NO944241L - Fremstilling og anvendelse av cykliske heksapeptider - Google Patents

Fremstilling og anvendelse av cykliske heksapeptider

Info

Publication number
NO944241L
NO944241L NO944241A NO944241A NO944241L NO 944241 L NO944241 L NO 944241L NO 944241 A NO944241 A NO 944241A NO 944241 A NO944241 A NO 944241A NO 944241 L NO944241 L NO 944241L
Authority
NO
Norway
Prior art keywords
alkyl
cycloalkyl
alkoxy
alpha
amino acid
Prior art date
Application number
NO944241A
Other languages
English (en)
Other versions
NO944241D0 (no
Inventor
Mitsuhiro Wakimasu
Takashi Kikuchi
Akira Kawada
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO944241D0 publication Critical patent/NO944241D0/no
Publication of NO944241L publication Critical patent/NO944241L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cyklisk heksapeptid representert ved formel:. der A representerer et D-sur-a-aminosyreresidie; Y er et sur-a-aminosyreresidie; C er et L-a-aminosyreresidie; Rer en gruppe representert ved formel:der Xog Xuavhengig av hverandre er H, en-alkyl, en C-alkoksy, halogen, eller nitro, og kan binde sammen for å danne en ring 1 samvirke med det tilgrensende karbonatom; Rer C_alkyl, C_cykloalkyl, C3 7-cykloalkyl-C1_3-alkyl, C-alkyltlo-C-alkyl, C-cykloalkyltlo-C_-alkyl, Calkoksy-C-alkyl, C_-cykloalkoksy-C-alkyl,alkyltlo, C-cykloalkyltlo, C-alkoksy eller c_cykloalkoksy;3 er H, C-alkyl, Cg_-cykloalkyl, -C, -COReller -CONHRnår2 ogalle er hydrogenatomer, er RIkke en isobutylgruppe eller et salt derav. Forbindelsene utviser ypperlig anta-gonistisk virkning mot endotelinreseptorer, særlig endotelin B-reseptorer.
NO944241A 1993-11-08 1994-11-07 Fremstilling og anvendelse av cykliske heksapeptider NO944241L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27872293 1993-11-08
JP11236594 1994-05-26

Publications (2)

Publication Number Publication Date
NO944241D0 NO944241D0 (no) 1994-11-07
NO944241L true NO944241L (no) 1995-05-09

Family

ID=26451544

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944241A NO944241L (no) 1993-11-08 1994-11-07 Fremstilling og anvendelse av cykliske heksapeptider

Country Status (7)

Country Link
US (1) US5948754A (no)
EP (1) EP0655463B1 (no)
AT (1) ATE184021T1 (no)
CA (1) CA2135151A1 (no)
DE (1) DE69420361T2 (no)
FI (1) FI945227A (no)
NO (1) NO944241L (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714909A1 (en) * 1994-12-01 1996-06-05 Takeda Chemical Industries, Ltd. Composition for prophylaxis or treatment of pulmonary circulatory diseases
EP0815870A3 (en) * 1996-06-27 2000-05-03 Takeda Chemical Industries, Ltd. Composition for prohylaxis or treatment of cerebral infarction
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
US6894071B2 (en) 2001-11-01 2005-05-17 Spectrum Pharmaceuticals, Inc. Medical compositions for intravesical treatment of bladder cancer
JP2006508086A (ja) 2002-10-24 2006-03-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 固形腫瘍を予防および治療するための方法および組成物
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
US8217010B2 (en) 2002-10-24 2012-07-10 The Board Of Trustees Of The University Of Illinois Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
US20070032422A1 (en) 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
RU2009111605A (ru) 2006-08-31 2010-10-10 Спектрум Фармасьютикалз, Инк. (Us) Сенсибилизация опухолевых клеток к лучевой терапии посредством введения агонистов эндотелина
US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
ATE155486T1 (de) * 1991-08-13 1997-08-15 Takeda Chemical Industries Ltd Zyklische peptide und ihre verwendung
ES2133295T3 (es) * 1991-11-19 1999-09-16 Takeda Chemical Industries Ltd Peptidos ciclicos y su uso.
TW217417B (no) * 1991-12-04 1993-12-11 Manyu Seiyaku Kk

Also Published As

Publication number Publication date
US5948754A (en) 1999-09-07
FI945227A (fi) 1995-05-09
EP0655463B1 (en) 1999-09-01
EP0655463A1 (en) 1995-05-31
DE69420361D1 (de) 1999-10-07
FI945227A0 (fi) 1994-11-07
NO944241D0 (no) 1994-11-07
CA2135151A1 (en) 1995-05-09
ATE184021T1 (de) 1999-09-15
DE69420361T2 (de) 1999-12-16

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application