 94902374T AT 94902374 T AT94902374 T AT 94902374T AT E232529 T1 ATE232529 T1 AT E232529T1
Authority
AT
Austria
Prior art keywords
compounds
benzisoxazoles
aminoalkylamino
substituted
related compounds
Prior art date
Application number
AT94902374T
Other languages
English (en)
Inventor
Mark G Palermo
Gerard J O'malley
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/150,301 external-priority patent/US5494908A/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE232529T1 publication Critical patent/ATE232529T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
AT94902374T 1992-11-23 1993-11-22 Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungen ATE232529T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98002192A 1992-11-23 1992-11-23
US08/150,301 US5494908A (en) 1992-11-23 1993-11-12 Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
PCT/US1993/011416 WO1994012495A1 (en) 1992-11-23 1993-11-22 Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds

Publications (1)

Publication Number Publication Date
ATE232529T1 true ATE232529T1 (de) 2003-02-15

Family

ID=26847521

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94902374T ATE232529T1 (de) 1992-11-23 1993-11-22 Substituierte 3-(aminoalkylamino)-1,2- benzisoxazole und verwandte verbindungen

Country Status (14)

Country Link
US (2) US5580982A (de)
EP (1) EP0669920B1 (de)
JP (1) JP3462501B2 (de)
AT (1) ATE232529T1 (de)
AU (1) AU690529B2 (de)
CA (1) CA2149918A1 (de)
DE (1) DE69332691T2 (de)
DK (1) DK0669920T3 (de)
ES (1) ES2187518T3 (de)
FI (1) FI952481A (de)
MX (1) MX9307332A (de)
NO (1) NO304980B1 (de)
NZ (1) NZ258747A (de)
PT (1) PT669920E (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
KR20030005306A (ko) * 2000-04-28 2003-01-17 아카디아 파마슈티칼스 인코포레이티드 무스카린성 작용제
ES2339794T3 (es) * 2004-11-29 2010-05-25 Warner-Lambert Company Llc Pirazolo(3,4-b)piridinas e indazoles terapeuticos.
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
KR20120123089A (ko) * 2010-02-16 2012-11-07 화이자 인코포레이티드 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올
RU2014121984A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Бензолсульфонамидные соединения и их применение в качестве терапевтических средств
MX2014005304A (es) 2011-10-31 2015-03-20 Xenon Pharmaceuticals Inc Biaril eter sulfonamidas y su uso como agentes terapeuticos.
AU2013266398A1 (en) 2012-05-22 2015-01-22 Genentech, Inc. N-substituted benzamides and their use in the treatment of pain
MX2015000164A (es) 2012-07-06 2015-08-12 Genentech Inc Benzamidas n-sustituidas y metodos para usarlas.
RU2015143906A (ru) 2013-03-14 2017-04-18 Дженентек, Инк. Замещенные триазолопиридины и способы их применения
RU2015143834A (ru) 2013-03-15 2017-04-24 Дженентек, Инк. Замещенные бензоксазолы и способы их применения
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
EA201691085A1 (ru) 2013-11-27 2017-02-28 Дженентек, Инк. Замещенные бензамиды и способы их применения
CN106715418A (zh) 2014-07-07 2017-05-24 基因泰克公司 治疗化合物及其使用方法
CR20170591A (es) 2015-05-22 2018-05-07 Genentech Inc Benzamidas sustituidas y métodos para utilizarlas
CN108137477A (zh) 2015-08-27 2018-06-08 基因泰克公司 治疗化合物及其使用方法
CA2999769A1 (en) 2015-09-28 2017-04-06 Genentech, Inc. Therapeutic compounds and methods of use thereof
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3854782A1 (de) 2016-03-30 2021-07-28 Genentech, Inc. Substituierte benzamide und verfahren zur verwendung davon
MX2019004232A (es) 2016-10-17 2019-08-01 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos.
US10793550B2 (en) 2017-03-24 2020-10-06 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
US11028075B2 (en) 2018-02-26 2021-06-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
US11548882B2 (en) 2018-04-27 2023-01-10 Osaka University Benzisoxazole compound
WO2021079962A1 (ja) * 2019-10-24 2021-04-29 国立大学法人大阪大学 難聴の予防および／または治療用医薬組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533731A (en) * 1982-03-17 1985-08-06 Asahi Kasei Kogyo Kabushiki Kaisha Aminoindazole derivatives
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
US5134236A (en) * 1987-08-07 1992-07-28 Hoechst-Roussel Pharmaceuticals Incorporated Phenylhydrazones as intermediates 1-phenyl-3-(1-piperazenyl)-1H-indazoles
EP0302423A3 (de) * 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-Phenyl-3-(1-piperazinyl)-1H-Indazole, Verfahren und Zwischenprodukte zu deren Herstellung und deren Anwendung als Arzneimittel
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
PL171914B1 (pl) * 1991-03-28 1997-06-30 Eisai Co Ltd Sposób wytwarzania pochodnych aminy heterocyklicznej PL PL PL PL PL PL PL

Also Published As

Publication number Publication date
FI952481A0 (fi) 1995-05-22
DE69332691D1 (de) 2003-03-20
FI952481A (fi) 1995-05-22
DE69332691T2 (de) 2003-12-18
PT669920E (pt) 2003-06-30
NO952018D0 (no) 1995-05-22
CA2149918A1 (en) 1994-06-09
ES2187518T3 (es) 2003-06-16
AU690529B2 (en) 1998-04-30
JPH08506094A (ja) 1996-07-02
NO952018L (no) 1995-05-22
JP3462501B2 (ja) 2003-11-05
US5580982A (en) 1996-12-03
US6046203A (en) 2000-04-04
NO304980B1 (no) 1999-03-15
NZ258747A (en) 1997-02-24
DK0669920T3 (da) 2003-05-26
EP0669920A4 (de) 1995-10-25
MX9307332A (es) 1994-07-29
EP0669920A1 (de) 1995-09-06
EP0669920B1 (de) 2003-02-12
AU5676594A (en) 1994-06-22

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties